TR199901381A2 - Diaza-spiro[3,5]nonan türevleri. - Google Patents

Diaza-spiro[3,5]nonan türevleri.

Info

Publication number
TR199901381A2
TR199901381A2 TR1999/01381A TR9901381A TR199901381A2 TR 199901381 A2 TR199901381 A2 TR 199901381A2 TR 1999/01381 A TR1999/01381 A TR 1999/01381A TR 9901381 A TR9901381 A TR 9901381A TR 199901381 A2 TR199901381 A2 TR 199901381A2
Authority
TR
Turkey
Prior art keywords
revleri
nonan
diaza
spiro
receptor
Prior art date
Application number
TR1999/01381A
Other languages
English (en)
Other versions
TR199901381A3 (tr
Inventor
Adam Geo
Cesura Andrea
Jenck Fran�Ois
Kolczewski Sabine
R�Ver Stephan
Wichmann J�Rgen
Original Assignee
F.Hoffmann-La Roche Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by F.Hoffmann-La Roche Ag filed Critical F.Hoffmann-La Roche Ag
Publication of TR199901381A3 publication Critical patent/TR199901381A3/tr
Publication of TR199901381A2 publication Critical patent/TR199901381A2/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Vascular Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Child & Adolescent Psychology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Cardiology (AREA)
  • Addiction (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Bu bulus, genel formülü asagidaki gibi olan bilesikleri kapsamakta olup, (Formül(I)); rasemik karisimlari ve rasemik karisimlarin ilgili enantiomerlerini ve bunlarin farmasötik olarak kabul edilebilir asit ilaveli tuzlarini de kapsar. Bu bulusun, bilesikleri orfanin FQ (OFQ) alicisinin agonistleri ve/veya antagonistleridir ve bu nedenle de bu alici ile ilgili olan hastaliklarin tedavisinde yararlidirlar.
TR1999/01381A 1998-06-12 1999-06-11 Diaza-spiro[3,5]nonan türevleri. TR199901381A2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP98110804 1998-06-12

Publications (2)

Publication Number Publication Date
TR199901381A3 TR199901381A3 (tr) 2000-01-21
TR199901381A2 true TR199901381A2 (tr) 2000-01-21

Family

ID=8232114

Family Applications (1)

Application Number Title Priority Date Filing Date
TR1999/01381A TR199901381A2 (tr) 1998-06-12 1999-06-11 Diaza-spiro[3,5]nonan türevleri.

Country Status (28)

Country Link
US (1) US6113527A (tr)
EP (1) EP0970957B1 (tr)
JP (1) JP3286268B2 (tr)
KR (1) KR100344732B1 (tr)
CN (1) CN1107066C (tr)
AR (1) AR019859A1 (tr)
AT (1) ATE204279T1 (tr)
AU (1) AU743983B2 (tr)
BR (1) BR9902651A (tr)
CA (1) CA2274202A1 (tr)
DE (1) DE69900220T2 (tr)
DK (1) DK0970957T3 (tr)
ES (1) ES2162503T3 (tr)
HR (1) HRP990188A2 (tr)
HU (1) HU220894B1 (tr)
ID (1) ID23304A (tr)
IL (1) IL130377A0 (tr)
MA (1) MA26644A1 (tr)
NO (1) NO312590B1 (tr)
NZ (1) NZ336189A (tr)
PE (1) PE20000548A1 (tr)
PL (1) PL333695A1 (tr)
PT (1) PT970957E (tr)
SG (1) SG79259A1 (tr)
SI (1) SI0970957T1 (tr)
TR (1) TR199901381A2 (tr)
YU (1) YU26499A (tr)
ZA (1) ZA993852B (tr)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2005502619A (ja) * 2001-07-02 2005-01-27 オメロス コーポレイション オピオイドレセプター様レセプター１アゴニストと交替でオピオイドレセプターアゴニストを投与することを含む、痛覚脱失を生成するための方法
US20030040479A1 (en) * 2001-07-02 2003-02-27 Omeros Corporation Rotational intrathecal analgesia method and device
EP1491212B1 (en) * 2002-03-29 2012-08-08 Mitsubishi Tanabe Pharma Corporation Remedy for sleep disturbance
JP2005289816A (ja) 2002-05-14 2005-10-20 Banyu Pharmaceut Co Ltd ベンズイミダゾール誘導体
EP1519939B9 (en) * 2002-07-05 2011-04-06 Targacept, Inc. N-aryl diazaspirocyclic compounds and methods of preparation and use thereof
PL377047A1 (pl) * 2002-09-09 2006-01-23 Janssen Pharmaceutica, N.V. Hydroksyalkilopodstawione pochodne 1,3,8-triazaspiro [4,5]-dekan-4-onu przydatne w leczeniu zaburzeń, w których pośredniczy receptor ORL-1
GB0323204D0 (en) 2003-10-03 2003-11-05 Novartis Ag Organic compounds
US20050228023A1 (en) * 2003-12-19 2005-10-13 Sri International Agonist and antagonist ligands of the nociceptin receptor
US20060178390A1 (en) * 2004-08-02 2006-08-10 Alfonzo Jordan 1,3,8-Triazaspiro[4,5]decan-4-one derivatives useful for the treatment of ORL-1 receptor mediated disorders
UA92327C2 (ru) * 2004-08-20 2010-10-25 Таргасепт, Инк. Применение n-арилдиазаспироциклических соединений для лечения зависимостей
US20080247964A1 (en) * 2006-05-08 2008-10-09 Yuelian Xu Substituted azaspiro derivatives
CN103202840B (zh) * 2006-11-28 2015-02-11 詹森药业有限公司 3-(3-氨基-2-(r)-羟基-丙基)-1-(4-氟-苯基)-8-(8-甲基-萘-1-基甲基)-1,3,8-三氮杂-螺[4.5]癸烷-4-酮的盐
CN101679430B (zh) * 2007-04-09 2013-12-25 詹森药业有限公司 用于治疗焦虑和抑郁症的作为orl-1受体的配体的1,3,8-三取代-1,3,8-三氮杂-螺[4.5]癸-4-酮衍生物
KR101704226B1 (ko) 2015-06-30 2017-02-07 현대자동차주식회사 자동차의 쿼터글라스 어셈블리
TW202340202A (zh) * 2021-12-22 2023-10-16 美國加利福尼亞大學董事會 Gtp酶抑制劑及其用途

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5756743A (en) * 1996-04-10 1998-05-26 Hoechst Marion Roussel Inc. Spiro cyclopent b!indole-piperidines!

Also Published As

Publication number Publication date
HU220894B1 (en) 2002-06-29
DE69900220T2 (de) 2002-05-08
ATE204279T1 (de) 2001-09-15
HRP990188A2 (en) 2000-02-29
AU743983B2 (en) 2002-02-14
ZA993852B (en) 1999-12-13
AR019859A1 (es) 2002-03-20
NZ336189A (en) 2000-10-27
ES2162503T3 (es) 2001-12-16
EP0970957B1 (en) 2001-08-16
JP3286268B2 (ja) 2002-05-27
TR199901381A3 (tr) 2000-01-21
NO992873L (no) 1999-12-13
EP0970957A1 (en) 2000-01-12
PT970957E (pt) 2002-02-28
DK0970957T3 (da) 2001-12-03
NO992873D0 (no) 1999-06-11
KR20000006060A (ko) 2000-01-25
ID23304A (id) 2000-04-05
CA2274202A1 (en) 1999-12-12
PL333695A1 (en) 1999-12-20
MA26644A1 (fr) 2004-12-20
SI0970957T1 (tr) 2001-12-31
HU9901911D0 (en) 1999-08-30
BR9902651A (pt) 2000-05-16
CN1242366A (zh) 2000-01-26
YU26499A (sh) 2002-09-19
DE69900220D1 (de) 2001-09-20
US6113527A (en) 2000-09-05
JP2000053679A (ja) 2000-02-22
HUP9901911A1 (hu) 2000-05-28
AU3498799A (en) 1999-12-23
KR100344732B1 (ko) 2002-07-19
CN1107066C (zh) 2003-04-30
NO312590B1 (no) 2002-06-03
PE20000548A1 (es) 2000-07-15
SG79259A1 (en) 2001-03-20
IL130377A0 (en) 2000-06-01

Similar Documents

Publication Publication Date Title
TR199901381A2 (tr) Diaza-spiro[3,5]nonan türevleri.
TR199800085A2 (tr) 8-Sübstitüye edilmis-1,3,8-triaza- spiro(4,5)dekan-4-on türevleri.
TR200200985T2 (tr) Pürin türevleri
ATE226247T1 (de) Menschliche neuronale nikotin-acetylcholin- rezeptor-verbindungen und methoden ihres einsatzes
PE20001225A1 (es) Derivados de adenina
NO902954L (no) Fremgangsmaate for fremstilling av substituerte kinazolinoner som angiotensin ii-antagonister.
ATE37375T1 (de) Phosphonyl-hydroxyacyl-aminosaeure-derivate und ihre verwendung als antihypertensiva.
DE60042762D1 (de) Zwischenprodukte für die Herstellung von Harnstoffderivaten mit Muskarinrezeptor-antagonistischer Aktivität
SE9702773D0 (sv) Novel compounds
TR200101398T2 (tr) Pirolidin türevleri-CCR-3 reseptörü antagonistleri.
DE69724777D1 (de) Pentafluorobenzensulfonamiden und analoge
ES2061684T3 (es) Compuestos de benzoxazina y su uso farmaceutico.
ATE219077T1 (de) Endothelin antagoniste
TW333527B (en) Benzimidazoles, pharmaceutical compositions containing these compounds and processes for preparing them
TR199900486T2 (tr) Aziniloksi ve fenoksi-diaril-karbonasit türevleri.
TR199902848T2 (tr) Ergolin türevleri ve bunlarin somatostatin reseptör antagonist olarak kullanimlari
ATE119524T1 (de) Substituierte n-(imidazolyl)alkyl-alanin- derivate.
DK0692484T3 (da) Benzothiadiazinderivat, fremgangsmåde til fremstilling deraf samt farmaceutiske sammensætninger indeholdende derivatet
TR200101493T2 (tr) Eletriptan hidrobromid monohidrat
TR200001182T2 (tr) Yeni karbonik asit türevleri, üretimleri ve kullanımları.
TR199901380A2 (tr) Di-ya da triazo-spiro[4,5] dekan türevleri
TR199901416T2 (tr) Heterosiklik karbonikasit türevleri.
ES2059677T3 (es) 1,2,3,4-tetrahidro-1,9-acridindiaminas, un procedimiento para su preparacion y su uso como medicamentos.
TR200001080T2 (tr) 2 ile ikame edilmiş 1,2-Benisotiyazol türevleri ve bunların serrotonın antagonistleri
TR199802661T2 (tr) 5-HT-2C Reseptör karsitlari olarak faydali indolin türevleri.