SK288100B6 - Human IL-2 mutein, pharmaceutical composition containing thereof and use, vector and prokaryotic host cell - Google Patents

Human IL-2 mutein, pharmaceutical composition containing thereof and use, vector and prokaryotic host cell Download PDF

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Publication number
SK288100B6
SK288100B6 SK1724-2000A SK17242000A SK288100B6 SK 288100 B6 SK288100 B6 SK 288100B6 SK 17242000 A SK17242000 A SK 17242000A SK 288100 B6 SK288100 B6 SK 288100B6
Authority
SK
Slovakia
Prior art keywords
cells
cell
mutant
human
proleukin
Prior art date
Application number
SK1724-2000A
Other languages
English (en)
Slovak (sk)
Other versions
SK17242000A3 (sk
Inventor
Armen B. Shanafelt
Jeffrey M. Greve
Gary Jesmok
Kenneth J. Lembach
Gayle D. Wetzel
Original Assignee
Aicuris Gmbh & Co. Kg
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aicuris Gmbh & Co. Kg filed Critical Aicuris Gmbh & Co. Kg
Publication of SK17242000A3 publication Critical patent/SK17242000A3/sk
Publication of SK288100B6 publication Critical patent/SK288100B6/sk

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/54—Interleukins [IL]
    • C07K14/55—IL-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Communicable Diseases (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Virology (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • AIDS & HIV (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
SK1724-2000A 1998-05-15 1999-05-13 Human IL-2 mutein, pharmaceutical composition containing thereof and use, vector and prokaryotic host cell SK288100B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8008098A 1998-05-15 1998-05-15
PCT/US1999/010643 WO1999060128A1 (en) 1998-05-15 1999-05-13 Il-2 selective agonists and antagonists

Publications (2)

Publication Number Publication Date
SK17242000A3 SK17242000A3 (sk) 2001-07-10
SK288100B6 true SK288100B6 (sk) 2013-07-02

Family

ID=22155135

Family Applications (1)

Application Number Title Priority Date Filing Date
SK1724-2000A SK288100B6 (sk) 1998-05-15 1999-05-13 Human IL-2 mutein, pharmaceutical composition containing thereof and use, vector and prokaryotic host cell

Country Status (39)

Country Link
EP (1) EP1076704B1 (de)
JP (1) JP4276783B2 (de)
KR (1) KR100607609B1 (de)
CN (2) CN101319247B (de)
AR (1) AR020322A1 (de)
AT (1) ATE351907T1 (de)
AU (1) AU759697B2 (de)
BG (1) BG65139B1 (de)
BR (1) BRPI9910504B1 (de)
CA (1) CA2327349C (de)
CO (1) CO5070701A1 (de)
CU (2) CU23273B7 (de)
CY (1) CY1107533T1 (de)
CZ (1) CZ302071B6 (de)
DE (1) DE69934881T2 (de)
DK (1) DK1076704T3 (de)
DZ (1) DZ2788A1 (de)
ES (1) ES2281175T3 (de)
HK (1) HK1039963B (de)
HN (1) HN1999000075A (de)
HU (1) HU226142B1 (de)
IL (2) IL139136A0 (de)
MY (1) MY130274A (de)
NO (1) NO329235B1 (de)
NZ (1) NZ508098A (de)
PA (1) PA8472601A1 (de)
PE (1) PE20000475A1 (de)
PL (1) PL201675B1 (de)
PT (1) PT1076704E (de)
RO (1) RO122150B1 (de)
RU (1) RU2235729C2 (de)
SI (1) SI20643B (de)
SK (1) SK288100B6 (de)
SV (1) SV1999000061A (de)
TN (1) TNSN99090A1 (de)
TR (1) TR200003354T2 (de)
TW (1) TWI223663B (de)
UA (1) UA73719C2 (de)
WO (1) WO1999060128A1 (de)

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US6689353B1 (en) * 2000-06-28 2004-02-10 Bayer Pharmaceuticals Corporation Stabilized interleukin 2
US7723102B2 (en) * 2000-09-28 2010-05-25 Bayer Corporation Enhanced transfection system
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US6992174B2 (en) 2001-03-30 2006-01-31 Emd Lexigen Research Center Corp. Reducing the immunogenicity of fusion proteins
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US7569215B2 (en) * 2003-07-18 2009-08-04 Massachusetts Institute Of Technology Mutant interleukin-2 (IL-2) polypeptides
DE602004031341D1 (de) 2003-07-21 2011-03-24 Transgene Sa Multifunktionelle cytokine
DE602004031681D1 (de) 2003-07-21 2011-04-14 Transgene Sa Multifunktionelle Cytokine
JP4765039B2 (ja) 2003-11-04 2011-09-07 ノバルティス バクシンズ アンド ダイアグノスティックス，インコーポレーテッド Ｃｄ４０抗原を発現する癌に対する治療方法。
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BRPI0508470A (pt) * 2004-03-05 2007-07-31 Chiron Corp sistema de teste in vitro para prever toleráncia do paciente aos agentes terapêuticos
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PT2637694T (pt) 2010-11-12 2021-05-05 Nektar Therapeutics Conjugados de uma fração de il-2 e um polímero
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EP3211001B1 (de) 2010-12-22 2020-10-07 The Board of Trustees of the Leland Stanford Junior University Superagonisten und antagonisten von interleukin-2
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WO2012119093A1 (en) * 2011-03-03 2012-09-07 Board Of Trustees Of The Leland Stanford Junior University Superagonists and antagonists of interleukin-2
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Also Published As

Publication number Publication date
UA73719C2 (en) 2005-09-15
ES2281175T3 (es) 2007-09-16
TNSN99090A1 (fr) 2005-11-10
ATE351907T1 (de) 2007-02-15
TWI223663B (en) 2004-11-11
BG104929A (en) 2001-09-28
CZ20004213A3 (en) 2001-05-16
HUP0101948A3 (en) 2003-08-28
PE20000475A1 (es) 2000-07-07
RO122150B1 (ro) 2009-01-30
IL139136A0 (en) 2001-11-25
DZ2788A1 (fr) 2003-12-01
AR020322A1 (es) 2002-05-08
CN101319247B (zh) 2012-12-12
DE69934881D1 (de) 2007-03-08
CZ302071B6 (cs) 2010-09-29
SK17242000A3 (sk) 2001-07-10
PT1076704E (pt) 2007-02-28
CO5070701A1 (es) 2001-08-28
JP2002515247A (ja) 2002-05-28
SI20643B (sl) 2008-02-29
CN1309705A (zh) 2001-08-22
NO20005762D0 (no) 2000-11-14
BR9910504A (pt) 2001-01-09
NZ508098A (en) 2003-09-26
HN1999000075A (es) 1999-09-29
PL344407A1 (en) 2001-11-05
AU4078499A (en) 1999-12-06
CN101319247A (zh) 2008-12-10
CY1107533T1 (el) 2013-03-13
DK1076704T3 (da) 2007-03-12
DE69934881T2 (de) 2007-11-08
BRPI9910504B1 (pt) 2016-08-09
PA8472601A1 (es) 2000-09-29
WO1999060128A1 (en) 1999-11-25
CA2327349C (en) 2010-10-26
NO329235B1 (no) 2010-09-20
SV1999000061A (es) 2000-03-14
PL201675B1 (pl) 2009-04-30
CN100366742C (zh) 2008-02-06
HUP0101948A2 (hu) 2001-09-28
JP4276783B2 (ja) 2009-06-10
MY130274A (en) 2007-06-29
HK1039963B (zh) 2008-09-05
KR100607609B1 (ko) 2006-08-02
TR200003354T2 (tr) 2001-03-21
NO20005762L (no) 2001-01-11
IL139136A (en) 2009-05-04
CU23273B7 (es) 2008-04-09
KR20010043602A (ko) 2001-05-25
BG65139B1 (bg) 2007-03-30
CU23272A1 (es) 2008-04-09
HU226142B1 (en) 2008-05-28
EP1076704B1 (de) 2007-01-17
HK1039963A1 (en) 2002-05-17
SI20643A (sl) 2002-02-28
CA2327349A1 (en) 1999-11-25
RU2235729C2 (ru) 2004-09-10
AU759697B2 (en) 2003-04-17
EP1076704A1 (de) 2001-02-21

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MK4A Patent expired

Expiry date: 20190513