SK282335B6 - Deriváty 5-fenyl-3-(piperidin-4-yl)-1,3,4,-oxadiazol-2(3H)-ónu, spôsob ich prípravy a farmaceutický prostriedok, ktorý ich obsahuje - Google Patents

Deriváty 5-fenyl-3-(piperidin-4-yl)-1,3,4,-oxadiazol-2(3H)-ónu, spôsob ich prípravy a farmaceutický prostriedok, ktorý ich obsahuje Download PDF

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Publication number
SK282335B6
SK282335B6 SK599-98A SK59998A SK282335B6 SK 282335 B6 SK282335 B6 SK 282335B6 SK 59998 A SK59998 A SK 59998A SK 282335 B6 SK282335 B6 SK 282335B6
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SK
Slovakia
Prior art keywords
piperidin
group
oxadiazol
phenyl
dihydro
Prior art date
Application number
SK599-98A
Other languages
English (en)
Slovak (sk)
Other versions
SK59998A3 (en
Inventor
Samir Jegham
Alistair Lochead
Fr�D�Ric Galli
Alain Nedelec
Axelle Solignac
Cruz Laurence De
Original Assignee
Sanofi-Synthelabo
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from FR9513253A external-priority patent/FR2741070B1/fr
Priority claimed from FR9513252A external-priority patent/FR2741069B1/fr
Priority claimed from FR9602663A external-priority patent/FR2745574B1/fr
Application filed by Sanofi-Synthelabo filed Critical Sanofi-Synthelabo
Publication of SK59998A3 publication Critical patent/SK59998A3/sk
Publication of SK282335B6 publication Critical patent/SK282335B6/sk

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/06—Antiarrhythmics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
SK599-98A 1995-11-09 1996-11-05 Deriváty 5-fenyl-3-(piperidin-4-yl)-1,3,4,-oxadiazol-2(3H)-ónu, spôsob ich prípravy a farmaceutický prostriedok, ktorý ich obsahuje SK282335B6 (sk)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
FR9513253A FR2741070B1 (fr) 1995-11-09 1995-11-09 Derives de 5-phenyl-3-(piperidin-4-yl)-1,3,4-oxadiazol-2(3h) -one, leur preparation et leur application en therapeutique
FR9513252A FR2741069B1 (fr) 1995-11-09 1995-11-09 Derives de 5-phenyl-3-(piperidin-4-yl)-1,3,4-oxadiazol-2(3h) -one, leur preparation et leur application en therapeutique
FR9602663A FR2745574B1 (fr) 1996-03-04 1996-03-04 Derives de 5-phenyl-3-(piperidin-4-yl)-1, 3, 4-oxadiazol-2 (3h)-one, leur preparation et leur application en therapeutique
PCT/FR1996/001730 WO1997017345A1 (fr) 1995-11-09 1996-11-05 Derives de 5-phenyl-3-(piperidin-4-yl)-1,3,4-oxadiazol-2(3h)-one, utiles comme ligands des recepteurs 5-ht4 ou h¿3?

Publications (2)

Publication Number Publication Date
SK59998A3 SK59998A3 (en) 1998-11-04
SK282335B6 true SK282335B6 (sk) 2002-01-07

Family

ID=27253120

Family Applications (1)

Application Number Title Priority Date Filing Date
SK599-98A SK282335B6 (sk) 1995-11-09 1996-11-05 Deriváty 5-fenyl-3-(piperidin-4-yl)-1,3,4,-oxadiazol-2(3H)-ónu, spôsob ich prípravy a farmaceutický prostriedok, ktorý ich obsahuje

Country Status (30)

Country Link
US (1) US5929089A (es)
EP (1) EP0863897B1 (es)
JP (1) JP4263240B2 (es)
CN (1) CN1077891C (es)
AR (1) AR004708A1 (es)
AT (1) ATE181328T1 (es)
AU (1) AU707325B2 (es)
BG (1) BG63463B1 (es)
BR (1) BR9611311A (es)
CA (1) CA2236357C (es)
CO (1) CO4770968A1 (es)
CZ (1) CZ287268B6 (es)
DE (1) DE69602970T2 (es)
EE (1) EE03487B1 (es)
ES (1) ES2135934T3 (es)
GR (1) GR3030823T3 (es)
HK (1) HK1016165A1 (es)
HU (1) HUP0001168A3 (es)
IL (1) IL124364A (es)
MX (1) MX9803696A (es)
NO (1) NO309606B1 (es)
NZ (1) NZ321626A (es)
PL (1) PL186204B1 (es)
RU (1) RU2167160C2 (es)
SI (1) SI0863897T1 (es)
SK (1) SK282335B6 (es)
TR (1) TR199800827T2 (es)
TW (1) TW371303B (es)
UA (1) UA50748C2 (es)
WO (1) WO1997017345A1 (es)

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Publication number Priority date Publication date Assignee Title
TW467902B (en) * 1996-07-31 2001-12-11 Bristol Myers Squibb Co Diphenyl heterocycles as potassium channel modulators
FR2762316B1 (fr) * 1997-04-18 1999-12-17 Sanofi Synthelabo Derives de 5-aryl-3-(8-azabicyclo[3.2.1] octan-3-yl)-1,3,4- oxadiazol-2(3h)-one, leur preparation et leur application en therapeutique
FR2763068B1 (fr) * 1997-05-06 1999-06-04 Synthelabo Derives de 3-(pyrrolidin-3-yl)-1,3,4-oxadiazol-2(3h)-one, leur preparation et leur application en therapeutique
WO1998050383A1 (fr) * 1997-05-06 1998-11-12 Sanofi-Synthelabo Derives de 5-phenyl-1,3,4-oxadiazol-2(3h)-one et leur utilisation comme ligands 5-ht4
GB9715816D0 (en) * 1997-07-25 1997-10-01 Black James Foundation Histamine H receptor ligands
US6960579B1 (en) 1998-05-19 2005-11-01 Alcon Manufacturing, Ltd. Serotonergic 5HT7 receptor compounds for treating ocular and CNS disorders
US6664286B1 (en) 1998-09-18 2003-12-16 Alcon Manufacturing, Ltd. Serotonergic 5ht2 agonists for treating glaucoma
JP2002542287A (ja) * 1999-04-28 2002-12-10 レスピラトリウス アクチボラゲット 医 薬
AU5861900A (en) * 1999-06-15 2001-01-02 Respiratorius Ab Receptor agonists and antagonists
MXPA03001267A (es) * 2000-08-08 2004-07-30 Johnson & Johnson Ariloxialquilaminas sin imidazol.
MXPA03001268A (es) * 2000-08-08 2004-09-06 Johnson & Johnson Ariloxipiperidinas sin imidazol.
DK1311499T3 (da) * 2000-08-08 2006-08-07 Ortho Mcneil Pharm Inc Bicycliske forbindelser som H3-receptorligander
AU2002344951A1 (en) 2001-07-02 2003-01-21 Boehringer Ingelheim International Gmbh Substituted piperazine and diazepanes as histamine h3 receptor agonists
US7208497B2 (en) 2001-07-02 2007-04-24 Novo Nordisk A/S Substituted piperazines and diazepanes
WO2003024929A1 (en) * 2001-09-14 2003-03-27 Novo Nordisk A/S Substituted piperidines with selective binding to histamine h3-receptor
US6673829B2 (en) 2001-09-14 2004-01-06 Novo Nordisk A/S Aminoazetidine,-pyrrolidine and -piperidine derivatives
US20030186963A1 (en) 2001-09-14 2003-10-02 Dorwald Florencio Zaragoza Substituted piperidines
JP4619655B2 (ja) 2001-09-14 2011-01-26 ハイ・ポイント・ファーマスーティカルズ、エルエルシー 新規アミノアゼチジン、−ピロリジンおよび−ピペリジン誘導体
US7064135B2 (en) 2001-10-12 2006-06-20 Novo Nordisk Inc. Substituted piperidines
EP2243776A1 (en) 2001-10-12 2010-10-27 High Point Pharmaceuticals, LLC Substituted piperidines and their use for the treatment of diseases related to the histamine H3 receptor
WO2003051352A1 (en) 2001-12-14 2003-06-26 Alcon, Inc. Aminoalkyl-benzofuran-5-ol compounds for the treatment of glaucoma
US20030236259A1 (en) * 2002-02-05 2003-12-25 Rolf Hohlweg Novel aryl- and heteroarylpiperazines
GB0211230D0 (en) 2002-05-16 2002-06-26 Medinnova Sf Treatment of heart failure
US7332508B2 (en) * 2002-12-18 2008-02-19 Novo Nordisk A/S Substituted homopiperidine, piperidine or pyrrolidine derivatives
US7737163B2 (en) 2004-06-15 2010-06-15 Pfizer Inc. Benzimidazolone carboxylic acid derivatives
MXPA06014486A (es) 2004-06-15 2007-03-01 Pfizer Derivados de acido carboxilico de bencimidazolona.
WO2007003604A2 (en) 2005-07-04 2007-01-11 Novo Nordisk A/S Hists1mine h3 receptor antagonists
PL2079732T3 (pl) 2006-05-29 2012-05-31 High Point Pharmaceuticals Llc 3-(1,3-benzodioksol-5-ylo)-6-(4-cyklopropylopiperazyn-1-ylo)-pirydazyna, jej sole i solwaty oraz jej zastosowanie jako antagonisty receptora histaminowego h3
EP2014656A3 (en) * 2007-06-11 2011-08-24 High Point Pharmaceuticals, LLC New heteocyclic h3 antagonists
PL2758394T3 (pl) * 2011-09-19 2015-08-31 Suven Life Sciences Ltd Związki heteroarylowe jako ligandy receptora 5-HT4

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WO1993003725A1 (en) * 1991-08-20 1993-03-04 Smithkline Beecham Plc 5-ht4 receptor antagonists
CZ283619B6 (cs) * 1991-09-12 1998-05-13 Smithkline Beecham P.L.C Použití derivátů kyseliny benzoové pro výrobu farmaceutických prostředků, deriváty kyseliny benzoo vé, způsob jejich výroby a farmaceutické prostředky s jejich obsahem
CA2129112A1 (en) * 1992-02-06 1993-08-19 Francis David King Benzopyran, benzothiopyran and benzofuran derivatives as 5-ht4 antagonists
GB9219163D0 (en) * 1992-09-10 1992-10-28 Smithkline Beecham Plc Pharmaceuticals
JPH06157518A (ja) * 1992-11-27 1994-06-03 Yamanouchi Pharmaceut Co Ltd 新規なオキサジアゾール誘導体又はその塩

Also Published As

Publication number Publication date
TR199800827T2 (xx) 1999-02-22
RU2167160C2 (ru) 2001-05-20
CA2236357A1 (en) 1997-05-15
MX9803696A (es) 1998-09-30
SI0863897T1 (en) 1999-10-31
BG63463B1 (bg) 2002-02-28
EP0863897B1 (fr) 1999-06-16
NO982092L (no) 1998-06-29
AU7500196A (en) 1997-05-29
CN1077891C (zh) 2002-01-16
HK1016165A1 (en) 1999-10-29
SK59998A3 (en) 1998-11-04
IL124364A0 (en) 1998-12-06
CZ142198A3 (cs) 1998-08-12
JP4263240B2 (ja) 2009-05-13
NZ321626A (en) 1998-10-28
EE03487B1 (et) 2001-08-15
EE9800155A (et) 1998-12-15
CN1202169A (zh) 1998-12-16
US5929089A (en) 1999-07-27
NO982092D0 (no) 1998-05-07
BG102412A (en) 1999-08-31
AR004708A1 (es) 1999-03-10
EP0863897A1 (fr) 1998-09-16
DE69602970T2 (de) 2000-01-20
ATE181328T1 (de) 1999-07-15
TW371303B (en) 1999-10-01
DE69602970D1 (de) 1999-07-22
AU707325B2 (en) 1999-07-08
PL186204B1 (pl) 2003-11-28
HUP0001168A2 (hu) 2001-04-28
CZ287268B6 (en) 2000-10-11
CA2236357C (en) 2006-10-17
ES2135934T3 (es) 1999-11-01
IL124364A (en) 2001-08-08
HUP0001168A3 (en) 2001-07-30
BR9611311A (pt) 1999-06-29
GR3030823T3 (en) 1999-11-30
PL326671A1 (en) 1998-10-12
WO1997017345A1 (fr) 1997-05-15
JP2000500125A (ja) 2000-01-11
UA50748C2 (uk) 2002-11-15
NO309606B1 (no) 2001-02-26
CO4770968A1 (es) 1999-04-30

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MM4A Patent lapsed due to non-payment of maintenance fees

Effective date: 20131105