SV1999000016A - Derivados de 2-(purin-9-il-tetrahidrofuran-3,4-diol ref. pg3443/sv - Google Patents
Derivados de 2-(purin-9-il-tetrahidrofuran-3,4-diol ref. pg3443/svInfo
- Publication number
- SV1999000016A SV1999000016A SV1999000016A SV1999000016A SV1999000016A SV 1999000016 A SV1999000016 A SV 1999000016A SV 1999000016 A SV1999000016 A SV 1999000016A SV 1999000016 A SV1999000016 A SV 1999000016A SV 1999000016 A SV1999000016 A SV 1999000016A
- Authority
- SV
- El Salvador
- Prior art keywords
- tetrahidrofuran
- purin
- diol
- derivatives
- ref
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/06—Antipsoriatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
Abstract
DERIVADOS DE 2-(PURIN-9-IL)-TETRAHIDROFURAN-3,4-DIOL.DE ACUERDO CON LA INVENCION, SE PROPORCIONAN LOS COMPUESTOS NOVEDOSOS DE LA FORMULA (I), VER FORMULA, EN DONDE R1, R2, Y R3 SON COMO SE DESCRIEBN EN LA ESPECIFICACION, PROCEDIMIENTOS PARA LA PREPARACION DE ESTOS, FORMULACIONES QUE LOS CONTIENEN Y SU USO EN LA TERAPIA PARA EL TRATAMIENTO DE ENFERMEDADES INFLAMATORIAS.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB9803169.3A GB9803169D0 (en) | 1998-02-14 | 1998-02-14 | Chemical compounds |
GBGB9813533.8A GB9813533D0 (en) | 1998-06-23 | 1998-06-23 | Chemical compounds |
Publications (1)
Publication Number | Publication Date |
---|---|
SV1999000016A true SV1999000016A (es) | 1999-10-27 |
Family
ID=26313119
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SV1999000016A SV1999000016A (es) | 1998-02-14 | 1999-02-12 | Derivados de 2-(purin-9-il-tetrahidrofuran-3,4-diol ref. pg3443/sv |
Country Status (32)
Country | Link |
---|---|
US (1) | US6610665B1 (es) |
EP (1) | EP1056759B1 (es) |
JP (1) | JP2002503669A (es) |
KR (1) | KR20010082512A (es) |
AP (1) | AP2000001881A0 (es) |
AR (1) | AR017457A1 (es) |
AT (1) | ATE223429T1 (es) |
AU (1) | AU757156B2 (es) |
BR (1) | BR9907886A (es) |
CA (1) | CA2319009A1 (es) |
CO (1) | CO4990969A1 (es) |
DE (1) | DE69902758T2 (es) |
DK (1) | DK1056759T3 (es) |
EA (1) | EA200000759A1 (es) |
EE (1) | EE200000358A (es) |
ES (1) | ES2183516T3 (es) |
HK (1) | HK1032062A1 (es) |
HR (1) | HRP20000538A2 (es) |
HU (1) | HUP0100702A3 (es) |
IL (1) | IL137402A0 (es) |
IS (1) | IS5576A (es) |
MA (1) | MA27121A1 (es) |
NO (1) | NO20004045D0 (es) |
NZ (1) | NZ505812A (es) |
PE (1) | PE20000270A1 (es) |
PL (1) | PL342396A1 (es) |
PT (1) | PT1056759E (es) |
SK (1) | SK12002000A3 (es) |
SV (1) | SV1999000016A (es) |
TR (1) | TR200002355T2 (es) |
WO (1) | WO1999041267A1 (es) |
YU (1) | YU50800A (es) |
Families Citing this family (50)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6514949B1 (en) | 1994-07-11 | 2003-02-04 | University Of Virginia Patent Foundation | Method compositions for treating the inflammatory response |
YU44900A (sh) | 1998-01-31 | 2003-01-31 | Glaxo Group Limited | Derivati 2-(purin-9-il)tetrahidrofuran-3,4-diola |
CO4990969A1 (es) * | 1998-02-14 | 2000-12-26 | Glaxo Group Ltd | Derivados de 2-(purin-9-il)-tetrahidrofuran-3,4-diol |
GB9813565D0 (en) * | 1998-06-23 | 1998-08-19 | Glaxo Group Ltd | Chemical compounds |
EA200001224A1 (ru) | 1998-06-23 | 2001-08-27 | Глаксо Груп Лимитед | Производные 2-(пурин-9-ил)-тетрагидрофуран-3,4-диола |
GB9813554D0 (en) | 1998-06-23 | 1998-08-19 | Glaxo Group Ltd | Chemical compounds |
US6232297B1 (en) | 1999-02-01 | 2001-05-15 | University Of Virginia Patent Foundation | Methods and compositions for treating inflammatory response |
US7378400B2 (en) | 1999-02-01 | 2008-05-27 | University Of Virginia Patent Foundation | Method to reduce an inflammatory response from arthritis |
US7427606B2 (en) | 1999-02-01 | 2008-09-23 | University Of Virginia Patent Foundation | Method to reduce inflammatory response in transplanted tissue |
GB9930075D0 (en) * | 1999-12-20 | 2000-02-09 | Glaxo Group Ltd | Medicaments |
US7638496B2 (en) | 2000-02-15 | 2009-12-29 | Valeant Pharmaceuticals North America | Nucleoside analogs with carboxamidine modified monocyclic base |
GB0022695D0 (en) | 2000-09-15 | 2000-11-01 | Pfizer Ltd | Purine Derivatives |
GB0115178D0 (en) * | 2001-06-20 | 2001-08-15 | Glaxo Group Ltd | Compounds |
JP4514452B2 (ja) | 2001-10-01 | 2010-07-28 | ユニバーシティ オブ バージニア パテント ファウンデーション | A2aアゴニスト活性を有する2−プロピルアデノシン・アナログおよびその組成物 |
AR044519A1 (es) | 2003-05-02 | 2005-09-14 | Novartis Ag | Derivados de piridin-tiazol amina y de pirimidin-tiazol amina |
US6930093B2 (en) * | 2003-07-10 | 2005-08-16 | Valeant Research & Development | Use of ribofuranose derivatives against inflammatory bowel diseases |
GB0401334D0 (en) | 2004-01-21 | 2004-02-25 | Novartis Ag | Organic compounds |
TWI346109B (en) | 2004-04-30 | 2011-08-01 | Otsuka Pharma Co Ltd | 4-amino-5-cyanopyrimidine derivatives |
GB0411056D0 (en) | 2004-05-18 | 2004-06-23 | Novartis Ag | Organic compounds |
PE20060272A1 (es) | 2004-05-24 | 2006-05-22 | Glaxo Group Ltd | (2r,3r,4s,5r,2'r,3'r,4's,5's)-2,2'-{trans-1,4-ciclohexanodiilbis-[imino(2-{[2-(1-metil-1h-imidazol-4-il)etil]amino}-9h-purin-6,9-diil)]}bis[5-(2-etil-2h-tetrazol-5-il)tetrahidro-3,4-furanodiol] como agonista a2a |
WO2006015357A2 (en) | 2004-08-02 | 2006-02-09 | University Of Virginia Patent Foundation | 2-propynyl adenosine analogs with modified 5'-ribose groups having a2a agonist activity |
WO2006023272A1 (en) | 2004-08-02 | 2006-03-02 | University Of Virginia Patent Foundation | 2-polycyclic propynyl adenosine analogs having a2a agonist activity |
WO2006028618A1 (en) | 2004-08-02 | 2006-03-16 | University Of Virginia Patent Foundation | 2-polycyclic propynyl adenosine analogs with modified 5'-ribose groups having a2a agonist activity |
GB0424284D0 (en) | 2004-11-02 | 2004-12-01 | Novartis Ag | Organic compounds |
GB0426164D0 (en) | 2004-11-29 | 2004-12-29 | Novartis Ag | Organic compounds |
GB0510390D0 (en) | 2005-05-20 | 2005-06-29 | Novartis Ag | Organic compounds |
GB0514809D0 (en) | 2005-07-19 | 2005-08-24 | Glaxo Group Ltd | Compounds |
JP5006330B2 (ja) | 2005-10-21 | 2012-08-22 | ノバルティス アーゲー | Il13に対するヒト抗体および治療的使用 |
GB0601951D0 (en) | 2006-01-31 | 2006-03-15 | Novartis Ag | Organic compounds |
US20090286779A1 (en) | 2006-09-29 | 2009-11-19 | Novartis Ag | Pyrazolopyrimidines as lipid kinase inhibitors |
RU2009120389A (ru) | 2006-10-30 | 2010-12-10 | Новартис АГ (CH) | Гетероциклические соединения в качестве противовоспалительных агентов |
US8431578B2 (en) | 2008-01-11 | 2013-04-30 | Novartis Ag | Organic compounds |
PL2391366T3 (pl) | 2009-01-29 | 2013-04-30 | Novartis Ag | Podstawione benzimidazole do leczenia gwiaździaków |
US8389526B2 (en) | 2009-08-07 | 2013-03-05 | Novartis Ag | 3-heteroarylmethyl-imidazo[1,2-b]pyridazin-6-yl derivatives |
EP2464649A1 (en) | 2009-08-12 | 2012-06-20 | Novartis AG | Heterocyclic hydrazone compounds and their uses to treat cancer and inflammation |
EA026693B1 (ru) | 2009-08-17 | 2017-05-31 | Интелликайн ЭлЭлСи | Производные бензоксазола и бензотиазола в качестве ингибиторов pi3-киназы |
IN2012DN01453A (es) | 2009-08-20 | 2015-06-05 | Novartis Ag | |
WO2012034095A1 (en) | 2010-09-09 | 2012-03-15 | Irm Llc | Compounds and compositions as trk inhibitors |
US8637516B2 (en) | 2010-09-09 | 2014-01-28 | Irm Llc | Compounds and compositions as TRK inhibitors |
WO2012107500A1 (en) | 2011-02-10 | 2012-08-16 | Novartis Ag | [1, 2, 4] triazolo [4, 3 -b] pyridazine compounds as inhibitors of the c-met tyrosine kinase |
WO2012116237A2 (en) | 2011-02-23 | 2012-08-30 | Intellikine, Llc | Heterocyclic compounds and uses thereof |
WO2012116217A1 (en) | 2011-02-25 | 2012-08-30 | Irm Llc | Compounds and compositions as trk inhibitors |
AU2012310168B2 (en) | 2011-09-15 | 2015-07-16 | Novartis Ag | 6 - substituted 3 - (quinolin- 6 - ylthio) - [1,2,4] triazolo [4, 3 -a] pyradines as tyrosine kinase |
JP6130391B2 (ja) | 2011-11-23 | 2017-05-17 | インテリカイン, エルエルシー | Mtor阻害剤を使用する強化された治療レジメン |
WO2013149581A1 (en) | 2012-04-03 | 2013-10-10 | Novartis Ag | Combination products with tyrosine kinase inhibitors and their use |
JP2016512835A (ja) | 2013-03-15 | 2016-05-09 | インテリカイン, エルエルシー | キナーゼ阻害剤の組み合わせ及びそれらの使用 |
TW201605450A (zh) | 2013-12-03 | 2016-02-16 | 諾華公司 | Mdm2抑制劑與BRAF抑制劑之組合及其用途 |
WO2016011658A1 (en) | 2014-07-25 | 2016-01-28 | Novartis Ag | Combination therapy |
WO2016016822A1 (en) | 2014-07-31 | 2016-02-04 | Novartis Ag | Combination therapy |
TW202140550A (zh) | 2020-01-29 | 2021-11-01 | 瑞士商諾華公司 | 使用抗tslp抗體治療炎性或阻塞性氣道疾病之方法 |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9414193D0 (en) * | 1994-07-14 | 1994-08-31 | Glaxo Group Ltd | Compounds |
TW528755B (en) | 1996-12-24 | 2003-04-21 | Glaxo Group Ltd | 2-(purin-9-yl)-tetrahydrofuran-3,4-diol derivatives |
CO4990969A1 (es) * | 1998-02-14 | 2000-12-26 | Glaxo Group Ltd | Derivados de 2-(purin-9-il)-tetrahidrofuran-3,4-diol |
EA200001224A1 (ru) * | 1998-06-23 | 2001-08-27 | Глаксо Груп Лимитед | Производные 2-(пурин-9-ил)-тетрагидрофуран-3,4-диола |
-
1999
- 1999-02-11 CO CO99008188A patent/CO4990969A1/es unknown
- 1999-02-11 PE PE1999000123A patent/PE20000270A1/es not_active Application Discontinuation
- 1999-02-11 AR ARP990100570A patent/AR017457A1/es active IP Right Grant
- 1999-02-12 JP JP2000531459A patent/JP2002503669A/ja active Pending
- 1999-02-12 CA CA002319009A patent/CA2319009A1/en not_active Abandoned
- 1999-02-12 AP APAP/P/2000/001881A patent/AP2000001881A0/en unknown
- 1999-02-12 YU YU50800A patent/YU50800A/sh unknown
- 1999-02-12 US US09/622,313 patent/US6610665B1/en not_active Expired - Fee Related
- 1999-02-12 NZ NZ505812A patent/NZ505812A/en unknown
- 1999-02-12 ES ES99906229T patent/ES2183516T3/es not_active Expired - Lifetime
- 1999-02-12 AT AT99906229T patent/ATE223429T1/de not_active IP Right Cessation
- 1999-02-12 SV SV1999000016A patent/SV1999000016A/es not_active Application Discontinuation
- 1999-02-12 HU HU0100702A patent/HUP0100702A3/hu unknown
- 1999-02-12 PT PT99906229T patent/PT1056759E/pt unknown
- 1999-02-12 EP EP99906229A patent/EP1056759B1/en not_active Expired - Lifetime
- 1999-02-12 KR KR1020007008866A patent/KR20010082512A/ko not_active Application Discontinuation
- 1999-02-12 PL PL99342396A patent/PL342396A1/xx unknown
- 1999-02-12 TR TR2000/02355T patent/TR200002355T2/xx unknown
- 1999-02-12 MA MA25462A patent/MA27121A1/fr unknown
- 1999-02-12 WO PCT/EP1999/000915 patent/WO1999041267A1/en not_active Application Discontinuation
- 1999-02-12 EA EA200000759A patent/EA200000759A1/ru unknown
- 1999-02-12 DE DE69902758T patent/DE69902758T2/de not_active Expired - Fee Related
- 1999-02-12 EE EEP200000358A patent/EE200000358A/xx unknown
- 1999-02-12 BR BR9907886-4A patent/BR9907886A/pt not_active IP Right Cessation
- 1999-02-12 IL IL13740299A patent/IL137402A0/xx unknown
- 1999-02-12 DK DK99906229T patent/DK1056759T3/da active
- 1999-02-12 SK SK1200-2000A patent/SK12002000A3/sk unknown
- 1999-02-12 AU AU26235/99A patent/AU757156B2/en not_active Ceased
-
2000
- 2000-07-25 IS IS5576A patent/IS5576A/is unknown
- 2000-08-11 HR HR20000538A patent/HRP20000538A2/hr not_active Application Discontinuation
- 2000-08-11 NO NO20004045A patent/NO20004045D0/no unknown
-
2001
- 2001-04-10 HK HK01102563A patent/HK1032062A1/xx not_active IP Right Cessation
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