TR201909584T4 - İşlenmiş anti-IL-23p19 antikorların solüsyon formülasyonları. - Google Patents

İşlenmiş anti-IL-23p19 antikorların solüsyon formülasyonları. Download PDF

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Publication number
TR201909584T4
TR201909584T4 TR2019/09584T TR201909584T TR201909584T4 TR 201909584 T4 TR201909584 T4 TR 201909584T4 TR 2019/09584 T TR2019/09584 T TR 2019/09584T TR 201909584 T TR201909584 T TR 201909584T TR 201909584 T4 TR201909584 T4 TR 201909584T4
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TR
Turkey
Prior art keywords
antibodies
solution formulations
engineered anti
formulations
engineered
Prior art date
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TR2019/09584T
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English (en)
Inventor
S Kashi Ramesh
Badkar Aniket
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Merck Sharp & Dohme
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=50934859&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TR201909584(T4) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck Sharp & Dohme filed Critical Merck Sharp & Dohme
Publication of TR201909584T4 publication Critical patent/TR201909584T4/tr

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39591—Stabilisation, fragmentation
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
    • C07K16/244—Interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/51—Complete heavy chain or Fd fragment, i.e. VH + CH1
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/515—Complete light chain, i.e. VL + CL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Transplantation (AREA)
  • Pain & Pain Management (AREA)
  • Dermatology (AREA)
  • Rheumatology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Mevcut buluş, anti-insan interlökin-23 p19 (IL-23p19) antikoru hum13B8-b'nin yüksek konsantrasyonlu solüsyon formülasyonlarını ve bunların çeşitli rahatsızlıkların tedavi edilmesinde kullanımlarını sağlar.
TR2019/09584T 2012-12-13 2013-12-09 İşlenmiş anti-IL-23p19 antikorların solüsyon formülasyonları. TR201909584T4 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201261737035P 2012-12-13 2012-12-13

Publications (1)

Publication Number Publication Date
TR201909584T4 true TR201909584T4 (tr) 2019-07-22

Family

ID=50934859

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2019/09584T TR201909584T4 (tr) 2012-12-13 2013-12-09 İşlenmiş anti-IL-23p19 antikorların solüsyon formülasyonları.

Country Status (31)

Country Link
US (3) US20150329632A1 (tr)
EP (1) EP2931313B1 (tr)
JP (1) JP6266012B2 (tr)
KR (1) KR102004585B1 (tr)
CN (1) CN104870016B (tr)
AU (1) AU2013359767B2 (tr)
BR (1) BR112015013540B1 (tr)
CA (1) CA2894869C (tr)
CL (1) CL2015001608A1 (tr)
CY (1) CY1121895T1 (tr)
DK (1) DK2931313T3 (tr)
EA (1) EA034616B1 (tr)
ES (1) ES2732861T3 (tr)
HK (1) HK1215194A1 (tr)
HR (1) HRP20191137T1 (tr)
HU (1) HUE045668T2 (tr)
IL (3) IL307581A (tr)
LT (1) LT2931313T (tr)
MX (1) MX357936B (tr)
MY (1) MY187921A (tr)
NZ (1) NZ708443A (tr)
PE (1) PE20151524A1 (tr)
PH (1) PH12015501296A1 (tr)
PL (1) PL2931313T3 (tr)
PT (1) PT2931313T (tr)
RS (1) RS59057B1 (tr)
SI (1) SI2931313T1 (tr)
TR (1) TR201909584T4 (tr)
UA (1) UA117466C2 (tr)
WO (1) WO2014093203A1 (tr)
ZA (1) ZA201504408B (tr)

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TWI761959B (zh) * 2014-11-07 2022-04-21 瑞士商諾華公司 治療眼部疾病之方法
KR20190129061A (ko) * 2017-03-31 2019-11-19 메이지 세이카 파루마 가부시키가이샤 수성 제제 및 주사기 내 수성 제제, 및 항체 단백질 탈응집제 및 항체 단백질 탈응집 방법
KR20200129125A (ko) * 2018-03-05 2020-11-17 얀센 바이오테크 인코포레이티드 항-il23 특이적 항체로 크론병을 치료하는 방법
JP2022532965A (ja) * 2018-11-21 2022-07-21 リジェネロン・ファーマシューティカルズ・インコーポレイテッド 高濃度タンパク質製剤
WO2020172002A1 (en) 2019-02-18 2020-08-27 Eli Lilly And Company Therapeutic antibody formulation
AU2020226619A1 (en) * 2019-02-20 2021-08-05 Amgen Inc. Methods of determining protein stability
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WO2021126435A1 (en) * 2019-12-20 2021-06-24 Novarock Biotherapeutics, Ltd. Anti-interleukin-23 p19 antibodies and methods of use thereof
BR112022022919A2 (pt) * 2020-05-13 2022-12-20 Innovent Biologics Suzhou Co Ltd Formulação compreendendo o anticorpo anti-il-23p19, método para preparar o mesmo e uso do mesmo".

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Also Published As

Publication number Publication date
PL2931313T3 (pl) 2019-10-31
EA201591133A1 (ru) 2015-10-30
IL278295A (tr) 2020-12-31
JP2016505572A (ja) 2016-02-25
CY1121895T1 (el) 2020-10-14
DK2931313T3 (da) 2019-07-15
WO2014093203A1 (en) 2014-06-19
EA034616B1 (ru) 2020-02-27
IL278295B1 (en) 2023-11-01
KR102004585B1 (ko) 2019-07-26
PH12015501296B1 (en) 2015-08-24
PH12015501296A1 (en) 2015-08-24
RS59057B1 (sr) 2019-08-30
EP2931313A1 (en) 2015-10-21
BR112015013540B1 (pt) 2021-04-27
ZA201504408B (en) 2017-09-27
CA2894869A1 (en) 2014-06-19
MX2015007213A (es) 2016-08-03
IL239150A0 (en) 2015-07-30
IL278295B2 (en) 2024-03-01
IL307581A (en) 2023-12-01
IL239150B (en) 2020-11-30
US20210188964A1 (en) 2021-06-24
SI2931313T1 (sl) 2019-09-30
AU2013359767B2 (en) 2018-04-05
AU2013359767A1 (en) 2015-07-23
MX357936B (es) 2018-07-31
CL2015001608A1 (es) 2015-10-30
EP2931313B1 (en) 2019-05-08
PE20151524A1 (es) 2015-11-06
JP6266012B2 (ja) 2018-01-24
EP2931313A4 (en) 2016-08-03
CN104870016B (zh) 2018-05-08
UA117466C2 (uk) 2018-08-10
US20240239884A1 (en) 2024-07-18
HK1215194A1 (zh) 2016-08-19
BR112015013540A8 (pt) 2018-04-17
CA2894869C (en) 2021-06-15
HRP20191137T1 (hr) 2019-09-20
CN104870016A (zh) 2015-08-26
ES2732861T3 (es) 2019-11-26
BR112015013540A2 (pt) 2017-11-14
LT2931313T (lt) 2019-09-25
HUE045668T2 (hu) 2020-01-28
MY187921A (en) 2021-10-28
KR20150092763A (ko) 2015-08-13
NZ708443A (en) 2018-05-25
PT2931313T (pt) 2019-07-10
US20150329632A1 (en) 2015-11-19

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