PT97602A - Processo para a preparacao de indolonas neuroprotectoras e de derivados relacionados com as mesmas - Google Patents

Processo para a preparacao de indolonas neuroprotectoras e de derivados relacionados com as mesmas

Info

Publication number
PT97602A
PT97602A PT97602A PT9760291A PT97602A PT 97602 A PT97602 A PT 97602A PT 97602 A PT97602 A PT 97602A PT 9760291 A PT9760291 A PT 9760291A PT 97602 A PT97602 A PT 97602A
Authority
PT
Portugal
Prior art keywords
pct
preparation
neuroprotectal
indolones
same
Prior art date
Application number
PT97602A
Other languages
English (en)
Other versions
PT97602B (pt
Inventor
Bertrand Leo Chenard
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of PT97602A publication Critical patent/PT97602A/pt
Publication of PT97602B publication Critical patent/PT97602B/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
PT97602A 1990-05-10 1991-05-08 Processo para a preparacao de indolonas neuroprotectoras e de derivados relacionados com as mesmas PT97602B (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US52233290A 1990-05-10 1990-05-10

Publications (2)

Publication Number Publication Date
PT97602A true PT97602A (pt) 1992-02-28
PT97602B PT97602B (pt) 1998-08-31

Family

ID=24080448

Family Applications (1)

Application Number Title Priority Date Filing Date
PT97602A PT97602B (pt) 1990-05-10 1991-05-08 Processo para a preparacao de indolonas neuroprotectoras e de derivados relacionados com as mesmas

Country Status (30)

Country Link
US (1) US5306723A (pt)
EP (1) EP0554247B1 (pt)
JP (1) JPH0699423B2 (pt)
KR (1) KR0163355B1 (pt)
CN (1) CN1037439C (pt)
AT (1) ATE192149T1 (pt)
AU (1) AU642994B2 (pt)
BR (1) BR9106432A (pt)
CA (1) CA2080475C (pt)
CZ (1) CZ280560B6 (pt)
DE (1) DE69132141T2 (pt)
DK (1) DK0554247T3 (pt)
EG (1) EG19647A (pt)
ES (1) ES2146578T3 (pt)
FI (1) FI109121B (pt)
GR (1) GR3034005T3 (pt)
HU (1) HU221193B1 (pt)
IE (1) IE911569A1 (pt)
IL (1) IL98056A (pt)
MY (1) MY107799A (pt)
NO (1) NO301979B1 (pt)
PH (1) PH29902A (pt)
PL (1) PL169267B1 (pt)
PT (1) PT97602B (pt)
RU (1) RU2068414C1 (pt)
SK (1) SK280833B6 (pt)
TW (1) TW198720B (pt)
WO (1) WO1991017156A1 (pt)
YU (1) YU48528B (pt)
ZA (1) ZA913494B (pt)

Families Citing this family (39)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5594007A (en) * 1991-04-18 1997-01-14 Pfizer Inc. Method for treating spinal cord trauma with phenolic 2-piperidino-1-alkanols
HUT65836A (en) * 1991-04-18 1994-07-28 Pfizer Process for producing phenol-esters of 1-(hydroxy-phenyl)-2-piperidino-1-alkanol derivatives and pharmaceutical compositions containing them
EP0594729A1 (en) * 1991-07-17 1994-05-04 Pfizer Inc. 2-(4-hydroxypiperidino)-1-alkanol derivatives as antiischemic agents
FR2688504B1 (fr) * 1992-03-13 1995-05-05 Synthelabo Derives de 2-(piperidin-1-yl)ethanol, leur preparation et leur application en therapeutique.
US5319096A (en) * 1992-04-03 1994-06-07 Hoechst-Roussel Pharmaceuticals Inc. (1H-indol-1-yl)-2-(amino) acetamides and related (1H-indol-1-yl)-(aminoalkyl)amides, pharmaceutical composition and use
US6255322B1 (en) 1992-06-19 2001-07-03 Pfizer Inc. 2-(4-hydroxypiperidino)-1-alkanol derivatives as antiischemic agents
US5436255A (en) * 1992-07-23 1995-07-25 Pfizer Inc. Method of treating diseases susceptable to treatment by blocking NMDA-receptors
DE69309297T2 (de) * 1992-10-30 1997-07-03 Pfizer Neuroprotektive 3,4-dihydro-2(1h)-chinolone
US5498610A (en) * 1992-11-06 1996-03-12 Pfizer Inc. Neuroprotective indolone and related derivatives
KR100224961B1 (ko) * 1994-08-18 1999-10-15 디. 제이. 우드 신경보호성 3-(피페리디닐-1)-크로만-4,7-디올 및 1-(4-하이드로페닐)-2-(피페리디닐-1)-알칸올 유도체
GB9510459D0 (en) 1995-05-24 1995-07-19 Zeneca Ltd Bicyclic amines
ZA9610741B (en) 1995-12-22 1997-06-24 Warner Lambert Co 4-Substituted piperidine analogs and their use as subtype selective nmda receptor antagonists
ZA9610745B (en) * 1995-12-22 1997-06-24 Warner Lambert Co 4-Subsituted piperidine analogs and their use as subtype selective nmda receptor antagonists
ZA9610736B (en) * 1995-12-22 1997-06-27 Warner Lambert Co 2-Substituted piperidine analogs and their use as subtypeselective nmda receptor antagonists
ZA9610738B (en) 1995-12-22 1997-06-24 Warner Lambert Co Subtype selective nmda receptor ligands and the use thereof
TW427978B (en) * 1996-02-03 2001-04-01 Hoffmann La Roche Tetrahydroisoquinoline derivatives
AU722015B2 (en) * 1996-05-13 2000-07-20 Zeneca Limited Bicyclic amines
GB9623944D0 (en) * 1996-11-15 1997-01-08 Zeneca Ltd Bicyclic amine derivatives
GB9624114D0 (en) * 1996-11-20 1997-01-08 Zeneca Ltd Pesticidal bicyclic amine derivatives
GB9624611D0 (en) 1996-11-26 1997-01-15 Zeneca Ltd Bicyclic amine compounds
BR9713136A (pt) 1996-11-26 2000-02-08 Zeneca Ltd Composto, composição inseticida, acaricida, ou nematicida, e, processos para combate e controle de pestes de inseto, acarino ou nematóide em um local e para preparação de um composto.
EP0846683B1 (en) * 1996-12-03 2001-09-19 F. Hoffmann-La Roche Ag 4-Hydroxy-piperidine derivatives
CA2220649C (en) 1996-12-03 2007-02-13 F. Hoffmann-La Roche Ag 4-hydroxy-piperidine derivatives
AU4556800A (en) * 1999-04-27 2000-11-10 Smithkline Beecham Plc Novel treatment
US6369076B1 (en) 1999-10-29 2002-04-09 Merck & Co. Inc. 5-benzyl-octahydroindole and 6-benzyl-decahydroquinoline NMDA/NR2B antagonists
US6489477B1 (en) 1999-10-29 2002-12-03 Merck & Co., Inc. 2-aza-bicyclo[2.2.2]octane NMDA/NR2B antigonists
JP2003512422A (ja) 1999-10-29 2003-04-02 メルク シャープ エンド ドーム リミテッド ベンズイミダゾールｎｍｄａ／ｎｒ２ｂアンタゴニストを使用する疼痛の治療方法
US6316474B1 (en) 1999-10-29 2001-11-13 Merck & Co., Inc. 2-benzyl and 2-heteroaryl benzimidazole NMDA/NR2B antagonists
US6495561B2 (en) 1999-10-29 2002-12-17 Merck & Co., Inc. 2-cyclohexyl imidazopyridine NMDA/NR2B antagonists
US6432976B1 (en) 1999-10-29 2002-08-13 Merck & Co., Inc. 8-aza-bicyclo[3.2.1]octane NMDA/NR2B antagonists
US6476041B1 (en) 1999-10-29 2002-11-05 Merck & Co., Inc. 1,4 substituted piperidinyl NMDA/NR2B antagonists
US6291499B1 (en) 1999-10-29 2001-09-18 Merck & Co., Inc. 2-cyclohexyl benzimidazole NMDA/NR2B antagonists
US6380205B1 (en) 1999-10-29 2002-04-30 Merck & Co., Inc. 2-cyclohexyl quinazoline NMDA/NR2B antagonists
EP1379520B2 (en) 2001-02-23 2014-04-09 Merck Sharp & Dohme Corp. N-substituted nonaryl-heterocyclic nmda/nr2b antagonists
AU2002338334B8 (en) * 2001-04-03 2008-09-18 Merck & Co., Inc. N-substituted nonaryl-heterocyclo amidyl NMDA/NR2B antagonists
WO2003062235A1 (en) * 2002-01-17 2003-07-31 Eli Lilly And Company Modulators of acetylcholine receptors
US6713490B2 (en) * 2002-04-26 2004-03-30 Pfizer, Inc. 3,4-dihydroquinolin-2(1H)-one compounds as NR2B receptor antagonists
CA2541162A1 (en) * 2003-10-08 2005-04-21 Pfizer Inc. Fused lactam compounds
WO2006075004A2 (en) * 2005-01-13 2006-07-20 Neurosearch A/S 3, 8 - substituted 8-aza-bicyclo[3.2.1] octane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3294804A (en) * 1961-01-27 1966-12-27 Sterling Drug Inc 1-(3-hydroxy-3-phenylpropyl)-4-phenyl-4-propionoxy-piperidine
FR5733M (pt) * 1966-09-27 1968-01-22
JPS51118772A (en) * 1975-04-09 1976-10-18 Otsuka Pharmaceut Co Ltd Method for preparing carbostyryl derivatives
US4082755A (en) * 1977-02-14 1978-04-04 Janssen Pharmaceutica N.V. 1-[(Diarylmethyl)aminoalkyl]piperidimes
WO1980000152A1 (en) * 1978-07-03 1980-02-07 Sandoz Ag 3-aminopropoxy-aryl derivates,preparation and use thereof
PH17194A (en) * 1980-03-06 1984-06-19 Otsuka Pharma Co Ltd Novel carbostyril derivatives,and pharmaceutical composition containing the same
US4358456A (en) * 1980-05-03 1982-11-09 John Wyeth & Brother Limited Antipsychotic piperidinomethyl-indole derivatives
DE3045688A1 (de) * 1980-12-04 1982-07-08 C.H. Boehringer Sohn, 6507 Ingelheim Neue 8-arylalkyl-3-phenyl-3-nortropanole, deren saeureadditionssalze, diese enthaltende arzneimittel und verfahren zu ihrer herstellung
JPS57142972A (en) * 1981-02-27 1982-09-03 Otsuka Pharmaceut Co Ltd Carbostyril derivative
FR2534580A1 (fr) * 1982-10-13 1984-04-20 Synthelabo Derives de phenyl-1 piperidino-2 propanol, leur preparation, et medicaments qui les contiennent
FR2546166B1 (fr) * 1983-05-19 1985-10-25 Synthelabo Enantiomeres du erythro (benzyl-4 piperidino)-2 (hydroxy-4 ou benzyloxy-4 phenyl)-1 propanol, leur preparation et leur application en therapeutique
FR2581993B1 (fr) * 1985-05-14 1988-03-18 Synthelabo Derives de (benzoyl-4 piperidino)-2 phenyl-1 alcanols, leur preparation et leur application en therapeutique
KR910006138B1 (ko) * 1986-09-30 1991-08-16 에자이 가부시끼가이샤 환상아민 유도체
EP0322361A3 (de) * 1987-12-23 1990-01-24 Ciba-Geigy Ag Weitere hydrierte 1-Benzooxacycloalkylpyridincarbonsäureverbindungen
FR2640266B2 (fr) * 1988-07-12 1992-07-10 Synthelabo Derives de (hydroxy-1 piperidinyl-2 alkyl) indolones-2, quinoleinones-2, benzo(b)azepinones-2 et benzimidazolones-2, leur preparation et leur application en therapeutique
ES2098248T3 (es) * 1989-05-17 1997-05-01 Pfizer Derivados de 2-piperidino-1-alcanoles como agentes antiisquemicos.

Also Published As

Publication number Publication date
PH29902A (en) 1996-09-16
EP0554247B1 (en) 2000-04-26
DK0554247T3 (da) 2000-08-07
FI925069A (fi) 1992-11-09
JPH05506433A (ja) 1993-09-22
DE69132141D1 (de) 2000-05-31
DE69132141T2 (de) 2000-09-21
GR3034005T3 (en) 2000-11-30
HUT62879A (en) 1993-06-28
CN1056497A (zh) 1991-11-27
HU221193B1 (en) 2002-08-28
YU81091A (sh) 1993-11-16
KR0163355B1 (ko) 1998-12-01
NO301979B1 (no) 1998-01-05
CS135491A3 (en) 1992-05-13
JPH0699423B2 (ja) 1994-12-07
RU2068414C1 (ru) 1996-10-27
YU48528B (sh) 1998-11-05
IE911569A1 (en) 1991-11-20
BR9106432A (pt) 1993-05-04
US5306723A (en) 1994-04-26
WO1991017156A1 (en) 1991-11-14
CA2080475A1 (en) 1991-11-11
IL98056A0 (en) 1992-06-21
SK280833B6 (sk) 2000-08-14
IL98056A (en) 1995-11-27
AU7456591A (en) 1991-11-27
ZA913494B (en) 1992-12-30
CA2080475C (en) 2001-04-17
HU9203515D0 (en) 1993-01-28
FI109121B (fi) 2002-05-31
CN1037439C (zh) 1998-02-18
NO924310L (no) 1992-11-09
CZ280560B6 (cs) 1996-02-14
PL169267B1 (pl) 1996-06-28
TW198720B (pt) 1993-01-21
ATE192149T1 (de) 2000-05-15
ES2146578T3 (es) 2000-08-16
EP0554247A1 (en) 1993-08-11
FI925069A0 (fi) 1992-11-09
NO924310D0 (no) 1992-11-09
KR930700482A (ko) 1993-03-15
PT97602B (pt) 1998-08-31
MY107799A (en) 1996-06-29
EG19647A (en) 1995-08-30
AU642994B2 (en) 1993-11-04

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Legal Events

Date Code Title Description
BB1A Laying open of patent application

Effective date: 19911009

FG3A Patent granted, date of granting

Effective date: 19980520