TR199700876T1 - Prokinetik oksadiazoller. - Google Patents

Prokinetik oksadiazoller.

Info

Publication number
TR199700876T1
TR199700876T1 TR97/00876T TR9700876T TR199700876T1 TR 199700876 T1 TR199700876 T1 TR 199700876T1 TR 97/00876 T TR97/00876 T TR 97/00876T TR 9700876 T TR9700876 T TR 9700876T TR 199700876 T1 TR199700876 T1 TR 199700876T1
Authority
TR
Turkey
Prior art keywords
alkyl
hydrogen
alk
alkylcarbonyl
aryl
Prior art date
Application number
TR97/00876T
Other languages
English (en)
Inventor
Rene Marie Andre Bosmans Jean-Paul
Original Assignee
Janssen Pharmaceutica N.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica N.V. filed Critical Janssen Pharmaceutica N.V.
Publication of TR199700876T1 publication Critical patent/TR199700876T1/tr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/14—Prodigestives, e.g. acids, enzymes, appetite stimulants, antidyspeptics, tonics, antiflatulents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Abstract

Bu bulus, formülü (I) olan yeni aksidiazol türevleri, bunlarin N-oksit sekilleri, farmasötik açidan kabul edilebilir asit katilma tuzlari ve stereokimyasal izomer sekilleri ile ilgili olup, burada: R1, hidrojen veya halojendir; R2, C1-6 alkil, C2-6 alkenil veya C2-6 alkindir; R3, halojendir; veya R2 ile R3 birlikte, bir C2-3 alkandiil radikalini olusturabilir ve burada bir veya iki hidrojen atomunun yerini C1-4 alkil alabilir; R4, hidrojen veya C1-6 alkiloksidir; X, formülü (a-1) veya (a-2) olan bir iki degerlikli radikaldir; L, formülü -Alk-R5 veya -Alk-O-R6 olan bir radikal olup, burada, Alk, C1-12 alkandiildir; R5, hidrojen, siyano, C1-6 alkilkarbonil, C1-6 alkilsülfinil, C1-6 alkilsülfonil, aril, alkilkarbonil, tetrahidrofuran, diokzolan, C1-6 alkil ile sübstitüe edilmis diokzolan, dioksan, C1-6 alkil ile sübstitüe edilmis dioksandir; R6, hidrojen,aril, C1-6 alkil, hidroksi C1-6 alkil, C1-6 alkilkarbonildir; Aril, fenil; veya halo, C1-6 alkil veya C1-6 alkiloksi ... (DEVAMI VAR)
TR97/00876T 1995-03-01 1996-02-21 Prokinetik oksadiazoller. TR199700876T1 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP95200501 1995-03-01

Publications (1)

Publication Number Publication Date
TR199700876T1 true TR199700876T1 (tr) 1998-02-21

Family

ID=8220055

Family Applications (1)

Application Number Title Priority Date Filing Date
TR97/00876T TR199700876T1 (tr) 1995-03-01 1996-02-21 Prokinetik oksadiazoller.

Country Status (25)

Country Link
US (1) US5854261A (tr)
EP (1) EP0812321B1 (tr)
JP (1) JP3980056B2 (tr)
KR (1) KR100443554B1 (tr)
CN (1) CN1092656C (tr)
AR (1) AR003932A1 (tr)
AT (1) ATE384716T1 (tr)
AU (1) AU702932B2 (tr)
BR (1) BR9607316A (tr)
CA (1) CA2212893C (tr)
CZ (1) CZ286992B6 (tr)
DE (1) DE69637412T2 (tr)
EA (1) EA001084B1 (tr)
ES (1) ES2301166T3 (tr)
FI (1) FI973562A0 (tr)
HU (1) HUP9702395A3 (tr)
IL (1) IL117315A (tr)
MY (1) MY113584A (tr)
NO (1) NO309425B1 (tr)
NZ (1) NZ301699A (tr)
PL (1) PL183712B1 (tr)
TR (1) TR199700876T1 (tr)
TW (1) TW360653B (tr)
WO (1) WO1996026937A1 (tr)
ZA (1) ZA961652B (tr)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9603755D0 (en) * 1996-02-22 1996-04-24 Pfizer Ltd Therapeutic agents
US6107313A (en) * 1998-10-02 2000-08-22 Combichem, Inc. Dopamine receptor antagonists
US7332508B2 (en) 2002-12-18 2008-02-19 Novo Nordisk A/S Substituted homopiperidine, piperidine or pyrrolidine derivatives
GB0910667D0 (en) * 2009-06-19 2009-08-05 Glaxo Wellcome Mfg Pte Ltd Novel compounds
BR112014001083B8 (pt) * 2011-09-19 2022-06-14 Suven Life Sciences Ltd Composto, processo para a preparação de um composto, composição farmacêutica, uso da composiçâo farmacêutica e uso do composto
WO2018081167A1 (en) * 2016-10-24 2018-05-03 Yumanity Therapeutics Compounds and uses thereof
EP3700934A4 (en) 2017-10-24 2021-10-27 Yumanity Therapeutics, Inc. COMPOUNDS AND USES OF THESE COMPOUNDS

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA1183847A (en) * 1981-10-01 1985-03-12 Georges Van Daele N-(3-hydroxy-4-piperidinyl)benzamide derivatives
US5374637A (en) * 1989-03-22 1994-12-20 Janssen Pharmaceutica N.V. N-(3-hydroxy-4-piperidinyl)(dihydrobenzofuran, dihydro-2H-benzopyran or dihydrobenzodioxin)carboxamide derivatives
GB9005014D0 (en) * 1990-03-06 1990-05-02 Janssen Pharmaceutica Nv N.(4.piperidinyl)(dihydrobenzofuran or dihydro.2h.benzopyran)carboxamide derivatives
US5492919A (en) * 1991-08-03 1996-02-20 Smithkline Beecham P.L.C. 5-HT4 receptor antagonists
GB9202797D0 (en) * 1992-02-11 1992-03-25 Milsom Jonathan Glazed units
JPH08502273A (ja) * 1992-10-13 1996-03-12 スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー ５−ｈｔ▲下４▼レセプターアンタゴニスト用複素環式エステルまたはアミド
MX9306311A (es) * 1992-10-13 1994-04-29 Smithkline Beecham Plc Compuestos antagonistas del receptor de 5-ht4, procedimiento para su preparacion y composiciones farmaceuticas que los contienen
AU680453B2 (en) * 1992-11-05 1997-07-31 Smithkline Beecham Plc Piperidine derivatives as 5-HT4 receptor antagonists
JPH06157518A (ja) * 1992-11-27 1994-06-03 Yamanouchi Pharmaceut Co Ltd 新規なオキサジアゾール誘導体又はその塩
WO1995032965A1 (fr) * 1994-06-01 1995-12-07 Yamanouchi Pharmaceutical Co. Ltd. Derive de l'oxadiazole et composition medicinale a base de ce dernier

Also Published As

Publication number Publication date
NZ301699A (en) 1998-02-26
CZ286992B6 (en) 2000-08-16
NO973808D0 (no) 1997-08-19
CA2212893C (en) 2007-01-16
HUP9702395A2 (hu) 1999-09-28
EA001084B1 (ru) 2000-10-30
MX9706622A (es) 1997-11-29
MY113584A (en) 2002-04-30
IL117315A0 (en) 1996-06-18
PL183712B1 (pl) 2002-07-31
AU4718896A (en) 1996-09-18
NO973808L (no) 1997-08-19
NO309425B1 (no) 2001-01-29
US5854261A (en) 1998-12-29
AR003932A1 (es) 1998-09-30
FI973562A (fi) 1997-08-29
WO1996026937A1 (en) 1996-09-06
KR19980702304A (ko) 1998-07-15
TW360653B (en) 1999-06-11
IL117315A (en) 2000-07-26
BR9607316A (pt) 1997-12-30
CN1092656C (zh) 2002-10-16
CZ272397A3 (cs) 1998-02-18
EP0812321B1 (en) 2008-01-23
EA199700205A1 (ru) 1998-02-26
FI973562A0 (fi) 1997-08-29
KR100443554B1 (ko) 2004-10-06
CA2212893A1 (en) 1996-09-06
EP0812321A1 (en) 1997-12-17
AU702932B2 (en) 1999-03-11
DE69637412T2 (de) 2009-01-22
DE69637412D1 (de) 2008-03-13
ATE384716T1 (de) 2008-02-15
ES2301166T3 (es) 2008-06-16
HUP9702395A3 (en) 1999-10-28
PL322019A1 (en) 1998-01-05
CN1177352A (zh) 1998-03-25
ZA961652B (en) 1997-09-11
JPH11501021A (ja) 1999-01-26
JP3980056B2 (ja) 2007-09-19

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