|
IL99066A
(en)
*
|
1990-08-03 |
1996-01-31 |
Sterling Winthrop Inc |
Nuclease-resistant compounds containing oligonucleotide sequences having either or both of the ends, and preparations containing them
|
|
US5965722A
(en)
*
|
1991-05-21 |
1999-10-12 |
Isis Pharmaceuticals, Inc. |
Antisense inhibition of ras gene with chimeric and alternating oligonucleotides
|
|
US6335434B1
(en)
|
1998-06-16 |
2002-01-01 |
Isis Pharmaceuticals, Inc., |
Nucleosidic and non-nucleosidic folate conjugates
|
|
US8153602B1
(en)
|
1991-11-19 |
2012-04-10 |
Isis Pharmaceuticals, Inc. |
Composition and methods for the pulmonary delivery of nucleic acids
|
|
US5571903A
(en)
*
|
1993-07-09 |
1996-11-05 |
Lynx Therapeutics, Inc. |
Auto-ligating oligonucleotide compounds
|
|
ATE247128T1
(de)
|
1993-09-03 |
2003-08-15 |
Isis Pharmaceuticals Inc |
Aminoderivatisierte nukleoside und oligonukleoside
|
|
US5646155A
(en)
*
|
1994-05-12 |
1997-07-08 |
University Of Massachusetts Medical Center |
Drugs to prevent recurrent herpes virus infections
|
|
US5693791A
(en)
*
|
1995-04-11 |
1997-12-02 |
Truett; William L. |
Antibiotics and process for preparation
|
|
US6420549B1
(en)
|
1995-06-06 |
2002-07-16 |
Isis Pharmaceuticals, Inc. |
Oligonucleotide analogs having modified dimers
|
|
US5856464A
(en)
*
|
1995-06-07 |
1999-01-05 |
Lajolla Pharmaceutical Company |
Selective capping solution phase oligonucleotide synthesis
|
|
US5854033A
(en)
|
1995-11-21 |
1998-12-29 |
Yale University |
Rolling circle replication reporter systems
|
|
US5898031A
(en)
|
1996-06-06 |
1999-04-27 |
Isis Pharmaceuticals, Inc. |
Oligoribonucleotides for cleaving RNA
|
|
US7812149B2
(en)
|
1996-06-06 |
2010-10-12 |
Isis Pharmaceuticals, Inc. |
2′-Fluoro substituted oligomeric compounds and compositions for use in gene modulations
|
|
US20040266706A1
(en)
*
|
2002-11-05 |
2004-12-30 |
Muthiah Manoharan |
Cross-linked oligomeric compounds and their use in gene modulation
|
|
US20040171028A1
(en)
*
|
1996-06-06 |
2004-09-02 |
Baker Brenda F. |
Phosphorous-linked oligomeric compounds and their use in gene modulation
|
|
US20070275921A1
(en)
*
|
1996-06-06 |
2007-11-29 |
Isis Pharmaceuticals, Inc. |
Oligomeric Compounds That Facilitate Risc Loading
|
|
US20050042647A1
(en)
*
|
1996-06-06 |
2005-02-24 |
Baker Brenda F. |
Phosphorous-linked oligomeric compounds and their use in gene modulation
|
|
US9096636B2
(en)
|
1996-06-06 |
2015-08-04 |
Isis Pharmaceuticals, Inc. |
Chimeric oligomeric compounds and their use in gene modulation
|
|
US20030044941A1
(en)
|
1996-06-06 |
2003-03-06 |
Crooke Stanley T. |
Human RNase III and compositions and uses thereof
|
|
SE9603171D0
(sv)
*
|
1996-08-30 |
1996-08-30 |
Marek Kwiatkowski |
Solid phase synthesis
|
|
US6111085A
(en)
*
|
1996-09-13 |
2000-08-29 |
Isis Pharmaceuticals, Inc. |
Carbamate-derivatized nucleosides and oligonucleosides
|
|
US6172209B1
(en)
|
1997-02-14 |
2001-01-09 |
Isis Pharmaceuticals Inc. |
Aminooxy-modified oligonucleotides and methods for making same
|
|
US6576752B1
(en)
|
1997-02-14 |
2003-06-10 |
Isis Pharmaceuticals, Inc. |
Aminooxy functionalized oligomers
|
|
US6127533A
(en)
|
1997-02-14 |
2000-10-03 |
Isis Pharmaceuticals, Inc. |
2'-O-aminooxy-modified oligonucleotides
|
|
US6887906B1
(en)
|
1997-07-01 |
2005-05-03 |
Isispharmaceuticals, Inc. |
Compositions and methods for the delivery of oligonucleotides via the alimentary canal
|
|
US6383808B1
(en)
|
2000-09-11 |
2002-05-07 |
Isis Pharmaceuticals, Inc. |
Antisense inhibition of clusterin expression
|
|
AU770896C
(en)
*
|
1998-09-29 |
2006-09-07 |
Gamida Cell Ltd. |
Methods of controlling proliferation and differentiation of stem and progenitor cells
|
|
US20040186071A1
(en)
*
|
1998-04-13 |
2004-09-23 |
Bennett C. Frank |
Antisense modulation of CD40 expression
|
|
US7321828B2
(en)
*
|
1998-04-13 |
2008-01-22 |
Isis Pharmaceuticals, Inc. |
System of components for preparing oligonucleotides
|
|
JP2002515514A
(ja)
|
1998-05-21 |
2002-05-28 |
アイシス・ファーマシューティカルス・インコーポレーテッド |
オリゴヌクレオチドの局所送逹のための組成物及び方法
|
|
EP1469009A2
(en)
*
|
1998-05-21 |
2004-10-20 |
Isis Parmaceuticals, Inc. |
Compositions and methods for non-parenteral delivery of oligonucleotides
|
|
US6867294B1
(en)
|
1998-07-14 |
2005-03-15 |
Isis Pharmaceuticals, Inc. |
Gapped oligomers having site specific chiral phosphorothioate internucleoside linkages
|
|
US6242589B1
(en)
|
1998-07-14 |
2001-06-05 |
Isis Pharmaceuticals, Inc. |
Phosphorothioate oligonucleotides having modified internucleoside linkages
|
|
US20040009938A1
(en)
*
|
1998-08-07 |
2004-01-15 |
Muthiah Manoharan |
Methods of enhancing renal uptake of oligonucleotides
|
|
US6673912B1
(en)
|
1998-08-07 |
2004-01-06 |
Isis Pharmaceuticals, Inc. |
2′-O-aminoethyloxyethyl-modified oligonucleotides
|
|
US6043352A
(en)
|
1998-08-07 |
2000-03-28 |
Isis Pharmaceuticals, Inc. |
2'-O-Dimethylaminoethyloxyethyl-modified oligonucleotides
|
|
US6225293B1
(en)
|
1998-09-02 |
2001-05-01 |
Isis Pharmaceuticals, Inc. |
Methods and compounds for tracking the biodistribution of macromolecule-carrier combinations
|
|
US6077709A
(en)
|
1998-09-29 |
2000-06-20 |
Isis Pharmaceuticals Inc. |
Antisense modulation of Survivin expression
|
|
US6300320B1
(en)
|
1999-01-05 |
2001-10-09 |
Isis Pharmaceuticals, Inc. |
Modulation of c-jun using inhibitors of protein kinase C
|
|
US6127124A
(en)
*
|
1999-01-20 |
2000-10-03 |
Isis Pharmaceuticals, Inc. |
Fluorescence based nuclease assay
|
|
US7098192B2
(en)
|
1999-04-08 |
2006-08-29 |
Isis Pharmaceuticals, Inc. |
Antisense oligonucleotide modulation of STAT3 expression
|
|
US7534605B2
(en)
*
|
1999-06-08 |
2009-05-19 |
Yissum Research Development Company Of The Hebrew University Of Jerusalem |
CD44 polypeptides, polynucleotides encoding same, antibodies directed thereagainst and method of using same for diagnosing and treating inflammatory diseases
|
|
US6656730B1
(en)
|
1999-06-15 |
2003-12-02 |
Isis Pharmaceuticals, Inc. |
Oligonucleotides conjugated to protein-binding drugs
|
|
US6593466B1
(en)
|
1999-07-07 |
2003-07-15 |
Isis Pharmaceuticals, Inc. |
Guanidinium functionalized nucleotides and precursors thereof
|
|
US6147200A
(en)
*
|
1999-08-19 |
2000-11-14 |
Isis Pharmaceuticals, Inc. |
2'-O-acetamido modified monomers and oligomers
|
|
US7332275B2
(en)
*
|
1999-10-13 |
2008-02-19 |
Sequenom, Inc. |
Methods for detecting methylated nucleotides
|
|
US20020055479A1
(en)
|
2000-01-18 |
2002-05-09 |
Cowsert Lex M. |
Antisense modulation of PTP1B expression
|
|
US6261840B1
(en)
|
2000-01-18 |
2001-07-17 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of PTP1B expression
|
|
US20030176385A1
(en)
*
|
2000-02-15 |
2003-09-18 |
Jingfang Ju |
Antisense modulation of protein expression
|
|
ATE452906T1
(de)
*
|
2000-04-13 |
2010-01-15 |
Thomas N Wight |
Therapeutische zusammenfassungen und verfahren zur modulierung von v3, eine isoform von versican
|
|
US6680172B1
(en)
|
2000-05-16 |
2004-01-20 |
Regents Of The University Of Michigan |
Treatments and markers for cancers of the central nervous system
|
|
US6686188B2
(en)
*
|
2000-05-26 |
2004-02-03 |
Amersham Plc |
Polynucleotide encoding a human myosin-like polypeptide expressed predominantly in heart and muscle
|
|
US6656700B2
(en)
*
|
2000-05-26 |
2003-12-02 |
Amersham Plc |
Isoforms of human pregnancy-associated protein-E
|
|
US20060166227A1
(en)
*
|
2000-06-20 |
2006-07-27 |
Stephen Kingsmore |
Protein expression profiling
|
|
US6323009B1
(en)
*
|
2000-06-28 |
2001-11-27 |
Molecular Staging, Inc. |
Multiply-primed amplification of nucleic acid sequences
|
|
US6958214B2
(en)
|
2000-07-10 |
2005-10-25 |
Sequenom, Inc. |
Polymorphic kinase anchor proteins and nucleic acids encoding the same
|
|
US8568766B2
(en)
|
2000-08-24 |
2013-10-29 |
Gattadahalli M. Anantharamaiah |
Peptides and peptide mimetics to treat pathologies associated with eye disease
|
|
US20020123474A1
(en)
*
|
2000-10-04 |
2002-09-05 |
Shannon Mark E. |
Human GTP-Rho binding protein2
|
|
AU2001296846B2
(en)
|
2000-10-12 |
2007-07-05 |
University Of Rochester |
Compositions that inhibit proliferation of cancer cells
|
|
US7767802B2
(en)
|
2001-01-09 |
2010-08-03 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of anti-apoptotic genes
|
|
US6573051B2
(en)
*
|
2001-03-09 |
2003-06-03 |
Molecular Staging, Inc. |
Open circle probes with intramolecular stem structures
|
|
ES2328796T3
(es)
|
2001-03-14 |
2009-11-18 |
Myriad Genetics, Inc. |
Interaccion tsg101-gag y uso de la misma.
|
|
US20050107595A1
(en)
*
|
2001-06-20 |
2005-05-19 |
Genentech, Inc. |
Compositions and methods for the diagnosis and treatment of tumor
|
|
CA2633171C
(en)
|
2001-06-20 |
2012-11-20 |
Genentech, Inc. |
Antibodies against tumor-associated antigenic target (tat) polypeptides
|
|
US7803915B2
(en)
*
|
2001-06-20 |
2010-09-28 |
Genentech, Inc. |
Antibody compositions for the diagnosis and treatment of tumor
|
|
CA2790034A1
(en)
|
2001-06-21 |
2003-01-03 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of superoxide dismutase 1, soluble expression
|
|
US6964950B2
(en)
|
2001-07-25 |
2005-11-15 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of C-reactive protein expression
|
|
US7425545B2
(en)
|
2001-07-25 |
2008-09-16 |
Isis Pharmaceuticals, Inc. |
Modulation of C-reactive protein expression
|
|
US20030096772A1
(en)
|
2001-07-30 |
2003-05-22 |
Crooke Rosanne M. |
Antisense modulation of acyl CoA cholesterol acyltransferase-2 expression
|
|
US7407943B2
(en)
|
2001-08-01 |
2008-08-05 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of apolipoprotein B expression
|
|
US7227014B2
(en)
|
2001-08-07 |
2007-06-05 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of apolipoprotein (a) expression
|
|
AU2002326589B2
(en)
*
|
2001-08-07 |
2008-06-05 |
University Of Delaware |
Compositions and methods for the prevention and treatment of Huntington's disease
|
|
US20040096880A1
(en)
*
|
2001-08-07 |
2004-05-20 |
Kmiec Eric B. |
Compositions and methods for the treatment of diseases exhibiting protein misassembly and aggregation
|
|
US20060068405A1
(en)
*
|
2004-01-27 |
2006-03-30 |
Alex Diber |
Methods and systems for annotating biomolecular sequences
|
|
NZ573831A
(en)
|
2001-09-18 |
2010-07-30 |
Genentech Inc |
Compositions and methods for the diagnosis and treatment of tumor, particularly breast tumor - TAT193
|
|
NZ585001A
(en)
|
2001-10-09 |
2011-08-26 |
Isis Pharmaceuticals Inc |
Antisense modulation of insulin-like growth factor binding protein 5 expression
|
|
US6750019B2
(en)
|
2001-10-09 |
2004-06-15 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of insulin-like growth factor binding protein 5 expression
|
|
AU2002364945A1
(en)
*
|
2001-10-25 |
2003-07-09 |
Neurogenetics, Inc. |
Genes and polymorphisms on chromosome 10 associated with alzheimer's disease and other neurodegenerative diseases
|
|
US20030224380A1
(en)
*
|
2001-10-25 |
2003-12-04 |
The General Hospital Corporation |
Genes and polymorphisms on chromosome 10 associated with Alzheimer's disease and other neurodegenerative diseases
|
|
US20030170678A1
(en)
*
|
2001-10-25 |
2003-09-11 |
Neurogenetics, Inc. |
Genetic markers for Alzheimer's disease and methods using the same
|
|
US6965025B2
(en)
|
2001-12-10 |
2005-11-15 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of connective tissue growth factor expression
|
|
KR20080106369A
(ko)
|
2002-01-02 |
2008-12-04 |
제넨테크, 인크. |
종양의 진단 및 치료 방법 및 이를 위한 조성물
|
|
IL152904A0
(en)
*
|
2002-01-24 |
2003-06-24 |
Gamida Cell Ltd |
Utilization of retinoid and vitamin d receptor antagonists for expansion of renewable stem cell populations
|
|
WO2003062404A1
(en)
*
|
2002-01-25 |
2003-07-31 |
Gamida-Cell Ltd. |
Methods of expanding stem and progenitor cells and expanded cell populations obtained thereby
|
|
US7553619B2
(en)
*
|
2002-02-08 |
2009-06-30 |
Qiagen Gmbh |
Detection method using dissociated rolling circle amplification
|
|
US20030180712A1
(en)
|
2002-03-20 |
2003-09-25 |
Biostratum Ab |
Inhibition of the beta3 subunit of L-type Ca2+ channels
|
|
US6800751B2
(en)
*
|
2002-04-11 |
2004-10-05 |
Isis Pharmaceuticals, Inc. |
Reagent and process for protecting nucleoside hydroxyl groups
|
|
KR20040101502A
(ko)
|
2002-04-16 |
2004-12-02 |
제넨테크, 인크. |
종양의 진단 및 치료 방법 및 이를 위한 조성물
|
|
CA2484676A1
(en)
*
|
2002-05-03 |
2003-11-13 |
Sequenom, Inc. |
Kinase anchor protein muteins, peptides thereof, and related methods
|
|
US7199107B2
(en)
|
2002-05-23 |
2007-04-03 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of kinesin-like 1 expression
|
|
US20050221326A1
(en)
*
|
2002-06-12 |
2005-10-06 |
Avi Orr-Urtreger |
Oligonucleotides antibodies and kits including same for treating prostate cancer and determining predisposition thereto
|
|
US20040092470A1
(en)
*
|
2002-06-18 |
2004-05-13 |
Leonard Sherry A. |
Dry powder oligonucleotide formualtion, preparation and its uses
|
|
CA2495478A1
(en)
|
2002-08-05 |
2004-02-12 |
University Of Rochester |
Protein transducing domain/deaminase chimeric proteins, related compounds, and uses thereof
|
|
CA2498777C
(en)
|
2002-09-13 |
2015-01-13 |
Replicor, Inc. |
Non-sequence complementary antiviral oligonucleotides
|
|
EP2322535A3
(en)
*
|
2002-09-20 |
2011-09-28 |
Yale University |
Riboswitches, methods for their use, and compositions for use with riboswitches
|
|
US7229976B2
(en)
|
2002-09-26 |
2007-06-12 |
Isis Pharmaceuticals, Inc. |
Modulation of forkhead box O1A expression
|
|
AU2003304203A1
(en)
*
|
2002-10-29 |
2005-01-04 |
Pharmacia Corporation |
Differentially expressed genes involved in cancer, the polypeptides encoded thereby, and methods of using the same
|
|
US9150605B2
(en)
*
|
2002-11-05 |
2015-10-06 |
Isis Pharmaceuticals, Inc. |
Compositions comprising alternating 2′-modified nucleosides for use in gene modulation
|
|
US9150606B2
(en)
*
|
2002-11-05 |
2015-10-06 |
Isis Pharmaceuticals, Inc. |
Compositions comprising alternating 2'-modified nucleosides for use in gene modulation
|
|
EP1560839A4
(en)
|
2002-11-05 |
2008-04-23 |
Isis Pharmaceuticals Inc |
CHIMERIC OLIGOMER COMPOUNDS AND THEIR USE IN GENE MODULATION
|
|
AU2003290598A1
(en)
|
2002-11-05 |
2004-06-03 |
Isis Pharmaceuticals, Inc. |
Modified oligonucleotides for use in rna interference
|
|
CA2505801A1
(en)
|
2002-11-13 |
2004-05-27 |
Rosanne Crooke |
Antisense modulation of apolipoprotein b expression
|
|
ES2420914T3
(es)
|
2002-11-13 |
2013-08-27 |
Genzyme Corporation |
Modulación antisentido de la expresión de la apolipoproteína B
|
|
US20060009378A1
(en)
*
|
2002-11-14 |
2006-01-12 |
Itshak Golan |
Novel galectin sequences and compositions and methods utilizing same for treating or diagnosing arthritis and other chronic inflammatory diseases
|
|
DK1569685T3
(da)
|
2002-11-15 |
2012-11-12 |
Univ Colorado Regents |
Komplementmodulatorer rettet mod komplementreceptor-2
|
|
WO2004046330A2
(en)
*
|
2002-11-15 |
2004-06-03 |
Morphotek, Inc. |
Methods of generating high-production of antibodies from hybridomas created by in vitro immunization
|
|
WO2004047749A2
(en)
|
2002-11-21 |
2004-06-10 |
University Of Utah Research Foundation |
Purinergic modulation of smell
|
|
US7144999B2
(en)
|
2002-11-23 |
2006-12-05 |
Isis Pharmaceuticals, Inc. |
Modulation of hypoxia-inducible factor 1 alpha expression
|
|
US9487823B2
(en)
|
2002-12-20 |
2016-11-08 |
Qiagen Gmbh |
Nucleic acid amplification
|
|
JP4886298B2
(ja)
|
2002-12-20 |
2012-02-29 |
キアゲン ゲゼルシャフト ミット ベシュレンクテル ハフツング |
核酸増幅
|
|
US6977153B2
(en)
*
|
2002-12-31 |
2005-12-20 |
Qiagen Gmbh |
Rolling circle amplification of RNA
|
|
JP4753863B2
(ja)
|
2003-02-11 |
2011-08-24 |
アンチセンス セラピューティクス リミテッド |
インスリン様増殖因子ｉ受容体発現の調節
|
|
US7002006B2
(en)
*
|
2003-02-12 |
2006-02-21 |
Isis Pharmaceuticals, Inc. |
Protection of nucleosides
|
|
JP2006525796A
(ja)
|
2003-02-27 |
2006-11-16 |
イェダ リサーチ アンド デベロップメント カンパニー リミテッド |
インフルエンザウイルス感染を処置および検出するために有用な核酸分子、ポリペプチド、抗体、およびそれらを含有する組成物
|
|
US7803781B2
(en)
|
2003-02-28 |
2010-09-28 |
Isis Pharmaceuticals, Inc. |
Modulation of growth hormone receptor expression and insulin-like growth factor expression
|
|
US20070141570A1
(en)
*
|
2003-03-07 |
2007-06-21 |
Sequenom, Inc. |
Association of polymorphic kinase anchor proteins with cardiac phenotypes and related methods
|
|
US20040185559A1
(en)
|
2003-03-21 |
2004-09-23 |
Isis Pharmaceuticals Inc. |
Modulation of diacylglycerol acyltransferase 1 expression
|
|
US8043834B2
(en)
*
|
2003-03-31 |
2011-10-25 |
Qiagen Gmbh |
Universal reagents for rolling circle amplification and methods of use
|
|
US7598227B2
(en)
|
2003-04-16 |
2009-10-06 |
Isis Pharmaceuticals Inc. |
Modulation of apolipoprotein C-III expression
|
|
US7399853B2
(en)
|
2003-04-28 |
2008-07-15 |
Isis Pharmaceuticals |
Modulation of glucagon receptor expression
|
|
US7276599B2
(en)
*
|
2003-06-02 |
2007-10-02 |
Isis Pharmaceuticals, Inc. |
Oligonucleotide synthesis with alternative solvents
|
|
CN1984921B
(zh)
|
2003-06-03 |
2010-06-16 |
Isis药物公司 |
存活蛋白表达的调节
|
|
ES2905724T3
(es)
|
2003-06-13 |
2022-04-11 |
Alnylam Europe Ag |
Acido ribonucleico bicatenario con elevada eficacia en un organismo
|
|
US20050016555A1
(en)
*
|
2003-07-24 |
2005-01-27 |
Lyles Mark B. |
Nucleic acid based filters
|
|
US7056332B2
(en)
*
|
2003-07-24 |
2006-06-06 |
Materials Evolution And Development Usa, Inc. |
Nucleic acid biomaterials and methods of formation and use
|
|
US7125859B2
(en)
*
|
2003-07-24 |
2006-10-24 |
Materials Evolution And Development Usa, Inc. |
Nucleic acid antioxidant compositions, methods for obtaining such compositions and formulations thereof
|
|
CA2533701A1
(en)
|
2003-07-31 |
2005-02-17 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds and compositions for use in modulation of small non-coding rnas
|
|
US7825235B2
(en)
|
2003-08-18 |
2010-11-02 |
Isis Pharmaceuticals, Inc. |
Modulation of diacylglycerol acyltransferase 2 expression
|
|
US20050053981A1
(en)
*
|
2003-09-09 |
2005-03-10 |
Swayze Eric E. |
Gapped oligomeric compounds having linked bicyclic sugar moieties at the termini
|
|
US20070123480A1
(en)
*
|
2003-09-11 |
2007-05-31 |
Replicor Inc. |
Oligonucleotides targeting prion diseases
|
|
JP5379347B2
(ja)
*
|
2003-09-18 |
2013-12-25 |
アイシス ファーマシューティカルズ， インコーポレーテッド |
４’−チオヌクレオシドおよびオリゴマー化合物
|
|
US7425544B2
(en)
|
2003-09-18 |
2008-09-16 |
Eli Lilly And Company |
Modulation of eIF4E expression
|
|
US7125945B2
(en)
*
|
2003-09-19 |
2006-10-24 |
Varian, Inc. |
Functionalized polymer for oligonucleotide purification
|
|
US20050191653A1
(en)
|
2003-11-03 |
2005-09-01 |
Freier Susan M. |
Modulation of SGLT2 expression
|
|
NZ596981A
(en)
|
2003-11-17 |
2013-10-25 |
Genentech Inc |
Compositions and methods for the treatment of tumor of hematopoietic origin
|
|
WO2006054296A2
(en)
|
2004-11-17 |
2006-05-26 |
Spectrum Dynamics Llc |
Methods of detecting prostate cancer
|
|
EP1711606A2
(en)
|
2004-01-20 |
2006-10-18 |
Isis Pharmaceuticals, Inc. |
Modulation of glucocorticoid receptor expression
|
|
US7468431B2
(en)
*
|
2004-01-22 |
2008-12-23 |
Isis Pharmaceuticals, Inc. |
Modulation of eIF4E-BP2 expression
|
|
US8778900B2
(en)
*
|
2004-01-22 |
2014-07-15 |
Isis Pharmaceuticals, Inc. |
Modulation of eIF4E-BP1 expression
|
|
US7842459B2
(en)
*
|
2004-01-27 |
2010-11-30 |
Compugen Ltd. |
Nucleotide and amino acid sequences, and assays and methods of use thereof for diagnosis
|
|
US8569474B2
(en)
|
2004-03-09 |
2013-10-29 |
Isis Pharmaceuticals, Inc. |
Double stranded constructs comprising one or more short strands hybridized to a longer strand
|
|
EP2700720A3
(en)
|
2004-03-15 |
2015-01-28 |
Isis Pharmaceuticals, Inc. |
Compositions and methods for optimizing cleavage of RNA by RNASE H
|
|
JP2007531794A
(ja)
|
2004-04-05 |
2007-11-08 |
アルニラム ファーマスーティカルズ インコーポレイテッド |
オリゴヌクレオチドの合成および精製に使用する方法および反応試薬
|
|
US20050244869A1
(en)
*
|
2004-04-05 |
2005-11-03 |
Brown-Driver Vickie L |
Modulation of transthyretin expression
|
|
US20050260755A1
(en)
*
|
2004-04-06 |
2005-11-24 |
Isis Pharmaceuticals, Inc. |
Sequential delivery of oligomeric compounds
|
|
EP3034510A1
(en)
|
2004-04-30 |
2016-06-22 |
Alnylam Pharmaceuticals Inc. |
Oligonucleotides comprising a c5-modified pyrimidine
|
|
WO2006083275A2
(en)
|
2004-05-21 |
2006-08-10 |
The Uab Research Foundation |
Variable lymphocyte receptors, related polypeptides and nucleic acids, and uses thereof
|
|
EP1766052A4
(en)
*
|
2004-06-03 |
2009-12-16 |
Isis Pharmaceuticals Inc |
CHIMERIC OLIGOMER COMPOSITIONS WITH CAP
|
|
US20090048192A1
(en)
*
|
2004-06-03 |
2009-02-19 |
Isis Pharmaceuticals, Inc. |
Double Strand Compositions Comprising Differentially Modified Strands for Use in Gene Modulation
|
|
JP2008501694A
(ja)
*
|
2004-06-03 |
2008-01-24 |
アイシス ファーマシューティカルズ、インク． |
遺伝子調節の使用のために個別に修飾された鎖を有する二本鎖組成物
|
|
US8394947B2
(en)
|
2004-06-03 |
2013-03-12 |
Isis Pharmaceuticals, Inc. |
Positionally modified siRNA constructs
|
|
WO2006023880A2
(en)
*
|
2004-08-23 |
2006-03-02 |
Isis Pharmaceuticals, Inc. |
Compounds and methods for the characterization of oligonucleotides
|
|
US7884086B2
(en)
|
2004-09-08 |
2011-02-08 |
Isis Pharmaceuticals, Inc. |
Conjugates for use in hepatocyte free uptake assays
|
|
WO2006030442A2
(en)
*
|
2004-09-16 |
2006-03-23 |
Gamida-Cell Ltd. |
Methods of ex vivo progenitor and stem cell expansion by co-culture with mesenchymal cells
|
|
PL1809303T3
(pl)
|
2004-09-23 |
2019-11-29 |
Arc Medical Devices Inc |
Kompozycje farmaceutyczne i sposoby dotyczące hamowania zrostów włóknistych lub stanów zapalnych przy użyciu fukanów o niskiej zawartości siarczanów
|
|
CA2588087A1
(en)
*
|
2004-11-15 |
2006-05-18 |
Obe Therapy Biotechnology S.A.S. |
Methods of reducing body fat
|
|
MX2007010922A
(es)
|
2005-03-10 |
2007-10-12 |
Genentech Inc |
Metodos y composiciones para modular la integridad vascular.
|
|
US7476733B2
(en)
*
|
2005-03-25 |
2009-01-13 |
The United States Of America As Represented By The Department Of Health And Human Services |
Development of a real-time PCR assay for detection of pneumococcal DNA and diagnosis of pneumococccal disease
|
|
EP1863908B1
(de)
|
2005-04-01 |
2010-11-17 |
Qiagen GmbH |
Reverse transkription und amplifikation von rna bei simultaner degradierung von dna
|
|
US9505867B2
(en)
|
2005-05-31 |
2016-11-29 |
Ecole Polytechmique Fédérale De Lausanne |
Triblock copolymers for cytoplasmic delivery of gene-based drugs
|
|
WO2006133022A2
(en)
|
2005-06-03 |
2006-12-14 |
The Johns Hopkins University |
Compositions and methods for decreasing microrna expression for the treatment of neoplasia
|
|
WO2006138145A1
(en)
|
2005-06-14 |
2006-12-28 |
Northwestern University |
Nucleic acid functionalized nanoparticles for therapeutic applications
|
|
WO2007007317A1
(en)
*
|
2005-07-07 |
2007-01-18 |
Yissum Research Development Company Of The Hebrew University Of Jerusalem |
Nucleic acid agents for downregulating h19, and methods of using same
|
|
US7776532B2
(en)
|
2005-08-11 |
2010-08-17 |
Synthetic Genomics, Inc. |
Method for in vitro recombination
|
|
US20100015604A1
(en)
|
2005-08-17 |
2010-01-21 |
Evriklia Lianidou |
Composition and method for determination of ck19 expression
|
|
ATE494372T1
(de)
|
2005-08-29 |
2011-01-15 |
Regulus Therapeutics Inc |
Verfahren für mir-122a-modulation
|
|
EP1762627A1
(de)
|
2005-09-09 |
2007-03-14 |
Qiagen GmbH |
Verfahren zur Aktivierung einer Nukleinsäure für eine Polymerase-Reaktion
|
|
IL172297A
(en)
|
2005-10-03 |
2016-03-31 |
Compugen Ltd |
Soluble vegfr-1 variants for the diagnosis of preeclampsia
|
|
EP1934331A4
(en)
|
2005-10-14 |
2009-01-21 |
Musc Found For Res Dev |
PAX2 AS A TARGET FOR THE INDUCTION OF DEFB1-MEDIATED TUMORIMMUNITY AND CANCER THERAPY
|
|
US8080534B2
(en)
|
2005-10-14 |
2011-12-20 |
Phigenix, Inc |
Targeting PAX2 for the treatment of breast cancer
|
|
CA2627025A1
(en)
|
2005-10-28 |
2007-05-03 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of huntingtin gene
|
|
EP2363134B1
(en)
|
2005-11-09 |
2014-01-08 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of factor V Leiden mutant gene
|
|
WO2007062380A2
(en)
|
2005-11-21 |
2007-05-31 |
Isis Pharmaceuticals, Inc. |
Modulation of eif4e-bp2 expression
|
|
US8846393B2
(en)
|
2005-11-29 |
2014-09-30 |
Gamida-Cell Ltd. |
Methods of improving stem cell homing and engraftment
|
|
US8313901B2
(en)
*
|
2005-12-21 |
2012-11-20 |
Yale University |
Methods and compositions related to the modulation of riboswitches
|
|
CN103301475B
(zh)
|
2005-12-28 |
2016-08-03 |
斯克里普斯研究所 |
药物组合物和表达载体以及调节基因表达的方法和核酸分子的应用
|
|
EP2216339A1
(en)
|
2006-01-16 |
2010-08-11 |
Compugen Ltd. |
Novel nucleotide and amino acid sequences, and methods of use thereof for diagnosis
|
|
PL2314594T3
(pl)
|
2006-01-27 |
2014-12-31 |
Isis Pharmaceuticals Inc |
Zmodyfikowane w pozycji 6 analogi bicykliczne kwasów nukleinowych
|
|
EP2388328A1
(en)
|
2006-01-27 |
2011-11-23 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds and compositions for the use in modulation of micrornas
|
|
US7569686B1
(en)
|
2006-01-27 |
2009-08-04 |
Isis Pharmaceuticals, Inc. |
Compounds and methods for synthesis of bicyclic nucleic acid analogs
|
|
SG170780A1
(en)
|
2006-03-31 |
2011-05-30 |
Alnylam Pharmaceuticals Inc |
Compositions and methods for inhibiting expression of eg5 gene
|
|
WO2007125173A2
(en)
*
|
2006-05-03 |
2007-11-08 |
Baltic Technology Development, Ltd. |
Antisense agents combining strongly bound base - modified oligonucleotide and artificial nuclease
|
|
WO2007134014A2
(en)
*
|
2006-05-05 |
2007-11-22 |
Isis Pharmaceuticals, Inc. |
Compounds and methods for modulating expression of gcgr
|
|
ES2874149T3
(es)
|
2006-05-11 |
2021-11-04 |
Alnylam Pharmaceuticals Inc |
Composiciones y métodos para inhibir la expresión del gen PCSK9
|
|
US7666854B2
(en)
*
|
2006-05-11 |
2010-02-23 |
Isis Pharmaceuticals, Inc. |
Bis-modified bicyclic nucleic acid analogs
|
|
DK2066684T3
(da)
*
|
2006-05-11 |
2012-10-22 |
Isis Pharmaceuticals Inc |
5´-Modificerede bicycliske nukleinsyreanaloge
|
|
CA2652770A1
(en)
|
2006-05-19 |
2007-11-29 |
Alnylam Pharmaceuticals, Inc. |
Rnai modulation of aha and therapeutic uses thereof
|
|
US7888498B2
(en)
|
2006-05-22 |
2011-02-15 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of IKK-B gene
|
|
EP2023938A4
(en)
*
|
2006-05-23 |
2010-11-10 |
Isis Pharmaceuticals Inc |
MODULATION OF THE EXPRESSION OF ChREBP
|
|
WO2008011473A2
(en)
|
2006-07-19 |
2008-01-24 |
Isis Pharmaceuticals, Inc. |
Compositions and their uses directed to hbxip
|
|
EP2061799A4
(en)
*
|
2006-09-11 |
2010-12-22 |
Univ Yale |
METHOD AND COMPOSITIONS FOR USE OF LYSIN RIBOSWITCHES
|
|
AU2007299629C1
(en)
|
2006-09-21 |
2012-05-10 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of the HAMP gene
|
|
MX2009003548A
(es)
|
2006-10-03 |
2009-04-15 |
Alnylam Pharmaceuticals Inc |
Formulaciones que contienen lipidos.
|
|
US20100166743A1
(en)
|
2006-10-06 |
2010-07-01 |
University Of Utah Research Foundation |
Method of detecting ocular diseases and pathologic conditions and treatment of same
|
|
WO2008136852A2
(en)
|
2006-11-01 |
2008-11-13 |
University Of Rochester |
Methods and compositions related to the structure and function of apobec3g
|
|
EP2104509A4
(en)
*
|
2006-12-11 |
2010-03-24 |
Univ Utah Res Found |
COMPOSITIONS AND METHODS FOR TREATMENT OF PATHOLOGICAL ANGIOGENESIS AND VASCULAR PERMEABILITY
|
|
EP2913341A1
(en)
|
2006-12-22 |
2015-09-02 |
University of Utah Research Foundation |
Method of detecting ocular diseases and pathologic conditions and treatment of same
|
|
EP2111450A2
(en)
*
|
2007-01-16 |
2009-10-28 |
Yissum Research Development Company of the Hebrew University of Jerusalem |
Nucleic acid constructs and methods for specific silencing of h19
|
|
US20100196403A1
(en)
*
|
2007-01-29 |
2010-08-05 |
Jacob Hochman |
Antibody conjugates for circumventing multi-drug resistance
|
|
WO2008098248A2
(en)
|
2007-02-09 |
2008-08-14 |
Northwestern University |
Particles for detecting intracellular targets
|
|
JP2010520749A
(ja)
*
|
2007-02-27 |
2010-06-17 |
ノースウェスタン ユニバーシティ |
ナノ粒子への分子の結合
|
|
EP2471925A1
(en)
|
2007-03-22 |
2012-07-04 |
Yale University |
Methods and compositions related to riboswitches that control alternative splicing
|
|
PE20090064A1
(es)
|
2007-03-26 |
2009-03-02 |
Novartis Ag |
Acido ribonucleico de doble cadena para inhibir la expresion del gen e6ap humano y composicion farmaceutica que lo comprende
|
|
AP2014007971A0
(en)
|
2007-03-29 |
2014-09-30 |
Alnylam Pharmaceuticals Inc |
Compositions and methods for inhibiting expressionof a gene from the ebola
|
|
AU2008251381B2
(en)
|
2007-05-11 |
2014-10-30 |
The Johns Hopkins University |
Biomarkers for melanoma
|
|
AU2008266684A1
(en)
|
2007-05-29 |
2008-12-24 |
Yale University |
Riboswitches and methods and compositions for use of and with riboswitches
|
|
CN101688251A
(zh)
*
|
2007-05-29 |
2010-03-31 |
耶鲁大学 |
与控制可变剪接和rna加工的核糖开关有关的方法和组合物
|
|
ES2388590T3
(es)
|
2007-05-30 |
2012-10-16 |
Isis Pharmaceuticals, Inc. |
Análogos de ácidos nucleicos bicíclicos con puente aminometileno N-sustituido.
|
|
EP2160464B1
(en)
|
2007-05-30 |
2014-05-21 |
Northwestern University |
Nucleic acid functionalized nanoparticles for therapeutic applications
|
|
US7807372B2
(en)
*
|
2007-06-04 |
2010-10-05 |
Northwestern University |
Screening sequence selectivity of oligonucleotide-binding molecules using nanoparticle based colorimetric assay
|
|
ES2386492T3
(es)
|
2007-06-08 |
2012-08-21 |
Isis Pharmaceuticals, Inc. |
Análogos de ácidos nucleicos bicíclicos carbocíclicos
|
|
ES2376507T5
(es)
*
|
2007-07-05 |
2015-08-31 |
Isis Pharmaceuticals, Inc. |
Análogos de ácidos nucleicos bicíclicos 6-disustituidos
|
|
EP2319926B1
(en)
|
2007-07-05 |
2016-08-31 |
Arrowhead Research Corporation |
DSRNA for treating viral infection
|
|
ES2439591T3
(es)
|
2007-08-15 |
2014-01-23 |
Isis Pharmaceuticals, Inc. |
Análogos de ácido nucleico de tetrahidropirano
|
|
DK2682400T5
(da)
|
2007-08-28 |
2017-11-27 |
Uab Research Foundation |
Syntetiske apolipoprotein E-efterlignende polypeptider og fremgangsmåder til anvendelse
|
|
CA2697957A1
(en)
|
2007-08-28 |
2009-03-12 |
Uab Research Foundation |
Synthetic apolipoprotein e mimicking polypeptides and methods of use
|
|
PL2769729T3
(pl)
|
2007-09-04 |
2019-09-30 |
Compugen Ltd. |
Polipeptydy i polinukleotydy i ich zastosowanie jako cel dla leków do wytwarzania leków i środków biologicznych
|
|
US8445217B2
(en)
|
2007-09-20 |
2013-05-21 |
Vanderbilt University |
Free solution measurement of molecular interactions by backscattering interferometry
|
|
WO2009039442A1
(en)
*
|
2007-09-21 |
2009-03-26 |
California Institute Of Technology |
Nfia in glial fate determination, glioma therapy and astrocytoma treatment
|
|
JP2010539978A
(ja)
|
2007-10-02 |
2010-12-24 |
アムジェン インコーポレイテッド |
マイクロ−ｒｎａおよびその前駆体にハイブリダイズしうる核酸を用いるエリスロポエチンの増加
|
|
AU2008324068A1
(en)
*
|
2007-11-05 |
2009-05-14 |
Baltic Technology Development, Ltd. |
Use of oligonucleotides with modified bases in hybridization of nucleic acids
|
|
US8097712B2
(en)
|
2007-11-07 |
2012-01-17 |
Beelogics Inc. |
Compositions for conferring tolerance to viral disease in social insects, and the use thereof
|
|
ES2641290T3
(es)
|
2007-11-20 |
2017-11-08 |
Ionis Pharmaceuticals, Inc |
Modulación de la expresión de CD40
|
|
US8546556B2
(en)
*
|
2007-11-21 |
2013-10-01 |
Isis Pharmaceuticals, Inc |
Carbocyclic alpha-L-bicyclic nucleic acid analogs
|
|
US7871985B2
(en)
|
2007-12-10 |
2011-01-18 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of factor VII gene
|
|
WO2009086558A1
(en)
|
2008-01-02 |
2009-07-09 |
Tekmira Pharmaceuticals Corporation |
Improved compositions and methods for the delivery of nucleic acids
|
|
US8530640B2
(en)
*
|
2008-02-07 |
2013-09-10 |
Isis Pharmaceuticals, Inc. |
Bicyclic cyclohexitol nucleic acid analogs
|
|
EA201301171A1
(ru)
|
2008-03-05 |
2014-10-30 |
Элнилэм Фармасьютикалз, Инк. |
Композиции и способы ингибирования экспрессии генов eg5 и vegf
|
|
EP2282744B1
(en)
*
|
2008-03-21 |
2018-01-17 |
Ionis Pharmaceuticals, Inc. |
Oligomeric compounds comprising tricyclic nucleosides and methods for their use
|
|
WO2009124238A1
(en)
*
|
2008-04-04 |
2009-10-08 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds comprising neutrally linked terminal bicyclic nucleosides
|
|
ES2554168T3
(es)
|
2008-04-18 |
2015-12-16 |
Baxter International Inc. |
Composición basada en microesferas para prevenir y/o revertir la diabetes autoinmune de nueva aparición
|
|
WO2009134917A2
(en)
*
|
2008-04-29 |
2009-11-05 |
Wyeth |
Methods for treating inflammation
|
|
US8082730B2
(en)
*
|
2008-05-20 |
2011-12-27 |
Caterpillar Inc. |
Engine system having particulate reduction device and method
|
|
CA2728467A1
(en)
*
|
2008-07-15 |
2010-01-21 |
F. Hoffmann-La Roche Ag |
Compositions and methods for inhibiting expression of tgf-beta receptor genes
|
|
WO2010017509A1
(en)
*
|
2008-08-07 |
2010-02-11 |
Isis Pharmaceuticals, Inc. |
Modulation of transthyretin expression for the treatment of cns related disorders
|
|
CN103429270B
(zh)
|
2008-08-25 |
2016-11-23 |
埃克斯雷德制药有限公司 |
阻止***生长因子的反义核苷酸及其用途
|
|
US8318693B2
(en)
|
2008-09-02 |
2012-11-27 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of mutant EGFR gene
|
|
EP2356129B1
(en)
|
2008-09-24 |
2013-04-03 |
Isis Pharmaceuticals, Inc. |
Substituted alpha-l-bicyclic nucleosides
|
|
US8604192B2
(en)
*
|
2008-09-24 |
2013-12-10 |
Isis Pharmaceuticals, Inc. |
Cyclohexenyl nucleic acids analogs
|
|
WO2010036962A1
(en)
|
2008-09-25 |
2010-04-01 |
Alnylam Pharmaceuticals, Inc. |
Lipid formulated compositions and methods for inhibiting expression of serum amyloid a gene
|
|
US9139554B2
(en)
|
2008-10-09 |
2015-09-22 |
Tekmira Pharmaceuticals Corporation |
Amino lipids and methods for the delivery of nucleic acids
|
|
NZ592203A
(en)
|
2008-10-15 |
2013-01-25 |
Isis Pharmaceuticals Inc |
Modulation of factor 11 expression
|
|
AU2009307677C1
(en)
|
2008-10-20 |
2022-09-22 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of transthyretin
|
|
EP2447274B1
(en)
|
2008-10-24 |
2017-10-04 |
Ionis Pharmaceuticals, Inc. |
Oligomeric compounds and methods
|
|
AU2009308217B2
(en)
|
2008-10-24 |
2016-01-21 |
Ionis Pharmaceuticals, Inc. |
5' and 2' bis-substituted nucleosides and oligomeric compounds prepared therefrom
|
|
RU2011124146A
(ru)
*
|
2008-11-17 |
2012-12-27 |
Ф.Хоффманн-Ля Рош Аг |
Композиции и способы подавления экспрессии генов фактора vii
|
|
EP3335705A1
(en)
|
2008-11-24 |
2018-06-20 |
Northwestern University |
Polyvalent rna-nanoparticle compositions
|
|
WO2010061393A1
(en)
|
2008-11-30 |
2010-06-03 |
Compugen Ltd. |
He4 variant nucleotide and amino acid sequences, and methods of use thereof
|
|
US20110294870A1
(en)
|
2008-12-04 |
2011-12-01 |
Opko Curna, Llc |
Treatment of tumor suppressor gene related diseases by inhibition of natural antisense transcript to the gene
|
|
CN108042560A
(zh)
|
2008-12-04 |
2018-05-18 |
库尔纳公司 |
通过抑制针对沉默调节蛋白1的天然反义转录物来治疗沉默调节蛋白1相关的疾病
|
|
MX2011005910A
(es)
|
2008-12-04 |
2011-06-17 |
Opko Curna Llc |
Tratamiento de enfermedades relacionadas con eritropoyetina (epo) mediante inhibicion del transcrito antisentido natural a eritropoyetina.
|
|
US8734759B2
(en)
|
2008-12-05 |
2014-05-27 |
Yeda Research And Development Co. Ltd. |
Methods of diagnosing and treating motor neuron diseases
|
|
NZ593618A
(en)
|
2008-12-10 |
2013-02-22 |
Alnylam Pharmaceuticals Inc |
Gnaq targeted dsrna compositions and methods for inhibiting expression
|
|
CA2746508A1
(en)
*
|
2008-12-17 |
2010-07-15 |
Avi Biopharma, Inc. |
Antisense compositions and methods for modulating contact hypersensitivity or contact dermatitis
|
|
CN102307470B
(zh)
*
|
2009-01-08 |
2015-05-20 |
西北大学 |
通过多价寡核苷酸修饰的纳米颗粒缀合物抑制细菌蛋白的产生
|
|
US20100233270A1
(en)
*
|
2009-01-08 |
2010-09-16 |
Northwestern University |
Delivery of Oligonucleotide-Functionalized Nanoparticles
|
|
CA2751342C
(en)
|
2009-01-29 |
2019-05-07 |
Alnylam Pharmaceuticals, Inc. |
Lipid formulations comprising cationic lipid and a targeting lipid comprising n-acetyl galactosamine for delivery of nucleic acid
|
|
AU2010211133A1
(en)
*
|
2009-02-03 |
2011-07-21 |
F. Hoffmann-La Roche Ag |
Compositions and methods for inhibiting expression of PTP1B genes
|
|
US9745574B2
(en)
|
2009-02-04 |
2017-08-29 |
Rxi Pharmaceuticals Corporation |
RNA duplexes with single stranded phosphorothioate nucleotide regions for additional functionality
|
|
US8536320B2
(en)
|
2009-02-06 |
2013-09-17 |
Isis Pharmaceuticals, Inc. |
Tetrahydropyran nucleic acid analogs
|
|
EP2396408B1
(en)
|
2009-02-12 |
2017-09-20 |
CuRNA, Inc. |
Treatment of glial cell derived neurotrophic factor (gdnf) related diseases by inhibition of natural antisense transcript to gdnf
|
|
KR101682735B1
(ko)
|
2009-02-12 |
2016-12-06 |
큐알엔에이, 인크. |
뇌 유래된 신경영양성 인자 (ｂｄｎｆ)에 대한 자연 안티센스 전사체의 저해에 의한 뇌 유래된 신경영양성 인자 (ｂｄｎｆ) 관련된 질환의 치료
|
|
US20120041051A1
(en)
|
2009-02-26 |
2012-02-16 |
Kevin Fitzgerald |
Compositions And Methods For Inhibiting Expression Of MIG-12 Gene
|
|
EP2669290A1
(en)
|
2009-03-02 |
2013-12-04 |
Alnylam Pharmaceuticals Inc. |
Nucleic Acid Chemical Modifications
|
|
CA2754749C
(en)
|
2009-03-04 |
2019-04-30 |
Opko Curna, Llc |
Treatment of sirtuin 1 (sirt1) related diseases by inhibition of natural antisense transcript to sirt1
|
|
CN104922699B
(zh)
|
2009-03-12 |
2020-07-24 |
阿尔尼拉姆医药品有限公司 |
脂质配制的组合物以及用于抑制Eg5和VEGF基因表达的方法
|
|
WO2010107733A2
(en)
|
2009-03-16 |
2010-09-23 |
Curna, Inc. |
Treatment of nuclear factor (erythroid-derived 2)-like 2 (nrf2) related diseases by inhibition of natural antisense transcript to nrf2
|
|
CN102549159B
(zh)
|
2009-03-17 |
2016-08-10 |
库尔纳公司 |
通过抑制针对δ样1同源物(DLK1)的天然反义转录物来治疗DLK1相关的疾病
|
|
CN108451968A
(zh)
|
2009-04-15 |
2018-08-28 |
西北大学 |
寡核苷酸功能化的纳米颗粒的递送
|
|
EP3524275A1
(en)
|
2009-04-22 |
2019-08-14 |
Massachusetts Institute Of Technology |
Innate immune supression enables repeated delivery of long rna molecules
|
|
US8318690B2
(en)
|
2009-05-01 |
2012-11-27 |
Curna, Inc. |
Treatment of hemoglobin (HBF/HBG) related diseases by inhibition of natural antisense transcript to HBF/HBG
|
|
KR20220150411A
(ko)
|
2009-05-05 |
2022-11-10 |
알닐람 파마슈티칼스 인코포레이티드 |
지질 조성물
|
|
EP2416652B1
(en)
|
2009-05-05 |
2018-11-07 |
Arbutus Biopharma Corporation |
Methods of delivering oligonucleotides to immune cells
|
|
KR101835889B1
(ko)
|
2009-05-06 |
2018-03-08 |
큐알엔에이, 인크. |
지질 수송 및 대사 유전자에 대한 천연 안티센스 전사체의 억제에 의해 지질 수송 및 대사 유전자 관련된 질환의 치료
|
|
CA2761142C
(en)
|
2009-05-06 |
2021-06-08 |
Opko Curna, Llc |
Treatment of tristetraproline (ttp) related diseases by inhibition of natural antisense transcript to ttp
|
|
EP2429657A2
(en)
*
|
2009-05-15 |
2012-03-21 |
F. Hoffmann-La Roche AG |
Compositions and methods for inhibiting expression of glucocorticoid receptor (gcr) genes
|
|
US20120107331A1
(en)
|
2009-05-15 |
2012-05-03 |
Yale University |
Gemm riboswitches, structure-based compound design with gemm riboswitches, and methods and compositions for use of and with gemm riboswitches
|
|
DK2432881T3
(en)
|
2009-05-18 |
2018-02-26 |
Curna Inc |
TREATMENT OF REPROGRAMMING FACTOR-RELATED DISEASES BY INHIBITING NATURAL ANTISENSE TRANSCRIPTS TO A REPROGRAMMING FACTOR
|
|
WO2010135695A2
(en)
|
2009-05-22 |
2010-11-25 |
Curna, Inc. |
TREATMENT OF TRANSCRIPTION FACTOR E3 (TFE3) and INSULIN RECEPTOR SUBSTRATE 2 (IRS2) RELATED DISEASES BY INHIBITION OF NATURAL ANTISENSE TRANSCRIPT TO TFE3
|
|
CN103221541B
(zh)
|
2009-05-28 |
2017-03-01 |
库尔纳公司 |
通过抑制抗病毒基因的天然反义转录物来治疗抗病毒基因相关疾病
|
|
SI3431076T1
(sl)
|
2009-06-10 |
2022-04-29 |
Arbutus Biopharma Corporation |
Izboljšana lipidna formulacija
|
|
JP5944311B2
(ja)
|
2009-06-16 |
2016-07-05 |
クルナ・インコーポレーテッド |
コラーゲン遺伝子に対する天然アンチセンス転写物の抑制によるコラーゲン遺伝子関連疾患の治療
|
|
ES2629339T3
(es)
|
2009-06-16 |
2017-08-08 |
Curna, Inc. |
Tratamiento de enfermedades relacionadas con la paraoxonasa 1 (pon1) por inhibición de transcrito antisentido natural a pon1
|
|
CA2765889A1
(en)
|
2009-06-24 |
2010-12-29 |
Opko Curna, Llc |
Treatment of tumor necrosis factor receptor 2 (tnfr2) related diseases by inhibition of natural antisense transcript to tnfr2
|
|
KR101807324B1
(ko)
|
2009-06-26 |
2017-12-08 |
큐알엔에이, 인크. |
다운 증후군 유전자에 대한 천연 안티센스 전사체의 억제에 의한 다운 증후군 유전자 관련된 질환의 치료
|
|
WO2011005860A2
(en)
|
2009-07-07 |
2011-01-13 |
Alnylam Pharmaceuticals, Inc. |
5' phosphate mimics
|
|
US9512164B2
(en)
|
2009-07-07 |
2016-12-06 |
Alnylam Pharmaceuticals, Inc. |
Oligonucleotide end caps
|
|
WO2011017516A2
(en)
|
2009-08-05 |
2011-02-10 |
Curna, Inc. |
Treatment of insulin gene (ins) related diseases by inhibition of natural antisense transcript to an insulin gene (ins)
|
|
US9012421B2
(en)
|
2009-08-06 |
2015-04-21 |
Isis Pharmaceuticals, Inc. |
Bicyclic cyclohexose nucleic acid analogs
|
|
EP2810643A3
(en)
|
2009-08-14 |
2015-03-11 |
Alnylam Pharmaceuticals Inc. |
Lipid formulated compositions and mehods for inhibiting expression of a gene from the ebola virus
|
|
WO2011022420A1
(en)
|
2009-08-17 |
2011-02-24 |
Yale University |
Methylation biomarkers and methods of use
|
|
EP2470657B1
(en)
|
2009-08-25 |
2019-10-23 |
CuRNA, Inc. |
Treatment of 'iq motif containing gtpase activating protein' (iqgap) related diseases by inhibition of natural antisense transcript to iqgap
|
|
US9321823B2
(en)
|
2009-09-02 |
2016-04-26 |
Genentech, Inc. |
Mutant smoothened and methods of using the same
|
|
CN102906263B
(zh)
|
2009-10-14 |
2017-05-31 |
耶路撒冷希伯来大学伊森姆研究发展公司 |
用于控制蜂中的瓦螨的组合物
|
|
US8962584B2
(en)
|
2009-10-14 |
2015-02-24 |
Yissum Research Development Company Of The Hebrew University Of Jerusalem, Ltd. |
Compositions for controlling Varroa mites in bees
|
|
WO2011050194A1
(en)
|
2009-10-22 |
2011-04-28 |
Genentech, Inc. |
Methods and compositions for modulating hepsin activation of macrophage-stimulating protein
|
|
AU2010315399B2
(en)
|
2009-10-27 |
2016-01-28 |
Swift Biosciences, Inc. |
Bimolecular primers
|
|
DK2494075T3
(en)
|
2009-10-30 |
2018-07-23 |
Univ Northwestern |
TABLE-MANAGED NANOCONJUGATES
|
|
EP2496716A1
(en)
|
2009-11-03 |
2012-09-12 |
University Of Virginia Patent Foundation |
Versatile, visible method for detecting polymeric analytes
|
|
AR078921A1
(es)
|
2009-11-09 |
2011-12-14 |
Hoffmann La Roche |
Composiciones y metodos para inhibir la expresion de genes de la superfamilia de quinesinas, kif10
|
|
WO2011058555A1
(en)
|
2009-11-12 |
2011-05-19 |
Yeda Research And Development Co. Ltd. |
A method of editing dna in a cell and constructs capable of same
|
|
WO2011060320A1
(en)
|
2009-11-13 |
2011-05-19 |
Avi Biopharma, Inc. |
Antisense antiviral compound and method for treating influenza viral infection
|
|
JP2013511285A
(ja)
|
2009-11-23 |
2013-04-04 |
スイフト・バイオサイエンシズ・インコーポレイテツド |
一本鎖標的分子を伸長させるデバイス
|
|
CN103724432B
(zh)
|
2009-11-30 |
2016-06-08 |
霍夫曼-拉罗奇有限公司 |
治疗和诊断表达slc34a2(tat211=seqid2)的肿瘤的抗体
|
|
CA2782366A1
(en)
|
2009-12-16 |
2011-07-14 |
Opko Curna, Llc |
Treatment of membrane bound transcription factor peptidase, site 1 (mbtps1) related diseases by inhibition of natural antisense transcript to mbtps1
|
|
US20110152349A1
(en)
|
2009-12-18 |
2011-06-23 |
Anke Geick |
Compositions and methods for inhibiting expression of il-18 genes
|
|
US9068183B2
(en)
|
2009-12-23 |
2015-06-30 |
Curna, Inc. |
Treatment of uncoupling protein 2 (UCP2) related diseases by inhibition of natural antisense transcript to UCP2
|
|
WO2011079261A2
(en)
|
2009-12-23 |
2011-06-30 |
Curna, Inc. |
Treatment of hepatocyte growth factor (hgf) related diseases by inhibition of natural antisense transcript to hgf
|
|
RU2611186C2
(ru)
|
2009-12-29 |
2017-02-21 |
Курна, Инк. |
ЛЕЧЕНИЕ ЗАБОЛЕВАНИЙ, СВЯЗАННЫХ С ОПУХОЛЕВЫМ БЕЛКОМ 63 (р63), ПУТЕМ ИНГИБИРОВАНИЯ ПРИРОДНОГО АНТИСМЫСЛОВОГО ТРАНСКРИПТА К р63
|
|
EP2519633B1
(en)
|
2009-12-29 |
2017-10-25 |
CuRNA, Inc. |
Treatment of nuclear respiratory factor 1 (nrf1) related diseases by inhibition of natural antisense transcript to nrf1
|
|
US8946181B2
(en)
|
2010-01-04 |
2015-02-03 |
Curna, Inc. |
Treatment of interferon regulatory factor 8 (IRF8) related diseases by inhibition of natural antisense transcript to IRF8
|
|
WO2011085066A2
(en)
|
2010-01-06 |
2011-07-14 |
Curna, Inc. |
Treatment of pancreatic developmental gene related diseases by inhibition of natural antisense transcript to a pancreatic developmental gene
|
|
US8779118B2
(en)
|
2010-01-11 |
2014-07-15 |
Isis Pharmaceuticals, Inc. |
Base modified bicyclic nucleosides and oligomeric compounds prepared therefrom
|
|
EP2524039B1
(en)
|
2010-01-11 |
2017-11-29 |
CuRNA, Inc. |
Treatment of sex hormone binding globulin (shbg) related diseases by inhibition of natural antisense transcript to shbg
|
|
US20120321647A1
(en)
|
2010-01-12 |
2012-12-20 |
Yale University |
Structured rna motifs and compounds and methods for their use
|
|
RU2611192C2
(ru)
|
2010-01-25 |
2017-02-21 |
Курна, Инк. |
ЛЕЧЕНИЕ ЗАБОЛЕВАНИЙ, СВЯЗАННЫХ С РНКазой Н1, ПУТЕМ ИНГИБИРОВАНИЯ ПРИРОДНОГО АНТИСМЫСЛОВОГО ТРАНСКРИПТА К РНКазе Н1
|
|
WO2011097407A1
(en)
|
2010-02-04 |
2011-08-11 |
Ico Therapeutics Inc. |
Dosing regimens for treating and preventing ocular disorders using c-raf antisense
|
|
TW201129365A
(en)
|
2010-02-05 |
2011-09-01 |
Hoffmann La Roche |
Compositions and methods for inhibiting expression of IKK2 genes
|
|
KR101838308B1
(ko)
|
2010-02-22 |
2018-03-13 |
큐알엔에이, 인크. |
피롤린-5-카르복실레이트 환원효소 1(ｐｙｃｒ1)에 대한 천연 안티센스 전사체의 억제에 의한 ｐｙｃｒ1과 관련된 질환의 치료
|
|
WO2011105902A2
(en)
|
2010-02-23 |
2011-09-01 |
Academisch Ziekenhuis Bij De Universiteit Van Amsterdam |
Antagonists of complement component 8-beta (c8-beta) and uses thereof
|
|
EP2538981B1
(en)
|
2010-02-23 |
2017-12-20 |
F. Hoffmann-La Roche AG |
Compositions and methods for the diagnosis and treatment of tumor
|
|
WO2011105901A2
(en)
|
2010-02-23 |
2011-09-01 |
Academisch Ziekenhuis Bij De Universiteit Van Amsterdam |
Antagonists of complement component 9 (c9) and uses thereof
|
|
WO2011105900A2
(en)
|
2010-02-23 |
2011-09-01 |
Academisch Ziekenhuis Bij De Universiteit Van Amsterdam |
Antagonists of complement component 8-alpha (c8-alpha) and uses thereof
|
|
MX2012010479A
(es)
|
2010-03-08 |
2012-10-09 |
Monsanto Technology Llc |
Moleculas polinucleotidicas para regulacion genetica en plantas.
|
|
WO2011112516A1
(en)
|
2010-03-08 |
2011-09-15 |
Ico Therapeutics Inc. |
Treating and preventing hepatitis c virus infection using c-raf kinase antisense oligonucleotides
|
|
EP2545173A2
(en)
|
2010-03-12 |
2013-01-16 |
Sarepta Therapeutics, Inc. |
Antisense modulation of nuclear hormone receptors
|
|
EP3210611B1
(en)
|
2010-03-12 |
2019-08-21 |
The Brigham and Women's Hospital, Inc. |
Methods of treating vascular inflammatory disorders
|
|
US20130101512A1
(en)
|
2010-03-12 |
2013-04-25 |
Chad A. Mirkin |
Crosslinked polynucleotide structure
|
|
WO2011115818A1
(en)
|
2010-03-17 |
2011-09-22 |
Isis Pharmaceuticals, Inc. |
5'-substituted bicyclic nucleosides and oligomeric compounds prepared therefrom
|
|
US8889350B2
(en)
|
2010-03-26 |
2014-11-18 |
Swift Biosciences, Inc. |
Methods and compositions for isolating polynucleotides
|
|
CA2792291A1
(en)
|
2010-03-29 |
2011-10-06 |
Kumamoto University |
Sirna therapy for transthyretin (ttr) related ocular amyloidosis
|
|
WO2011123621A2
(en)
|
2010-04-01 |
2011-10-06 |
Alnylam Pharmaceuticals Inc. |
2' and 5' modified monomers and oligonucleotides
|
|
RU2610661C2
(ru)
|
2010-04-09 |
2017-02-14 |
Курна, Инк. |
Лечение заболеваний, связанных с фактором роста фибробластов 21 (fgf21), путем ингибирования природного антисмыслового транскрипта к fgf21
|
|
US20110269194A1
(en)
|
2010-04-20 |
2011-11-03 |
Swift Biosciences, Inc. |
Materials and methods for nucleic acid fractionation by solid phase entrapment and enzyme-mediated detachment
|
|
US9725479B2
(en)
|
2010-04-22 |
2017-08-08 |
Ionis Pharmaceuticals, Inc. |
5′-end derivatives
|
|
CN103154014B
(zh)
|
2010-04-28 |
2015-03-25 |
Isis制药公司 |
修饰核苷、其类似物以及由它们制备的寡聚化合物
|
|
US9127033B2
(en)
|
2010-04-28 |
2015-09-08 |
Isis Pharmaceuticals, Inc. |
5′ modified nucleosides and oligomeric compounds prepared therefrom
|
|
RS56011B1
(sr)
|
2010-04-29 |
2017-09-29 |
Ionis Pharmaceuticals Inc |
Modulacija ekspresije transtiretina
|
|
RU2693462C2
(ru)
|
2010-05-03 |
2019-07-03 |
Курна, Инк. |
Лечение заболеваний, связанных с сиртуином (sirt), путем ингибирования природного антисмыслового транскрипта к сиртуину (sirt)
|
|
WO2011139985A1
(en)
|
2010-05-03 |
2011-11-10 |
Genentech, Inc. |
Compositions and methods for the diagnosis and treatment of tumor
|
|
ES2816898T3
(es)
|
2010-05-13 |
2021-04-06 |
Sarepta Therapeutics Inc |
Compuestos que modulan la actividad de señalización de las interleucinas 17 y 23
|
|
TWI586356B
(zh)
|
2010-05-14 |
2017-06-11 |
可娜公司 |
藉由抑制ｐａｒ４天然反股轉錄本治療ｐａｒ４相關疾病
|
|
WO2011150226A1
(en)
|
2010-05-26 |
2011-12-01 |
Landers James P |
Method for detecting nucleic acids based on aggregate formation
|
|
EP2576783B1
(en)
|
2010-05-26 |
2017-11-29 |
CuRNA, Inc. |
Treatment of atonal homolog 1 (atoh1) related diseases by inhibition of natural antisense transcript to atoh1
|
|
US9944671B2
(en)
|
2010-06-02 |
2018-04-17 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods directed to treating liver fibrosis
|
|
WO2011156278A1
(en)
|
2010-06-07 |
2011-12-15 |
Isis Pharmaceuticals, Inc. |
Bicyclic nucleosides and oligomeric compounds prepared therefrom
|
|
WO2011156202A1
(en)
|
2010-06-08 |
2011-12-15 |
Isis Pharmaceuticals, Inc. |
Substituted 2 '-amino and 2 '-thio-bicyclic nucleosides and oligomeric compounds prepared therefrom
|
|
WO2011156713A1
(en)
|
2010-06-11 |
2011-12-15 |
Vanderbilt University |
Multiplexed interferometric detection system and method
|
|
WO2011163466A1
(en)
|
2010-06-23 |
2011-12-29 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Regulation of skin pigmentation by neuregulin-1 (nrg-1)
|
|
EP2588123A2
(en)
|
2010-06-30 |
2013-05-08 |
Compugen Ltd. |
C1orf32 for the treatment of multiple sclerosis, rheumatoid arthritis and other autoimmune disorders
|
|
JP5998131B2
(ja)
|
2010-07-14 |
2016-09-28 |
カッパーアールエヌエー，インコーポレイテッド |
Ｄｉｓｃｓｌａｒｇｅｈｏｍｏｌｏｇ（ｄｌｇ）ｄｌｇ１への天然アンチセンス転写物の阻害によるｄｌｇ関連疾患の治療
|
|
WO2012021554A1
(en)
|
2010-08-09 |
2012-02-16 |
Yale University |
Cyclic di-gmp-ii riboswitches, motifs, and compounds, and methods for their use
|
|
WO2012038956A1
(en)
|
2010-09-20 |
2012-03-29 |
Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. |
Method of treating neurodegenerative diseases
|
|
EP2625197B1
(en)
|
2010-10-05 |
2016-06-29 |
Genentech, Inc. |
Mutant smoothened and methods of using the same
|
|
ES2640755T3
(es)
|
2010-10-06 |
2017-11-06 |
Curna, Inc. |
Tratamiento de enfermedades relacionadas con la Sialidasa 4 (neu4) mediante inhibición del transcrito antisentido natural al gen neu4
|
|
US20140031250A1
(en)
|
2010-10-07 |
2014-01-30 |
David Tsai Ting |
Biomarkers of Cancer
|
|
WO2012052872A2
(en)
|
2010-10-17 |
2012-04-26 |
Yeda Research And Development Co. Ltd. |
Methods and compositions for the treatment of insulin-associated medical conditions
|
|
WO2012052258A1
(en)
|
2010-10-18 |
2012-04-26 |
Arrowhead Research Corporation |
Compositions and methods for inhibiting expression of rrm2 genes
|
|
EP2630241B1
(en)
|
2010-10-22 |
2018-10-17 |
CuRNA, Inc. |
Treatment of alpha-l-iduronidase (idua) related diseases by inhibition of natural antisense transcript to idua
|
|
DK2633052T3
(en)
|
2010-10-27 |
2018-07-16 |
Curna Inc |
TREATMENT OF INTERFERON-RELATED DEVELOPMENT REGULATOR 1 (IFRD1) -RELATED DISEASES BY INHIBITION OF NATURAL ANTISENCE TRANSCRIPT TO IFRD1
|
|
JP2012111933A
(ja)
*
|
2010-11-02 |
2012-06-14 |
Nitto Denko Corp |
熱可塑性シリコーン樹脂
|
|
US9339513B2
(en)
|
2010-11-09 |
2016-05-17 |
Alnylam Pharmaceuticals, Inc. |
Lipid formulated compositions and methods for inhibiting expression of Eg5 and VEGF genes
|
|
JP6336755B2
(ja)
|
2010-11-12 |
2018-06-06 |
ザ ジェネラル ホスピタル コーポレイション |
ポリコームに関連する非コードｒｎａ
|
|
EP3521451A1
(en)
|
2010-11-17 |
2019-08-07 |
Ionis Pharmaceuticals, Inc. |
Modulation of alpha synuclein expression
|
|
US8987225B2
(en)
|
2010-11-23 |
2015-03-24 |
Curna, Inc. |
Treatment of NANOG related diseases by inhibition of natural antisense transcript to NANOG
|
|
US9150926B2
(en)
|
2010-12-06 |
2015-10-06 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Diagnosis and treatment of adrenocortical tumors using human microRNA-483
|
|
EP2648763A4
(en)
|
2010-12-10 |
2014-05-14 |
Alnylam Pharmaceuticals Inc |
COMPOSITIONS AND METHODS FOR EXPRESSION INHIBITION OF GENES KLF-1 AND BCL11A
|
|
EP2649182A4
(en)
|
2010-12-10 |
2015-05-06 |
Alnylam Pharmaceuticals Inc |
COMPOSITIONS AND METHOD FOR INCREASING AN ERYTHROPOIETIN (EPO) PREPARATION
|
|
US9045749B2
(en)
|
2011-01-14 |
2015-06-02 |
The General Hospital Corporation |
Methods targeting miR-128 for regulating cholesterol/lipid metabolism
|
|
CA2825059A1
(en)
|
2011-02-02 |
2012-08-09 |
Excaliard Pharmaceuticals, Inc. |
Method of treating keloids or hypertrophic scars using antisense compounds targeting connective tissue growth factor (ctgf)
|
|
JP2014505705A
(ja)
|
2011-02-02 |
2014-03-06 |
ザ トラスティーズ オブ プリンストン ユニヴァシティ |
ウイルス生成モジュレーターとしてのサーチュインモジュレーター
|
|
US9562853B2
(en)
|
2011-02-22 |
2017-02-07 |
Vanderbilt University |
Nonaqueous backscattering interferometric methods
|
|
RU2702501C2
(ru)
|
2011-03-29 |
2019-10-08 |
Элнилэм Фармасьютикалз, Инк. |
Композиции и способы ингибирования экспрессии гена tmprss6
|
|
US10086043B2
(en)
|
2011-04-03 |
2018-10-02 |
The General Hospital Corporation |
Efficient protein expression in vivo using modified RNA (MOD-RNA)
|
|
US9409987B2
(en)
|
2011-04-15 |
2016-08-09 |
Compugen Ltd |
Polypeptides and polynucleotides, and uses thereof for treatment of immune related disorders and cancer
|
|
US20140186844A1
(en)
|
2011-04-26 |
2014-07-03 |
Swift Biosciences, Inc. |
Polynucleotide primers and probes
|
|
WO2012151268A1
(en)
|
2011-05-02 |
2012-11-08 |
University Of Virginia Patent Foundation |
Method and system for high throughput optical and label free detection of analytes
|
|
WO2012151289A2
(en)
|
2011-05-02 |
2012-11-08 |
University Of Virginia Patent Foundation |
Method and system to detect aggregate formation on a substrate
|
|
ES2653247T3
(es)
|
2011-06-09 |
2018-02-06 |
Curna, Inc. |
Tratamiento de enfermedades relacionadas con la frataxina (FXN) mediante inhibición del transcrito antisentido natural al gen FXN
|
|
WO2012170347A1
(en)
|
2011-06-09 |
2012-12-13 |
Isis Pharmaceuticals, Inc. |
Bicyclic nucleosides and oligomeric compounds prepared therefrom
|
|
AU2012272970A1
(en)
|
2011-06-21 |
2014-02-06 |
Alnylam Pharmaceuticals, Inc. |
Angiopoietin-like 3 (ANGPTL3) iRNA compositions and methods of use thereof
|
|
EP3388068A1
(en)
|
2011-06-21 |
2018-10-17 |
Alnylam Pharmaceuticals, Inc. |
Composition and methods for inhibition of expression of protein c (proc) genes
|
|
CN107201364A
(zh)
|
2011-06-21 |
2017-09-26 |
阿尔尼拉姆医药品有限公司 |
用于抑制载脂蛋白c‑iii（apoc3）基因表达的组合物与方法
|
|
WO2012178033A2
(en)
|
2011-06-23 |
2012-12-27 |
Alnylam Pharmaceuticals, Inc. |
Serpina1 sirnas: compositions of matter and methods of treatment
|
|
WO2013001517A1
(en)
|
2011-06-30 |
2013-01-03 |
Compugen Ltd. |
Polypeptides and uses thereof for treatment of autoimmune disorders and infection
|
|
CN113430196A
(zh)
|
2011-06-30 |
2021-09-24 |
箭头药业股份有限公司 |
用于抑制乙型肝炎病毒的基因表达的组合物和方法
|
|
US20140328811A1
(en)
|
2011-08-01 |
2014-11-06 |
Alnylam Pharmaceuticals, Inc. |
Method for improving the success rate of hematopoietic stem cell transplants
|
|
EP3524679B1
(en)
|
2011-08-04 |
2021-10-06 |
Yeda Research and Development Co., Ltd. |
Micro-rna mir-19 and compositions comprising same for the treatment of medical conditions in which low adrenaline or noradrenaline level is therapeutically beneficial
|
|
US9840715B1
(en)
|
2011-09-13 |
2017-12-12 |
Monsanto Technology Llc |
Methods and compositions for delaying senescence and improving disease tolerance and yield in plants
|
|
EP2755466A4
(en)
|
2011-09-13 |
2015-04-15 |
Monsanto Technology Llc |
METHODS AND COMPOSITIONS FOR CONTROLLING WEEDS
|
|
US10806146B2
(en)
|
2011-09-13 |
2020-10-20 |
Monsanto Technology Llc |
Methods and compositions for weed control
|
|
EP2755988B1
(en)
|
2011-09-13 |
2018-08-22 |
Monsanto Technology LLC |
Methods and compositions for weed control
|
|
EP3296402B1
(en)
|
2011-09-13 |
2020-04-15 |
Monsanto Technology LLC |
Methods and compositions for weed control
|
|
CA2848680C
(en)
|
2011-09-13 |
2020-05-19 |
Monsanto Technology Llc |
Methods and compositions for weed control
|
|
US10760086B2
(en)
|
2011-09-13 |
2020-09-01 |
Monsanto Technology Llc |
Methods and compositions for weed control
|
|
US10829828B2
(en)
|
2011-09-13 |
2020-11-10 |
Monsanto Technology Llc |
Methods and compositions for weed control
|
|
WO2013040429A1
(en)
|
2011-09-14 |
2013-03-21 |
Rana Therapeutics Inc. |
Multimeric oligonucleotide compounds
|
|
ES2856091T3
(es)
|
2011-09-14 |
2021-09-27 |
Univ Northwestern |
Nanoconjugados capaces de atravesar la barrera hematoencefálica
|
|
US9920326B1
(en)
|
2011-09-14 |
2018-03-20 |
Monsanto Technology Llc |
Methods and compositions for increasing invertase activity in plants
|
|
WO2013040548A2
(en)
|
2011-09-17 |
2013-03-21 |
Yale University |
Fluoride-responsive riboswitchs, fluoride transporters, and methods of use
|
|
EP3170899B1
(en)
|
2011-10-11 |
2020-06-24 |
The Brigham and Women's Hospital, Inc. |
Microrna mir-155 in neurodegenerative disorders
|
|
BR112014008862A2
(pt)
|
2011-10-14 |
2018-08-07 |
Genentech Inc |
anticorpo isolado que se liga à htra1, ácido nucleico isolado, célula hospedeira, imunoconjugado, formulação farmacêutica, métodos e usos
|
|
WO2013061328A2
(en)
|
2011-10-27 |
2013-05-02 |
Yeda Research And Development Co. Ltd. |
Method of treating cancer
|
|
CA2895077A1
(en)
|
2011-12-12 |
2013-06-20 |
Beverly Packard |
In vivo delivery of oligonucleotides
|
|
BR112014018481A2
(pt)
|
2012-02-01 |
2017-07-04 |
Compugen Ltd |
anticorpo monoclonal ou policlonal ou um fragmento de ligação a antígeno do mesmo, polinucleotídeo, anticorpo monoclonal, vetor, hibridoma, anticorpo, hibridoma 5166-2 e/ou 5166-9, anticorpo ou fragmento de ligação a antígeno, composição farmacêutica, uso do anticorpo ou fragmento de ligação a anticorpo, método para tratar câncer, método para diagnosticar câncer em um indivíduo, anticorpo, método, composição ou uso
|
|
SG11201404608WA
(en)
|
2012-02-13 |
2014-09-26 |
Gamida Cell Ltd |
Mesenchymal stem cells conditioned medium and methods of generating and using the same
|
|
JP2015509366A
(ja)
|
2012-02-22 |
2015-03-30 |
ブレインステム バイオテック リミテッド |
神経幹細胞および運動ニューロンの生成
|
|
JP6329911B2
(ja)
|
2012-02-22 |
2018-05-23 |
ブレインステム バイオテック リミテッド |
星状膠細胞作製のためのミクロｒｎａ
|
|
CA2866625C
(en)
|
2012-03-13 |
2020-12-08 |
Swift Biosciences, Inc. |
Methods and compositions for size-controlled homopolymer tailing of substrate polynucleotides by a nucleic acid polymerase
|
|
US20150031750A1
(en)
|
2012-03-15 |
2015-01-29 |
The Scripps Research Institute |
Treatment of brain derived neurotrophic factor (bdnf) related diseases by inhibition of natural antisense transcript to bdnf
|
|
EP2639238A1
(en)
|
2012-03-15 |
2013-09-18 |
Universität Bern |
Tricyclic nucleosides and oligomeric compounds prepared therefrom
|
|
WO2013154799A1
(en)
|
2012-04-09 |
2013-10-17 |
Isis Pharmaceuticals, Inc. |
Tricyclic nucleosides and oligomeric compounds prepared therefrom
|
|
WO2013154798A1
(en)
|
2012-04-09 |
2013-10-17 |
Isis Pharmaceuticals, Inc. |
Tricyclic nucleic acid analogs
|
|
US9133461B2
(en)
|
2012-04-10 |
2015-09-15 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of the ALAS1 gene
|
|
CN107083385A
(zh)
|
2012-04-20 |
2017-08-22 |
艾珀特玛治疗公司 |
产热的miRNA调节剂
|
|
US9127274B2
(en)
|
2012-04-26 |
2015-09-08 |
Alnylam Pharmaceuticals, Inc. |
Serpinc1 iRNA compositions and methods of use thereof
|
|
EP2841572B1
(en)
|
2012-04-27 |
2019-06-19 |
Duke University |
Genetic correction of mutated genes
|
|
US9273949B2
(en)
|
2012-05-11 |
2016-03-01 |
Vanderbilt University |
Backscattering interferometric methods
|
|
JP2015523854A
(ja)
|
2012-05-16 |
2015-08-20 |
ラナ セラピューティクス インコーポレイテッド |
Ｓｍｎ遺伝子ファミリー発現を調節するための組成物及び方法
|
|
DK2850189T3
(en)
|
2012-05-16 |
2019-02-25 |
Translate Bio Ma Inc |
COMPOSITIONS AND PROCEDURES FOR MODULATING GENEPRESSION
|
|
US10240161B2
(en)
|
2012-05-24 |
2019-03-26 |
A.B. Seeds Ltd. |
Compositions and methods for silencing gene expression
|
|
WO2013184209A1
(en)
|
2012-06-04 |
2013-12-12 |
Ludwig Institute For Cancer Research Ltd. |
Mif for use in methods of treating subjects with a neurodegenerative disorder
|
|
US20140038182A1
(en)
|
2012-07-17 |
2014-02-06 |
Dna Logix, Inc. |
Cooperative primers, probes, and applications thereof
|
|
US9567569B2
(en)
|
2012-07-23 |
2017-02-14 |
Gamida Cell Ltd. |
Methods of culturing and expanding mesenchymal stem cells
|
|
US9175266B2
(en)
|
2012-07-23 |
2015-11-03 |
Gamida Cell Ltd. |
Enhancement of natural killer (NK) cell proliferation and activity
|
|
CA2880833A1
(en)
|
2012-08-03 |
2014-02-06 |
Aptamir Therapeutics, Inc. |
Cell-specific delivery of mirna modulators for the treatment of obesity and related disorders
|
|
CN104736551B
(zh)
|
2012-08-15 |
2017-07-28 |
Ionis制药公司 |
使用改进的封端方案制备寡聚化合物的方法
|
|
JP2015529073A
(ja)
|
2012-08-20 |
2015-10-05 |
ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア |
生物可逆性基を有するポリヌクレオチド
|
|
US9029335B2
(en)
|
2012-10-16 |
2015-05-12 |
Isis Pharmaceuticals, Inc. |
Substituted 2′-thio-bicyclic nucleosides and oligomeric compounds prepared therefrom
|
|
CA2888264A1
(en)
|
2012-10-18 |
2014-04-24 |
Monsanto Technology Llc |
Methods and compositions for plant pest control
|
|
WO2014071358A2
(en)
|
2012-11-05 |
2014-05-08 |
Foundation Medicine, Inc. |
Novel ntrk1 fusion molecules and uses thereof
|
|
US10683505B2
(en)
|
2013-01-01 |
2020-06-16 |
Monsanto Technology Llc |
Methods of introducing dsRNA to plant seeds for modulating gene expression
|
|
MX2015008611A
(es)
|
2013-01-01 |
2016-02-03 |
Seeds Ltd Ab |
Metodos para introducir dsrna en semillas de plantas para modular la expresion genetica.
|
|
EP2945652B1
(en)
|
2013-01-18 |
2021-07-07 |
Foundation Medicine, Inc. |
Methods of treating cholangiocarcinoma
|
|
US10000767B2
(en)
|
2013-01-28 |
2018-06-19 |
Monsanto Technology Llc |
Methods and compositions for plant pest control
|
|
WO2014120861A2
(en)
|
2013-01-31 |
2014-08-07 |
Isis Pharmaceuticals, Inc. |
Method of preparing oligomeric compounds using modified coupling protocols
|
|
WO2014130922A1
(en)
|
2013-02-25 |
2014-08-28 |
Trustees Of Boston University |
Compositions and methods for treating fungal infections
|
|
BR112015023051A2
(pt)
|
2013-03-13 |
2017-11-14 |
Monsanto Technology Llc |
método para controle de ervas daninhas, composição herbicida, cassete de expressão microbiano e método de produção de polinucleotídeo
|
|
EP2967082A4
(en)
|
2013-03-13 |
2016-11-02 |
Monsanto Technology Llc |
METHOD AND COMPOSITIONS FOR WEED CONTROL
|
|
US20140283211A1
(en)
|
2013-03-14 |
2014-09-18 |
Monsanto Technology Llc |
Methods and Compositions for Plant Pest Control
|
|
KR102605775B1
(ko)
|
2013-03-14 |
2023-11-29 |
알닐람 파마슈티칼스 인코포레이티드 |
보체 성분 Ｃ5 ｉＲＮＡ 조성물 및 그 이용 방법
|
|
US10568328B2
(en)
|
2013-03-15 |
2020-02-25 |
Monsanto Technology Llc |
Methods and compositions for weed control
|
|
EP4286517A3
(en)
|
2013-04-04 |
2024-03-13 |
President and Fellows of Harvard College |
Therapeutic uses of genome editing with crispr/cas systems
|
|
IL284593B2
(en)
|
2013-05-01 |
2023-02-01 |
Ionis Pharmaceuticals Inc |
Compositions and methods for modulation of hbv and ttr expression
|
|
SG11201510565TA
(en)
|
2013-05-22 |
2016-01-28 |
Alnylam Pharmaceuticals Inc |
Tmprss6 irna compositions and methods of use thereof
|
|
KR102463973B1
(ko)
|
2013-05-22 |
2022-11-07 |
알닐람 파마슈티칼스 인코포레이티드 |
ＳＥＲＰＩＮＡ1 ｉＲＮＡ 조성물 및 이의 사용 방법
|
|
EP3004396B1
(en)
|
2013-06-06 |
2019-10-16 |
The General Hospital Corporation |
Compositions for the treatment of cancer
|
|
EP3007704B1
(en)
|
2013-06-13 |
2021-01-06 |
Antisense Therapeutics Ltd |
Combination therapy for acromegaly
|
|
US9850496B2
(en)
|
2013-07-19 |
2017-12-26 |
Monsanto Technology Llc |
Compositions and methods for controlling Leptinotarsa
|
|
JP6668236B2
(ja)
|
2013-07-19 |
2020-03-18 |
モンサント テクノロジー エルエルシー |
Ｌｅｐｔｉｎｏｔａｒｓａ防除用組成物及びその方法
|
|
EA202191796A2
(ru)
|
2013-08-08 |
2022-03-31 |
Дзе Скриппс Рисёч Инститьют |
Способ сайт-специфического ферментативного мечения нуклеиновых кислот in vitro введением не встречающихся в природе нуклеотидов
|
|
US10077444B2
(en)
|
2013-10-02 |
2018-09-18 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of the LECT2 gene
|
|
US9988627B2
(en)
|
2013-10-04 |
2018-06-05 |
Novartis Ag |
Formats for organic compounds for use in RNA interference
|
|
WO2015050871A2
(en)
|
2013-10-04 |
2015-04-09 |
Novartis Ag |
Organic compounds to treat hepatitis b virus
|
|
CA2925129C
(en)
|
2013-10-04 |
2023-04-04 |
Novartis Ag |
3' end caps for rnai agents for use in rna interference
|
|
PE20161130A1
(es)
|
2013-10-04 |
2016-11-25 |
Icahn School Med Mount Sinai |
Composiciones y metodos para inhibir la expresion del gen alas1
|
|
EP3055426B1
(en)
|
2013-10-09 |
2019-06-19 |
The United States of America as represented by The Secretary Department of Health and Human Services |
Detection of hepatitis delta virus (hdv) for the diagnosis and treatment of sjögren's syndrome and lymphoma
|
|
US11162096B2
(en)
|
2013-10-14 |
2021-11-02 |
Ionis Pharmaceuticals, Inc |
Methods for modulating expression of C9ORF72 antisense transcript
|
|
US9758546B2
(en)
|
2013-10-21 |
2017-09-12 |
Ionis Pharmaceuticals, Inc. |
Method for solution phase detritylation of oligomeric compounds
|
|
CN105899679A
(zh)
|
2013-10-21 |
2016-08-24 |
通用医疗公司 |
与循环肿瘤细胞簇有关的方法以及癌症的治疗
|
|
MX2016005778A
(es)
|
2013-11-04 |
2016-12-20 |
Monsanto Technology Llc |
Composiciones y metodos para controlar infestaciones de plagas y parasitos de los artropodos.
|
|
WO2015066708A1
(en)
|
2013-11-04 |
2015-05-07 |
Northwestern University |
Quantification and spatio-temporal tracking of a target using a spherical nucleic acid (sna)
|
|
CA2932122C
(en)
|
2013-12-03 |
2022-04-19 |
Northwestern University |
Liposomal particles, methods of making same and uses thereof
|
|
WO2015085183A2
(en)
|
2013-12-06 |
2015-06-11 |
Swift Biosciences, Inc. |
Cleavable competitor polynucleotides
|
|
CA2844640A1
(en)
|
2013-12-06 |
2015-06-06 |
The University Of British Columbia |
Method for treatment of castration-resistant prostate cancer
|
|
UA119253C2
(uk)
|
2013-12-10 |
2019-05-27 |
Біолоджикс, Інк. |
Спосіб боротьби із вірусом у кліща varroa та у бджіл
|
|
IL282401B
(en)
|
2013-12-12 |
2022-08-01 |
Alnylam Pharmaceuticals Inc |
Complementary component irna compositions and methods for using them
|
|
EP3082840B1
(en)
|
2013-12-20 |
2021-03-24 |
The General Hospital Corporation |
Methods and assays relating to circulating tumor cells
|
|
AR099092A1
(es)
|
2014-01-15 |
2016-06-29 |
Monsanto Technology Llc |
Métodos y composiciones para el control de malezas utilizando polinucleótidos epsps
|
|
CA2937539A1
(en)
|
2014-02-04 |
2015-08-13 |
Genentech, Inc. |
Mutant smoothened and methods of using the same
|
|
JP2017506228A
(ja)
|
2014-02-05 |
2017-03-02 |
イェダ リサーチ アンド ディベロップメント カンパニー リミテッドＹｅｄａ Ｒｅｓｅａｒｃｈ Ａｎｄ Ｄｅｖｅｌｏｐｍｅｎｔ Ｃｏ．Ｌｔｄ． |
セロトニン放出ホルモン、アドレナリン放出ホルモン、ノルアドレナリン放出ホルモン、グルタミン酸放出ホルモンおよび副腎皮質刺激ホルモン放出ホルモン関連の医学的状態の処置および診断のためのマイクロｒｎａおよび該マイクロｒｎａを含む組成物
|
|
CN113057959A
(zh)
|
2014-02-11 |
2021-07-02 |
阿尔尼拉姆医药品有限公司 |
己酮糖激酶（KHK）iRNA组合物及其使用方法
|
|
WO2015142910A1
(en)
|
2014-03-17 |
2015-09-24 |
Isis Pharmaceuticals, Inc. |
Bicyclic carbocyclic nucleosides and oligomeric compounds prepared therefrom
|
|
WO2015143245A1
(en)
|
2014-03-19 |
2015-09-24 |
Isis Pharmaceuticals, Inc. |
Methods for modulating ataxin 2 expression
|
|
JP6902869B2
(ja)
|
2014-03-19 |
2021-07-14 |
アイオーニス ファーマシューティカルズ， インコーポレーテッドＩｏｎｉｓ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． |
アタキシン２の発現を調節するための組成物
|
|
SG11201608109TA
(en)
|
2014-04-01 |
2016-10-28 |
Ionis Pharmaceuticals Inc |
Compositions for modulating sod-1 expression
|
|
EP3125676A4
(en)
|
2014-04-01 |
2018-02-14 |
Monsanto Technology LLC |
Compositions and methods for controlling insect pests
|
|
US10513706B2
(en)
|
2014-04-09 |
2019-12-24 |
The Scripps Research Institute |
Import of unnatural or modified nucleoside triphosphates into cells via nucleic acid triphosphate transporters
|
|
WO2015164693A1
(en)
|
2014-04-24 |
2015-10-29 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds comprising alpha-beta-constrained nucleic acid
|
|
BR112016022593B1
(pt)
|
2014-05-01 |
2022-04-26 |
Ionis Pharmaceuticals, Inc |
Compostos oligoméricos, composições que os compreendem, e usos dos mesmos
|
|
EP4223315A3
(en)
|
2014-05-01 |
2023-08-23 |
Ionis Pharmaceuticals, Inc. |
Method for synthesis of reactive conjugate clusters
|
|
WO2015175510A1
(en)
|
2014-05-12 |
2015-11-19 |
Alnylam Pharmaceuticals, Inc. |
Methods and compositions for treating a serpinc1-associated disorder
|
|
JP6811094B2
(ja)
|
2014-05-22 |
2021-01-13 |
アルナイラム ファーマシューティカルズ， インコーポレイテッドＡｌｎｙｌａｍ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ， Ｉｎｃ． |
アンジオテンシノーゲン（ＡＧＴ）ｉＲＮＡ組成物およびその使用
|
|
EP3148564B1
(en)
|
2014-06-02 |
2020-01-08 |
Children's Medical Center Corporation |
Methods and compositions for immunomodulation
|
|
TR201908550T4
(tr)
|
2014-06-04 |
2019-07-22 |
Exicure Inc |
Profilaktik veya terapötik uygulamalar için lipozomal sferik nükleik asitler tarafından immün modülatörlerin çok değerlikli teslimi.
|
|
US10308940B2
(en)
|
2014-06-10 |
2019-06-04 |
Erasmus University Medical Center Rotterdam |
Antisense oligonucleotides useful in treatment of Pompe disease
|
|
CA2953347A1
(en)
|
2014-06-23 |
2015-12-30 |
Monsanto Technology Llc |
Compositions and methods for regulating gene expression via rna interference
|
|
US11807857B2
(en)
|
2014-06-25 |
2023-11-07 |
Monsanto Technology Llc |
Methods and compositions for delivering nucleic acids to plant cells and regulating gene expression
|
|
EP3161159B1
(en)
|
2014-06-25 |
2020-08-05 |
The General Hospital Corporation |
Targeting human satellite ii (hsatii)
|
|
JP6671363B2
(ja)
|
2014-07-15 |
2020-03-25 |
イッサム リサーチ ディヴェロップメント カンパニー オブ ザ ヘブリュー ユニバーシティー オブ エルサレム リミティッド |
Ｃｄ４４の単離されたポリペプチドおよびその使用
|
|
US9951327B1
(en)
|
2014-07-17 |
2018-04-24 |
Integrated Dna Technologies, Inc. |
Efficient and rapid method for assembling and cloning double-stranded DNA fragments
|
|
CN114009454A
(zh)
|
2014-07-29 |
2022-02-08 |
孟山都技术公司 |
用于控制昆虫害虫的组合物和方法
|
|
WO2016018665A1
(en)
|
2014-07-31 |
2016-02-04 |
Uab Research Foundation |
Apoe mimetic peptides and higher potency to clear plasma cholesterol
|
|
CN106794256B
(zh)
|
2014-08-19 |
2021-04-30 |
西北大学 |
蛋白质/寡核苷酸核-壳纳米颗粒治疗剂
|
|
WO2016030899A1
(en)
|
2014-08-28 |
2016-03-03 |
Yeda Research And Development Co. Ltd. |
Methods of treating amyotrophic lateral scleroses
|
|
CN107106704A
(zh)
|
2014-08-29 |
2017-08-29 |
儿童医疗中心有限公司 |
用于治疗癌症的方法和组合物
|
|
WO2016033424A1
(en)
|
2014-08-29 |
2016-03-03 |
Genzyme Corporation |
Methods for the prevention and treatment of major adverse cardiovascular events using compounds that modulate apolipoprotein b
|
|
PT3185957T
(pt)
|
2014-08-29 |
2022-09-05 |
Alnylam Pharmaceuticals Inc |
Patisiran para utilização no tratamento de amoloidose mediada por transtirretina
|
|
EP3191591A1
(en)
|
2014-09-12 |
2017-07-19 |
Alnylam Pharmaceuticals, Inc. |
Polynucleotide agents targeting complement component c5 and methods of use thereof
|
|
WO2016049512A1
(en)
|
2014-09-26 |
2016-03-31 |
University Of Massachusetts |
Rna-modulating agents
|
|
JOP20200115A1
(ar)
|
2014-10-10 |
2017-06-16 |
Alnylam Pharmaceuticals Inc |
تركيبات وطرق لتثبيط التعبير الجيني عن hao1 (حمض أوكسيداز هيدروكسيلي 1 (أوكسيداز جليكولات))
|
|
WO2016061487A1
(en)
|
2014-10-17 |
2016-04-21 |
Alnylam Pharmaceuticals, Inc. |
Polynucleotide agents targeting aminolevulinic acid synthase-1 (alas1) and uses thereof
|
|
EP3904519A1
(en)
|
2014-10-30 |
2021-11-03 |
Genzyme Corporation |
Polynucleotide agents targeting serpinc1 (at3) and methods of use thereof
|
|
JOP20200092A1
(ar)
|
2014-11-10 |
2017-06-16 |
Alnylam Pharmaceuticals Inc |
تركيبات iRNA لفيروس الكبد B (HBV) وطرق لاستخدامها
|
|
EP3221451A1
(en)
|
2014-11-17 |
2017-09-27 |
Alnylam Pharmaceuticals, Inc. |
Apolipoprotein c3 (apoc3) irna compositions and methods of use thereof
|
|
US11213593B2
(en)
|
2014-11-21 |
2022-01-04 |
Northwestern University |
Sequence-specific cellular uptake of spherical nucleic acid nanoparticle conjugates
|
|
WO2016094845A2
(en)
|
2014-12-12 |
2016-06-16 |
Woolf Tod M |
Compositions and methods for editing nucleic acids in cells utilizing oligonucleotides
|
|
US9688707B2
(en)
|
2014-12-30 |
2017-06-27 |
Ionis Pharmaceuticals, Inc. |
Bicyclic morpholino compounds and oligomeric compounds prepared therefrom
|
|
US10793855B2
(en)
|
2015-01-06 |
2020-10-06 |
Ionis Pharmaceuticals, Inc. |
Compositions for modulating expression of C9ORF72 antisense transcript
|
|
US10538763B2
(en)
|
2015-01-16 |
2020-01-21 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for modulation of DUX4
|
|
CN108064288B
(zh)
|
2015-01-22 |
2021-11-26 |
孟山都技术公司 |
用于控制叶甲属的组合物和方法
|
|
EP3247988A4
(en)
|
2015-01-23 |
2018-12-19 |
Vanderbilt University |
A robust interferometer and methods of using same
|
|
EP3256487A4
(en)
|
2015-02-09 |
2018-07-18 |
Duke University |
Compositions and methods for epigenome editing
|
|
EP3256587A2
(en)
|
2015-02-13 |
2017-12-20 |
Alnylam Pharmaceuticals, Inc. |
Patatin-like phospholipase domain containing 3 (pnpla3) irna compositions and methods of use thereof
|
|
US20180200387A1
(en)
|
2015-02-23 |
2018-07-19 |
Crispr Therapeutics Ag |
Materials and methods for treatment of human genetic diseases including hemoglobinopathies
|
|
WO2016137923A1
(en)
|
2015-02-23 |
2016-09-01 |
Ionis Pharmaceuticals, Inc. |
Method for solution phase detritylation of oligomeric compounds
|
|
US11129844B2
(en)
|
2015-03-03 |
2021-09-28 |
Ionis Pharmaceuticals, Inc. |
Compositions and methods for modulating MECP2 expression
|
|
EP3268475B1
(en)
|
2015-03-11 |
2020-10-21 |
Yissum Research and Development Company of the Hebrew University of Jerusalem Ltd. |
Decoy oligonucleotides for the treatment of diseases
|
|
US20180064748A1
(en)
|
2015-03-27 |
2018-03-08 |
Yeda Research And Development Co. Ltd. |
Methods of treating motor neuron diseases
|
|
CN107847524A
(zh)
|
2015-03-27 |
2018-03-27 |
哈佛学院校长同事会 |
经过修饰的t细胞及其制备和使用方法
|
|
US10961532B2
(en)
|
2015-04-07 |
2021-03-30 |
The General Hospital Corporation |
Methods for reactivating genes on the inactive X chromosome
|
|
WO2016164746A1
(en)
|
2015-04-08 |
2016-10-13 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of the lect2 gene
|
|
US10407678B2
(en)
|
2015-04-16 |
2019-09-10 |
Ionis Pharmaceuticals, Inc. |
Compositions for modulating expression of C9ORF72 antisense transcript
|
|
EP3291677A4
(en)
|
2015-05-04 |
2019-02-13 |
Monsanto Technology LLC |
COMPOSITIONS AND METHODS FOR COMBATING AN ATTACK FROM ARTHROPODES AND OTHER PESTS
|
|
US20180161300A1
(en)
|
2015-05-11 |
2018-06-14 |
Yeda Research And Development Co., Ltd. |
Citrin inhibitors for the treatment of cancer
|
|
EP3302053B1
(en)
|
2015-06-02 |
2021-03-17 |
Monsanto Technology LLC |
Compositions and methods for delivery of a polynucleotide into a plant
|
|
US10655136B2
(en)
|
2015-06-03 |
2020-05-19 |
Monsanto Technology Llc |
Methods and compositions for introducing nucleic acids into plants
|
|
EP4365291A2
(en)
|
2015-06-12 |
2024-05-08 |
Alnylam Pharmaceuticals, Inc. |
Complement component c5 irna compositions and methods of use thereof
|
|
EP3310918B1
(en)
|
2015-06-18 |
2020-08-05 |
Alnylam Pharmaceuticals, Inc. |
Polynucleotide agents targeting hydroxyacid oxidase (glycolate oxidase, hao1) and methods of use thereof
|
|
WO2016209862A1
(en)
|
2015-06-23 |
2016-12-29 |
Alnylam Pharmaceuticals, Inc. |
Glucokinase (gck) irna compositions and methods of use thereof
|
|
EP3314250A4
(en)
|
2015-06-26 |
2018-12-05 |
Beth Israel Deaconess Medical Center, Inc. |
Cancer therapy targeting tetraspanin 33 (tspan33) in myeloid derived suppressor cells
|
|
EP3314027A4
(en)
|
2015-06-29 |
2019-07-03 |
Caris Science, Inc. |
THERAPEUTIC OLIGONUCLEOTIDES
|
|
US10494632B2
(en)
|
2015-07-10 |
2019-12-03 |
Alnylam Pharmaceuticals, Inc. |
Insulin-like growth factor binding protein, acid labile subunit (IGFALS) compositions and methods of use thereof
|
|
AU2016298317B2
(en)
|
2015-07-28 |
2021-02-18 |
Caris Science, Inc. |
Targeted oligonucleotides
|
|
US20180221393A1
(en)
|
2015-08-03 |
2018-08-09 |
Biokine Therapeutics Ltd. |
Cxcr4 binding agents for treatment of diseases
|
|
WO2017021961A1
(en)
|
2015-08-04 |
2017-02-09 |
Yeda Research And Development Co. Ltd. |
Methods of screening for riboswitches and attenuators
|
|
CA2991639A1
(en)
|
2015-08-07 |
2017-02-16 |
Arrowhead Pharmaceuticals, Inc. |
Rnai therapy for hepatitis b virus infection
|
|
CN108368507B
(zh)
|
2015-09-02 |
2022-03-22 |
阿尔尼拉姆医药品有限公司 |
程序性细胞死亡1配体1(PD-L1)的iRNA组合物及其使用方法
|
|
CA2998287A1
(en)
|
2015-09-24 |
2017-04-20 |
Crispr Therapeutics Ag |
Novel family of rna-programmable endonucleases and their uses in genome editing and other applications
|
|
US10533175B2
(en)
|
2015-09-25 |
2020-01-14 |
Ionis Pharmaceuticals, Inc. |
Compositions and methods for modulating Ataxin 3 expression
|
|
US11970710B2
(en)
|
2015-10-13 |
2024-04-30 |
Duke University |
Genome engineering with Type I CRISPR systems in eukaryotic cells
|
|
US11369692B2
(en)
|
2015-10-28 |
2022-06-28 |
Vertex Pharmaceuticals Incorporated |
Materials and methods for treatment of Duchenne Muscular Dystrophy
|
|
EP3368578B1
(en)
|
2015-10-30 |
2021-03-17 |
H. Hoffnabb-La Roche Ag |
Anti-htra1 antibodies and methods of use thereof
|
|
CA3007424A1
(en)
|
2015-11-05 |
2017-05-11 |
Children's Hospital Los Angeles |
"mobilizing leukemia cells"
|
|
EP3371305A1
(en)
|
2015-11-06 |
2018-09-12 |
Crispr Therapeutics AG |
Materials and methods for treatment of glycogen storage disease type 1a
|
|
IL289849B2
(en)
|
2015-11-10 |
2024-01-01 |
Nat Inst Biotechnology Negev Ltd |
Means and methods for reducing the tumorigenicity of cancer stem cells
|
|
US11001622B2
(en)
|
2015-11-19 |
2021-05-11 |
The Brigham And Women's Hospital, Inc. |
Method of treating autoimmune disease with lymphocyte antigen CD5-like (CD5L) protein
|
|
JP2019500899A
(ja)
|
2015-11-23 |
2019-01-17 |
ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア |
ＣＲＩＳＰＲ／Ｃａｓ９の核送達を通じた細胞ＲＮＡの追跡と操作
|
|
EP3384024B1
(en)
|
2015-12-01 |
2022-02-02 |
CRISPR Therapeutics AG |
Materials and methods for treatment of alpha-1 antitrypsin deficiency
|
|
WO2017096395A1
(en)
|
2015-12-04 |
2017-06-08 |
Ionis Pharmaceuticals, Inc. |
Methods of treating breast cancer
|
|
US10993995B2
(en)
|
2015-12-07 |
2021-05-04 |
Erasmus University Medical Center Rotterdam |
Enzymatic replacement therapy and antisense therapy for pompe disease
|
|
WO2017106767A1
(en)
|
2015-12-18 |
2017-06-22 |
The Scripps Research Institute |
Production of unnatural nucleotides using a crispr/cas9 system
|
|
BR112018012894A2
(pt)
|
2015-12-23 |
2018-12-04 |
Crispr Therapeutics Ag |
materiais e métodos para tratamento de esclerose lateral amiotrófica e/ou degeneração lobular frontotemporal
|
|
CA3006599A1
(en)
|
2016-01-05 |
2017-07-13 |
Ionis Pharmaceuticals, Inc. |
Methods for reducing lrrk2 expression
|
|
US10627396B2
(en)
|
2016-01-29 |
2020-04-21 |
Vanderbilt University |
Free-solution response function interferometry
|
|
EP3411078A1
(en)
|
2016-02-02 |
2018-12-12 |
Crispr Therapeutics AG |
Materials and methods for treatment of severe combined immunodeficiency (scid) or omenn syndrome
|
|
EP3411396A1
(en)
|
2016-02-04 |
2018-12-12 |
Curis, Inc. |
Mutant smoothened and methods of using the same
|
|
WO2017141109A1
(en)
|
2016-02-18 |
2017-08-24 |
Crispr Therapeutics Ag |
Materials and methods for treatment of severe combined immunodeficiency (scid) or omenn syndrome
|
|
WO2017147087A1
(en)
|
2016-02-25 |
2017-08-31 |
The Brigham And Women's Hospital, Inc. |
Treatment methods for fibrosis targeting smoc2
|
|
EP3429690A4
(en)
|
2016-03-16 |
2019-10-23 |
Ionis Pharmaceuticals, Inc. |
METHOD FOR MODULATING KEAP1
|
|
WO2017158422A1
(en)
|
2016-03-16 |
2017-09-21 |
Crispr Therapeutics Ag |
Materials and methods for treatment of hereditary haemochromatosis
|
|
WO2017161168A1
(en)
|
2016-03-16 |
2017-09-21 |
Ionis Pharmaceuticals, Inc. |
Modulation of dyrk1b expression
|
|
CN109715802A
(zh)
|
2016-03-18 |
2019-05-03 |
卡里斯科学公司 |
寡核苷酸探针及其用途
|
|
CN109715198B
(zh)
|
2016-04-18 |
2022-09-06 |
克里斯珀医疗股份公司 |
用于治疗血红蛋白病的材料和方法
|
|
MA45295A
(fr)
|
2016-04-19 |
2019-02-27 |
Alnylam Pharmaceuticals Inc |
Composition d'arni de protéine de liaison de lipoprotéines haute densité (hdlbp/vigiline) et procédés pour les utiliser
|
|
WO2017191503A1
(en)
|
2016-05-05 |
2017-11-09 |
Crispr Therapeutics Ag |
Materials and methods for treatment of hemoglobinopathies
|
|
US11293017B2
(en)
|
2016-05-25 |
2022-04-05 |
Caris Science, Inc. |
Oligonucleotide probes and uses thereof
|
|
US20190256845A1
(en)
|
2016-06-10 |
2019-08-22 |
Alnylam Pharmaceuticals, Inc. |
COMPLEMENT COMPONENT C5 iRNA COMPOSITIONS AND METHODS OF USE THEREOF FOR TREATING PAROXYSMAL NOCTURNAL HEMOGLOBINURIA (PNH)
|
|
EP3471781A4
(en)
|
2016-06-17 |
2020-05-06 |
Ionis Pharmaceuticals, Inc. |
MODULATING THE GYS1 EXPRESSION
|
|
HUE060123T2
(hu)
|
2016-06-24 |
2023-01-28 |
Scripps Research Inst |
Új nukleozid-trifoszfát-transzporter és alkalmazásai
|
|
EP3478313B1
(en)
|
2016-06-29 |
2022-05-04 |
CRISPR Therapeutics AG |
Materials and methods for treatment of amyotrophic lateral sclerosis (als) and other related disorders
|
|
US11427838B2
(en)
|
2016-06-29 |
2022-08-30 |
Vertex Pharmaceuticals Incorporated |
Materials and methods for treatment of myotonic dystrophy type 1 (DM1) and other related disorders
|
|
CA3029119A1
(en)
|
2016-06-29 |
2018-01-04 |
Crispr Therapeutics Ag |
Materials and methods for treatment of friedreich ataxia and other related disorders
|
|
EP3481857A1
(en)
|
2016-07-06 |
2019-05-15 |
Crispr Therapeutics AG |
Materials and methods for treatment of pain related disorders
|
|
CA3029132A1
(en)
|
2016-07-06 |
2018-01-11 |
Crispr Therapeutics Ag |
Materials and methods for treatment of pain related disorders
|
|
WO2018007871A1
(en)
|
2016-07-08 |
2018-01-11 |
Crispr Therapeutics Ag |
Materials and methods for treatment of transthyretin amyloidosis
|
|
EP3481430A4
(en)
|
2016-07-11 |
2020-04-01 |
Translate Bio Ma, Inc. |
NUCLEIC ACID CONJUGATES AND USES THEREOF
|
|
US20190247436A1
(en)
|
2016-07-21 |
2019-08-15 |
Maxcyte, Inc. |
Methods and compositions for modifying genomic dna
|
|
WO2018020323A2
(en)
|
2016-07-25 |
2018-02-01 |
Crispr Therapeutics Ag |
Materials and methods for treatment of fatty acid disorders
|
|
JOP20170161A1
(ar)
|
2016-08-04 |
2019-01-30 |
Arrowhead Pharmaceuticals Inc |
عوامل RNAi للعدوى بفيروس التهاب الكبد ب
|
|
NL2017294B1
(en)
|
2016-08-05 |
2018-02-14 |
Univ Erasmus Med Ct Rotterdam |
Natural cryptic exon removal by pairs of antisense oligonucleotides.
|
|
NL2017295B1
(en)
|
2016-08-05 |
2018-02-14 |
Univ Erasmus Med Ct Rotterdam |
Antisense oligomeric compound for Pompe disease
|
|
WO2018039629A2
(en)
|
2016-08-25 |
2018-03-01 |
Northwestern University |
Micellar spherical nucleic acids from thermoresponsive, traceless templates
|
|
CN110072530A
(zh)
|
2016-09-02 |
2019-07-30 |
迪克纳制药公司 |
4′-磷酸酯类似物和包含其的寡核苷酸
|
|
KR20190065341A
(ko)
|
2016-10-06 |
2019-06-11 |
아이오니스 파마수티컬즈, 인코포레이티드 |
올리고머 화합물들의 접합 방법
|
|
WO2018081817A2
(en)
|
2016-10-31 |
2018-05-03 |
University Of Massachusetts |
Targeting microrna-101-3p in cancer therapy
|
|
JOP20190104A1
(ar)
|
2016-11-10 |
2019-05-07 |
Ionis Pharmaceuticals Inc |
مركبات وطرق لتقليل التعبير عن atxn3
|
|
TWI788312B
(zh)
|
2016-11-23 |
2023-01-01 |
美商阿尼拉製藥公司 |
絲胺酸蛋白酶抑制因子Ａ１ ｉＲＮＡ組成物及其使用方法
|
|
EP3330276A1
(en)
|
2016-11-30 |
2018-06-06 |
Universität Bern |
Novel bicyclic nucleosides and oligomers prepared therefrom
|
|
EP3548620A4
(en)
|
2016-12-02 |
2020-07-22 |
Cold Spring Harbor Laboratory |
MODULATION OF THE EXPRESSION OF LNC05
|
|
CA3045667A1
(en)
|
2016-12-13 |
2018-06-21 |
Seattle Children's Hospital (dba Seattle Children's Research Institute) |
Methods of exogenous drug activation of chemical-induced signaling complexes expressed in engineered cells in vitro and in vivo
|
|
WO2018112320A1
(en)
|
2016-12-16 |
2018-06-21 |
Alnylam Pharmaceuticals, Inc. |
Methods for treating or preventing ttr-associated diseases using transthyretin (ttr) irna compositions
|
|
SG11201906735RA
(en)
|
2017-01-23 |
2019-08-27 |
Regeneron Pharma |
Hydroxysteroid 17-beta dehydrogenase 13 (hsd17b13) variants and uses thereof
|
|
US20200040061A1
(en)
|
2017-02-22 |
2020-02-06 |
Crispr Therapeutics Ag |
Materials and methods for treatment of early onset parkinson's disease (park1) and other synuclein, alpha (snca) gene related conditions or disorders
|
|
US20200216857A1
(en)
|
2017-02-22 |
2020-07-09 |
Crispr Therapeutics Ag |
Materials and methods for treatment of spinocerebellar ataxia type 2 (sca2) and other spinocerebellar ataxia type 2 protein (atxn2) gene related conditions or disorders
|
|
US11407997B2
(en)
|
2017-02-22 |
2022-08-09 |
Crispr Therapeutics Ag |
Materials and methods for treatment of primary hyperoxaluria type 1 (PH1) and other alanine-glyoxylate aminotransferase (AGXT) gene related conditions or disorders
|
|
EP3585895A1
(en)
|
2017-02-22 |
2020-01-01 |
CRISPR Therapeutics AG |
Compositions and methods for gene editing
|
|
US11559588B2
(en)
|
2017-02-22 |
2023-01-24 |
Crispr Therapeutics Ag |
Materials and methods for treatment of Spinocerebellar Ataxia Type 1 (SCA1) and other Spinocerebellar Ataxia Type 1 Protein (ATXN1) gene related conditions or disorders
|
|
US11180756B2
(en)
|
2017-03-09 |
2021-11-23 |
Ionis Pharmaceuticals |
Morpholino modified oligomeric compounds
|
|
WO2018183969A1
(en)
|
2017-03-30 |
2018-10-04 |
California Institute Of Technology |
Barcoded rapid assay platform for efficient analysis of candidate molecules and methods of making and using the platform
|
|
CA3059446A1
(en)
|
2017-04-18 |
2018-10-25 |
Alnylam Pharmaceuticals, Inc. |
Methods for the treatment of subjects having a hepatitis b virus (hbv) infection
|
|
WO2018193428A1
(en)
|
2017-04-20 |
2018-10-25 |
Synthena Ag |
Modified oligomeric compounds comprising tricyclo-dna nucleosides and uses thereof
|
|
WO2018195338A1
(en)
|
2017-04-20 |
2018-10-25 |
Atyr Pharma, Inc. |
Compositions and methods for treating lung inflammation
|
|
CN110945005A
(zh)
|
2017-04-20 |
2020-03-31 |
新特纳股份公司 |
包含三环dna核苷的修饰的寡聚化合物及其用途
|
|
WO2018195486A1
(en)
|
2017-04-21 |
2018-10-25 |
The Broad Institute, Inc. |
Targeted delivery to beta cells
|
|
CA3062595A1
(en)
|
2017-05-10 |
2018-11-15 |
The Regents Of The University Of California |
Directed editing of cellular rna via nuclear delivery of crispr/cas9
|
|
EP3621981A2
(en)
|
2017-05-12 |
2020-03-18 |
CRISPR Therapeutics AG |
Materials and methods for engineering cells and uses thereof in immuno-oncology
|
|
AU2018300069A1
(en)
|
2017-07-11 |
2020-02-27 |
Synthorx, Inc. |
Incorporation of unnatural nucleotides and methods thereof
|
|
JP7277432B2
(ja)
|
2017-07-13 |
2023-05-19 |
アルナイラム ファーマシューティカルズ， インコーポレイテッド |
乳酸脱水素酵素Ａ（ＬＤＨＡ）ｉＲＮＡ組成物及びその使用方法
|
|
MX2020000387A
(es)
|
2017-07-13 |
2020-08-17 |
Univ Northwestern |
Método general y directo para preparar nanopartículas de estructura organometálica funcionalizadas con oligonucleotidos.
|
|
US20200181220A1
(en)
|
2017-08-03 |
2020-06-11 |
Synthorx, Inc. |
Cytokine conjugates for the treatment of proliferative and infectious diseases
|
|
AU2018318231A1
(en)
|
2017-08-18 |
2020-02-13 |
Ionis Pharmaceuticals, Inc. |
Modulation of the notch signaling pathway for treatment of respiratory disorders
|
|
WO2019051173A1
(en)
|
2017-09-08 |
2019-03-14 |
Ionis Pharmaceuticals, Inc. |
MODULATORS OF SMAD7 EXPRESSION
|
|
AU2018336806A1
(en)
|
2017-09-19 |
2020-05-07 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for treating transthyretin (TTR) mediated amyloidosis
|
|
AU2018353012A1
(en)
|
2017-10-17 |
2020-04-23 |
Bayer Healthcare Llc |
Compositions and methods for gene editing for Hemophilia A
|
|
MA50849A
(fr)
|
2017-10-26 |
2020-09-02 |
Vertex Pharma |
Substances et procédés pour le traitement d'hémoglobinopathies
|
|
US11866701B2
(en)
|
2017-11-01 |
2024-01-09 |
Alnylam Pharmaceuticals, Inc. |
Complement component C3 iRNA compositions and methods of use thereof
|
|
TWI809004B
(zh)
|
2017-11-09 |
2023-07-21 |
美商Ionis製藥公司 |
用於降低snca表現之化合物及方法
|
|
MA50578A
(fr)
|
2017-11-09 |
2021-09-15 |
Vertex Pharma |
Systèmes crispr/cas pour le traitement de dmd
|
|
US20200385719A1
(en)
|
2017-11-16 |
2020-12-10 |
Alnylam Pharmaceuticals, Inc. |
Kisspeptin 1 (kiss1) irna compositions and methods of use thereof
|
|
WO2019100039A1
(en)
|
2017-11-20 |
2019-05-23 |
Alnylam Pharmaceuticals, Inc. |
Serum amyloid p component (apcs) irna compositions and methods of use thereof
|
|
MA50877A
(fr)
|
2017-11-21 |
2020-09-30 |
Bayer Healthcare Llc |
Matériaux et méthodes pour le traitement de la rétinite pigmentaire autosomique dominante
|
|
AU2018378479A1
(en)
|
2017-12-05 |
2020-06-18 |
Vertex Pharmaceuticals Incorporated |
CRISPR-Cas9 modified CD34+ human hematopoietic stem and progenitor cells and uses thereof
|
|
WO2019118935A1
(en)
|
2017-12-14 |
2019-06-20 |
Casebia Therapeutics Limited Liability Partnership |
Novel rna-programmable endonuclease systems and their use in genome editing and other applications
|
|
EP3728593A1
(en)
|
2017-12-18 |
2020-10-28 |
Alnylam Pharmaceuticals, Inc. |
High mobility group box-1 (hmgb1) irna compositions and methods of use thereof
|
|
EP3728595A1
(en)
|
2017-12-21 |
2020-10-28 |
CRISPR Therapeutics AG |
Materials and methods for treatment of usher syndrome type 2a and/or non-syndromic autosomal recessive retinitis pigmentosa (arrp)
|
|
WO2019126641A2
(en)
|
2017-12-21 |
2019-06-27 |
Ionis Pharmaceuticals, Inc. |
Modulation of frataxin expression
|
|
JP7402163B2
(ja)
|
2017-12-21 |
2023-12-20 |
クリスパー セラピューティクス アーゲー |
２ａ型アッシャー症候群の処置のための材料および方法
|
|
US20210254057A1
(en)
|
2018-01-12 |
2021-08-19 |
Crispr Therapeutics Ag |
Compositions and methods for gene editing by targeting transferrin
|
|
MA51645A
(fr)
|
2018-01-15 |
2020-11-25 |
Ionis Pharmaceuticals Inc |
Modulateurs de l'expression de dnm2
|
|
CN111801321A
(zh)
|
2018-01-19 |
2020-10-20 |
新特纳股份公司 |
三环-dna核苷前体和其制备方法
|
|
WO2019147743A1
(en)
|
2018-01-26 |
2019-08-01 |
Massachusetts Institute Of Technology |
Structure-guided chemical modification of guide rna and its applications
|
|
US11566236B2
(en)
|
2018-02-05 |
2023-01-31 |
Vertex Pharmaceuticals Incorporated |
Materials and methods for treatment of hemoglobinopathies
|
|
EP3749768A1
(en)
|
2018-02-05 |
2020-12-16 |
Vertex Pharmaceuticals Incorporated |
Materials and methods for treatment of hemoglobinopathies
|
|
WO2019155465A1
(en)
|
2018-02-08 |
2019-08-15 |
Yeda Research And Development Co. Ltd. |
Methods of identifying and using agents for treating diseases associated with intestinal barrier dysfunction
|
|
WO2019161310A1
(en)
|
2018-02-16 |
2019-08-22 |
Casebia Therapeutics Limited Liability Partnership |
Compositions and methods for gene editing by targeting fibrinogen-alpha
|
|
CN112004547A
(zh)
|
2018-02-26 |
2020-11-27 |
新索思股份有限公司 |
Il-15缀合物及其用途
|
|
US11241451B2
(en)
|
2018-03-02 |
2022-02-08 |
Ionis Pharmaceuticals, Inc. |
Modulators of IRF4 expression
|
|
EP3759127A4
(en)
|
2018-03-02 |
2022-03-30 |
Ionis Pharmaceuticals, Inc. |
COMPOUNDS AND METHODS FOR MODULATING AMYLOID BETA PRECURSOR PROTEIN
|
|
US11897911B2
(en)
|
2018-03-07 |
2024-02-13 |
Sanofi |
Nucleotide precursors, nucleotide analogs and oligomeric compounds containing the same
|
|
WO2019183150A1
(en)
|
2018-03-19 |
2019-09-26 |
Casebia Therapeutics Limited Liability Partnership |
Novel rna-programmable endonuclease systems and uses thereof
|
|
WO2019183440A1
(en)
|
2018-03-22 |
2019-09-26 |
Ionis Pharmaceuticals, Inc. |
Methods for modulating fmr1 expression
|
|
EP4051799A2
(en)
|
2018-03-30 |
2022-09-07 |
Rheinische Friedrich-Wilhelms-Universität Bonn |
Aptamers for targeted activaton of t cell-mediated immunity
|
|
US20210155959A1
(en)
|
2018-04-06 |
2021-05-27 |
Children's Medical Center Corporation |
Compositions and methods for somatic cell reprogramming and modulating imprinting
|
|
KR20200141481A
(ko)
|
2018-04-11 |
2020-12-18 |
아이오니스 파마수티컬즈, 인코포레이티드 |
Ezh2 발현의 조절제
|
|
WO2019204668A1
(en)
|
2018-04-18 |
2019-10-24 |
Casebia Therapeutics Limited Liability Partnership |
Compositions and methods for knockdown of apo(a) by gene editing for treatment of cardiovascular disease
|
|
BR112020020957B1
(pt)
|
2018-05-09 |
2022-05-10 |
Ionis Pharmaceuticals, Inc |
Compostos oligoméricos, população e composição farmacêutica dos mesmos e seus usos
|
|
AU2019266307A1
(en)
|
2018-05-09 |
2020-11-19 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for reducing ATXN3 expression
|
|
TW202016304A
(zh)
|
2018-05-14 |
2020-05-01 |
美商阿尼拉製藥公司 |
血管收縮素原（ＡＧＴ）ｉＲＮＡ組成物及其使用方法
|
|
JP2021526823A
(ja)
|
2018-06-14 |
2021-10-11 |
アイオーニス ファーマシューティカルズ， インコーポレーテッドＩｏｎｉｓ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ，Ｉｎｃ． |
Ｓｔｍｎ２発現を増加させるための化合物及び方法
|
|
CN112400019B
(zh)
|
2018-06-27 |
2024-05-07 |
Ionis制药公司 |
用于减少lrrk2表达的化合物和方法
|
|
MX2020014248A
(es)
|
2018-06-28 |
2021-03-09 |
Crispr Therapeutics Ag |
Composiciones y metodos para edicion genomica mediante insercion de polinucleotidos donadores.
|
|
AR115847A1
(es)
|
2018-07-25 |
2021-03-03 |
Ionis Pharmaceuticals Inc |
Compuestos y métodos para reducir la expresión de la atxn2
|
|
MX2021001056A
(es)
|
2018-08-13 |
2021-04-12 |
Alnylam Pharmaceuticals Inc |
Composiciones de agente de acido ribonucleico bicatenario (arnbc) de virus de la hepatitis b (vhb) y metodos de uso de las mismas.
|
|
EP3837367A1
(en)
|
2018-08-16 |
2021-06-23 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of the lect2 gene
|
|
US20210292766A1
(en)
|
2018-08-29 |
2021-09-23 |
University Of Massachusetts |
Inhibition of Protein Kinases to Treat Friedreich Ataxia
|
|
EP3849584A4
(en)
|
2018-09-14 |
2022-06-22 |
Northwestern University |
PROGRAMMING PROTEIN POLYMERIZATION WITH DNA
|
|
US20210332367A1
(en)
|
2018-09-18 |
2021-10-28 |
Alnylam Pharmaceuticals, Inc. |
KETOHEXOKINASE (KHK) iRNA COMPOSITIONS AND METHODS OF USE THEREOF
|
|
MX2021004455A
(es)
|
2018-10-17 |
2021-08-11 |
Crispr Therapeutics Ag |
Composiciones y métodos para administrar transgenes.
|
|
US10913951B2
(en)
|
2018-10-31 |
2021-02-09 |
University of Pittsburgh—of the Commonwealth System of Higher Education |
Silencing of HNF4A-P2 isoforms with siRNA to improve hepatocyte function in liver failure
|
|
TW202028222A
(zh)
|
2018-11-14 |
2020-08-01 |
美商Ionis製藥公司 |
Foxp3表現之調節劑
|
|
JOP20210108A1
(ar)
|
2018-11-15 |
2023-01-30 |
Ionis Pharmaceuticals Inc |
معدِّلات تعبير irf5
|
|
IL263184A
(en)
|
2018-11-21 |
2020-05-31 |
Yarden Yosef |
Method of treating cancer and compositions for same
|
|
US20210332495A1
(en)
|
2018-12-06 |
2021-10-28 |
Northwestern University |
Protein Crystal Engineering Through DNA Hybridization Interactions
|
|
US20220056455A1
(en)
|
2018-12-20 |
2022-02-24 |
Praxis Precision Medicines, Inc. |
Compositions and methods for the treatment of kcnt1 related disorders
|
|
HRP20231338T1
(hr)
|
2018-12-20 |
2024-02-16 |
Vir Biotechnology, Inc. |
Kombinirana terapija hbv
|
|
WO2020150431A1
(en)
|
2019-01-16 |
2020-07-23 |
Genzyme Corporation |
Serpinc1 irna compositions and methods of use thereof
|
|
AU2020216444A1
(en)
|
2019-01-31 |
2021-07-29 |
Ionis Pharmaceuticals, Inc. |
Modulators of YAP1 expression
|
|
CN114949240A
(zh)
|
2019-02-06 |
2022-08-30 |
新索思股份有限公司 |
Il-2缀合物及其使用方法
|
|
SG11202108357PA
(en)
|
2019-02-15 |
2021-08-30 |
Crispr Therapeutics Ag |
Gene editing for hemophilia a with improved factor viii expression
|
|
WO2020171889A1
(en)
|
2019-02-19 |
2020-08-27 |
University Of Rochester |
Blocking lipid accumulation or inflammation in thyroid eye disease
|
|
JP2022521010A
(ja)
|
2019-02-21 |
2022-04-04 |
イッスム・リサーチ・デベロプメント・カムパニー・オブ・ザ・ヘブリュー・ユニバシティー・オブ・エルサレム リミテッド |
薬物誘導性腎毒性を減少させるための方法
|
|
EP3931328A4
(en)
|
2019-02-27 |
2023-09-13 |
Ionis Pharmaceuticals, Inc. |
MODULATORS OF MALAT1 EXPRESSION
|
|
EP3937963A2
(en)
|
2019-03-12 |
2022-01-19 |
CRISPR Therapeutics AG |
Novel high fidelity rna-programmable endonuclease systems and uses thereof
|
|
US20220154189A1
(en)
|
2019-03-29 |
2022-05-19 |
Dicerna Pharmaceuticals, Inc. |
Compositions and methods for the treatment of kras associated diseases or disorders
|
|
PE20220284A1
(es)
|
2019-03-29 |
2022-02-25 |
Ionis Pharmaceuticals Inc |
Compuestos y metodos para modular ube3a-ats
|
|
CN113795581A
(zh)
|
2019-05-03 |
2021-12-14 |
迪克纳制药公司 |
具有缩短的有义链的双链核酸抑制剂分子
|
|
WO2020225606A1
(en)
|
2019-05-08 |
2020-11-12 |
Crispr Therapeutics Ag |
Crispr/cas all-in-two vector systems for treatment of dmd
|
|
MX2021013698A
(es)
|
2019-05-13 |
2021-12-10 |
Vir Biotechnology Inc |
Composiciones y metodos para el tratamiento de la infeccion por virus de la hepatitis b (vhb).
|
|
AU2020291535A1
(en)
|
2019-06-14 |
2022-01-20 |
The Scripps Research Institute |
Reagents and methods for replication, transcription, and translation in semi-synthetic organisms
|
|
US20230022146A1
(en)
|
2019-06-17 |
2023-01-26 |
Vertex Pharmaceuticals Incorporated |
Compositions and methods for editing beta-globin for treatment of hemaglobinopathies
|
|
EP3956450A4
(en)
|
2019-07-26 |
2022-11-16 |
Ionis Pharmaceuticals, Inc. |
COMPOUNDS AND METHODS FOR MODULATION OF GFAP
|
|
EP4007811A2
(en)
|
2019-08-01 |
2022-06-08 |
Alnylam Pharmaceuticals, Inc. |
Carboxypeptidase b2 (cpb2) irna compositions and methods of use thereof
|
|
EP4007812A1
(en)
|
2019-08-01 |
2022-06-08 |
Alnylam Pharmaceuticals, Inc. |
Serpin family f member 2 (serpinf2) irna compositions and methods of use thereof
|
|
EP4013870A1
(en)
|
2019-08-13 |
2022-06-22 |
Alnylam Pharmaceuticals, Inc. |
Small ribosomal protein subunit 25 (rps25) irna agent compositions and methods of use thereof
|
|
WO2021030778A1
(en)
|
2019-08-15 |
2021-02-18 |
Ionis Pharmaceuticals, Inc. |
Linkage modified oligomeric compounds and uses thereof
|
|
TW202120128A
(zh)
|
2019-08-15 |
2021-06-01 |
美商欣爍克斯公司 |
使用ｉｌ－２接合物之免疫腫瘤學組合療法
|
|
TW202122401A
(zh)
|
2019-08-23 |
2021-06-16 |
美商欣爍克斯公司 |
新穎之ｉｌ－１５接合物及其用途
|
|
CN114616331A
(zh)
|
2019-09-03 |
2022-06-10 |
阿尔尼拉姆医药品有限公司 |
抑制lect2基因表达的组合物和方法
|
|
JP2022547078A
(ja)
|
2019-09-10 |
2022-11-10 |
シンソークス， インコーポレイテッド |
Ｉｌ－２コンジュゲートおよび自己免疫疾患を治療するための使用方法
|
|
EP4038189A1
(en)
|
2019-10-04 |
2022-08-10 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for silencing ugt1a1 gene expression
|
|
EP4045652A1
(en)
|
2019-10-18 |
2022-08-24 |
Alnylam Pharmaceuticals, Inc. |
Solute carrier family member irna compositions and methods of use thereof
|
|
WO2021081026A1
(en)
|
2019-10-22 |
2021-04-29 |
Alnylam Pharmaceuticals, Inc. |
Complement component c3 irna compositions and methods of use thereof
|
|
EP4051795A1
(en)
|
2019-11-01 |
2022-09-07 |
Alnylam Pharmaceuticals, Inc. |
Huntingtin (htt) irna agent compositions and methods of use thereof
|
|
WO2021087325A1
(en)
|
2019-11-01 |
2021-05-06 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for silencing dnajb1-prkaca fusion gene expression
|
|
JP2022554272A
(ja)
|
2019-11-04 |
2022-12-28 |
シンソークス， インコーポレイテッド |
インターロイキン１０コンジュゲートおよびその使用
|
|
JP2023502038A
(ja)
|
2019-11-13 |
2023-01-20 |
アルナイラム ファーマシューティカルズ， インコーポレイテッド |
アンギオテンシノーゲン（ａｇｔ）関連障害を処置するための方法および組成物
|
|
US20230056569A1
(en)
|
2019-11-22 |
2023-02-23 |
Alnylam Pharmaceuticals, Inc. |
Ataxin3 (atxn3) rnai agent compositions and methods of use thereof
|
|
CN115335521A
(zh)
|
2019-11-27 |
2022-11-11 |
克里斯珀医疗股份公司 |
合成rna分子的方法
|
|
BR112022011417A2
(pt)
|
2019-12-13 |
2022-08-30 |
Alnylam Pharmaceuticals Inc |
Composições do agente de irna da fase de leitura aberta 72 do cromossomo humano 9 (c9orf72) e métodos de uso das mesmas
|
|
TW202138559A
(zh)
|
2019-12-16 |
2021-10-16 |
美商阿尼拉製藥公司 |
含類ＰＡＴＡＴＩＮ磷脂酶結構域３（ＰＮＰＬＡ３）ｉＲＮＡ組成物及其使用方法
|
|
WO2021122944A1
(en)
|
2019-12-18 |
2021-06-24 |
Alia Therapeutics Srl |
Compositions and methods for treating retinitis pigmentosa
|
|
CN115298192A
(zh)
|
2020-01-15 |
2022-11-04 |
迪克纳制药公司 |
4′-o-亚甲基膦酸酯核酸及其类似物
|
|
US20230057461A1
(en)
|
2020-01-27 |
2023-02-23 |
The U.S.A., As Represented By The Secretary, Department Of Health And Human Services |
Rab13 and net1 antisense oligonucleotides to treat metastatic cancer
|
|
WO2021154941A1
(en)
|
2020-01-31 |
2021-08-05 |
Alnylam Pharmaceuticals, Inc. |
Complement component c5 irna compositions for use in the treatment of amyotrophic lateral sclerosis (als)
|
|
JP2023514190A
(ja)
|
2020-02-10 |
2023-04-05 |
アルナイラム ファーマシューティカルズ， インコーポレイテッド |
Ｖｅｇｆ－ａ発現をサイレンシングするための組成物および方法
|
|
JP2023514336A
(ja)
|
2020-02-18 |
2023-04-05 |
アルナイラム ファーマシューティカルズ， インコーポレイテッド |
アポリポタンパク質Ｃ３（ＡＰＯＣ３）ｉＲＮＡ組成物およびその使用法
|
|
KR20220148230A
(ko)
|
2020-02-28 |
2022-11-04 |
아이오니스 파마수티컬즈, 인코포레이티드 |
Smn2를 조절하기 위한 화합물 및 방법
|
|
WO2021178607A1
(en)
|
2020-03-05 |
2021-09-10 |
Alnylam Pharmaceuticals, Inc. |
Complement component c3 irna compositions and methods of use thereof for treating or preventing complement component c3-associated diseases
|
|
JP2023516095A
(ja)
|
2020-03-06 |
2023-04-17 |
アルナイラム ファーマシューティカルズ， インコーポレイテッド |
ケトヘキソキナーゼ（ＫＨＫ）ｉＲＮＡ組成物およびその使用方法
|
|
EP4121534A1
(en)
|
2020-03-18 |
2023-01-25 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for treating subjects having a heterozygous alanine-glyoxylate aminotransferase gene (agxt) variant
|
|
EP4127168A1
(en)
|
2020-03-26 |
2023-02-08 |
Alnylam Pharmaceuticals, Inc. |
Coronavirus irna compositions and methods of use thereof
|
|
US20230190785A1
(en)
|
2020-03-30 |
2023-06-22 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for silencing dnajc15 gene expression
|
|
KR20230008729A
(ko)
|
2020-04-06 |
2023-01-16 |
알닐람 파마슈티칼스 인코포레이티드 |
Myoc 발현을 사일런싱하기 위한 조성물 및 방법
|
|
WO2021206922A1
(en)
|
2020-04-07 |
2021-10-14 |
Alnylam Pharmaceuticals, Inc. |
Transmembrane serine protease 2 (tmprss2) irna compositions and methods of use thereof
|
|
WO2021206917A1
(en)
|
2020-04-07 |
2021-10-14 |
Alnylam Pharmaceuticals, Inc. |
ANGIOTENSIN-CONVERTING ENZYME 2 (ACE2) iRNA COMPOSITIONS AND METHODS OF USE THEREOF
|
|
WO2021207189A1
(en)
|
2020-04-07 |
2021-10-14 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for silencing scn9a expression
|
|
BR112022021813A2
(pt)
|
2020-04-27 |
2023-01-17 |
Alnylam Pharmaceuticals Inc |
Composições de agente de apolipoproteína e (apoe) irna e métodos de uso das mesmas
|
|
IL297680A
(en)
|
2020-04-30 |
2022-12-01 |
Alnylam Pharmaceuticals Inc |
IRNA compounds complement factor b (cfb) and methods of using them
|
|
WO2021222768A2
(en)
|
2020-05-01 |
2021-11-04 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for modulating atxn1
|
|
EP4150088A1
(en)
|
2020-05-15 |
2023-03-22 |
Korro Bio, Inc. |
Methods and compositions for the adar-mediated editing of argininosuccinate synthetase (ass1)
|
|
WO2021231685A1
(en)
|
2020-05-15 |
2021-11-18 |
Korro Bio, Inc. |
Methods and compositions for the adar-mediated editing of transmembrane channel-like protein 1 (tmc1)
|
|
EP4150089A1
(en)
|
2020-05-15 |
2023-03-22 |
Korro Bio, Inc. |
Methods and compositions for the adar-mediated editing of retinoschisin 1 (rs1)
|
|
WO2021231698A1
(en)
|
2020-05-15 |
2021-11-18 |
Korro Bio, Inc. |
Methods and compositions for the adar-mediated editing of argininosuccinate lyase (asl)
|
|
WO2021231673A1
(en)
|
2020-05-15 |
2021-11-18 |
Korro Bio, Inc. |
Methods and compositions for the adar-mediated editing of leucine rich repeat kinase 2 (lrrk2)
|
|
EP4150076A1
(en)
|
2020-05-15 |
2023-03-22 |
Korro Bio, Inc. |
Methods and compositions for the adar-mediated editing of methyl-cpg binding protein 2 (mecp2)
|
|
WO2021231679A1
(en)
|
2020-05-15 |
2021-11-18 |
Korro Bio, Inc. |
Methods and compositions for the adar-mediated editing of gap junction protein beta 2 (gjb2)
|
|
EP4150090A1
(en)
|
2020-05-15 |
2023-03-22 |
Korro Bio, Inc. |
Methods and compositions for the adar-mediated editing of otoferlin (otof)
|
|
US20230183707A1
(en)
|
2020-05-21 |
2023-06-15 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting marc1 gene expression
|
|
CA3179051A1
(en)
|
2020-05-22 |
2021-11-25 |
Chandra Vargeese |
Double stranded oligonucleotide compositions and methods relating thereto
|
|
US11408000B2
(en)
|
2020-06-03 |
2022-08-09 |
Triplet Therapeutics, Inc. |
Oligonucleotides for the treatment of nucleotide repeat expansion disorders associated with MSH3 activity
|
|
WO2021248052A1
(en)
|
2020-06-05 |
2021-12-09 |
The Broad Institute, Inc. |
Compositions and methods for treating neoplasia
|
|
WO2021252557A1
(en)
|
2020-06-09 |
2021-12-16 |
Alnylam Pharmaceuticals, Inc. |
Rnai compositions and methods of use thereof for delivery by inhalation
|
|
EP4168546A1
(en)
|
2020-06-18 |
2023-04-26 |
Alnylam Pharmaceuticals, Inc. |
Xanthine dehydrogenase (xdh) irna compositions and methods of use thereof
|
|
KR20230042023A
(ko)
|
2020-06-24 |
2023-03-27 |
비르 바이오테크놀로지, 인코포레이티드 |
조작된 b형 간염 바이러스 중화 항체 및 이의 용도
|
|
IL299074A
(en)
|
2020-06-25 |
2023-02-01 |
Synthorx Inc |
Immuno-oncology therapeutic combination with IL-2 and anti-AGFR antibody conjugates
|
|
WO2022006134A2
(en)
|
2020-06-29 |
2022-01-06 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for modulating plp1
|
|
AU2021321289A1
(en)
|
2020-08-04 |
2023-03-02 |
Dicerna Pharmaceuticals, Inc. |
Systemic delivery of oligonucleotides
|
|
EP4217489A1
(en)
|
2020-09-24 |
2023-08-02 |
Alnylam Pharmaceuticals, Inc. |
Dipeptidyl peptidase 4 (dpp4) irna compositions and methods of use thereof
|
|
WO2022070107A1
(en)
|
2020-09-30 |
2022-04-07 |
Crispr Therapeutics Ag |
Materials and methods for treatment of amyotrophic lateral sclerosis
|
|
EP3978608A1
(en)
|
2020-10-05 |
2022-04-06 |
SQY Therapeutics |
Oligomeric compound for dystrophin rescue in dmd patients throughout skipping of exon-51
|
|
JP2023544413A
(ja)
|
2020-10-05 |
2023-10-23 |
アルナイラム ファーマシューティカルズ， インコーポレイテッド |
Ｇタンパク質共役受容体７５（ＧＰＲ７５）ｉＲＮＡ組成物およびその使用方法
|
|
BR112023006364A2
(pt)
|
2020-10-09 |
2023-05-09 |
Synthorx Inc |
Terapia de combinação de imuno-oncologia com conjugados de il-2 e pembrolizumabe
|
|
WO2022076859A1
(en)
|
2020-10-09 |
2022-04-14 |
Synthorx, Inc. |
Immuno oncology therapies with il-2 conjugates
|
|
WO2022079719A1
(en)
|
2020-10-15 |
2022-04-21 |
Yeda Research And Development Co. Ltd. |
Method of treating myeloid malignancies
|
|
WO2022084331A2
(en)
|
2020-10-20 |
2022-04-28 |
Sanofi |
Novel ligands for asialoglycoprotein receptor
|
|
EP4232581A1
(en)
|
2020-10-21 |
2023-08-30 |
Alnylam Pharmaceuticals, Inc. |
Methods and compositions for treating primary hyperoxaluria
|
|
EP4232582A1
(en)
|
2020-10-23 |
2023-08-30 |
Alnylam Pharmaceuticals, Inc. |
Mucin 5b (muc5b) irna compositions and methods of use thereof
|
|
MX2023005490A
(es)
|
2020-11-13 |
2023-05-23 |
Alnylam Pharmaceuticals Inc |
Composiciones de acido ribonucleico de interferencia (arni) del factor de coagulacion v (f5) y sus metodos de uso.
|
|
KR20230108728A
(ko)
|
2020-11-18 |
2023-07-18 |
아이오니스 파마수티컬즈, 인코포레이티드 |
앤지오텐시노겐 발현을 조절하기 위한 화합물 및 방법
|
|
WO2022119873A1
(en)
|
2020-12-01 |
2022-06-09 |
Alnylam Pharmaceuticals, Inc. |
Methods and compositions for inhibition of hao1 (hydroxyacid oxidase 1 (glycolate oxidase)) gene expression
|
|
WO2022125490A1
(en)
|
2020-12-08 |
2022-06-16 |
Alnylam Pharmaceuticals, Inc. |
Coagulation factor x (f10) irna compositions and methods of use thereof
|
|
WO2022140702A1
(en)
|
2020-12-23 |
2022-06-30 |
Flagship Pioneering, Inc. |
Compositions of modified trems and uses thereof
|
|
WO2022150260A1
(en)
|
2021-01-05 |
2022-07-14 |
Alnylam Pharmaceuticals, Inc. |
COMPLEMENT COMPONENT 9 (C9) iRNA COMPOSITIONS AND METHODS OF USE THEREOF
|
|
WO2022174000A2
(en)
|
2021-02-12 |
2022-08-18 |
Alnylam Pharmaceuticals, Inc. |
Superoxide dismutase 1 (sod1) irna compositions and methods of use thereof for treating or preventing superoxide dismutase 1- (sod1-) associated neurodegenerative diseases
|
|
EP4291243A1
(en)
|
2021-02-12 |
2023-12-20 |
Synthorx, Inc. |
Lung cancer combination therapy with il-2 conjugates and an anti-pd-1 antibody or antigen-binding fragment thereof
|
|
TW202245843A
(zh)
|
2021-02-12 |
2022-12-01 |
美商欣爍克斯公司 |
Ｉｌ－２接合物及西米普利單抗（ｃｅｍｉｐｌｉｍａｂ）之皮膚癌組合療法
|
|
CN117222739A
(zh)
|
2021-02-25 |
2023-12-12 |
阿尔尼拉姆医药品有限公司 |
朊病毒蛋白(prnp)irna组合物和其使用方法
|
|
AU2022226098A1
(en)
|
2021-02-26 |
2023-08-24 |
Alnylam Pharmaceuticals, Inc. |
KETOHEXOKINASE (KHK) iRNA COMPOSITIONS AND METHODS OF USE THEREOF
|
|
WO2022187435A1
(en)
|
2021-03-04 |
2022-09-09 |
Alnylam Pharmaceuticals, Inc. |
Angiopoietin-like 3 (angptl3) irna compositions and methods of use thereof
|
|
WO2022192519A1
(en)
|
2021-03-12 |
2022-09-15 |
Alnylam Pharmaceuticals, Inc. |
Glycogen synthase kinase 3 alpha (gsk3a) irna compositions and methods of use thereof
|
|
WO2022192038A1
(en)
|
2021-03-12 |
2022-09-15 |
Northwestern University |
Antiviral vaccines using spherical nucleic acids
|
|
BR112023019981A2
(pt)
|
2021-03-29 |
2023-12-12 |
Alnylam Pharmaceuticals Inc |
Composições do agente irna de huntingtina (htt) e métodos de uso das mesmas
|
|
WO2022212153A1
(en)
|
2021-04-01 |
2022-10-06 |
Alnylam Pharmaceuticals, Inc. |
Proline dehydrogenase 2 (prodh2) irna compositions and methods of use thereof
|
|
BR112023022284A2
(pt)
|
2021-04-26 |
2023-12-26 |
Alnylam Pharmaceuticals Inc |
Composições de irna de protease transmembrana, serina 6 (tmprss6) e métodos de uso da mesma
|
|
EP4330396A1
(en)
|
2021-04-29 |
2024-03-06 |
Alnylam Pharmaceuticals, Inc. |
Signal transducer and activator of transcription factor 6 (stat6) irna compositions and methods of use thereof
|
|
EP4334448A1
(en)
|
2021-05-03 |
2024-03-13 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for treating transthyretin (ttr) mediated amyloidosis
|
|
WO2022245583A1
(en)
|
2021-05-18 |
2022-11-24 |
Alnylam Pharmaceuticals, Inc. |
Sodium-glucose cotransporter-2 (sglt2) irna compositions and methods of use thereof
|
|
WO2022246023A1
(en)
|
2021-05-20 |
2022-11-24 |
Korro Bio, Inc. |
Methods and compositions for adar-mediated editing
|
|
WO2022256283A2
(en)
|
2021-06-01 |
2022-12-08 |
Korro Bio, Inc. |
Methods for restoring protein function using adar
|
|
EP4347823A1
(en)
|
2021-06-02 |
2024-04-10 |
Alnylam Pharmaceuticals, Inc. |
Patatin-like phospholipase domain containing 3 (pnpla3) irna compositions and methods of use thereof
|
|
EP4346904A1
(en)
|
2021-06-03 |
2024-04-10 |
Synthorx, Inc. |
Head and neck cancer combination therapy comprising an il-2 conjugate and cetuximab
|
|
EP4347822A2
(en)
|
2021-06-04 |
2024-04-10 |
Alnylam Pharmaceuticals, Inc. |
Human chromosome 9 open reading frame 72 (c9orf72) irna agent compositions and methods of use thereof
|
|
AR126070A1
(es)
|
2021-06-08 |
2023-09-06 |
Alnylam Pharmaceuticals Inc |
Composiciones y métodos para tratar o prevenir la enfermedad de stargardt y/o trastornos asociados con la proteína transportadora de retinol 4 (rbp4)
|
|
EP4101928A1
(en)
|
2021-06-11 |
2022-12-14 |
Bayer AG |
Type v rna programmable endonuclease systems
|
|
BR112023023768A2
(pt)
|
2021-06-11 |
2024-02-27 |
Bayer Ag |
Sistemas de endonucleases programáveis por rna tipo v
|
|
CA3223192A1
(en)
|
2021-06-18 |
2022-12-22 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for reducing ifnar1 expression
|
|
US20230194709A9
(en)
|
2021-06-29 |
2023-06-22 |
Seagate Technology Llc |
Range information detection using coherent pulse sets with selected waveform characteristics
|
|
EP4363574A1
(en)
|
2021-06-29 |
2024-05-08 |
Korro Bio, Inc. |
Methods and compositions for adar-mediated editing
|
|
WO2023278576A1
(en)
|
2021-06-30 |
2023-01-05 |
Alnylam Pharmaceuticals, Inc. |
Methods and compositions for treating an angiotensinogen- (agt-) associated disorder
|
|
WO2023285431A1
(en)
|
2021-07-12 |
2023-01-19 |
Alia Therapeutics Srl |
Compositions and methods for allele specific treatment of retinitis pigmentosa
|
|
WO2023003805A1
(en)
|
2021-07-19 |
2023-01-26 |
Alnylam Pharmaceuticals, Inc. |
Methods and compositions for treating subjects having or at risk of developing a non-primary hyperoxaluria disease or disorder
|
|
IL309905A
(en)
|
2021-07-23 |
2024-03-01 |
Alnylam Pharmaceuticals Inc |
IRNA compositions in β-catenin (CTNNB1) and methods of using them
|
|
WO2023009687A1
(en)
|
2021-07-29 |
2023-02-02 |
Alnylam Pharmaceuticals, Inc. |
3-hydroxy-3-methylglutaryl-coa reductase (hmgcr) irna compositions and methods of use thereof
|
|
KR20240042004A
(ko)
|
2021-08-03 |
2024-04-01 |
알닐람 파마슈티칼스 인코포레이티드 |
트랜스티레틴(TTR) iRNA 조성물 및 이의 사용 방법
|
|
AU2022324003A1
(en)
|
2021-08-04 |
2024-02-08 |
Alnylam Pharmaceuticals, Inc. |
iRNA COMPOSITIONS AND METHODS FOR SILENCING ANGIOTENSINOGEN (AGT)
|
|
KR20240045300A
(ko)
|
2021-08-13 |
2024-04-05 |
알닐람 파마슈티칼스 인코포레이티드 |
인자 XII (F12) iRNA 조성물 및 이의 사용 방법
|
|
EP4144841A1
(en)
|
2021-09-07 |
2023-03-08 |
Bayer AG |
Novel small rna programmable endonuclease systems with impoved pam specificity and uses thereof
|
|
WO2023044370A2
(en)
|
2021-09-17 |
2023-03-23 |
Alnylam Pharmaceuticals, Inc. |
Irna compositions and methods for silencing complement component 3 (c3)
|
|
AU2022345881A1
(en)
|
2021-09-20 |
2024-03-21 |
Alnylam Pharmaceuticals, Inc. |
Inhibin subunit beta e (inhbe) modulator compositions and methods of use thereof
|
|
CA3234835A1
(en)
|
2021-10-22 |
2023-04-27 |
Korro Bio, Inc. |
Methods and compositions for disrupting nrf2-keap1 protein interaction by adar mediated rna editing
|
|
WO2023076451A1
(en)
|
2021-10-29 |
2023-05-04 |
Alnylam Pharmaceuticals, Inc. |
Complement factor b (cfb) irna compositions and methods of use thereof
|
|
TW202334418A
(zh)
|
2021-10-29 |
2023-09-01 |
美商艾拉倫製藥股份有限公司 |
杭丁頓（ＨＴＴ）ｉＲＮＡ劑組成物及其使用方法
|
|
WO2023122573A1
(en)
|
2021-12-20 |
2023-06-29 |
Synthorx, Inc. |
Head and neck cancer combination therapy comprising an il-2 conjugate and pembrolizumab
|
|
WO2023118349A1
(en)
|
2021-12-21 |
2023-06-29 |
Alia Therapeutics Srl |
Type ii cas proteins and applications thereof
|
|
WO2023122750A1
(en)
|
2021-12-23 |
2023-06-29 |
Synthorx, Inc. |
Cancer combination therapy with il-2 conjugates and cetuximab
|
|
WO2023118068A1
(en)
|
2021-12-23 |
2023-06-29 |
Bayer Aktiengesellschaft |
Novel small type v rna programmable endonuclease systems
|
|
WO2023141314A2
(en)
|
2022-01-24 |
2023-07-27 |
Alnylam Pharmaceuticals, Inc. |
Heparin sulfate biosynthesis pathway enzyme irna agent compositions and methods of use thereof
|
|
WO2023177866A1
(en)
|
2022-03-18 |
2023-09-21 |
Dicerna Pharmaceuticals, Inc. |
Decarboxylative acetoxylation using mn(ii) or mn(iii) reagent for synthesis of 4'-acetoxy- nucleoside and use thereof for synthesis of corresponding 4'-(dimethoxyphosphoryl)methoxy- nucleotide
|
|
WO2023194359A1
(en)
|
2022-04-04 |
2023-10-12 |
Alia Therapeutics Srl |
Compositions and methods for treatment of usher syndrome type 2a
|
|
WO2023237587A1
(en)
|
2022-06-10 |
2023-12-14 |
Bayer Aktiengesellschaft |
Novel small type v rna programmable endonuclease systems
|
|
WO2024039776A2
(en)
|
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