AU2002344951A1 - Substituted piperazine and diazepanes as histamine h3 receptor agonists - Google Patents

Substituted piperazine and diazepanes as histamine h3 receptor agonists

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Publication number
AU2002344951A1
AU2002344951A1 AU2002344951A AU2002344951A AU2002344951A1 AU 2002344951 A1 AU2002344951 A1 AU 2002344951A1 AU 2002344951 A AU2002344951 A AU 2002344951A AU 2002344951 A AU2002344951 A AU 2002344951A AU 2002344951 A1 AU2002344951 A1 AU 2002344951A1
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AU
Australia
Prior art keywords
histamine
diazepanes
receptor agonists
substituted piperazine
receptor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
AU2002344951A
Inventor
Knud Erik Andersen
Florencio Zaragoza Dorwald
Jan Lindy Sorensen
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim International GmbH
Novo Nordisk AS
Original Assignee
Boehringer Ingelheim International GmbH
Novo Nordisk AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim International GmbH, Novo Nordisk AS filed Critical Boehringer Ingelheim International GmbH
Publication of AU2002344951A1 publication Critical patent/AU2002344951A1/en
Abandoned legal-status Critical Current

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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/72—Nitrogen atoms
    • C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
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    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
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    • C07D263/54—Benzoxazoles; Hydrogenated benzoxazoles
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    • C07D277/62—Benzothiazoles
    • C07D277/68—Benzothiazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
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    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
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    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/18—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carboxylic acids, or sulfur or nitrogen analogues thereof
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    • C07D295/16—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms
    • C07D295/20—Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms acylated on ring nitrogen atoms by radicals derived from carbonic acid, or sulfur or nitrogen analogues thereof
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Abstract

A novel class of substituted piperazines and diazepanes, pharmaceutical compositions comprising them and use thereof in the treatment of diseases and disorders related to the histamine H3 receptor. More particularly, the compounds are useful for the treatment of diseases and disorders in which an interaction with the histamine H3 receptor is beneficial.
AU2002344951A 2001-07-02 2002-06-27 Substituted piperazine and diazepanes as histamine h3 receptor agonists Abandoned AU2002344951A1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
DKPA200101046 2001-07-02
DKPA200101046 2001-07-02
DKPA200101878 2001-12-14
DKPA200101878 2001-12-14
PCT/DK2002/000438 WO2003004480A2 (en) 2001-07-02 2002-06-27 Substituted piperazine and diazepanes as histamine h3 receptor agonists

Publications (1)

Publication Number Publication Date
AU2002344951A1 true AU2002344951A1 (en) 2003-01-21

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AU2002344951A Abandoned AU2002344951A1 (en) 2001-07-02 2002-06-27 Substituted piperazine and diazepanes as histamine h3 receptor agonists

Country Status (6)

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EP (1) EP1421071B1 (en)
JP (1) JP2005502623A (en)
AT (1) ATE449090T1 (en)
AU (1) AU2002344951A1 (en)
DE (1) DE60234453D1 (en)
WO (1) WO2003004480A2 (en)

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