ATE219077T1 - Endothelin antagoniste - Google Patents

Endothelin antagoniste

Info

Publication number: ATE219077T1
Authority: AT; Austria
Prior art keywords: endothelin antagonist; processes; preparing; endothelin; chem
Prior art date: 1994-08-19

Application number

AT95928323T

Other languages

English (en)

Inventor

Martin Winn

Steven A Boyd

Charles W Hutchins

Hwan-Soo Jae

Andrew S Tasker

Thomas W Vongeldern

Jeffrey A Kester

Bryan K Sorensen

Original Assignee

Abbott Lab

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1994-08-19

Filing date

1995-08-04

Publication date

2002-06-15

1995-05-30 Priority claimed from US08/442,575 external-priority patent/US5767144A/en

1995-08-04 Application filed by Abbott Lab filed Critical Abbott Lab

2002-06-15 Application granted granted Critical

2002-06-15 Publication of ATE219077T1 publication Critical patent/ATE219077T1/de

Links

239000002308 endothelin receptor antagonist Substances 0.000 title 1
102000002045 Endothelin Human genes 0.000 abstract 1
108050009340 Endothelin Proteins 0.000 abstract 1
239000005557 antagonist Substances 0.000 abstract 1
ZUBDGKVDJUIMQQ-UBFCDGJISA-N endothelin-1 Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(O)=O)NC(=O)[C@H]1NC(=O)[C@H](CC=2C=CC=CC=2)NC(=O)[C@@H](CC=2C=CC(O)=CC=2)NC(=O)[C@H](C(C)C)NC(=O)[C@H]2CSSC[C@@H](C(N[C@H](CO)C(=O)N[C@@H](CO)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CCSC)C(=O)N[C@H](CC(O)=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCC(O)=O)C(=O)N2)=O)NC(=O)[C@@H](CO)NC(=O)[C@H](N)CSSC1)C1=CNC=N1 ZUBDGKVDJUIMQQ-UBFCDGJISA-N 0.000 abstract 1
239000000543 intermediate Substances 0.000 abstract 1
150000003839 salts Chemical class 0.000 abstract 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D207/16—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/572—Five-membered rings
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
- C07F9/553—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having one nitrogen atom as the only ring hetero atom
- C07F9/576—Six-membered rings
- C07F9/59—Hydrogenated pyridine rings

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Medicinal Chemistry (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Molecular Biology (AREA)
Biochemistry (AREA)
Urology & Nephrology (AREA)
Vascular Medicine (AREA)
Pain & Pain Management (AREA)
Rheumatology (AREA)
Hospice & Palliative Care (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Steroid Compounds (AREA)

AT95928323T 1994-08-19 1995-08-04 Endothelin antagoniste ATE219077T1 (de)

Applications Claiming Priority (5)

Application Number	Priority Date	Filing Date	Title
US29334994A	1994-08-19	1994-08-19
US33471794A	1994-11-04	1994-11-04
US08/442,575 US5767144A (en)	1994-08-19	1995-05-30	Endothelin antagonists
US49799895A	1995-08-02	1995-08-02
PCT/US1995/009924 WO1996006095A1 (en)	1994-08-19	1995-08-04	Endothelin antagonists

Publications (1)

Publication Number	Publication Date
ATE219077T1 true ATE219077T1 (de)	2002-06-15

Family

ID=27501591

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
AT95928323T ATE219077T1 (de)	1994-08-19	1995-08-04	Endothelin antagoniste

Country Status (13)

Country	Link
EP (2)	EP0776324B1 (de)
JP (1)	JP3741441B2 (de)
KR (2)	KR100483222B1 (de)
AT (1)	ATE219077T1 (de)
AU (1)	AU711832B2 (de)
CA (2)	CA2517691A1 (de)
DE (1)	DE69527072T2 (de)
DK (1)	DK0776324T3 (de)
ES (1)	ES2179881T3 (de)
HK (1)	HK1008328A1 (de)
IL (2)	IL134905A (de)
PT (1)	PT776324E (de)
WO (1)	WO1996006095A1 (de)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US5852046A (en) *	1993-08-03	1998-12-22	Hoechst Aktiengesellschaft	Benzo-fused heterocyclic compounds having a 5-membered ring processes for their preparation their use as medicaments their use as diagnostic agents and medicaments containing them
US5767144A (en) *	1994-08-19	1998-06-16	Abbott Laboratories	Endothelin antagonists
US7208517B1 (en)	1994-08-19	2007-04-24	Abbott Labortories	Endothelin antagonists
US6162927A (en) *	1994-08-19	2000-12-19	Abbott Laboratories	Endothelin antagonists
BR9707509A (pt) *	1996-02-13	1999-07-27	Abbott Lab	Composto composto farmacêutica e processos para antagonizar endotelina para tratar hipertensão insuficiência cardiaca congestiva congestiva restenose emseguida a lessão arterial isquemia cerebral ou miocárdica ou aterosclerose angina coronariana vasosespasmo cerebral insuficiência renal aguda e crônica ulceração gástrica nefrotoxicidade induzida por ciclosporina toxicidade induzida por endotoxina asma distúrbio da lipoproteina relacionados com lpl doenças proliferatives hipertensão pulmonar aguda ou cronica agregação plaquetaria tombose cardiotoxiadade mediada por il-2 noncicepção colite disturbio da permeabulidade vascilar lesão por reperfusão-isquemia doença deraynaud e enxaqueca e para a preparar um composto.
AU2763602A (en) *	1996-02-13	2002-05-16	Abbott Laboratories	Endothelin antagonists
AU781355B2 (en) *	1996-02-13	2005-05-19	Abbott Laboratories	Novel benzo-1,3-dioxolyl-and benzofuranyl substituted pyrrolidine derivatives as endothelin antagonists
BR9707394A (pt) *	1996-02-13	1999-04-06	Abbott Lab	Derivados de ácido 4-(benzo-1,3-dioxolil) pirrolidino-3-carboxílico como antagonistas endotelina
US5801250A (en) *	1996-12-13	1998-09-01	Abbott Laboratories	Process for the stereoselective production of nitro-enamine compounds
US6030975A (en) *	1997-03-14	2000-02-29	Basf Aktiengesellschaft	Carboxylic acid derivatives, their preparation and use in treating cancer
HUP0002681A3 (en) *	1997-06-17	2001-09-28	Abbott Lab	Pyrrolidine carboxylic acid derivatives as endothelin antagonists and pharmaceutical compositions containing the same
PL342500A1 (en) *	1997-08-04	2001-06-04	Abbott Lab	Derivatives of pyrolydin-3-carboxylic acid and their application as endothelin antagonists
US6339087B1 (en)	1997-08-18	2002-01-15	Syntex (U.S.A.) Llc	Cyclic amine derivatives-CCR-3 receptor antagonists
IL125658A0 (en)	1997-08-18	1999-04-11	Hoffmann La Roche	Ccr-3 receptor antagonists
DE19743681A1 (de) *	1997-10-02	1999-04-08	Knoll Ag	Methode zur Verhinderung der Transplantatabstoßung
US6410554B1 (en)	1998-03-23	2002-06-25	Merck & Co., Inc.	Combination therapy for the treatment of benign prostatic hyperplasia
US6245801B1 (en)	1998-09-14	2001-06-12	Warner-Lambert Company	Branched alkyl pyrrolidine-3-carboxylic acids
DE69938193D1 (de)	1998-11-20	2008-04-03	Hoffmann La Roche	Piperidin ccr-3 rezeptor-hemmer
WO2002017912A1 (en) *	2000-08-31	2002-03-07	Abbott Laboratories	Endothelin antagonists
US8168616B1 (en)	2000-11-17	2012-05-01	Novartis Ag	Combination comprising a renin inhibitor and an angiotensin receptor inhibitor for hypertension
GB0327839D0 (en)	2003-12-01	2003-12-31	Novartis Ag	Organic compounds
US20080161321A1 (en)	2004-03-17	2008-07-03	David Louis Feldman	Use of Renin Inhibitors in Therapy
US20090054473A1 (en)	2007-08-22	2009-02-26	Gilead Colorado, Inc.	Therapy for complications of diabetes
WO2011114103A1 (en)	2010-03-18	2011-09-22	Biolipox Ab	Pyrimidinones for use as medicaments
JO2998B1 (ar)	2010-06-04	2016-09-05	Amgen Inc	مشتقات بيبيريدينون كمثبطات mdm2 لعلاج السرطان
MX352672B (es)	2011-09-27	2017-12-04	Amgen Inc	Compuestos heterocíclicos como inhibidores de mdm2 para el tratamiento del cáncer.
US11407721B2 (en)	2013-02-19	2022-08-09	Amgen Inc.	CIS-morpholinone and other compounds as MDM2 inhibitors for the treatment of cancer
EP2961735B1 (de)	2013-02-28	2017-09-27	Amgen Inc.	Von der benzoesäure abgeleiteter mdm2-hemmer zur behandlung von krebs
US9758495B2 (en)	2013-03-14	2017-09-12	Amgen Inc.	Heteroaryl acid morpholinone compounds as MDM2 inhibitors for the treatment of cancer
JOP20200296A1 (ar)	2013-06-10	2017-06-16	Amgen Inc	عمليات صنع وأشكال بلورية من mdm2 مثبط
US8962675B1 (en) *	2013-09-12	2015-02-24	Abbvie Inc.	Atrasentan mandelate salts
KR102091932B1 (ko)	2018-08-16	2020-03-20	장남순	안전하고 간편한 접첩구조를 갖는 접이식 트램펄린

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US3342833A (en) *	1964-08-07	1967-09-19	Shell Oil Co	Pyrrolidine production from aziridines and olefins
CA2122820A1 (en) *	1991-11-05	1993-05-13	Russell Donavan Cousins	Endothelin receptor antagonists
JPH07509465A (ja) *	1992-07-17	1995-10-19	スミスクライン・ビーチャム・コーポレイション	エンドセリン受容体アンタゴニスト

1995
- 1995-08-04 AT AT95928323T patent/ATE219077T1/de active
- 1995-08-04 CA CA002517691A patent/CA2517691A1/en not_active Abandoned
- 1995-08-04 WO PCT/US1995/009924 patent/WO1996006095A1/en active Search and Examination
- 1995-08-04 KR KR10-2004-7004682A patent/KR100483222B1/ko not_active IP Right Cessation
- 1995-08-04 CA CA002195677A patent/CA2195677C/en not_active Expired - Lifetime
- 1995-08-04 JP JP50810196A patent/JP3741441B2/ja not_active Expired - Lifetime
- 1995-08-04 ES ES95928323T patent/ES2179881T3/es not_active Expired - Lifetime
- 1995-08-04 DK DK95928323T patent/DK0776324T3/da active
- 1995-08-04 DE DE69527072T patent/DE69527072T2/de not_active Expired - Lifetime
- 1995-08-04 PT PT95928323T patent/PT776324E/pt unknown
- 1995-08-04 AU AU32137/95A patent/AU711832B2/en not_active Expired
- 1995-08-04 KR KR1019970701079A patent/KR100447000B1/ko not_active IP Right Cessation
- 1995-08-04 EP EP95928323A patent/EP0776324B1/de not_active Expired - Lifetime
- 1995-08-04 EP EP01125462A patent/EP1186603A3/de not_active Withdrawn
- 1995-08-10 IL IL134905A patent/IL134905A/en not_active IP Right Cessation
- 1995-08-10 IL IL11489495A patent/IL114894A/xx not_active IP Right Cessation
1998
- 1998-07-15 HK HK98109192A patent/HK1008328A1/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
KR20040045036A (ko)	2004-05-31
DE69527072T2 (de)	2003-02-13
KR970705561A (ko)	1997-10-09
IL134905A (en)	2009-06-15
EP0776324A1 (de)	1997-06-04
AU711832B2 (en)	1999-10-21
CA2195677C (en)	2005-11-08
EP1186603A3 (de)	2003-07-09
DK0776324T3 (da)	2002-10-07
CA2195677A1 (en)	1996-02-29
IL114894A0 (en)	1995-12-08
KR100447000B1 (ko)	2004-12-10
PT776324E (pt)	2002-11-29
ES2179881T3 (es)	2003-02-01
EP0776324B1 (de)	2002-06-12
IL114894A (en)	2003-04-10
HK1008328A1 (en)	1999-05-07
DE69527072D1 (de)	2002-07-18
JPH10504565A (ja)	1998-05-06
JP3741441B2 (ja)	2006-02-01
AU3213795A (en)	1996-03-14
WO1996006095A1 (en)	1996-02-29
IL134905A0 (en)	2001-05-20
EP1186603A2 (de)	2002-03-13
KR100483222B1 (ko)	2005-04-15
CA2517691A1 (en)	1996-02-29

Legal Events

Date	Code	Title	Description
2002-12-15	UEP	Publication of translation of european patent specification

Publication	Publication Date	Title
ATE219077T1 (de)	2002-06-15	Endothelin antagoniste
NO930817L (no)	1993-09-08	Imidazolderivater med bifenylsulfonylurea- eller bifenylsulfonyluretan-sidekjeder, fremgangsmaate for deres fremstilling og deres anvendelse
DE69530690D1 (de)	2003-06-12	Benzoheterocyclische derivate verwendbar als vasopressin- oder oxytocin-modulatoren
TR200200579T2 (tr)	2002-12-23	Amino-tirazolpiridin türevleri.
DK0641325T3 (da)	2001-04-17	Inhibitorer af retroviral protease
ATE305781T1 (de)	2005-10-15	Non-peptidische vasopressin via antagonisten
ES2048109B1 (es)	1994-12-16	Procedimiento de preparacion de nuevos derivados piperidicos del bencimidazol.
ATE211732T1 (de)	2002-01-15	N-benzylpiperidin- und tetrahydropyridin-derivate
ATE157653T1 (de)	1997-09-15	Piperidin-derivate
GB9718903D0 (en)	1997-11-12	Method,compositions and kits for increasing the oral bioavailability of pharmaceutical agents
SK1452000A3 (en)	2001-05-10	Pyrrolidine-3-carboxylic acid derivatives and their use as endothelin antagonists
MX9800483A (es)	1998-04-30	Derivados de piperazina y su uso como antagonistas de 5-ht1a.
DK0428313T3 (da)	1994-03-07	Pyrimidonderivater samt analoge til behandling af astma og visse hudlidelser
DK1204658T3 (da)	2003-09-01	Benzofurylpiperazin-serotoninagonister
FI952420A (fi)	1995-11-21	Glukopyranosidibentsotiofeenit
EA199700147A1 (ru)	1997-12-30	Замещенные фенильные производные в качестве антагонистов эндотелина
DK0896822T3 (da)	2003-06-02	4-aminopyrrol (3,2-d) pyrimidiner som neuropeptide Y receptorantagonister
ATE330958T1 (de)	2006-07-15	Pyrazino 1'2':1,6öpyrido 3,4-böindolderivate
DE69600231T2 (de)	1998-12-17	N-Arylalkylphenylacetamidderivate
PT855398E (pt)	2003-07-31	Derivados sasquiterpeno tendo actividade antiviral
DK0417746T3 (da)	1994-12-12	N-Azabicyclo(3.3.0)octanamider af aromatiske syrer
BR9810031A (pt)	2000-09-12	Derivados de ácido pirrolidina carboxìlico como antagonistas á endotelina
MX9204939A (es)	1993-03-01	Inhibidores 5-bis-aminometilen-1,3-dioxan-4,6-diona n,n',n'-trisubstituidas, de la acil coenzima a: colesterol-aciltransferasa.