DE69830403D1 - Inhibitoren des faktors xa mit einer neutralen gruppe mit p1-spezifität - Google Patents
Inhibitoren des faktors xa mit einer neutralen gruppe mit p1-spezifitätInfo
- Publication number
- DE69830403D1 DE69830403D1 DE69830403T DE69830403T DE69830403D1 DE 69830403 D1 DE69830403 D1 DE 69830403D1 DE 69830403 T DE69830403 T DE 69830403T DE 69830403 T DE69830403 T DE 69830403T DE 69830403 D1 DE69830403 D1 DE 69830403D1
- Authority
- DE
- Germany
- Prior art keywords
- specificity
- inhibitors
- factor
- neutral group
- neutral
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/06—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom
- C07D213/16—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom containing only hydrogen and carbon atoms in addition to the ring nitrogen atom containing only one pyridine ring
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D257/00—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms
- C07D257/02—Heterocyclic compounds containing rings having four nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D257/04—Five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/14—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
- C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
- C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D277/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Life Sciences & Earth Sciences (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US87888597A | 1997-06-19 | 1997-06-19 | |
US878885 | 1997-06-19 | ||
US7669198P | 1998-02-27 | 1998-02-27 | |
US76691P | 1998-02-27 | ||
PCT/US1998/012681 WO1998057937A2 (en) | 1997-06-19 | 1998-06-18 | Inhibitors of factor xa with a neutral p1 specificity group |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69830403D1 true DE69830403D1 (de) | 2005-07-07 |
DE69830403T2 DE69830403T2 (de) | 2006-02-02 |
Family
ID=26758382
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69830403T Expired - Lifetime DE69830403T2 (de) | 1997-06-19 | 1998-06-18 | Inhibitoren des faktors xa mit einer neutralen gruppe mit p1-spezifität |
Country Status (22)
Country | Link |
---|---|
EP (1) | EP0991625B1 (de) |
JP (1) | JP2002507968A (de) |
KR (1) | KR20010013977A (de) |
AR (1) | AR015906A1 (de) |
AT (1) | ATE296805T1 (de) |
AU (1) | AU8150398A (de) |
BR (1) | BR9810151A (de) |
CA (1) | CA2290982A1 (de) |
DE (1) | DE69830403T2 (de) |
EA (1) | EA200000048A1 (de) |
EE (1) | EE9900584A (de) |
ES (1) | ES2239806T3 (de) |
HR (1) | HRP980334A2 (de) |
HU (1) | HUP0003906A2 (de) |
IL (1) | IL133526A0 (de) |
LV (1) | LV12516B (de) |
NO (1) | NO996316D0 (de) |
PL (1) | PL337831A1 (de) |
PT (1) | PT991625E (de) |
SI (1) | SI20208A (de) |
SK (1) | SK174699A3 (de) |
WO (1) | WO1998057937A2 (de) |
Families Citing this family (104)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1012150A4 (de) * | 1997-05-19 | 2002-05-29 | Sugen Inc | Heteroarylcarboxamid-verbindungen die gegen durch protein-tyrosin-kinase verursachte krankheiten wirksam sind |
US6271237B1 (en) | 1997-12-22 | 2001-08-07 | Dupont Pharmaceuticals Company | Nitrogen containing heteromatics with ortho-substituted P1s as factor Xa inhabitors |
JP2001526268A (ja) * | 1997-12-22 | 2001-12-18 | デュポン ファーマシューティカルズ カンパニー | Xa因子阻害剤としての、オルト−置換P1を有する、窒素含有複素環式芳香族化合物 |
AU2300699A (en) | 1998-02-17 | 1999-08-30 | Ono Pharmaceutical Co. Ltd. | Amidino derivatives and drugs containing the same as the active ingredient |
AU3110999A (en) | 1998-03-27 | 1999-10-18 | Du Pont Pharmaceuticals Company | Disubstituted pyrazolines and triazolines as factor xa inhibitors |
KR20010072080A (ko) * | 1998-07-31 | 2001-07-31 | 쓰끼하시 다미까따 | 페닐아졸 화합물, 그의 제조 방법 및 고지혈증용 약제 |
CA2348740A1 (en) * | 1998-12-23 | 2000-07-06 | Ruth R. Wexler | Thrombin or factor xa inhibitors |
EP1159273A1 (de) | 1999-03-02 | 2001-12-05 | Boehringer Ingelheim Pharmaceuticals Inc. | Verbindungen, verwendbar als reversible inhibitoren von cathepsin s |
DE60003025T2 (de) | 1999-04-02 | 2004-03-18 | Bristol-Myers Squibb Pharma Co. | Arylsulfonyle als faktor xa inhibitoren |
US7125875B2 (en) | 1999-04-15 | 2006-10-24 | Bristol-Myers Squibb Company | Cyclic protein tyrosine kinase inhibitors |
WO2000062778A1 (en) | 1999-04-15 | 2000-10-26 | Bristol-Myers Squibb Co. | Cyclic protein tyrosine kinase inhibitors |
BR0013200A (pt) | 1999-07-16 | 2002-05-07 | Bristol Myers Squibb Pharma Co | Compostos derivados de heterobiciclos contendo nitrogênio, composições farmacêuticas, método de tratamento ou prevenção de uma disfunção tromboembólica e uso dos compostos |
US6420364B1 (en) | 1999-09-13 | 2002-07-16 | Boehringer Ingelheim Pharmaceuticals, Inc. | Compound useful as reversible inhibitors of cysteine proteases |
US6407256B1 (en) | 1999-11-03 | 2002-06-18 | Bristol Myers Squibb Co | Cyano-pyrrole, cyano-imidazole, cyano-pyrazole, and cyano-triazole compounds as factor Xa inhibitors |
EP1226123A1 (de) * | 1999-11-03 | 2002-07-31 | Du Pont Pharmaceuticals Company | Cyanao-derivate als faktor xa hemmer |
MY138097A (en) | 2000-03-22 | 2009-04-30 | Du Pont | Insecticidal anthranilamides |
WO2002000655A1 (en) * | 2000-06-23 | 2002-01-03 | Bristol-Myers Squibb Pharma Company | 1 - (heteroaryl-phenyl) - condensed pyrazol derivatives as factor xa inhibitors |
WO2002000647A1 (en) | 2000-06-23 | 2002-01-03 | Bristol-Myers Squibb Pharma Company | Heteroaryl-phenyl substituted factor xa inhibitors |
WO2002002519A2 (en) * | 2000-06-29 | 2002-01-10 | Bristol-Myers Squibb Pharma Company | THROMBIN OR FACTOR Xa INHIBITORS |
US6906192B2 (en) | 2000-11-07 | 2005-06-14 | Bristol Myers Squibb Company | Processes for the preparation of acid derivatives useful as serine protease inhibitors |
US6713467B2 (en) | 2000-11-07 | 2004-03-30 | Bristol-Myers Squibb Company | Acid derivatives useful as serine protease inhibitors |
HUP0400651A2 (hu) * | 2000-11-07 | 2004-06-28 | Bristol-Myers Squibb Company | Szerin proteáz inhibitorokként alkalmazható savszármazékok és ezeket tartalmazó gyógyszerkészítmények |
AR036872A1 (es) | 2001-08-13 | 2004-10-13 | Du Pont | Compuesto de antranilamida, composicion que lo comprende y metodo para controlar una plaga de invertebrados |
TWI325302B (en) | 2001-08-13 | 2010-06-01 | Du Pont | Benzoxazinone compounds |
CN100528862C (zh) | 2001-08-15 | 2009-08-19 | 纳幕尔杜邦公司 | 用于控制无脊椎害虫的邻位取代的芳基酰胺化合物 |
JP4445751B2 (ja) | 2001-08-15 | 2010-04-07 | イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニー | 無脊椎有害生物を防除するためのo−複素環式置換アリールアミド |
DE60230421D1 (de) | 2001-08-16 | 2009-01-29 | Du Pont | Substituierte anthranilamide und ihre verwendung als pesticide |
TW200724033A (en) | 2001-09-21 | 2007-07-01 | Du Pont | Anthranilamide arthropodicide treatment |
ATE544750T1 (de) | 2001-09-21 | 2012-02-15 | Bristol Myers Squibb Co | Lactamhaltige verbindungen und ihre derivate als faktor-xa-hemmer |
TWI331526B (en) | 2001-09-21 | 2010-10-11 | Bristol Myers Squibb Pharma Co | Lactam-containing compounds and derivatives thereof as factor xa inhibitors |
EP1443930A1 (de) | 2001-10-25 | 2004-08-11 | AstraZeneca AB | Isoxazolinderivative verwendbar als antimikrobielle agenzien |
BR0307178A (pt) | 2002-01-22 | 2004-12-07 | Du Pont | Composto, composição e método para controle de pragas invertebradas |
AU2003273179A1 (en) | 2002-05-10 | 2003-12-12 | Bristol-Myers Squibb Company | 1,1-disubstituted cycloalkyl derivatives as factor xa inhibitors |
WO2003106427A2 (en) | 2002-06-13 | 2003-12-24 | E.I. Du Pont De Nemours And Company | Pyrazolecarboxamide insecticides |
DE10229070A1 (de) * | 2002-06-28 | 2004-01-15 | Merck Patent Gmbh | Phenylderivate 5 |
BR0315714A (pt) | 2002-11-15 | 2005-09-06 | Du Pont | Composto, composição para controle de pestes invertebradas, método para controle de pestes invertebradas, composição de aspersão, composição de isca e dispositivo para controle de pestes invertebradas |
EP2982668A3 (de) | 2002-12-03 | 2016-04-13 | Pharmacyclics LLC | 2-(2-hydroxybiphenyl-3-yl)-1h-benzoimidazole-5-carboxamidin-derivate als faktor viia inhibitoren zur behandlung von thromboembolischen erkrankungen |
PL209303B1 (pl) * | 2002-12-23 | 2011-08-31 | 4Sc Ag | Związek aromatyczny, kompozycja farmaceutyczna zawierająca związek aromatyczny i zastosowanie związku aromatycznego jako środka przeciwzapalnego, immunomodulującego i antyproliferacyjnego |
US7365094B2 (en) | 2002-12-23 | 2008-04-29 | 4Sc Ag | Compounds as anti-inflammatory, immunomodulatory and anti-proliferatory agents |
WO2004056746A1 (en) | 2002-12-23 | 2004-07-08 | 4Sc Ag | Cycloalkene dicarboxylic acid compounds as anti-inflammatory, immunomodulatory and anti-proliferatory agents |
US7247736B2 (en) | 2002-12-23 | 2007-07-24 | 4Sc Ag | Method of identifying inhibitors of DHODH |
EP1599463B1 (de) | 2003-01-28 | 2013-06-05 | E.I. Du Pont De Nemours And Company | Cyanoanthranilamid-insektizide |
US7122557B2 (en) | 2003-03-18 | 2006-10-17 | Bristol-Myers Squibb Company | Sulfonyl-amidino-containing and tetrahydropyrimidino-containing compounds as factor Xa inhibitors |
CA2525325A1 (en) * | 2003-05-01 | 2004-11-18 | Abbott Laboratories | Pyrazole-amides and sulfonamides as sodium channel modulators |
US20040220170A1 (en) * | 2003-05-01 | 2004-11-04 | Atkinson Robert N. | Pyrazole-amides and sulfonamides as sodium channel modulators |
JP4681548B2 (ja) | 2003-07-22 | 2011-05-11 | アステックス・セラピューティクス・リミテッド | 3,4−ジ置換1h−ピラゾール化合物および、そのサイクリン依存性キナーゼ(cdk)およびグリコーゲン・シンセターゼ・キナーゼ−3(gsk−3)調節剤としての使用 |
BRPI0412805A (pt) * | 2003-07-23 | 2006-09-26 | Synta Pharmaceuticals Corp | método para modular canais de ìon de cálcio ativado por liberação de ìon de cálcio |
DK3002283T3 (en) | 2003-12-26 | 2017-07-10 | Kyowa Hakko Kirin Co Ltd | THIAZOLE DERIVATIVES. |
ZA200607637B (en) | 2004-03-05 | 2008-05-28 | Nissan Chemical Ind Ltd | Isoxazoline-substituted benzamide compound and noxious organism control agent |
WO2005090313A1 (en) | 2004-03-18 | 2005-09-29 | Pfizer Limited | N-(1-arylpyrazol-4l)sulfonamides and their use as parasiticides |
JO2540B1 (en) | 2004-07-01 | 2010-09-05 | اي.اي.ديو بونت دي نيمورز اند كومباني | Control factors for pests from invertebrate insects include a symbiotic mixture of anthranilamide |
JP2008512364A (ja) * | 2004-09-06 | 2008-04-24 | エフ.ホフマン−ラ ロシュ アーゲー | 4−アミノメチルベンズアミジン誘導体及び第VIIa因子阻害剤としてのその使用 |
NZ556546A (en) | 2005-01-07 | 2011-02-25 | Synta Pharmaceuticals Corp | Compounds for inflammation and immune-related uses |
AR054425A1 (es) | 2005-01-21 | 2007-06-27 | Astex Therapeutics Ltd | Sales de adicion de piperidin 4-il- amida de acido 4-(2,6-dicloro-benzoilamino) 1h-pirazol-3-carboxilico. |
US8404718B2 (en) | 2005-01-21 | 2013-03-26 | Astex Therapeutics Limited | Combinations of pyrazole kinase inhibitors |
JPWO2006137527A1 (ja) | 2005-06-23 | 2009-01-22 | 協和発酵キリン株式会社 | チアゾール誘導体 |
KR101083506B1 (ko) * | 2005-07-15 | 2011-11-16 | 에프. 호프만-라 로슈 아게 | 신규한 헤테로아릴 융합된 환형 아민 |
BRPI0617046A2 (pt) | 2005-08-24 | 2011-07-12 | Du Pont | composto, composição de controle de pragas invertebradas, composição de isca para controle de pragas invertebradas, composição de pulverização para controlar pragas invertebradas, métodos de controle de pragas invertebradas, método de controle de baratas, formigas ou cupins e método de controle de mosquitos, moscas pretas, moscas dos estábulos, moscas do cervos, moscas dos cavalos, vespas, vespas americanas, vespões, carrapatos, aranhas, formigas ou mosquitos |
TWI324908B (en) | 2006-01-05 | 2010-05-21 | Du Pont | Liquid formulations of carboxamide arthropodicides |
US7943646B2 (en) * | 2006-01-31 | 2011-05-17 | Dong Wha Pharmaceutical Co., Ltd. | Benzamidine derivative, process for the preparation thereof and pharmaceutical composition comprising same |
JP5322935B2 (ja) * | 2006-07-31 | 2013-10-23 | アクティベサイト ファーマシューティカルズ インコーポレイティッド | 血漿カリクレインの阻害薬 |
EP1894928A1 (de) | 2006-08-29 | 2008-03-05 | PheneX Pharmaceuticals AG | Fxr bindende heterocyclische verbindungen |
KR20090064478A (ko) | 2006-11-13 | 2009-06-18 | 화이자 프로덕츠 인크. | 디아릴, 디피리디닐 및 아릴-피리디닐 유도체, 및 이들의 용도 |
AR072297A1 (es) | 2008-06-27 | 2010-08-18 | Novartis Ag | Derivados de indol-2-il-piridin-3-ilo, composicion farmaceutica que los comprende y su uso en medicamentos para el tratamiento de enfermedades mediadas por la sintasa aldosterona. |
AU2009316786A1 (en) * | 2008-11-19 | 2010-05-27 | Merck Sharp & Dohme Corp. | Inhibitors of diacylglycerol acyltransferase |
CN102753531B (zh) * | 2009-12-15 | 2015-07-01 | 拜尔农作物科学股份公司 | 制备1-烷基-/1-芳基-5-吡唑羧酸衍生物的方法 |
SG10201408429UA (en) | 2009-12-18 | 2015-02-27 | Activesite Pharmaceuticals Inc | Prodrugs of inhibitors of plasma kallikrein |
EA201300473A1 (ru) * | 2010-10-20 | 2013-09-30 | Байота Сайентифик Менеджмент Пти Лтд. | Ингибиторы вирусной полимеразы |
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EP2691379B1 (de) | 2011-03-31 | 2016-11-02 | Bayer Intellectual Property GmbH | Herbizid und fungizid wirksame 3-phenylisoxazolin-5-carboxamide und 3- phenylisoxazolin-5-thioamide |
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US9199975B2 (en) | 2011-09-30 | 2015-12-01 | Asana Biosciences, Llc | Biaryl imidazole derivatives for regulating CYP17 |
BR112014007694B1 (pt) | 2011-10-03 | 2022-09-27 | Respivert Limited | Compostos de 1-(3-(tert-butil)-1-(p-tolil)-1h-pirazol-5-il)-3-(4-((2-(fenilamino) pirimidin-4-il)óxi) naftalen-1-il)ureia, seus usos, composição e formulação farmacêutica compreendendo os mesmos |
EP2578582A1 (de) | 2011-10-03 | 2013-04-10 | Respivert Limited | 1-Pyrazolyl-3-(4-((2-anilinopyrimidin-4-yl)oxy)napththalen-1-yl) Harnstoffe als p38 MAP Kinasehemmer |
CA2885692C (en) * | 2012-09-25 | 2018-05-22 | Bayer Cropscience Ag | Herbicidal and fungicidal 5-oxy-substituted 3-phenylisoxazoline-5-carboxamides and 5-oxy-substituted 3-phenylisoxazoline-5-thioamides |
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JP6423372B2 (ja) | 2013-02-28 | 2018-11-14 | ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company | 強力なrock1およびrock2阻害剤としてのフェニルピラゾール誘導体 |
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-
1998
- 1998-06-18 HU HU0003906A patent/HUP0003906A2/hu unknown
- 1998-06-18 JP JP50478699A patent/JP2002507968A/ja active Pending
- 1998-06-18 KR KR19997012003A patent/KR20010013977A/ko not_active Application Discontinuation
- 1998-06-18 ES ES98931355T patent/ES2239806T3/es not_active Expired - Lifetime
- 1998-06-18 BR BR9810151-0A patent/BR9810151A/pt not_active IP Right Cessation
- 1998-06-18 IL IL13352698A patent/IL133526A0/xx unknown
- 1998-06-18 PT PT98931355T patent/PT991625E/pt unknown
- 1998-06-18 DE DE69830403T patent/DE69830403T2/de not_active Expired - Lifetime
- 1998-06-18 AU AU81503/98A patent/AU8150398A/en not_active Abandoned
- 1998-06-18 SK SK1746-99A patent/SK174699A3/sk unknown
- 1998-06-18 PL PL98337831A patent/PL337831A1/xx not_active Application Discontinuation
- 1998-06-18 EP EP98931355A patent/EP0991625B1/de not_active Revoked
- 1998-06-18 EE EEP199900584A patent/EE9900584A/xx unknown
- 1998-06-18 WO PCT/US1998/012681 patent/WO1998057937A2/en active IP Right Grant
- 1998-06-18 CA CA002290982A patent/CA2290982A1/en not_active Abandoned
- 1998-06-18 EA EA200000048A patent/EA200000048A1/ru unknown
- 1998-06-18 HR HR60/076,691A patent/HRP980334A2/hr not_active Application Discontinuation
- 1998-06-18 SI SI9820043A patent/SI20208A/sl not_active IP Right Cessation
- 1998-06-18 AT AT98931355T patent/ATE296805T1/de not_active IP Right Cessation
- 1998-06-19 AR ARP980102939A patent/AR015906A1/es unknown
-
1999
- 1999-12-16 LV LVP-99-177A patent/LV12516B/en unknown
- 1999-12-17 NO NO996316A patent/NO996316D0/no not_active Application Discontinuation
Also Published As
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LV12516B (en) | 2001-03-20 |
HUP0003906A2 (hu) | 2001-05-28 |
SI20208A (sl) | 2000-10-31 |
ES2239806T3 (es) | 2005-10-01 |
LV12516A (en) | 2000-07-20 |
WO1998057937A3 (en) | 1999-03-18 |
AU8150398A (en) | 1999-01-04 |
CA2290982A1 (en) | 1998-12-23 |
IL133526A0 (en) | 2001-04-30 |
DE69830403T2 (de) | 2006-02-02 |
JP2002507968A (ja) | 2002-03-12 |
NO996316L (no) | 1999-12-17 |
KR20010013977A (ko) | 2001-02-26 |
BR9810151A (pt) | 2000-08-08 |
NO996316D0 (no) | 1999-12-17 |
WO1998057937A2 (en) | 1998-12-23 |
SK174699A3 (en) | 2000-08-14 |
EA200000048A1 (ru) | 2000-08-28 |
EE9900584A (et) | 2000-08-15 |
ATE296805T1 (de) | 2005-06-15 |
EP0991625A2 (de) | 2000-04-12 |
PT991625E (pt) | 2005-10-31 |
HRP980334A2 (en) | 1999-04-30 |
AR015906A1 (es) | 2001-05-30 |
EP0991625B1 (de) | 2005-06-01 |
PL337831A1 (en) | 2000-09-11 |
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