SK280833B6 - Racemický alebo opticky aktívny 5-(1-hydroxy-2- -piperidínopropyl)-2-(1h,3h)-indolový derivát, 5-(1-oxo-2- -piperidínopropyl)-2-(1h,3h)-indol ako medziprodukt na jeho prípravu, farmaceutický prostriedok s jeho obsahom a ich použitie - Google Patents
Racemický alebo opticky aktívny 5-(1-hydroxy-2- -piperidínopropyl)-2-(1h,3h)-indolový derivát, 5-(1-oxo-2- -piperidínopropyl)-2-(1h,3h)-indol ako medziprodukt na jeho prípravu, farmaceutický prostriedok s jeho obsahom a ich použitie Download PDFInfo
- Publication number
- SK280833B6 SK280833B6 SK1354-91A SK135491A SK280833B6 SK 280833 B6 SK280833 B6 SK 280833B6 SK 135491 A SK135491 A SK 135491A SK 280833 B6 SK280833 B6 SK 280833B6
- Authority
- SK
- Slovakia
- Prior art keywords
- hydroxy
- piperidinopropyl
- racemic
- optically active
- indole derivative
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Hospice & Palliative Care (AREA)
- Psychiatry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Hydrogenated Pyridines (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US52233290A | 1990-05-10 | 1990-05-10 |
Publications (1)
Publication Number | Publication Date |
---|---|
SK280833B6 true SK280833B6 (sk) | 2000-08-14 |
Family
ID=24080448
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SK1354-91A SK280833B6 (sk) | 1990-05-10 | 1991-05-08 | Racemický alebo opticky aktívny 5-(1-hydroxy-2- -piperidínopropyl)-2-(1h,3h)-indolový derivát, 5-(1-oxo-2- -piperidínopropyl)-2-(1h,3h)-indol ako medziprodukt na jeho prípravu, farmaceutický prostriedok s jeho obsahom a ich použitie |
Country Status (30)
Country | Link |
---|---|
US (1) | US5306723A (cs) |
EP (1) | EP0554247B1 (cs) |
JP (1) | JPH0699423B2 (cs) |
KR (1) | KR0163355B1 (cs) |
CN (1) | CN1037439C (cs) |
AT (1) | ATE192149T1 (cs) |
AU (1) | AU642994B2 (cs) |
BR (1) | BR9106432A (cs) |
CA (1) | CA2080475C (cs) |
CZ (1) | CZ280560B6 (cs) |
DE (1) | DE69132141T2 (cs) |
DK (1) | DK0554247T3 (cs) |
EG (1) | EG19647A (cs) |
ES (1) | ES2146578T3 (cs) |
FI (1) | FI109121B (cs) |
GR (1) | GR3034005T3 (cs) |
HU (1) | HU221193B1 (cs) |
IE (1) | IE911569A1 (cs) |
IL (1) | IL98056A (cs) |
MY (1) | MY107799A (cs) |
NO (1) | NO301979B1 (cs) |
PH (1) | PH29902A (cs) |
PL (1) | PL169267B1 (cs) |
PT (1) | PT97602B (cs) |
RU (1) | RU2068414C1 (cs) |
SK (1) | SK280833B6 (cs) |
TW (1) | TW198720B (cs) |
WO (1) | WO1991017156A1 (cs) |
YU (1) | YU48528B (cs) |
ZA (1) | ZA913494B (cs) |
Families Citing this family (39)
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HUT65836A (en) * | 1991-04-18 | 1994-07-28 | Pfizer | Process for producing phenol-esters of 1-(hydroxy-phenyl)-2-piperidino-1-alkanol derivatives and pharmaceutical compositions containing them |
US5594007A (en) * | 1991-04-18 | 1997-01-14 | Pfizer Inc. | Method for treating spinal cord trauma with phenolic 2-piperidino-1-alkanols |
PL169884B1 (pl) * | 1991-07-17 | 1996-09-30 | Pfizer | Sposób wytwarzania nowych pochodnych 2-(4-hydroksypiperydyno)-1-alkanolowych PL PL PL |
FR2688504B1 (fr) * | 1992-03-13 | 1995-05-05 | Synthelabo | Derives de 2-(piperidin-1-yl)ethanol, leur preparation et leur application en therapeutique. |
US5319096A (en) * | 1992-04-03 | 1994-06-07 | Hoechst-Roussel Pharmaceuticals Inc. | (1H-indol-1-yl)-2-(amino) acetamides and related (1H-indol-1-yl)-(aminoalkyl)amides, pharmaceutical composition and use |
US6255322B1 (en) | 1992-06-19 | 2001-07-03 | Pfizer Inc. | 2-(4-hydroxypiperidino)-1-alkanol derivatives as antiischemic agents |
US5436255A (en) * | 1992-07-23 | 1995-07-25 | Pfizer Inc. | Method of treating diseases susceptable to treatment by blocking NMDA-receptors |
WO1994010166A1 (en) * | 1992-10-30 | 1994-05-11 | Pfizer Inc. | Neuroprotective 3,4-dihydro-2(1h)-quinolone compounds |
US5498610A (en) * | 1992-11-06 | 1996-03-12 | Pfizer Inc. | Neuroprotective indolone and related derivatives |
CA2197451C (en) * | 1994-08-18 | 2001-01-23 | Bertrand L. Chenard | Neuroprotective 3-(piperidinyl-1)-chroman-4,7-diol and 1-(4-hydrophenyl)-2-(piperidinyl-1)-alkanol derivatives |
GB9510459D0 (en) | 1995-05-24 | 1995-07-19 | Zeneca Ltd | Bicyclic amines |
ZA9610741B (en) | 1995-12-22 | 1997-06-24 | Warner Lambert Co | 4-Substituted piperidine analogs and their use as subtype selective nmda receptor antagonists |
ZA9610738B (en) | 1995-12-22 | 1997-06-24 | Warner Lambert Co | Subtype selective nmda receptor ligands and the use thereof |
ZA9610745B (en) * | 1995-12-22 | 1997-06-24 | Warner Lambert Co | 4-Subsituted piperidine analogs and their use as subtype selective nmda receptor antagonists |
ZA9610736B (en) * | 1995-12-22 | 1997-06-27 | Warner Lambert Co | 2-Substituted piperidine analogs and their use as subtypeselective nmda receptor antagonists |
TW427978B (en) * | 1996-02-03 | 2001-04-01 | Hoffmann La Roche | Tetrahydroisoquinoline derivatives |
IL126882A0 (en) * | 1996-05-13 | 1999-09-22 | Zeneca Ltd | Bicyclic amines as insecticides |
GB9623944D0 (en) * | 1996-11-15 | 1997-01-08 | Zeneca Ltd | Bicyclic amine derivatives |
GB9624114D0 (en) * | 1996-11-20 | 1997-01-08 | Zeneca Ltd | Pesticidal bicyclic amine derivatives |
GB9624611D0 (en) | 1996-11-26 | 1997-01-15 | Zeneca Ltd | Bicyclic amine compounds |
DE69727694T2 (de) | 1996-11-26 | 2004-07-29 | Syngenta Ltd., Guildford | 8-azabicyclo 3.2.1]octan-, 8-azabicyclo 3.2.1]oct-6-en-, 9-azabicyclo 3.3.1]nonan-, 9-aza-3-oxabicyclo 3.3.1]nonan- und 9-aza-3-thiabicyclo 3.3.1]nonan-derivate, ihre herstellung und ihre verwendung als insektizide |
EP0846683B1 (en) * | 1996-12-03 | 2001-09-19 | F. Hoffmann-La Roche Ag | 4-Hydroxy-piperidine derivatives |
CA2220649C (en) | 1996-12-03 | 2007-02-13 | F. Hoffmann-La Roche Ag | 4-hydroxy-piperidine derivatives |
WO2000064422A2 (en) * | 1999-04-27 | 2000-11-02 | Smithkline Beecham P.L.C. | Novel treatment of neurotraumatic conditions with raf inhibitor |
US6291499B1 (en) | 1999-10-29 | 2001-09-18 | Merck & Co., Inc. | 2-cyclohexyl benzimidazole NMDA/NR2B antagonists |
AU1153601A (en) | 1999-10-29 | 2001-05-08 | Merck Sharp & Dohme Limited | Method to treat pain utilizing benzimidazole NMDA NR2B antagonists |
US6316474B1 (en) | 1999-10-29 | 2001-11-13 | Merck & Co., Inc. | 2-benzyl and 2-heteroaryl benzimidazole NMDA/NR2B antagonists |
US6380205B1 (en) | 1999-10-29 | 2002-04-30 | Merck & Co., Inc. | 2-cyclohexyl quinazoline NMDA/NR2B antagonists |
US6476041B1 (en) | 1999-10-29 | 2002-11-05 | Merck & Co., Inc. | 1,4 substituted piperidinyl NMDA/NR2B antagonists |
US6432976B1 (en) | 1999-10-29 | 2002-08-13 | Merck & Co., Inc. | 8-aza-bicyclo[3.2.1]octane NMDA/NR2B antagonists |
US6489477B1 (en) | 1999-10-29 | 2002-12-03 | Merck & Co., Inc. | 2-aza-bicyclo[2.2.2]octane NMDA/NR2B antigonists |
US6495561B2 (en) | 1999-10-29 | 2002-12-17 | Merck & Co., Inc. | 2-cyclohexyl imidazopyridine NMDA/NR2B antagonists |
US6369076B1 (en) | 1999-10-29 | 2002-04-09 | Merck & Co. Inc. | 5-benzyl-octahydroindole and 6-benzyl-decahydroquinoline NMDA/NR2B antagonists |
CZ20032258A3 (cs) | 2001-02-23 | 2004-01-14 | Merck & Co., Inc. | N-substituované nearylové heterocyklické sloučeniny |
WO2002080928A1 (en) | 2001-04-03 | 2002-10-17 | Merck & Co., Inc. | N-substituted nonaryl-heterocyclo amidyl nmda/nr2b antagonists |
US7148236B2 (en) * | 2002-01-17 | 2006-12-12 | Merck & Co., Inc. | Modulators of acetylcholine receptors |
US6713490B2 (en) | 2002-04-26 | 2004-03-30 | Pfizer, Inc. | 3,4-dihydroquinolin-2(1H)-one compounds as NR2B receptor antagonists |
EP1673367A1 (en) * | 2003-10-08 | 2006-06-28 | Pfizer, Inc. | Fused lactam compounds |
EP1838705A2 (en) * | 2005-01-13 | 2007-10-03 | Neurosearch A/S | 3,8-substituted 8-aza-bicyclo [3.2.1] octane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors |
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US3294804A (en) * | 1961-01-27 | 1966-12-27 | Sterling Drug Inc | 1-(3-hydroxy-3-phenylpropyl)-4-phenyl-4-propionoxy-piperidine |
FR5733M (cs) * | 1966-09-27 | 1968-01-22 | ||
JPS51118772A (en) * | 1975-04-09 | 1976-10-18 | Otsuka Pharmaceut Co Ltd | Method for preparing carbostyryl derivatives |
US4082755A (en) * | 1977-02-14 | 1978-04-04 | Janssen Pharmaceutica N.V. | 1-[(Diarylmethyl)aminoalkyl]piperidimes |
WO1980000152A1 (en) * | 1978-07-03 | 1980-02-07 | Sandoz Ag | 3-aminopropoxy-aryl derivates,preparation and use thereof |
PH17194A (en) * | 1980-03-06 | 1984-06-19 | Otsuka Pharma Co Ltd | Novel carbostyril derivatives,and pharmaceutical composition containing the same |
US4358456A (en) * | 1980-05-03 | 1982-11-09 | John Wyeth & Brother Limited | Antipsychotic piperidinomethyl-indole derivatives |
DE3045688A1 (de) * | 1980-12-04 | 1982-07-08 | C.H. Boehringer Sohn, 6507 Ingelheim | Neue 8-arylalkyl-3-phenyl-3-nortropanole, deren saeureadditionssalze, diese enthaltende arzneimittel und verfahren zu ihrer herstellung |
JPS57142972A (en) * | 1981-02-27 | 1982-09-03 | Otsuka Pharmaceut Co Ltd | Carbostyril derivative |
FR2534580A1 (fr) * | 1982-10-13 | 1984-04-20 | Synthelabo | Derives de phenyl-1 piperidino-2 propanol, leur preparation, et medicaments qui les contiennent |
FR2546166B1 (fr) * | 1983-05-19 | 1985-10-25 | Synthelabo | Enantiomeres du erythro (benzyl-4 piperidino)-2 (hydroxy-4 ou benzyloxy-4 phenyl)-1 propanol, leur preparation et leur application en therapeutique |
FR2581993B1 (fr) * | 1985-05-14 | 1988-03-18 | Synthelabo | Derives de (benzoyl-4 piperidino)-2 phenyl-1 alcanols, leur preparation et leur application en therapeutique |
KR910006138B1 (ko) * | 1986-09-30 | 1991-08-16 | 에자이 가부시끼가이샤 | 환상아민 유도체 |
EP0322361A3 (de) * | 1987-12-23 | 1990-01-24 | Ciba-Geigy Ag | Weitere hydrierte 1-Benzooxacycloalkylpyridincarbonsäureverbindungen |
FR2640266B2 (fr) * | 1988-07-12 | 1992-07-10 | Synthelabo | Derives de (hydroxy-1 piperidinyl-2 alkyl) indolones-2, quinoleinones-2, benzo(b)azepinones-2 et benzimidazolones-2, leur preparation et leur application en therapeutique |
EP0398578B1 (en) * | 1989-05-17 | 1997-03-12 | Pfizer Inc. | 2-piperidino-1-alkanol derivatives as antiischemic agents |
-
1991
- 1991-03-04 EP EP91905608A patent/EP0554247B1/en not_active Expired - Lifetime
- 1991-03-04 KR KR1019920702794A patent/KR0163355B1/ko not_active IP Right Cessation
- 1991-03-04 WO PCT/US1991/001470 patent/WO1991017156A1/en active IP Right Grant
- 1991-03-04 CA CA002080475A patent/CA2080475C/en not_active Expired - Fee Related
- 1991-03-04 BR BR919106432A patent/BR9106432A/pt not_active Application Discontinuation
- 1991-03-04 HU HU9203515A patent/HU221193B1/hu not_active IP Right Cessation
- 1991-03-04 JP JP3505475A patent/JPH0699423B2/ja not_active Expired - Fee Related
- 1991-03-04 DK DK91905608T patent/DK0554247T3/da active
- 1991-03-04 RU RU9192016415A patent/RU2068414C1/ru not_active IP Right Cessation
- 1991-03-04 AU AU74565/91A patent/AU642994B2/en not_active Ceased
- 1991-03-04 AT AT91905608T patent/ATE192149T1/de not_active IP Right Cessation
- 1991-03-04 PL PL91296711A patent/PL169267B1/pl not_active IP Right Cessation
- 1991-03-04 ES ES91905608T patent/ES2146578T3/es not_active Expired - Lifetime
- 1991-03-04 DE DE69132141T patent/DE69132141T2/de not_active Expired - Fee Related
- 1991-03-04 US US07/941,118 patent/US5306723A/en not_active Expired - Fee Related
- 1991-04-02 TW TW080102540A patent/TW198720B/zh active
- 1991-04-24 PH PH42344A patent/PH29902A/en unknown
- 1991-05-03 IL IL9805691A patent/IL98056A/en not_active IP Right Cessation
- 1991-05-08 PT PT97602A patent/PT97602B/pt active IP Right Grant
- 1991-05-08 CZ CS911354A patent/CZ280560B6/cs not_active IP Right Cessation
- 1991-05-08 EG EG27191A patent/EG19647A/xx active
- 1991-05-08 MY MYPI91000778A patent/MY107799A/en unknown
- 1991-05-08 SK SK1354-91A patent/SK280833B6/sk unknown
- 1991-05-08 ZA ZA913494A patent/ZA913494B/xx unknown
- 1991-05-09 YU YU81091A patent/YU48528B/sh unknown
- 1991-05-09 CN CN91103022A patent/CN1037439C/zh not_active Expired - Fee Related
- 1991-05-09 IE IE156991A patent/IE911569A1/en not_active IP Right Cessation
-
1992
- 1992-11-09 NO NO924310A patent/NO301979B1/no not_active IP Right Cessation
- 1992-11-09 FI FI925069A patent/FI109121B/fi not_active IP Right Cessation
-
2000
- 2000-07-24 GR GR20000401691T patent/GR3034005T3/el not_active IP Right Cessation
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