YU81091A - Analozi 5-(1-hidroksi-2-piperidinopropil)-2-(1h,3h)-indolona - Google Patents

Analozi 5-(1-hidroksi-2-piperidinopropil)-2-(1h,3h)-indolona

Info

Publication number
YU81091A
YU81091A YU81091A YU81091A YU81091A YU 81091 A YU81091 A YU 81091A YU 81091 A YU81091 A YU 81091A YU 81091 A YU81091 A YU 81091A YU 81091 A YU81091 A YU 81091A
Authority
YU
Yugoslavia
Prior art keywords
pct
piperidinopropyl
hydroxy
indolone
analysis
Prior art date
Application number
YU81091A
Other languages
English (en)
Other versions
YU48528B (sh
Inventor
B.L. Chenard
Original Assignee
Pfizer Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Inc. filed Critical Pfizer Inc.
Publication of YU81091A publication Critical patent/YU81091A/sh
Publication of YU48528B publication Critical patent/YU48528B/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Indole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Hydrogenated Pyridines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

ANALOZI 5-(1-HIDROKSI-2-PIPERIDINOPROPIL)-2-(1H,3H)-INDOLONA, ovaj pronalazak se odnosi na 5-(1-Hidroksi-2-piperidinopropil)-2(1H,3H)-indolonske derivate i analoge, njihove farmaceutske kompozicije, postupke za tretiranje CNS oboljenja sa njima i intermedijere korisne za dobijanje ovih jedinjenja.
YU81091A 1990-05-10 1991-05-09 Analozi 5-(1-hidroksi-2-piperidinopropil)-2-(1h,3h)-indolona YU48528B (sh)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US52233290A 1990-05-10 1990-05-10

Publications (2)

Publication Number Publication Date
YU81091A true YU81091A (sh) 1993-11-16
YU48528B YU48528B (sh) 1998-11-05

Family

ID=24080448

Family Applications (1)

Application Number Title Priority Date Filing Date
YU81091A YU48528B (sh) 1990-05-10 1991-05-09 Analozi 5-(1-hidroksi-2-piperidinopropil)-2-(1h,3h)-indolona

Country Status (30)

Country Link
US (1) US5306723A (sh)
EP (1) EP0554247B1 (sh)
JP (1) JPH0699423B2 (sh)
KR (1) KR0163355B1 (sh)
CN (1) CN1037439C (sh)
AT (1) ATE192149T1 (sh)
AU (1) AU642994B2 (sh)
BR (1) BR9106432A (sh)
CA (1) CA2080475C (sh)
CZ (1) CZ280560B6 (sh)
DE (1) DE69132141T2 (sh)
DK (1) DK0554247T3 (sh)
EG (1) EG19647A (sh)
ES (1) ES2146578T3 (sh)
FI (1) FI109121B (sh)
GR (1) GR3034005T3 (sh)
HU (1) HU221193B1 (sh)
IE (1) IE911569A1 (sh)
IL (1) IL98056A (sh)
MY (1) MY107799A (sh)
NO (1) NO301979B1 (sh)
PH (1) PH29902A (sh)
PL (1) PL169267B1 (sh)
PT (1) PT97602B (sh)
RU (1) RU2068414C1 (sh)
SK (1) SK280833B6 (sh)
TW (1) TW198720B (sh)
WO (1) WO1991017156A1 (sh)
YU (1) YU48528B (sh)
ZA (1) ZA913494B (sh)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9205893A (pt) * 1991-04-18 1994-11-08 Pfizer Ésteres pró droga de 2-piperidino-1-alcanóis fenólicos
US5594007A (en) * 1991-04-18 1997-01-14 Pfizer Inc. Method for treating spinal cord trauma with phenolic 2-piperidino-1-alkanols
CZ284133B6 (cs) * 1991-07-17 1998-08-12 Pfizer Inc. 2-/4-Hydroxypiperidino/-1-alkanolové deriváty jako antiischemická činidla. způsob jejich přípravy a použití.
FR2688504B1 (fr) * 1992-03-13 1995-05-05 Synthelabo Derives de 2-(piperidin-1-yl)ethanol, leur preparation et leur application en therapeutique.
US5319096A (en) * 1992-04-03 1994-06-07 Hoechst-Roussel Pharmaceuticals Inc. (1H-indol-1-yl)-2-(amino) acetamides and related (1H-indol-1-yl)-(aminoalkyl)amides, pharmaceutical composition and use
US6255322B1 (en) 1992-06-19 2001-07-03 Pfizer Inc. 2-(4-hydroxypiperidino)-1-alkanol derivatives as antiischemic agents
US5436255A (en) * 1992-07-23 1995-07-25 Pfizer Inc. Method of treating diseases susceptable to treatment by blocking NMDA-receptors
BR9307331A (pt) * 1992-10-30 1999-05-25 Pfizer Compostos neuroprotetores 3,4-dihidro-2(1ho-quinolona
US5498610A (en) * 1992-11-06 1996-03-12 Pfizer Inc. Neuroprotective indolone and related derivatives
CN1151130C (zh) * 1994-08-18 2004-05-26 辉瑞大药厂 神经保护的3-(哌啶基-1)-苯并二氢吡喃-4,7-二醇和1-(4-氢化苯基)-2-(哌啶基-1)链烷醇衍生物
GB9510459D0 (en) 1995-05-24 1995-07-19 Zeneca Ltd Bicyclic amines
ZA9610738B (en) 1995-12-22 1997-06-24 Warner Lambert Co Subtype selective nmda receptor ligands and the use thereof
ZA9610736B (en) * 1995-12-22 1997-06-27 Warner Lambert Co 2-Substituted piperidine analogs and their use as subtypeselective nmda receptor antagonists
ZA9610745B (en) * 1995-12-22 1997-06-24 Warner Lambert Co 4-Subsituted piperidine analogs and their use as subtype selective nmda receptor antagonists
ZA9610741B (en) 1995-12-22 1997-06-24 Warner Lambert Co 4-Substituted piperidine analogs and their use as subtype selective nmda receptor antagonists
TW427978B (en) * 1996-02-03 2001-04-01 Hoffmann La Roche Tetrahydroisoquinoline derivatives
AU722015B2 (en) * 1996-05-13 2000-07-20 Zeneca Limited Bicyclic amines
GB9623944D0 (en) * 1996-11-15 1997-01-08 Zeneca Ltd Bicyclic amine derivatives
GB9624114D0 (en) * 1996-11-20 1997-01-08 Zeneca Ltd Pesticidal bicyclic amine derivatives
GB9624611D0 (en) * 1996-11-26 1997-01-15 Zeneca Ltd Bicyclic amine compounds
HUP0000582A3 (en) 1996-11-26 2001-10-29 Zeneca Ltd Insecticidal, acaricidal and nematocidal 8-azabicyclo[3.2.1]octane-, 8-azabicyclo[3.2.1]oct-6-ene-, 9-azabicyclo[3.3.1]nonane-, 9-aza-3-oxabicyclo[3.3.1]nonane- and 9-aza-3-thiabicyclo[3.3.1]nonane derivatives, preparation and use thereof
CA2220649C (en) 1996-12-03 2007-02-13 F. Hoffmann-La Roche Ag 4-hydroxy-piperidine derivatives
EP0846683B1 (en) * 1996-12-03 2001-09-19 F. Hoffmann-La Roche Ag 4-Hydroxy-piperidine derivatives
JP2002542280A (ja) * 1999-04-27 2002-12-10 スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー 新規な治療
US6432976B1 (en) 1999-10-29 2002-08-13 Merck & Co., Inc. 8-aza-bicyclo[3.2.1]octane NMDA/NR2B antagonists
US6476041B1 (en) 1999-10-29 2002-11-05 Merck & Co., Inc. 1,4 substituted piperidinyl NMDA/NR2B antagonists
US6489477B1 (en) 1999-10-29 2002-12-03 Merck & Co., Inc. 2-aza-bicyclo[2.2.2]octane NMDA/NR2B antigonists
US6369076B1 (en) 1999-10-29 2002-04-09 Merck & Co. Inc. 5-benzyl-octahydroindole and 6-benzyl-decahydroquinoline NMDA/NR2B antagonists
US6316474B1 (en) 1999-10-29 2001-11-13 Merck & Co., Inc. 2-benzyl and 2-heteroaryl benzimidazole NMDA/NR2B antagonists
CA2386441A1 (en) 1999-10-29 2001-05-03 Merck Sharp & Dohme Limited Method to treat pain utilizing benzimidazole nmda/nr2b antagonists
US6495561B2 (en) 1999-10-29 2002-12-17 Merck & Co., Inc. 2-cyclohexyl imidazopyridine NMDA/NR2B antagonists
US6291499B1 (en) 1999-10-29 2001-09-18 Merck & Co., Inc. 2-cyclohexyl benzimidazole NMDA/NR2B antagonists
US6380205B1 (en) 1999-10-29 2002-04-30 Merck & Co., Inc. 2-cyclohexyl quinazoline NMDA/NR2B antagonists
SI1379520T1 (sl) 2001-02-23 2006-08-31 Merck & Co Inc N-substituirani nonaril-heterociklicni NMDA/NR2B antagonisti
WO2002080928A1 (en) * 2001-04-03 2002-10-17 Merck & Co., Inc. N-substituted nonaryl-heterocyclo amidyl nmda/nr2b antagonists
EP1472248A1 (en) * 2002-01-17 2004-11-03 Eli Lilly And Company Modulators of acetylcholine receptors
US6713490B2 (en) * 2002-04-26 2004-03-30 Pfizer, Inc. 3,4-dihydroquinolin-2(1H)-one compounds as NR2B receptor antagonists
JP2007508288A (ja) * 2003-10-08 2007-04-05 ファイザー株式会社 縮合ラクタム化合物
EP1838705A2 (en) * 2005-01-13 2007-10-03 Neurosearch A/S 3,8-substituted 8-aza-bicyclo [3.2.1] octane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3294804A (en) * 1961-01-27 1966-12-27 Sterling Drug Inc 1-(3-hydroxy-3-phenylpropyl)-4-phenyl-4-propionoxy-piperidine
FR5733M (sh) * 1966-09-27 1968-01-22
JPS51118772A (en) * 1975-04-09 1976-10-18 Otsuka Pharmaceut Co Ltd Method for preparing carbostyryl derivatives
US4082755A (en) * 1977-02-14 1978-04-04 Janssen Pharmaceutica N.V. 1-[(Diarylmethyl)aminoalkyl]piperidimes
WO1980000152A1 (en) * 1978-07-03 1980-02-07 Sandoz Ag 3-aminopropoxy-aryl derivates,preparation and use thereof
PH17194A (en) * 1980-03-06 1984-06-19 Otsuka Pharma Co Ltd Novel carbostyril derivatives,and pharmaceutical composition containing the same
US4358456A (en) * 1980-05-03 1982-11-09 John Wyeth & Brother Limited Antipsychotic piperidinomethyl-indole derivatives
DE3045688A1 (de) * 1980-12-04 1982-07-08 C.H. Boehringer Sohn, 6507 Ingelheim Neue 8-arylalkyl-3-phenyl-3-nortropanole, deren saeureadditionssalze, diese enthaltende arzneimittel und verfahren zu ihrer herstellung
JPS57142972A (en) * 1981-02-27 1982-09-03 Otsuka Pharmaceut Co Ltd Carbostyril derivative
FR2534580A1 (fr) * 1982-10-13 1984-04-20 Synthelabo Derives de phenyl-1 piperidino-2 propanol, leur preparation, et medicaments qui les contiennent
FR2546166B1 (fr) * 1983-05-19 1985-10-25 Synthelabo Enantiomeres du erythro (benzyl-4 piperidino)-2 (hydroxy-4 ou benzyloxy-4 phenyl)-1 propanol, leur preparation et leur application en therapeutique
FR2581993B1 (fr) * 1985-05-14 1988-03-18 Synthelabo Derives de (benzoyl-4 piperidino)-2 phenyl-1 alcanols, leur preparation et leur application en therapeutique
KR910006138B1 (ko) * 1986-09-30 1991-08-16 에자이 가부시끼가이샤 환상아민 유도체
EP0322361A3 (de) * 1987-12-23 1990-01-24 Ciba-Geigy Ag Weitere hydrierte 1-Benzooxacycloalkylpyridincarbonsäureverbindungen
FR2640266B2 (fr) * 1988-07-12 1992-07-10 Synthelabo Derives de (hydroxy-1 piperidinyl-2 alkyl) indolones-2, quinoleinones-2, benzo(b)azepinones-2 et benzimidazolones-2, leur preparation et leur application en therapeutique
EP0398578B1 (en) * 1989-05-17 1997-03-12 Pfizer Inc. 2-piperidino-1-alkanol derivatives as antiischemic agents

Also Published As

Publication number Publication date
IL98056A (en) 1995-11-27
HUT62879A (en) 1993-06-28
YU48528B (sh) 1998-11-05
NO924310D0 (no) 1992-11-09
PH29902A (en) 1996-09-16
PT97602B (pt) 1998-08-31
ES2146578T3 (es) 2000-08-16
DE69132141D1 (de) 2000-05-31
AU642994B2 (en) 1993-11-04
IE911569A1 (en) 1991-11-20
BR9106432A (pt) 1993-05-04
DE69132141T2 (de) 2000-09-21
PL169267B1 (pl) 1996-06-28
TW198720B (sh) 1993-01-21
FI925069A0 (fi) 1992-11-09
DK0554247T3 (da) 2000-08-07
ATE192149T1 (de) 2000-05-15
EP0554247A1 (en) 1993-08-11
FI925069A (fi) 1992-11-09
CA2080475C (en) 2001-04-17
IL98056A0 (en) 1992-06-21
EP0554247B1 (en) 2000-04-26
CZ280560B6 (cs) 1996-02-14
PT97602A (pt) 1992-02-28
JPH05506433A (ja) 1993-09-22
GR3034005T3 (en) 2000-11-30
FI109121B (fi) 2002-05-31
CN1056497A (zh) 1991-11-27
MY107799A (en) 1996-06-29
KR0163355B1 (ko) 1998-12-01
KR930700482A (ko) 1993-03-15
SK280833B6 (sk) 2000-08-14
HU221193B1 (en) 2002-08-28
EG19647A (en) 1995-08-30
ZA913494B (en) 1992-12-30
AU7456591A (en) 1991-11-27
US5306723A (en) 1994-04-26
RU2068414C1 (ru) 1996-10-27
WO1991017156A1 (en) 1991-11-14
NO924310L (no) 1992-11-09
CS135491A3 (en) 1992-05-13
JPH0699423B2 (ja) 1994-12-07
HU9203515D0 (en) 1993-01-28
CA2080475A1 (en) 1991-11-11
NO301979B1 (no) 1998-01-05
CN1037439C (zh) 1998-02-18

Similar Documents

Publication Publication Date Title
YU81091A (sh) Analozi 5-(1-hidroksi-2-piperidinopropil)-2-(1h,3h)-indolona
DE69115280D1 (de) Indolderivate, die die leukotrienbiosynthese hemmen.
RU92016415A (ru) Нейрозащитные производные индолона и родственные производные
ES2164657T3 (es) Derivados aza-biciclicos puenteados como antagonistas de la sustancia p.
FI853625L (fi) Tetralinderivat, deras framstaellning och anvaendning.
PT772603E (pt) Compostos substituidos de pirimidina e sua utilizacao
FR2681784B1 (fr) Composition dermatologique et/ou cosmetologique contenant des retinouides et utilisation de nouveaux retinouides.
DE69516503T2 (de) Piperidinderivate mit paf antagonistischer wirkung
NO853698L (no) I-substituerte tetralinderivater, fremstilling og anvendel se derav.
ES496038A0 (es) Procedimiento para la obtencion de 2-hidroxialquil-3,4,5- trihidroxi-piperidinas
DE59010205D1 (de) Hirudin-Muteine und deren Polyalkylenglykolkonjugate
DK0545983T3 (da) Mellemprodukter for chelateringsmidler med forud fastsat symmetri samt fremgangsmåde til fremstilling heraf
MX9303605A (es) Derivados de azabicicloheptano n-substituidas, su obtencion y uso.
DK149590C (da) Analogifremgangsmaade til fremstilling af 2-aryl-3,4-diaza-bicyclo(4,1,0)hepten-(2)-on-(5)-forbindelser
DK0418990T3 (da) 13-brom- og 13,14-dibrom-ergoliner, deres fremstilling og anvendelse i lægemidler
ES2098119T3 (es) Nuevas triazoloquinazolinas, su obtencion y empleo.
MX9303607A (es) Derivados de azabicicloheptano sustituidos, su obtencion y uso.