AR019859A1 - Derivados diaza-espiro[3,5]nonano, un procedimiento para su preparacion, composiciones farmaceuticas que los comprenden y el uso de los mismos para la preparacion de un medicamento - Google Patents
Derivados diaza-espiro[3,5]nonano, un procedimiento para su preparacion, composiciones farmaceuticas que los comprenden y el uso de los mismos para la preparacion de un medicamentoInfo
- Publication number
- AR019859A1 AR019859A1 ARP990102763A ARP990102763A AR019859A1 AR 019859 A1 AR019859 A1 AR 019859A1 AR P990102763 A ARP990102763 A AR P990102763A AR P990102763 A ARP990102763 A AR P990102763A AR 019859 A1 AR019859 A1 AR 019859A1
- Authority
- AR
- Argentina
- Prior art keywords
- preparation
- lower alkyl
- naphthalen
- hydrogen
- diaza
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/10—Spiro-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Abstract
Derivados diaza-espiro[3,5]nonano, que comprenden compuestos de la formula general (1) en donde R1 es cicloalquilo de 6 a 12 átomos de carbono,opcionalmente sustituido con alquilo inferior o C(O)alquilo inferior; indan-1-ilo o indan-2-ilo,opcionalme nte sustituido con alquilo inferior; acenaften -1-ilo; biciclo [3.3.1]non-9-ilo; octahidro-inden-2-ilo; 2,3-dihidro-1H-fenalen-1-ilo; 2,3,3a,4,5,6-hexahidro-1H-fenalen-1-ilo; decahidro-azulen-2-ilo; biciclo[6.2.0.]dec-9-ilo; decahidro-naftalen-1-ilo, decahidro-naftalen-2-ilo; tetrahidro-naftalen-1-ilo; tetrahidro-naftalen-2-ilo o 2-oxo1,2-difenil-etilo;R2 es=O ohidrogeno; R3 es hidrogeno, isoindolil-1,3-diona, alcoxilo inferior, alquilo inferior, amino, benciloxilo, -CH2OR5 oCH2N(R5)2; R4 es hi drogeno o CH2OR5; R5 eshidrogeno o alquilo inferior, A es ciclohexilo o fenilo, opcionalmente sustituido con alquilo inferior, halogeno o alcoxilo, mezclas racémicas y suscorrespondientes enantiomeros y las sales de adicion deácido farmacéuticamente aceptables de los mismos; un procedimiento para su preparacion, medicamento quelos comprenden y el empleo de los mismos para la preparacion de un medicamento. Uso: trastornos psiquiátricos, neurologicos y fisiologicos.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP98110804 | 1998-06-12 |
Publications (1)
Publication Number | Publication Date |
---|---|
AR019859A1 true AR019859A1 (es) | 2002-03-20 |
Family
ID=8232114
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ARP990102763A AR019859A1 (es) | 1998-06-12 | 1999-06-10 | Derivados diaza-espiro[3,5]nonano, un procedimiento para su preparacion, composiciones farmaceuticas que los comprenden y el uso de los mismos para la preparacion de un medicamento |
Country Status (28)
Country | Link |
---|---|
US (1) | US6113527A (es) |
EP (1) | EP0970957B1 (es) |
JP (1) | JP3286268B2 (es) |
KR (1) | KR100344732B1 (es) |
CN (1) | CN1107066C (es) |
AR (1) | AR019859A1 (es) |
AT (1) | ATE204279T1 (es) |
AU (1) | AU743983B2 (es) |
BR (1) | BR9902651A (es) |
CA (1) | CA2274202A1 (es) |
DE (1) | DE69900220T2 (es) |
DK (1) | DK0970957T3 (es) |
ES (1) | ES2162503T3 (es) |
HR (1) | HRP990188A2 (es) |
HU (1) | HU220894B1 (es) |
ID (1) | ID23304A (es) |
IL (1) | IL130377A0 (es) |
MA (1) | MA26644A1 (es) |
NO (1) | NO312590B1 (es) |
NZ (1) | NZ336189A (es) |
PE (1) | PE20000548A1 (es) |
PL (1) | PL333695A1 (es) |
PT (1) | PT970957E (es) |
SG (1) | SG79259A1 (es) |
SI (1) | SI0970957T1 (es) |
TR (1) | TR199901381A3 (es) |
YU (1) | YU26499A (es) |
ZA (1) | ZA993852B (es) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US20030040479A1 (en) * | 2001-07-02 | 2003-02-27 | Omeros Corporation | Rotational intrathecal analgesia method and device |
CA2490386A1 (en) * | 2001-07-02 | 2003-01-16 | Omeros Corporation | Method for producing analgesia comprising administration of an opioid receptor agonist in rotation with an opioid receptor like-1 receptor agonist |
US7566728B2 (en) | 2002-03-29 | 2009-07-28 | Mitsubishi Tanabe Pharma Corporation | Remedy for sleep disturbance |
JP2005289816A (ja) | 2002-05-14 | 2005-10-20 | Banyu Pharmaceut Co Ltd | ベンズイミダゾール誘導体 |
JP4749715B2 (ja) | 2002-07-05 | 2011-08-17 | ターガセプト,インコーポレイテッド | N−アリールジアザスピロ環式化合物、並びにその製造及び使用方法 |
WO2004022558A2 (en) * | 2002-09-09 | 2004-03-18 | Janssen Pharmaceutica, N.V. | Hydroxy alkyl substituted 1,3,8-triazaspiro[4.5]decan-4-one derivatives useful for the treatment of orl-1 receptor mediated disorders |
GB0323204D0 (en) * | 2003-10-03 | 2003-11-05 | Novartis Ag | Organic compounds |
US20050228023A1 (en) * | 2003-12-19 | 2005-10-13 | Sri International | Agonist and antagonist ligands of the nociceptin receptor |
US20060178390A1 (en) * | 2004-08-02 | 2006-08-10 | Alfonzo Jordan | 1,3,8-Triazaspiro[4,5]decan-4-one derivatives useful for the treatment of ORL-1 receptor mediated disorders |
CN101022801A (zh) * | 2004-08-20 | 2007-08-22 | 塔加西普特公司 | N-芳基二氮杂螺环化合物在成瘾治疗中的用途 |
US20080247964A1 (en) * | 2006-05-08 | 2008-10-09 | Yuelian Xu | Substituted azaspiro derivatives |
WO2008067167A1 (en) * | 2006-11-28 | 2008-06-05 | Janssen Pharmaceutica N.V. | Salts of 3-(3-amino-2-(r)-hydroxy-propyl)-1-(4-fluoro-phenyl)-8-(8-methyl-naphthalen-1-ylmethyl)-1,3,8-triaza-spiro[4.5]decan-4-one |
CN101679430B (zh) * | 2007-04-09 | 2013-12-25 | 詹森药业有限公司 | 用于治疗焦虑和抑郁症的作为orl-1受体的配体的1,3,8-三取代-1,3,8-三氮杂-螺[4.5]癸-4-酮衍生物 |
KR101704226B1 (ko) | 2015-06-30 | 2017-02-07 | 현대자동차주식회사 | 자동차의 쿼터글라스 어셈블리 |
TW202340202A (zh) * | 2021-12-22 | 2023-10-16 | 美國加利福尼亞大學董事會 | Gtp酶抑制劑及其用途 |
Family Cites Families (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5756743A (en) * | 1996-04-10 | 1998-05-26 | Hoechst Marion Roussel Inc. | Spiro cyclopent b!indole-piperidines! |
-
1999
- 1999-06-07 AT AT99110943T patent/ATE204279T1/de not_active IP Right Cessation
- 1999-06-07 PT PT99110943T patent/PT970957E/pt unknown
- 1999-06-07 DE DE69900220T patent/DE69900220T2/de not_active Expired - Lifetime
- 1999-06-07 SI SI9930008T patent/SI0970957T1/xx unknown
- 1999-06-07 EP EP99110943A patent/EP0970957B1/en not_active Expired - Lifetime
- 1999-06-07 DK DK99110943T patent/DK0970957T3/da active
- 1999-06-07 ES ES99110943T patent/ES2162503T3/es not_active Expired - Lifetime
- 1999-06-08 ID IDP990543D patent/ID23304A/id unknown
- 1999-06-08 PE PE1999000487A patent/PE20000548A1/es not_active Application Discontinuation
- 1999-06-08 ZA ZA9903852A patent/ZA993852B/xx unknown
- 1999-06-09 HU HU9901911A patent/HU220894B1/hu not_active IP Right Cessation
- 1999-06-09 CA CA002274202A patent/CA2274202A1/en not_active Abandoned
- 1999-06-09 NZ NZ336189A patent/NZ336189A/xx unknown
- 1999-06-09 IL IL13037799A patent/IL130377A0/xx unknown
- 1999-06-09 SG SG9903066A patent/SG79259A1/en unknown
- 1999-06-10 MA MA25616A patent/MA26644A1/fr unknown
- 1999-06-10 KR KR1019990021485A patent/KR100344732B1/ko not_active IP Right Cessation
- 1999-06-10 JP JP16357099A patent/JP3286268B2/ja not_active Expired - Fee Related
- 1999-06-10 AR ARP990102763A patent/AR019859A1/es active IP Right Grant
- 1999-06-10 AU AU34987/99A patent/AU743983B2/en not_active Ceased
- 1999-06-10 YU YU26499A patent/YU26499A/sh unknown
- 1999-06-11 PL PL99333695A patent/PL333695A1/xx unknown
- 1999-06-11 US US09/330,851 patent/US6113527A/en not_active Expired - Fee Related
- 1999-06-11 HR HR98110804.6A patent/HRP990188A2/hr not_active Application Discontinuation
- 1999-06-11 CN CN99108373A patent/CN1107066C/zh not_active Expired - Fee Related
- 1999-06-11 BR BR9902651-1A patent/BR9902651A/pt not_active Application Discontinuation
- 1999-06-11 TR TR1999/01381A patent/TR199901381A3/tr unknown
- 1999-06-11 NO NO19992873A patent/NO312590B1/no unknown
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
FG | Grant, registration |