SK174699A3 - Inhibitors of factor xa with a neutral p1 specificity group - Google Patents
Inhibitors of factor xa with a neutral p1 specificity group Download PDFInfo
- Publication number
- SK174699A3 SK174699A3 SK1746-99A SK174699A SK174699A3 SK 174699 A3 SK174699 A3 SK 174699A3 SK 174699 A SK174699 A SK 174699A SK 174699 A3 SK174699 A3 SK 174699A3
- Authority
- SK
- Slovakia
- Prior art keywords
- phenyl
- pyrazole
- carboxamide
- methoxyphenyl
- aminosulfonyl
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
- C07D213/16—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom containing only one pyridine ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US87888597A | 1997-06-19 | 1997-06-19 | |
US7669198P | 1998-02-27 | 1998-02-27 | |
PCT/US1998/012681 WO1998057937A2 (en) | 1997-06-19 | 1998-06-18 | Inhibitors of factor xa with a neutral p1 specificity group |
Publications (1)
Publication Number | Publication Date |
---|---|
SK174699A3 true SK174699A3 (en) | 2000-08-14 |
Family
ID=26758382
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SK1746-99A SK174699A3 (en) | 1997-06-19 | 1998-06-18 | Inhibitors of factor xa with a neutral p1 specificity group |
Country Status (22)
Country | Link |
---|---|
EP (1) | EP0991625B1 (ja) |
JP (1) | JP2002507968A (ja) |
KR (1) | KR20010013977A (ja) |
AR (1) | AR015906A1 (ja) |
AT (1) | ATE296805T1 (ja) |
AU (1) | AU8150398A (ja) |
BR (1) | BR9810151A (ja) |
CA (1) | CA2290982A1 (ja) |
DE (1) | DE69830403T2 (ja) |
EA (1) | EA200000048A1 (ja) |
EE (1) | EE9900584A (ja) |
ES (1) | ES2239806T3 (ja) |
HR (1) | HRP980334A2 (ja) |
HU (1) | HUP0003906A2 (ja) |
IL (1) | IL133526A0 (ja) |
LV (1) | LV12516B (ja) |
NO (1) | NO996316L (ja) |
PL (1) | PL337831A1 (ja) |
PT (1) | PT991625E (ja) |
SI (1) | SI20208A (ja) |
SK (1) | SK174699A3 (ja) |
WO (1) | WO1998057937A2 (ja) |
Families Citing this family (104)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA2302438A1 (en) * | 1997-05-19 | 1998-11-26 | Sugen, Inc. | Heteroarylcarboxamide compounds active against protein tyrosine kinase related disorders |
US6271237B1 (en) | 1997-12-22 | 2001-08-07 | Dupont Pharmaceuticals Company | Nitrogen containing heteromatics with ortho-substituted P1s as factor Xa inhabitors |
WO1999032454A1 (en) * | 1997-12-22 | 1999-07-01 | Du Pont Pharmaceuticals Company | Nitrogen containing heteroaromatics with ortho-substituted p1's as factor xa inhibitors |
US6358960B1 (en) | 1998-02-17 | 2002-03-19 | Ono Pharmaceutical Co., Ltd. | Amidino derivatives and drugs containing the same as the active ingredient |
CA2321538A1 (en) | 1998-03-27 | 1999-10-07 | Dupont Pharmaceuticals Company | Disubstituted pyrazolines and triazolines as factor xa inhibitors |
KR20010072080A (ko) | 1998-07-31 | 2001-07-31 | 쓰끼하시 다미까따 | 페닐아졸 화합물, 그의 제조 방법 및 고지혈증용 약제 |
WO2000039102A1 (en) * | 1998-12-23 | 2000-07-06 | Du Pont Pharmaceuticals Company | THROMBIN OR FACTOR Xa INHIBITORS |
EP1159273A1 (en) | 1999-03-02 | 2001-12-05 | Boehringer Ingelheim Pharmaceuticals Inc. | Compounds useful as reversible inhibitors of cathepsin s |
DE60003025T2 (de) | 1999-04-02 | 2004-03-18 | Bristol-Myers Squibb Pharma Co. | Arylsulfonyle als faktor xa inhibitoren |
US7125875B2 (en) | 1999-04-15 | 2006-10-24 | Bristol-Myers Squibb Company | Cyclic protein tyrosine kinase inhibitors |
RU2312860C2 (ru) | 1999-04-15 | 2007-12-20 | Бристол-Маерс Сквибб Компани | Циклические ингибиторы протеинтирозинкиназ |
JP2004507439A (ja) | 1999-07-16 | 2004-03-11 | ブリストル−マイヤーズ スクイブ ファーマ カンパニー | Xa因子阻害剤としての窒素含有ヘテロ二環式化合物 |
US6420364B1 (en) | 1999-09-13 | 2002-07-16 | Boehringer Ingelheim Pharmaceuticals, Inc. | Compound useful as reversible inhibitors of cysteine proteases |
US6407256B1 (en) | 1999-11-03 | 2002-06-18 | Bristol Myers Squibb Co | Cyano-pyrrole, cyano-imidazole, cyano-pyrazole, and cyano-triazole compounds as factor Xa inhibitors |
EP1226123A1 (en) * | 1999-11-03 | 2002-07-31 | Du Pont Pharmaceuticals Company | Cyano compounds as factor xa inhibitors |
MY138097A (en) | 2000-03-22 | 2009-04-30 | Du Pont | Insecticidal anthranilamides |
CA2409762A1 (en) | 2000-06-23 | 2002-01-03 | Donald J.P. Pinto | Heteroaryl-phenyl substituted factor xa inhibitors |
EP1296982B1 (en) | 2000-06-23 | 2007-09-19 | Bristol-Myers Squibb Pharma Company | 1-(heteroaryl-phenyl)-condensed pyrazol derivatives as factor xa inhibitors |
AU2001275857A1 (en) | 2000-06-29 | 2002-01-14 | Bristol-Myers Squibb Pharma Company | Thrombin or factor xa inhibitors |
US6906192B2 (en) | 2000-11-07 | 2005-06-14 | Bristol Myers Squibb Company | Processes for the preparation of acid derivatives useful as serine protease inhibitors |
US6713467B2 (en) | 2000-11-07 | 2004-03-30 | Bristol-Myers Squibb Company | Acid derivatives useful as serine protease inhibitors |
WO2002042273A2 (en) * | 2000-11-07 | 2002-05-30 | Bristol-Myers Squibb Company | Acid derivatives useful as serine protease inhibitors |
AR036872A1 (es) | 2001-08-13 | 2004-10-13 | Du Pont | Compuesto de antranilamida, composicion que lo comprende y metodo para controlar una plaga de invertebrados |
TWI325302B (en) | 2001-08-13 | 2010-06-01 | Du Pont | Benzoxazinone compounds |
DE60226875D1 (de) | 2001-08-15 | 2008-07-10 | Du Pont | Orthosubstituierte arylamide zur bekämpfung von wirbellosen schädlingen |
US7375232B2 (en) | 2001-08-15 | 2008-05-20 | E.I. Du Pont De Nemours And Company | Ortho-heterocyclic substituted aryl amides for controlling invertebrate pests |
ES2319743T3 (es) | 2001-08-16 | 2009-05-12 | E.I. Du Pont De Nemours And Company | Antranilamidas sustituidas para controlar plagas de invertebrados. |
TW200724033A (en) | 2001-09-21 | 2007-07-01 | Du Pont | Anthranilamide arthropodicide treatment |
TWI320039B (en) | 2001-09-21 | 2010-02-01 | Lactam-containing compounds and derivatives thereof as factor xa inhibitors | |
CA2461202C (en) | 2001-09-21 | 2011-07-12 | Donald Pinto | Lactam-containing compounds and derivatives thereof as factor xa inhibitors |
WO2003035073A1 (en) | 2001-10-25 | 2003-05-01 | Astrazeneca Ab | Isoxazoline derivatives useful as antimicrobials |
JP4394953B2 (ja) | 2002-01-22 | 2010-01-06 | イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー | 無脊椎有害生物防除のためのキナゾリン(ジ)オン |
US7312214B2 (en) | 2002-05-10 | 2007-12-25 | Bristol-Myers Squibb Company | 1, 1-disubstituted cycloalkyl derivatives as factor Xa inhibitors |
JP4287816B2 (ja) | 2002-06-13 | 2009-07-01 | イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー | ピラゾールカルボキサミド殺虫剤 |
DE10229070A1 (de) * | 2002-06-28 | 2004-01-15 | Merck Patent Gmbh | Phenylderivate 5 |
ES2342595T3 (es) | 2002-11-15 | 2010-07-09 | E.I. Du Pont De Nemours And Company | Nuevos insecticidas de antranilamida. |
AU2003302238A1 (en) | 2002-12-03 | 2004-06-23 | Axys Pharmaceuticals, Inc. | 2-(2-hydroxybiphenyl-3-yl)-1h-benzoimidazole-5-carboxamidine derivatives as factor viia inhibitors |
MXPA05006889A (es) | 2002-12-23 | 2006-04-07 | 4Sc Ag | Compuestos aromaticos como agentes anti-inflamatorios, inmunomoduladores y anti-proliferativos. |
US7071355B2 (en) | 2002-12-23 | 2006-07-04 | 4 Sc Ag | Compounds as anti-inflammatory, immunomodulatory and anti-proliferatory agents |
US7247736B2 (en) | 2002-12-23 | 2007-07-24 | 4Sc Ag | Method of identifying inhibitors of DHODH |
US7365094B2 (en) | 2002-12-23 | 2008-04-29 | 4Sc Ag | Compounds as anti-inflammatory, immunomodulatory and anti-proliferatory agents |
AU2004207848B2 (en) | 2003-01-28 | 2010-03-25 | Fmc Agro Singapore Pte. Ltd. | Cyano anthranilamide insecticides |
US7122557B2 (en) | 2003-03-18 | 2006-10-17 | Bristol-Myers Squibb Company | Sulfonyl-amidino-containing and tetrahydropyrimidino-containing compounds as factor Xa inhibitors |
CA2525325A1 (en) * | 2003-05-01 | 2004-11-18 | Abbott Laboratories | Pyrazole-amides and sulfonamides as sodium channel modulators |
US20040220170A1 (en) * | 2003-05-01 | 2004-11-04 | Atkinson Robert N. | Pyrazole-amides and sulfonamides as sodium channel modulators |
CA2532965C (en) | 2003-07-22 | 2013-05-14 | Astex Therapeutics Limited | 3, 4-disubstituted 1h-pyrazole compounds and their use as cyclin dependent kinases (cdk) and glycogen synthase kinase-3 (gsk-3) modulators |
JP4979378B2 (ja) * | 2003-07-23 | 2012-07-18 | シンタ ファーマシューティカルズ コーポレーション | 炎症及び免疫関連の使用のための化合物 |
SI3002283T1 (en) | 2003-12-26 | 2018-06-29 | Kyowa Hakko Kirin Co., Ltd. | Thiazole derivatives |
WO2005085216A1 (ja) | 2004-03-05 | 2005-09-15 | Nissan Chemical Industries, Ltd. | イソキサゾリン置換ベンズアミド化合物及び有害生物防除剤 |
AU2005223483B2 (en) | 2004-03-18 | 2009-04-23 | Zoetis Llc | N-(1-arylpyrazol-4l)sulfonamides and their use as parasiticides |
GT200500179A (es) | 2004-07-01 | 2006-02-23 | Mezclas sinergistas de agentes de antranilamida para el control de plagas de invertebrados | |
EP1791810A1 (en) * | 2004-09-06 | 2007-06-06 | F. Hoffmann-Roche AG | 4-aminomethyl benzamidine derivatives and their use as factor viia inhibitors |
MX2007008290A (es) | 2005-01-07 | 2008-02-15 | Synta Pharmaceuticals Corp | Compuestos para inflamacion y usos inmuno-relacionados. |
AR054425A1 (es) | 2005-01-21 | 2007-06-27 | Astex Therapeutics Ltd | Sales de adicion de piperidin 4-il- amida de acido 4-(2,6-dicloro-benzoilamino) 1h-pirazol-3-carboxilico. |
US8404718B2 (en) | 2005-01-21 | 2013-03-26 | Astex Therapeutics Limited | Combinations of pyrazole kinase inhibitors |
JPWO2006137527A1 (ja) | 2005-06-23 | 2009-01-22 | 協和発酵キリン株式会社 | チアゾール誘導体 |
JP2009501187A (ja) * | 2005-07-15 | 2009-01-15 | エフ.ホフマン−ラ ロシュ アーゲー | 新規なヘテロアリール縮合環式アミン |
MX2008002236A (es) | 2005-08-24 | 2008-03-27 | Du Pont | Antranilamidas para controlar plagas de invertebrados. |
TWI324908B (en) | 2006-01-05 | 2010-05-21 | Du Pont | Liquid formulations of carboxamide arthropodicides |
MX2008009939A (es) * | 2006-01-31 | 2008-11-18 | Dongwha Pharmaceutical Ind Co | Derivados de benzamidina novedosos, procedimiento para la prepracion de los mismos y composicion farmaceutica que comprende los mismos. |
AU2007281220B2 (en) * | 2006-07-31 | 2013-08-15 | Activesite Pharmaceuticals, Inc. | Inhibitors of plasma kallikrein |
EP1894928A1 (en) | 2006-08-29 | 2008-03-05 | PheneX Pharmaceuticals AG | Heterocyclic fxr binding compounds |
JP2010509392A (ja) | 2006-11-13 | 2010-03-25 | ファイザー・プロダクツ・インク | ジアリール、ジピリジニルおよびアリール−ピリジニル誘導体ならびにその使用 |
AR072297A1 (es) | 2008-06-27 | 2010-08-18 | Novartis Ag | Derivados de indol-2-il-piridin-3-ilo, composicion farmaceutica que los comprende y su uso en medicamentos para el tratamiento de enfermedades mediadas por la sintasa aldosterona. |
AU2009316786A1 (en) * | 2008-11-19 | 2010-05-27 | Merck Sharp & Dohme Corp. | Inhibitors of diacylglycerol acyltransferase |
KR101758201B1 (ko) | 2009-12-15 | 2017-07-14 | 바이엘 크롭사이언스 악티엔게젤샤프트 | 1-알킬-/1-아릴-5-피라졸카복실산 유도체의 제조방법 |
JP2013515000A (ja) | 2009-12-18 | 2013-05-02 | アクティベサイト ファーマシューティカルズ インコーポレイティッド | 血漿カリクレインの阻害薬のプロドラッグ |
NZ610331A (en) * | 2010-10-20 | 2015-01-30 | Biota Scient Management | Viral polymerase inhibitors |
KR101373185B1 (ko) * | 2010-12-17 | 2014-03-13 | 주식회사경농 | 인다졸 유도체 및 이를 함유하는 살충제 조성물 |
JP5968999B2 (ja) | 2011-03-31 | 2016-08-10 | バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングBayer Intellectual Property GmbH | 除草剤としておよび殺菌剤として活性な3−フェニルイソオキサゾリン−5−カルボキサミドおよび3−フェニルイソオキサゾリン−5−チオアミド |
US8691861B2 (en) | 2011-04-13 | 2014-04-08 | Activesite Pharmaceuticals, Inc. | Prodrugs of inhibitors of plasma kallikrein |
US9199975B2 (en) | 2011-09-30 | 2015-12-01 | Asana Biosciences, Llc | Biaryl imidazole derivatives for regulating CYP17 |
MY167798A (en) | 2011-10-03 | 2018-09-26 | Respivert Ltd | 1-pyrazolyl-3- (4- ( (2 -anilinopyrimidin- 4 - yl) oxy) napththalen- 1 - yl) ureas as p38 map kinase inhibitors |
EP2578582A1 (en) | 2011-10-03 | 2013-04-10 | Respivert Limited | 1-Pyrazolyl-3-(4-((2-anilinopyrimidin-4-yl)oxy)napththalen-1-yl)ureas as p38 MAP kinase inhibitors |
PL2900644T3 (pl) * | 2012-09-25 | 2017-03-31 | Bayer Cropscience Ag | Skuteczne chwastobójczo i grzybobójczo 5-oksy-podstawione 3-fenyloizoksazolino-5-karboksamidy i 5-oksy-podstawione 3-fenylo-izoksazolino-5-tioamidy |
UA115451C2 (uk) | 2012-10-02 | 2017-11-10 | Байєр Кропсайєнс Акцієнгезелльшафт | Гетероциклічні сполуки як пестициди |
CN105102448B (zh) | 2013-02-28 | 2018-03-06 | 百时美施贵宝公司 | 作为rock1和rock2抑制剂的苯基吡唑衍生物 |
TW201444798A (zh) | 2013-02-28 | 2014-12-01 | 必治妥美雅史谷比公司 | 作爲強效rock1及rock2抑制劑之苯基吡唑衍生物 |
EP3828173B1 (en) | 2014-03-07 | 2022-08-31 | BioCryst Pharmaceuticals, Inc. | Substituted pyrazoles as human plasma kallikrein inhibitors |
CN104086498B (zh) * | 2014-07-23 | 2015-11-18 | 张远强 | 末端取代的***希夫碱类结构的化合物、其制备方法和用途 |
CN104086492B (zh) * | 2014-07-23 | 2015-12-30 | 张远强 | 抗血栓化合物、其制备方法和用途 |
CN104086501B (zh) * | 2014-07-23 | 2016-02-17 | 张远强 | 一种par-1拮抗剂、其制备方法和用途 |
CN104072435B (zh) * | 2014-07-23 | 2015-11-04 | 张远强 | 双烷基取代的四氮唑苯乙酮化合物和用途 |
CN104072439B (zh) * | 2014-07-23 | 2015-11-04 | 张远强 | 卤素取代的四氮唑苯乙酮化合物、其制备方法和用途 |
CN104072438B (zh) * | 2014-07-23 | 2015-10-14 | 张远强 | 二烷氧代四氮唑苯乙酮化合物、其制备方法和用途 |
CN104086503B (zh) * | 2014-07-23 | 2015-10-14 | 张远强 | Par-1拮抗剂及其用途 |
CN104072436B (zh) * | 2014-07-23 | 2015-10-14 | 张远强 | 对位取代的四氮唑苯乙酮化合物、其制备方法和用途 |
CN104072431B (zh) * | 2014-07-23 | 2015-11-18 | 张远强 | 烷氧基取代的苯基***希夫碱结构的化合物及用途 |
CN104072432B (zh) * | 2014-07-23 | 2015-12-30 | 张远强 | 含苯基取代***希夫碱类结构的化合物、其制备方法和用途 |
CN104086493B (zh) * | 2014-07-23 | 2016-05-18 | 张远强 | 末端取代的苯基***希夫碱结构的化合物及其用途 |
CN104086502B (zh) * | 2014-07-23 | 2015-10-14 | 张远强 | 卤代四氮唑苯乙酮化合物、其制备方法和用途 |
CN104086500B (zh) * | 2014-07-23 | 2015-08-26 | 张远强 | 一种par-1拮抗剂及其用途 |
CN104072437B (zh) * | 2014-07-23 | 2015-10-14 | 张远强 | 双取代的四氮唑苯乙酮化合物、其制备方法和用途 |
CN104086497B (zh) * | 2014-07-23 | 2016-03-02 | 张远强 | ***希夫碱类化合物、其制备方法和用途 |
CN104072434B (zh) * | 2014-07-23 | 2015-12-02 | 张远强 | 间位取代的四氮唑苯乙酮化合物、其制备方法和用途 |
SG11201701174VA (en) | 2014-08-29 | 2017-03-30 | Torrent Pharmaceuticals Ltd | P38 map kinase inhibiting indanyl urea compounds |
CN104529928A (zh) * | 2015-01-13 | 2015-04-22 | 佛山市赛维斯医药科技有限公司 | 一类恶二唑亚砜化合物、其制备方法和用途 |
JP7082425B2 (ja) * | 2017-06-13 | 2022-06-08 | バイエル・アクチエンゲゼルシヤフト | 除草活性を示すテトラヒドロ及びジヒドロフランカルボキサミドの3-フェニルイソオキサゾリン-5-カルボキサミド類 |
HRP20211611T1 (hr) | 2017-06-13 | 2022-02-04 | Bayer Aktiengesellschaft | Herbicidni 3-fenilizoksazolin-5-karboksamidi tetrahidro i dihidrofuran karboksilnih kiselina i estera |
WO2019034602A1 (de) | 2017-08-17 | 2019-02-21 | Bayer Aktiengesellschaft | Herbizid wirksame 3-phenyl-5-trifluormethylisoxazolin-5-carboxamide von cyclopentylcarbonsäuren und -estern |
WO2019145245A1 (de) | 2018-01-25 | 2019-08-01 | Bayer Aktiengesellschaft | Herbizid wirksame 3-phenylisoxazolin-5-carboxamide von cyclopentenylcarbonsäurederivaten |
AU2020238493A1 (en) | 2019-03-12 | 2021-10-07 | Bayer Aktiengesellschaft | Herbicidally active 3-phenylisoxazoline-5-carboxamides of s-containing cyclopentenyl carboxylic acid esters |
CA3166630A1 (en) | 2020-01-03 | 2021-07-08 | Berg Llc | Polycyclic amides as ube2k modulators for treating cancer |
EP4334301A1 (en) * | 2021-05-05 | 2024-03-13 | University College Cardiff Consultants Limited | Heteroaryl compounds useful in the treatment of cognitive disorders |
Family Cites Families (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4134987A (en) * | 1976-01-14 | 1979-01-16 | Huppatz John L | Compounds and compositions |
ES8103064A1 (es) * | 1979-02-22 | 1981-02-16 | Monsanto Co | Un procedimiento para preparar acido 2-(3-aril-5-isoxazolil)-benzoico |
US4226877A (en) * | 1979-05-14 | 1980-10-07 | Abbott Laboratories | Pyrazoles active in the central nervous system |
EP0028489B1 (en) | 1979-11-05 | 1983-10-05 | Beecham Group Plc | Enzyme derivatives, and their preparation |
DE3420985A1 (de) * | 1983-10-15 | 1985-04-25 | Bayer Ag, 5090 Leverkusen | Substituierte 5-acylamino-1-phenylpyrazole |
IL73419A (en) * | 1983-11-07 | 1988-02-29 | Lilly Co Eli | 1h-pyrazole-4-(thio)carboxamide derivatives,their preparation and herbicidal compositions containing them |
DE3540839A1 (de) * | 1985-11-18 | 1987-05-27 | Bayer Ag | 1-aryl-pyrazole |
DE3633840A1 (de) * | 1986-10-04 | 1988-04-14 | Hoechst Ag | Phenylpyrazolcarbonsaeurederivate, ihre herstellung und verwendung als pflanzenwachstumsregulatoren und safener |
DE3706993A1 (de) * | 1987-03-05 | 1988-09-15 | Bayer Ag | 5-amino-3-halogenalkyl-1-aryl-pyrazole |
JPS6425763A (en) * | 1987-04-24 | 1989-01-27 | Mitsubishi Chem Ind | Pyrazoles and insecticide and acaricide containing said pyrazoles as active ingredient |
US5187157A (en) | 1987-06-05 | 1993-02-16 | Du Pont Merck Pharmaceutical Company | Peptide boronic acid inhibitors of trypsin-like proteases |
DE3808896A1 (de) * | 1988-03-17 | 1989-09-28 | Hoechst Ag | Pflanzenschuetzende mittel auf basis von pyrazolcarbonsaeurederivaten |
PH27357A (en) * | 1989-09-22 | 1993-06-21 | Fujisawa Pharmaceutical Co | Pyrazole derivatives and pharmaceutical compositions comprising the same |
DE4013723A1 (de) * | 1990-04-28 | 1991-10-31 | Basf Ag | 5-(1,2,4-triazol-1-ylmethyl)-isoxazoline |
GB9017694D0 (en) | 1990-08-13 | 1990-09-26 | Sandoz Ltd | Improvements in or relating to organic chemistry |
CA2547947C (en) * | 1990-11-30 | 2007-09-25 | Masatoshi Chihiro | Azole derivatives as active superoxide radical inhibitors |
DE4124942A1 (de) * | 1991-07-27 | 1993-01-28 | Thomae Gmbh Dr K | 5-gliedrige heterocyclen, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
WO1994002477A1 (en) * | 1992-07-24 | 1994-02-03 | Merck Sharp & Dohme Limited | Imidazole, triazole and tetrazole derivatives |
US5262412A (en) * | 1993-03-10 | 1993-11-16 | Merck & Co., Inc. | Substituted pyrazoles, compositions and use |
WO1995014682A1 (en) * | 1993-11-24 | 1995-06-01 | The Du Pont Merck Pharmaceutical Company | Isoxazoline compounds useful as fibrinogen receptor antagonists |
US5849736A (en) * | 1993-11-24 | 1998-12-15 | The Dupont Merck Pharmaceutical Company | Isoxazoline and isoxazole fibrinogen receptor antagonists |
ATE198748T1 (de) * | 1993-11-24 | 2001-02-15 | Du Pont Pharm Co | Isoxazoline und isoxazole derivate als fibrinogen rezeptor antagonisten |
US5446056A (en) * | 1993-11-24 | 1995-08-29 | The Du Pont Merck Pharmaceutical Company | Isoxazoline compounds useful as fibrinogen receptor antagonists |
US5563158A (en) * | 1993-12-28 | 1996-10-08 | The Dupont Merck Pharmaceutical Company | Aromatic compounds containing basic and acidic termini useful as fibrinogen receptor antagonists |
DE4405207A1 (de) * | 1994-02-18 | 1995-08-24 | Bayer Ag | N-Pyrazolylaniline und N-Pyrazolylaminopyridine |
WO1996028427A1 (en) * | 1995-03-10 | 1996-09-19 | Berlex Laboratories, Inc. | Benzamidine derivatives their preparation and their use as anti-coagulants |
IL118007A0 (en) * | 1995-05-24 | 1996-08-04 | Du Pont Merck Pharma | Isoxazoline compounds pharmaceutical compositions containing them and their use |
-
1998
- 1998-06-18 AT AT98931355T patent/ATE296805T1/de not_active IP Right Cessation
- 1998-06-18 IL IL13352698A patent/IL133526A0/xx unknown
- 1998-06-18 PL PL98337831A patent/PL337831A1/xx not_active Application Discontinuation
- 1998-06-18 PT PT98931355T patent/PT991625E/pt unknown
- 1998-06-18 SI SI9820043A patent/SI20208A/sl not_active IP Right Cessation
- 1998-06-18 HU HU0003906A patent/HUP0003906A2/hu unknown
- 1998-06-18 KR KR19997012003A patent/KR20010013977A/ko not_active Application Discontinuation
- 1998-06-18 EP EP98931355A patent/EP0991625B1/en not_active Revoked
- 1998-06-18 CA CA002290982A patent/CA2290982A1/en not_active Abandoned
- 1998-06-18 BR BR9810151-0A patent/BR9810151A/pt not_active IP Right Cessation
- 1998-06-18 SK SK1746-99A patent/SK174699A3/sk unknown
- 1998-06-18 HR HR60/076,691A patent/HRP980334A2/hr not_active Application Discontinuation
- 1998-06-18 WO PCT/US1998/012681 patent/WO1998057937A2/en active IP Right Grant
- 1998-06-18 EE EEP199900584A patent/EE9900584A/xx unknown
- 1998-06-18 ES ES98931355T patent/ES2239806T3/es not_active Expired - Lifetime
- 1998-06-18 JP JP50478699A patent/JP2002507968A/ja active Pending
- 1998-06-18 EA EA200000048A patent/EA200000048A1/ru unknown
- 1998-06-18 AU AU81503/98A patent/AU8150398A/en not_active Abandoned
- 1998-06-18 DE DE69830403T patent/DE69830403T2/de not_active Expired - Lifetime
- 1998-06-19 AR ARP980102939A patent/AR015906A1/es unknown
-
1999
- 1999-12-16 LV LVP-99-177A patent/LV12516B/en unknown
- 1999-12-17 NO NO996316A patent/NO996316L/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
WO1998057937A2 (en) | 1998-12-23 |
AU8150398A (en) | 1999-01-04 |
EP0991625B1 (en) | 2005-06-01 |
LV12516B (en) | 2001-03-20 |
BR9810151A (pt) | 2000-08-08 |
JP2002507968A (ja) | 2002-03-12 |
HRP980334A2 (en) | 1999-04-30 |
EP0991625A2 (en) | 2000-04-12 |
PL337831A1 (en) | 2000-09-11 |
NO996316D0 (no) | 1999-12-17 |
KR20010013977A (ko) | 2001-02-26 |
LV12516A (en) | 2000-07-20 |
ATE296805T1 (de) | 2005-06-15 |
AR015906A1 (es) | 2001-05-30 |
PT991625E (pt) | 2005-10-31 |
DE69830403T2 (de) | 2006-02-02 |
SI20208A (sl) | 2000-10-31 |
IL133526A0 (en) | 2001-04-30 |
HUP0003906A2 (hu) | 2001-05-28 |
CA2290982A1 (en) | 1998-12-23 |
EE9900584A (et) | 2000-08-15 |
DE69830403D1 (de) | 2005-07-07 |
WO1998057937A3 (en) | 1999-03-18 |
NO996316L (no) | 1999-12-17 |
ES2239806T3 (es) | 2005-10-01 |
EA200000048A1 (ru) | 2000-08-28 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
US6403620B1 (en) | Inhibitors of factor Xa with a neutral P1 specificity group | |
SK174699A3 (en) | Inhibitors of factor xa with a neutral p1 specificity group | |
US7235575B2 (en) | Guanidine mimics as factor Xa inhibitors | |
KR100546522B1 (ko) | Xa 인자 억제제인 신규한 구아니딘 유사체 | |
SI20017A (sl) | Dušik vsebujoči heteroaromati kot inhibitorji faktorja Xa | |
JP2001526268A (ja) | Xa因子阻害剤としての、オルト−置換P1を有する、窒素含有複素環式芳香族化合物 | |
US6548512B1 (en) | Nitrogen containing heteroaromatics as factor Xa inhibitors | |
CZ444399A3 (cs) | Inhibitory faktoru Xa s neutrální Pl skupinovou specifičností | |
LT4702B (lt) | Xa faktoriaus inhibitorius su neutralia p1 specifine grupe | |
MXPA99010588A (en) | Inhibitors of factor xa with a neutral p1 specificity group | |
CZ442099A3 (cs) | Nové guanidinové deriváty jako inhibitory faktoru Xa | |
LT4673B (lt) | Azoto heteroaromatiniai junginiai kaip faktoriaus xa inhibitoriai |