SI8912489B - Novi IL-2 receptor specifični humani imunoglobulini - Google Patents
Novi IL-2 receptor specifični humani imunoglobulini Download PDFInfo
- Publication number
- SI8912489B SI8912489B SI8912489A SI8912489A SI8912489B SI 8912489 B SI8912489 B SI 8912489B SI 8912489 A SI8912489 A SI 8912489A SI 8912489 A SI8912489 A SI 8912489A SI 8912489 B SI8912489 B SI 8912489B
- Authority
- SI
- Slovenia
- Prior art keywords
- immunoglobulin
- human
- donor
- amino acid
- framework
- Prior art date
Links
- 108060003951 Immunoglobulin Proteins 0.000 title claims 29
- 102000018358 immunoglobulin Human genes 0.000 title claims 29
- 102000010789 Interleukin-2 Receptors Human genes 0.000 title claims 4
- 229940072221 immunoglobulins Drugs 0.000 title claims 2
- 108010038453 Interleukin-2 Receptors Proteins 0.000 title 1
- 238000000034 method Methods 0.000 claims abstract 6
- 150000001413 amino acids Chemical class 0.000 claims 9
- 102000004169 proteins and genes Human genes 0.000 claims 8
- 108090000623 proteins and genes Proteins 0.000 claims 8
- 125000003275 alpha amino acid group Chemical group 0.000 claims 5
- 102000040430 polynucleotide Human genes 0.000 claims 5
- 108091033319 polynucleotide Proteins 0.000 claims 5
- 239000002157 polynucleotide Substances 0.000 claims 5
- 101001002657 Homo sapiens Interleukin-2 Proteins 0.000 claims 4
- 238000006467 substitution reaction Methods 0.000 claims 4
- 230000000295 complement effect Effects 0.000 claims 3
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 2
- 239000000427 antigen Substances 0.000 claims 2
- 102000036639 antigens Human genes 0.000 claims 2
- 108091007433 antigens Proteins 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical compound COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 claims 1
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 claims 1
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 claims 1
- 108010002350 Interleukin-2 Proteins 0.000 claims 1
- 102000000588 Interleukin-2 Human genes 0.000 claims 1
- 238000004220 aggregation Methods 0.000 claims 1
- 230000002776 aggregation Effects 0.000 claims 1
- 125000000539 amino acid group Chemical group 0.000 claims 1
- 102000055277 human IL2 Human genes 0.000 claims 1
- 230000001900 immune effect Effects 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 108010047041 Complementarity Determining Regions Proteins 0.000 abstract 1
- 108091035707 Consensus sequence Proteins 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/081—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from DNA viruses
- C07K16/085—Herpetoviridae, e.g. pseudorabies virus, Epstein-Barr virus
- C07K16/087—Herpes simplex virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/081—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from DNA viruses
- C07K16/085—Herpetoviridae, e.g. pseudorabies virus, Epstein-Barr virus
- C07K16/088—Varicella-zoster virus
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
- C07K16/249—Interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2896—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against molecules with a "CD"-designation, not provided for elsewhere
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/461—Igs containing Ig-regions, -domains or -residues form different species
- C07K16/464—Igs containing CDR-residues from one specie grafted between FR-residues from another
- C07K16/465—Igs containing CDR-residues from one specie grafted between FR-residues from another with additional modified FR-residues
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Physical Education & Sports Medicine (AREA)
- Virology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Rheumatology (AREA)
- Neurology (AREA)
- Transplantation (AREA)
- Biomedical Technology (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Pain & Pain Management (AREA)
- Neurosurgery (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US29097588A | 1988-12-28 | 1988-12-28 | |
US31025289A | 1989-02-13 | 1989-02-13 | |
YU248989A YU48700B (sh) | 1988-12-28 | 1989-12-28 | Postupak za proizvodnju humaniziranog imunoglobulinskog lanca |
Publications (2)
Publication Number | Publication Date |
---|---|
SI8912489A SI8912489A (sl) | 1999-02-28 |
SI8912489B true SI8912489B (sl) | 2000-04-30 |
Family
ID=26966505
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI8912489A SI8912489B (sl) | 1988-12-28 | 1989-12-28 | Novi IL-2 receptor specifični humani imunoglobulini |
Country Status (32)
Country | Link |
---|---|
EP (6) | EP1491556B1 (da) |
JP (6) | JP2828340B2 (da) |
KR (1) | KR0178385B1 (da) |
CN (1) | CN1057013C (da) |
AT (2) | ATE133452T1 (da) |
AU (1) | AU647383B2 (da) |
BG (1) | BG61095B2 (da) |
CA (2) | CA2006865C (da) |
CZ (1) | CZ418691A3 (da) |
DD (1) | DD296964A5 (da) |
DE (14) | DE04076439T1 (da) |
DK (2) | DK119191D0 (da) |
ES (5) | ES2136760T3 (da) |
FI (1) | FI108797B (da) |
FR (1) | FR14C0070I1 (da) |
HK (1) | HK1014718A1 (da) |
HR (1) | HRP920500B1 (da) |
HU (1) | HU211174A9 (da) |
IE (1) | IE20000331A1 (da) |
IL (2) | IL162181A (da) |
LU (8) | LU90411I2 (da) |
MC (1) | MC2146A1 (da) |
NL (8) | NL990020I2 (da) |
NO (9) | NO310473B1 (da) |
NZ (2) | NZ231984A (da) |
PT (1) | PT92758B (da) |
RU (1) | RU2126046C1 (da) |
SG (1) | SG78258A1 (da) |
SI (1) | SI8912489B (da) |
WO (1) | WO1990007861A1 (da) |
YU (1) | YU48700B (da) |
ZA (1) | ZA899956B (da) |
Families Citing this family (971)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5800815A (en) * | 1903-05-05 | 1998-09-01 | Cytel Corporation | Antibodies to P-selectin and their uses |
US5851526A (en) * | 1985-04-19 | 1998-12-22 | Ludwig Institute For Cancer Research | Methods of treating colon cancer utilizing tumor-specific antibodies |
US5449760A (en) * | 1987-12-31 | 1995-09-12 | Tanox Biosystems, Inc. | Monoclonal antibodies that bind to soluble IGE but do not bind IGE on IGE expressing B lymphocytes or basophils |
US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
US7247453B1 (en) * | 1988-12-30 | 2007-07-24 | Oklahoma Medical Research Foundation | Calcium binding recombinant antibody against protein C |
DE3900534A1 (de) * | 1989-01-10 | 1990-07-12 | Boehringer Mannheim Gmbh | Diagnostischer nachweis unter verwendung von chimaeren antikoerpern |
US6750325B1 (en) | 1989-12-21 | 2004-06-15 | Celltech R&D Limited | CD3 specific recombinant antibody |
US5859205A (en) | 1989-12-21 | 1999-01-12 | Celltech Limited | Humanised antibodies |
GB8928874D0 (en) | 1989-12-21 | 1990-02-28 | Celltech Ltd | Humanised antibodies |
GR1001050B (el) * | 1990-01-09 | 1993-04-28 | Protein Design Labs Inc | Νεος il-2 υποδοχευς ιδιαζοντων ανθρωπινων ανοσοσφαιρινων. |
HUT60768A (en) | 1990-03-16 | 1992-10-28 | Sandoz Ag | Process for producing cd25 fixing molecules |
GB9020282D0 (en) | 1990-09-17 | 1990-10-31 | Gorman Scott D | Altered antibodies and their preparation |
US5858725A (en) * | 1990-10-10 | 1999-01-12 | Glaxo Wellcome Inc. | Preparation of chimaeric antibodies using the recombinant PCR strategy |
US5994510A (en) * | 1990-12-21 | 1999-11-30 | Celltech Therapeutics Limited | Recombinant antibodies specific for TNFα |
CA2082160C (en) * | 1991-03-06 | 2003-05-06 | Mary M. Bendig | Humanised and chimeric monoclonal antibodies |
IE920716A1 (en) * | 1991-03-07 | 1992-09-09 | Gen Hospital Corp | Redirection of cellular immunity by receptor chimeras |
WO1992017505A1 (en) * | 1991-04-05 | 1992-10-15 | Board Of Regents Of The University Of Washington | Monoclonal antibodies to stem cell factor receptors |
ES2134212T3 (es) * | 1991-04-25 | 1999-10-01 | Chugai Pharmaceutical Co Ltd | Anticuerpo humano reconstituido contra el receptor de la interleuquina 6 humano. |
EP0519596B1 (en) * | 1991-05-17 | 2005-02-23 | Merck & Co. Inc. | A method for reducing the immunogenicity of antibody variable domains |
WO1994004679A1 (en) * | 1991-06-14 | 1994-03-03 | Genentech, Inc. | Method for making humanized antibodies |
US6800738B1 (en) | 1991-06-14 | 2004-10-05 | Genentech, Inc. | Method for making humanized antibodies |
DK0590058T3 (da) * | 1991-06-14 | 2004-03-29 | Genentech Inc | Humaniseret heregulin-antistof |
GB9115010D0 (en) * | 1991-07-11 | 1991-08-28 | Wellcome Found | Antibody |
GB9115364D0 (en) | 1991-07-16 | 1991-08-28 | Wellcome Found | Antibody |
HU220295B (hu) * | 1991-07-25 | 2001-11-28 | Idec Pharmaceuticals Corp. | Antigénkészítmények és ezek alkalmazása citotoxikus T-limfocita reakciók indukálására |
US5756096A (en) * | 1991-07-25 | 1998-05-26 | Idec Pharmaceuticals Corporation | Recombinant antibodies for human therapy |
MX9204374A (es) * | 1991-07-25 | 1993-03-01 | Idec Pharma Corp | Anticuerpo recombinante y metodo para su produccion. |
US6136310A (en) * | 1991-07-25 | 2000-10-24 | Idec Pharmaceuticals Corporation | Recombinant anti-CD4 antibodies for human therapy |
US5709860A (en) * | 1991-07-25 | 1998-01-20 | Idec Pharmaceuticals Corporation | Induction of cytotoxic T-lymphocyte responses |
US6699472B2 (en) | 1991-08-14 | 2004-03-02 | Genentech, Inc. | Method of treating allergic disorders |
US6329509B1 (en) | 1991-08-14 | 2001-12-11 | Genentech, Inc. | Anti-IgE antibodies |
DE69230545T2 (de) * | 1991-08-21 | 2000-07-06 | Novartis Ag | Antikörperderivate |
GB9120467D0 (en) * | 1991-09-26 | 1991-11-06 | Celltech Ltd | Anti-hmfg antibodies and process for their production |
JP3024311B2 (ja) * | 1991-10-03 | 2000-03-21 | 味の素株式会社 | Il−2受容体重鎖に結合するポリペプチド |
US5474771A (en) | 1991-11-15 | 1995-12-12 | The Trustees Of Columbia University In The City Of New York | Murine monoclonal antibody (5c8) recognizes a human glycoprotein on the surface of T-lymphocytes, compositions containing same |
US7070777B1 (en) | 1991-11-15 | 2006-07-04 | The Trustees Of Columbia University In The City Of New York | Method for inhibiting inflammation with an antibody that binds the 5C8 protein |
US5817310A (en) | 1991-12-02 | 1998-10-06 | Cor Therapeutics, Inc. | Inhibitory immunoglobulin polypeptides to human PDGF beta receptor |
JPH05244982A (ja) * | 1991-12-06 | 1993-09-24 | Sumitomo Chem Co Ltd | 擬人化b−b10 |
ATE249840T1 (de) * | 1991-12-13 | 2003-10-15 | Xoma Corp | Verfahren und materialien zur herstellung von modifizierten variablen antikörperdomänen und ihre therapeutische verwendung |
US5869619A (en) * | 1991-12-13 | 1999-02-09 | Xoma Corporation | Modified antibody variable domains |
US5777085A (en) * | 1991-12-20 | 1998-07-07 | Protein Design Labs, Inc. | Humanized antibodies reactive with GPIIB/IIIA |
US5824307A (en) | 1991-12-23 | 1998-10-20 | Medimmune, Inc. | Human-murine chimeric antibodies against respiratory syncytial virus |
WO1993016185A2 (en) * | 1992-02-06 | 1993-08-19 | Creative Biomolecules, Inc. | Biosynthetic binding protein for cancer marker |
GB9203459D0 (en) * | 1992-02-19 | 1992-04-08 | Scotgen Ltd | Antibodies with germ-line variable regions |
US5714350A (en) | 1992-03-09 | 1998-02-03 | Protein Design Labs, Inc. | Increasing antibody affinity by altering glycosylation in the immunoglobulin variable region |
US5387676A (en) * | 1992-03-11 | 1995-02-07 | Ciba Corning Diagnostics Corp. | MN gene and protein |
US7381803B1 (en) | 1992-03-27 | 2008-06-03 | Pdl Biopharma, Inc. | Humanized antibodies against CD3 |
US6129914A (en) * | 1992-03-27 | 2000-10-10 | Protein Design Labs, Inc. | Bispecific antibody effective to treat B-cell lymphoma and cell line |
US6033667A (en) * | 1992-05-05 | 2000-03-07 | Cytel Corporation | Method for detecting the presence of P-selectin |
US5397703A (en) * | 1992-07-09 | 1995-03-14 | Cetus Oncology Corporation | Method for generation of antibodies to cell surface molecules |
US5874082A (en) * | 1992-07-09 | 1999-02-23 | Chiron Corporation | Humanized anti-CD40 monoclonal antibodies and fragments capable of blocking B cell proliferation |
US5639641A (en) * | 1992-09-09 | 1997-06-17 | Immunogen Inc. | Resurfacing of rodent antibodies |
US6066718A (en) * | 1992-09-25 | 2000-05-23 | Novartis Corporation | Reshaped monoclonal antibodies against an immunoglobulin isotype |
US5958708A (en) * | 1992-09-25 | 1999-09-28 | Novartis Corporation | Reshaped monoclonal antibodies against an immunoglobulin isotype |
GB9223377D0 (en) * | 1992-11-04 | 1992-12-23 | Medarex Inc | Humanized antibodies to fc receptors for immunoglobulin on human mononuclear phagocytes |
US5648267A (en) * | 1992-11-13 | 1997-07-15 | Idec Pharmaceuticals Corporation | Impaired dominant selectable marker sequence and intronic insertion strategies for enhancement of expression of gene product and expression vector systems comprising same |
US7744877B2 (en) | 1992-11-13 | 2010-06-29 | Biogen Idec Inc. | Expression and use of anti-CD20 Antibodies |
US5736137A (en) * | 1992-11-13 | 1998-04-07 | Idec Pharmaceuticals Corporation | Therapeutic application of chimeric and radiolabeled antibodies to human B lymphocyte restricted differentiation antigen for treatment of B cell lymphoma |
JP3095175B2 (ja) | 1992-11-13 | 2000-10-03 | アイデック ファーマシューティカルズ コーポレイション | B細胞リンパ腫の治療のためのヒトbリンパ球限定分化抗原に対するキメラ抗体と放射能標識抗体の療法利用 |
CA2149326C (en) * | 1992-11-13 | 2007-04-17 | Mitchell E. Reff | Fully impaired consensus kozak sequences for mammalian expression |
US5804187A (en) * | 1992-11-16 | 1998-09-08 | Cancer Research Fund Of Contra Costa | Modified antibodies with human milk fat globule specificity |
EP0678122B1 (en) * | 1993-01-12 | 1999-07-28 | Biogen, Inc. | Recombinant anti-vla4 antibody molecules |
US5817311A (en) * | 1993-03-05 | 1998-10-06 | Universite Catholique De Louvain | Methods of inhibiting T-cell medicated immune responses with LO-CD2a-specific antibodies |
US5951983A (en) * | 1993-03-05 | 1999-09-14 | Universite Catholique De Louvain | Methods of inhibiting T cell mediated immune responses with humanized LO-CD2A-specific antibodies |
US5730979A (en) * | 1993-03-05 | 1998-03-24 | Universite Catholique Delouvain | LO-CD2a antibody and uses thereof for inhibiting T cell activation and proliferation |
WO1994025067A1 (en) * | 1993-05-04 | 1994-11-10 | Cytel Corporation | Antibodies to p-selectin and their uses |
ATE335072T1 (de) | 1993-05-28 | 2006-08-15 | Scripps Research Inst | Methoden für inhibition der cd14-abhängigen zellaktivierung |
TW458985B (en) * | 1993-05-31 | 2001-10-11 | Chugai Pharmaceutical Co Ltd | Reconstructed human antibody against human interleukin-6 |
US6180377B1 (en) * | 1993-06-16 | 2001-01-30 | Celltech Therapeutics Limited | Humanized antibodies |
US5914110A (en) * | 1993-09-07 | 1999-06-22 | Smithkline Beecham Corporation | Recombinant IL4 antibodies useful in treatment of IL4 mediated disorders |
US20020193575A1 (en) | 1993-09-07 | 2002-12-19 | Smithkline Beecham P.L.C. | Recombinant IL4 antibodies useful in treatment of IL4 mediated disorders |
US5928904A (en) * | 1993-09-07 | 1999-07-27 | Smithkline Beecham Corporation | DNA encoding recombinant IL4 antibodies useful in treatment of IL4 mediated disorders |
SK285556B6 (sk) * | 1993-09-07 | 2007-03-01 | Smithkline Beecham Corporation | Fúzny proteín so špecifickou väzbou na ľudský IL-4, molekula nukleovej kyseliny, monoklonálne protilátky, farmaceutická kompozícia a použitie |
WO1995014041A1 (fr) | 1993-11-19 | 1995-05-26 | Chugai Seiyaku Kabushiki Kaisha | Anticorps humain reconstitue contre des cellules medulloblastomateuses humaines |
WO1995015181A1 (en) * | 1993-11-30 | 1995-06-08 | Protein Design Labs, Inc. | Reperfusion therapy using antibodies to l-selectin |
GB9325182D0 (en) * | 1993-12-08 | 1994-02-09 | T Cell Sciences Inc | Humanized antibodies or binding proteins thereof specific for t cell subpopulations exhibiting select beta chain variable regions |
WO1995019790A1 (en) * | 1994-01-25 | 1995-07-27 | Athena Neurosciences, Inc. | Humanized antibodies against leukocyte adhesion molecule vla-4 |
US7435802B2 (en) | 1994-01-25 | 2008-10-14 | Elan Pharaceuticals, Inc. | Humanized anti-VLA4 immunoglobulins |
US5840299A (en) * | 1994-01-25 | 1998-11-24 | Athena Neurosciences, Inc. | Humanized antibodies against leukocyte adhesion molecule VLA-4 |
EP0753065B1 (en) | 1994-03-29 | 2003-05-14 | Celltech Therapeutics Limited | Antibodies against e-selectin |
US5635597A (en) * | 1994-05-27 | 1997-06-03 | Affymax Technologies, N.V. | Peptides that bind IL-2 receptors |
US5622701A (en) * | 1994-06-14 | 1997-04-22 | Protein Design Labs, Inc. | Cross-reacting monoclonal antibodies specific for E- and P-selectin |
USRE39548E1 (en) * | 1994-06-17 | 2007-04-03 | Celltech R&D Limited | Interleukin-5 specific recombinant antibodies |
GB9412230D0 (en) * | 1994-06-17 | 1994-08-10 | Celltech Ltd | Interleukin-5 specific recombiant antibodies |
US6048972A (en) * | 1994-07-13 | 2000-04-11 | Chugai Pharmaceutical Co., Ltd. | Recombinant materials for producing humanized anti-IL-8 antibodies |
DE4425115A1 (de) * | 1994-07-15 | 1996-01-18 | Boehringer Mannheim Gmbh | Verfahren zur Modifizierung der Stabilität von Antikörpern |
EP0696455A1 (en) * | 1994-08-11 | 1996-02-14 | Cellena (Cell Engineering) A.G. | Transferrin compositions to alleviate the side effects of cytotoxic drugs |
US8771694B2 (en) * | 1994-08-12 | 2014-07-08 | Immunomedics, Inc. | Immunoconjugates and humanized antibodies specific for B-cell lymphoma and leukemia cells |
US5707621A (en) * | 1994-08-31 | 1998-01-13 | Chugai Pharmaceutical Co., Ltd. | Supression of nephritis-induced protein excretion by anti-IL-8 |
US6309636B1 (en) * | 1995-09-14 | 2001-10-30 | Cancer Research Institute Of Contra Costa | Recombinant peptides derived from the Mc3 anti-BA46 antibody, methods of use thereof, and methods of humanizing antibody peptides |
US5693323A (en) * | 1994-12-23 | 1997-12-02 | Smithkline Beecham Corporation | Recombinant IL-5 antagonists useful in treatment of IL-5 mediated disorders |
US5811524A (en) * | 1995-06-07 | 1998-09-22 | Idec Pharmaceuticals Corporation | Neutralizing high affinity human monoclonal antibodies specific to RSV F-protein and methods for their manufacture and therapeutic use thereof |
US6113898A (en) * | 1995-06-07 | 2000-09-05 | Idec Pharmaceuticals Corporation | Human B7.1-specific primatized antibodies and transfectomas expressing said antibodies |
US7153508B2 (en) | 1995-06-07 | 2006-12-26 | Biogen Idec Inc. | Treatment of B cell lymphoma using anti-CD80 antibodies that do not inhibit the binding of CD80 to CTLA-4 |
AU6171196A (en) * | 1995-06-07 | 1996-12-30 | Sloan-Kettering Institute For Cancer Research | Therapeutic uses of ta99 |
US7175847B1 (en) | 1995-06-07 | 2007-02-13 | Biogen Idec Inc. | Treating intestinal inflammation with anti-CD80 antibodies that do not inhibit CD80 binding to CTLA-4 |
US6440418B1 (en) | 1995-11-07 | 2002-08-27 | Idec Pharmaceuticals Corporation | Methods of treating autoimmune diseases with gp39-specific antibodies |
US6001358A (en) | 1995-11-07 | 1999-12-14 | Idec Pharmaceuticals Corporation | Humanized antibodies to human gp39, compositions containing thereof |
GB9600660D0 (en) | 1996-01-12 | 1996-03-13 | Ciba Geigy Ag | Protein |
WO1997033617A1 (en) * | 1996-03-13 | 1997-09-18 | Protein Design Labs, Inc. | Fas ligand fusion proteins and their uses |
US5882644A (en) * | 1996-03-22 | 1999-03-16 | Protein Design Labs, Inc. | Monoclonal antibodies specific for the platelet derived growth factor β receptor and methods of use thereof |
US6713305B1 (en) | 1996-04-29 | 2004-03-30 | Novartis Ag | Metastasis-associated antigen and antibodies thereto |
JP4503706B2 (ja) | 1996-06-07 | 2010-07-14 | ポニアード ファーマシューティカルズ,インコーポレイティド | グリコシル化が改質されたヒト化抗体 |
US6534311B2 (en) | 1996-07-24 | 2003-03-18 | Novartis Ag | Drosophila melanogaster p70S6 kinase |
US6833255B1 (en) | 1996-07-24 | 2004-12-21 | Novartis, Ag | Drosophila melanogaster p70 S6 kinase |
US7147851B1 (en) | 1996-08-15 | 2006-12-12 | Millennium Pharmaceuticals, Inc. | Humanized immunoglobulin reactive with α4β7 integrin |
AU725329B2 (en) * | 1996-09-02 | 2000-10-12 | Ko Okumura | Humanized immunoglobulin reacting specifically with Fas ligand or active fragments thereof and region inducing apoptosis originating in Fas ligand |
US6013256A (en) * | 1996-09-24 | 2000-01-11 | Protein Design Labs, Inc. | Method of preventing acute rejection following solid organ transplantation |
KR100847441B1 (ko) * | 1996-09-26 | 2008-07-21 | 츄가이 세이야꾸 가부시키가이샤 | 인간의 부갑상선 호르몬 관련 펩티드에 대한 항체 |
UA76934C2 (en) | 1996-10-04 | 2006-10-16 | Chugai Pharmaceutical Co Ltd | Reconstructed human anti-hm 1.24 antibody, coding dna, vector, host cell, method for production of reconstructed human antibody, pharmaceutical composition and drug for treating myeloma containing reconstructed human anti-hm 1.24 antibody |
US7883872B2 (en) | 1996-10-10 | 2011-02-08 | Dyadic International (Usa), Inc. | Construction of highly efficient cellulase compositions for enzymatic hydrolysis of cellulose |
US20020160005A1 (en) | 1996-11-15 | 2002-10-31 | Trustees Of Tufts College | Human neutralizing antibodies against hemolytic urmec syndrome |
US7910096B2 (en) | 1996-11-15 | 2011-03-22 | Trustees Of Tufts College | Human neutralizing antibodies against hemolytic uremic syndrome |
EP2371962A3 (en) | 1996-12-23 | 2011-12-21 | Immunex Corporation | Receptor activator of NF-KAPPA B, receptor is member of TNF receptor superfamily |
US6262238B1 (en) * | 1997-01-14 | 2001-07-17 | Roche Diagnostic, Gmbh | Process for modifying the stability of antibodies |
US6596850B1 (en) | 1998-01-30 | 2003-07-22 | Ixsys, Incorporated | Anti-αv3β3 recombinant human antibodies, nucleic acids encoding same |
US6590079B2 (en) | 1997-01-30 | 2003-07-08 | Ixsys, Incorporated | Anti-αvβ3 recombinant human antibodies, nucleic acids encoding same |
US5986065A (en) | 1997-03-10 | 1999-11-16 | Sunol Molecular Corporation | Antibodies for inhibiting blood coagulation and methods of use thereof |
US20030109680A1 (en) | 2001-11-21 | 2003-06-12 | Sunol Molecular Corporation | Antibodies for inhibiting blood coagulation and methods of use thereof |
US20060235209A9 (en) | 1997-03-10 | 2006-10-19 | Jin-An Jiao | Use of anti-tissue factor antibodies for treating thromboses |
US7749498B2 (en) | 1997-03-10 | 2010-07-06 | Genentech, Inc. | Antibodies for inhibiting blood coagulation and methods of use thereof |
ZA982371B (en) * | 1997-03-21 | 1998-09-28 | Sankyo Co | Humanized anti-human fas antibody |
US6972323B1 (en) | 1997-04-01 | 2005-12-06 | Sankyo Company, Limited | Anti-Fas antibodies |
US7365166B2 (en) | 1997-04-07 | 2008-04-29 | Genentech, Inc. | Anti-VEGF antibodies |
DE69829891T2 (de) | 1997-04-07 | 2005-10-06 | Genentech, Inc., South San Francisco | Anti-VEGF Antikörper |
US6884879B1 (en) | 1997-04-07 | 2005-04-26 | Genentech, Inc. | Anti-VEGF antibodies |
US20020032315A1 (en) | 1997-08-06 | 2002-03-14 | Manuel Baca | Anti-vegf antibodies |
UA74130C2 (uk) | 1997-05-15 | 2005-11-15 | Чугаі Сейяку Кабусікі Кайся | ЗАСТОСУВАННЯ АНТИТІЛА ПРОТИ БІЛКА, СПОРІДНЕНОГО З ПАРАТИРЕОЇДНИМ ГОРМОНОМ (PTHrP), АБО ЙОГО ФУНКЦІОНАЛЬНО АКТИВНОГО ФРАГМЕНТА І/АБО ЙОГО МОДИФІКОВАНОГО ФРАГМЕНТА ДЛЯ ВИРОБНИЦТВА ЛІКАРСЬКОГО ЗАСОБУ ДЛЯ ПРОФІЛАКТИКИ АБО ЛІКУВАННЯ КАХЕКСІЇ |
EP1724282B1 (en) | 1997-05-21 | 2013-05-15 | Merck Patent GmbH | Method for the production of non-immunogenic proteins |
DK1019082T4 (da) | 1997-10-02 | 2008-10-27 | Max Planck Gesellschaft | Fremgangsmåde til moduleringen af neovaskularisering og/eller væksten af kollaterale arterier og/eller andre arterier fra forudeksisterende arteriolære forbindelser |
JP3992298B2 (ja) * | 1997-10-03 | 2007-10-17 | 中外製薬株式会社 | 天然ヒト型化抗体 |
US7179892B2 (en) | 2000-12-06 | 2007-02-20 | Neuralab Limited | Humanized antibodies that recognize beta amyloid peptide |
US20080050367A1 (en) | 1998-04-07 | 2008-02-28 | Guriq Basi | Humanized antibodies that recognize beta amyloid peptide |
TWI239847B (en) | 1997-12-02 | 2005-09-21 | Elan Pharm Inc | N-terminal fragment of Abeta peptide and an adjuvant for preventing and treating amyloidogenic disease |
US7964192B1 (en) | 1997-12-02 | 2011-06-21 | Janssen Alzheimer Immunotherapy | Prevention and treatment of amyloidgenic disease |
EP1745799B1 (en) | 1998-03-04 | 2015-09-02 | The Trustees of The University of Pennsylvania | Compositions and methods of treating tumors |
BR9909382A (pt) | 1998-04-03 | 2000-12-05 | Chugai Pharmaceutical Co Ltd | Anticorpo humanizado contra o fator tissular humano (tf) e processo de produção de anticorpo humanizado |
PL195870B1 (pl) | 1998-08-11 | 2007-11-30 | Biogen Idec Inc | Zastosowanie przeciwciała anty-CD20, zastosowanieznakowanego radioaktywnie przeciwciała anty-CD20,zastosowanie przeciwciała anty-CD20 do przygotowania leku zwierającego przeciwciało i chemioterapięoraz zastosowanie przeciwciała anty-CD20 do przygotowania leku zawierającego przeciwciało i szpik kostny |
JP4689781B2 (ja) * | 1998-09-03 | 2011-05-25 | 独立行政法人科学技術振興機構 | アミノ酸輸送蛋白及びその遺伝子 |
PT1113810E (pt) | 1998-09-14 | 2009-03-10 | Univ Texas | Processos de tratamento de mieloma múltiplo e reabsorção óssea induzida por mieloma utilizando antagonistas da ligação do receptor de integrina |
DE69922978T2 (de) | 1998-10-06 | 2005-12-08 | Emalfarb, Mark Aaron, Jupiter | Transformationsystem in filamentösen fungiziden chrysosporium-wirtszellen |
EP1939215A1 (en) | 1998-10-22 | 2008-07-02 | The University of Montana | Omp85 proteins of neisseria gonorrhoeae and neisseria meningitidis, compositions containing same and methods of use thereof |
CA2350058C (en) | 1998-11-09 | 2015-10-13 | Idec Pharmaceuticals Corporation | Treatment of hematologic malignancies associated with circulating tumor cells using chimeric anti-cd20 antibody |
GB9825632D0 (en) | 1998-11-23 | 1999-01-13 | Novartis Ag | Organic compounds |
US20030035798A1 (en) | 2000-08-16 | 2003-02-20 | Fang Fang | Humanized antibodies |
IL139321A0 (en) | 1999-03-03 | 2001-11-25 | Biogen Inc | Methods and compositions for modulating lipid metabolism |
GB9906380D0 (en) * | 1999-03-19 | 1999-05-12 | Melvin William T | Monoclonal antibodies specific for cypibi |
EA006681B1 (ru) | 1999-04-22 | 2006-02-24 | Байоджен Айдек Ма Инк. | Применение антагонистов взаимодействия vla-4 и альфа-4-бета-7 с соответствующими альфа-4-лигандами для лечения фиброза |
IT1306704B1 (it) | 1999-05-26 | 2001-10-02 | Sirs Societa Italiana Per La R | Anticorpi monoclonali e suoi derivati sintetici o biotecnologici ingrado di agire come molecole antagoniste per il ngf. |
UA81216C2 (en) | 1999-06-01 | 2007-12-25 | Prevention and treatment of amyloid disease | |
CA2375827C (en) | 1999-06-01 | 2017-01-10 | Biogen, Inc. | A blocking monoclonal antibody to vla-1 and its use for the treatment of inflammatory disorders |
US7144991B2 (en) | 1999-06-07 | 2006-12-05 | Aletheon Pharmaceuticals, Inc. | Streptavidin expressed gene fusions and methods of use thereof |
US6531580B1 (en) | 1999-06-24 | 2003-03-11 | Ixsys, Inc. | Anti-αvβ3 recombinant human antibodies and nucleic acids encoding same |
TWI255718B (en) | 1999-07-02 | 2006-06-01 | Chugai Pharmaceutical Co Ltd | Ameliorative agent for low vasopressin concentration |
US8557244B1 (en) | 1999-08-11 | 2013-10-15 | Biogen Idec Inc. | Treatment of aggressive non-Hodgkins lymphoma with anti-CD20 antibody |
DE60038252T2 (de) * | 1999-09-30 | 2009-03-19 | Kyowa Hakko Kogyo Co., Ltd. | Menschlicher Antikörper gegen Gangliosid GD3 für die Transplantationskomplentarität bestimmende Region und Derivate des Antikörpers gegen das Gangliosid GD3 |
US6849425B1 (en) | 1999-10-14 | 2005-02-01 | Ixsys, Inc. | Methods of optimizing antibody variable region binding affinity |
EP1234031B2 (en) | 1999-11-30 | 2021-11-24 | Mayo Foundation For Medical Education And Research | B7-h1, a novel immunoregulatory molecule |
DK2140881T3 (da) | 1999-12-16 | 2013-05-06 | Biogen Idec Inc | Fremgangsmåder til behandling af iskæmisk eller hæmoragisk læsion i centralnervesystemet ved anvendelse af anti-alpha-4-integrin-antagonister |
DK1265928T3 (da) | 2000-01-27 | 2010-11-15 | Medimmune Llc | RSV-neutraliserende antistoffer med ultra høj affinitet |
ATE373719T1 (de) * | 2000-02-03 | 2007-10-15 | Millennium Pharm Inc | Humanisierte antikörper gegen ccr2 und verfahren zur deren verwendung |
CA2897626C (en) | 2000-02-11 | 2020-03-24 | Biogen Idec Ma Inc. | Heterologous polypeptide of the tnf family |
KR100767146B1 (ko) | 2000-02-24 | 2007-10-15 | 워싱톤 유니버시티 | Aβ 펩티드를 격리시키는 인간화 항체 |
AU4002001A (en) | 2000-03-01 | 2001-09-12 | Med Immune Inc | High potency recombinant antibodies and method for producing them |
WO2001070266A2 (en) | 2000-03-17 | 2001-09-27 | Millennium Pharmaceuticals, Inc. | Method of inhibiting stenosis and restenosis with a mixture of antibodies anti cd18 and anti ccr2 |
US20010046496A1 (en) | 2000-04-14 | 2001-11-29 | Brettman Lee R. | Method of administering an antibody |
DE60137417D1 (de) | 2000-04-28 | 2009-03-05 | Chugai Pharmaceutical Co Ltd | Zellproliferation-inhibitoren |
US7030219B2 (en) | 2000-04-28 | 2006-04-18 | Johns Hopkins University | B7-DC, Dendritic cell co-stimulatory molecules |
ES2316446T3 (es) | 2000-04-29 | 2009-04-16 | University Of Iowa Research Foundation | Diagnostico y terapeutica para trastornos relacionados con la degeneracion macular. |
TWI318983B (en) * | 2000-05-02 | 2010-01-01 | Uab Research Foundation | An antibody selective for a tumor necrosis factor-related apoptosis-inducing ligand receptor and uses thereof |
US7279160B2 (en) | 2000-05-02 | 2007-10-09 | The Uab Research Foundation | Combinations of DR5 antibodies and other therapeutic agents |
US7476383B2 (en) | 2000-05-02 | 2009-01-13 | The Uab Research Foundation | Antibody selective for DR4 and uses thereof |
GB0013810D0 (en) | 2000-06-06 | 2000-07-26 | Celltech Chiroscience Ltd | Biological products |
GB0020685D0 (en) | 2000-08-22 | 2000-10-11 | Novartis Ag | Organic compounds |
DE60143535D1 (de) | 2000-10-02 | 2011-01-05 | Novartis Vaccines & Diagnostic | Humane antikörper gegen cd40 |
US7179900B2 (en) | 2000-11-28 | 2007-02-20 | Medimmune, Inc. | Methods of administering/dosing anti-RSV antibodies for prophylaxis and treatment |
US6989247B2 (en) | 2000-11-28 | 2006-01-24 | Celltech R & D, Inc. | Compositions and methods for diagnosing or treating psoriasis |
TWI255272B (en) | 2000-12-06 | 2006-05-21 | Guriq Basi | Humanized antibodies that recognize beta amyloid peptide |
SK12212003A3 (sk) * | 2001-04-06 | 2004-05-04 | University Of Bristol | CD25 väzbová molekula na použitie na prevenciu alebo liečenie niektorých ochorení u pacientov rezistentných na liečbu steroidmi |
IL158376A0 (en) | 2001-04-13 | 2004-05-12 | Biogen Inc | Antibodies to vla-1 |
US6972324B2 (en) | 2001-05-18 | 2005-12-06 | Boehringer Ingelheim Pharmaceuticals, Inc. | Antibodies specific for CD44v6 |
EP1397387A1 (en) * | 2001-05-18 | 2004-03-17 | BOEHRINGER INGELHEIM INTERNATIONAL GmbH | Antibodies specific for cd44v6 |
US7541443B2 (en) * | 2001-06-14 | 2009-06-02 | Tolerrx, Inc. | Anti-CD4 antibodies |
IL159177A0 (en) | 2001-06-20 | 2004-06-01 | Prochon Biotech Ltd | Antibodies that block receptor protein tyrosine kinase activation, methods of screening for and uses thereof |
US20030013081A1 (en) | 2001-06-26 | 2003-01-16 | Olson William C. | Uses of DC-SIGN and DC-SIGNR for inhibiting hepatitis C virus infection |
JP4675512B2 (ja) * | 2001-07-10 | 2011-04-27 | 三井化学株式会社 | 熱殺菌方法 |
US20030138440A1 (en) | 2001-07-19 | 2003-07-24 | Fang Fang | Multimeric proteins and methods of making and using same |
WO2003014162A1 (en) * | 2001-08-03 | 2003-02-20 | Medical & Biological Laboratories Co., Ltd. | ANTIBODY RECOGNIZING GM1 GANGLIOSIDE-BOUND AMYLOID β-PROTEIN AND DNA ENCODING THE ANTIBODY |
AU2002329775C1 (en) | 2001-08-17 | 2011-04-07 | Eli Lilly And Company | Assay method for alzheimer's disease |
PT1434871T (pt) | 2001-09-20 | 2017-04-05 | Immunex Corp | Seleção de células que expressam polipéptidos heteroméricos |
RU2305111C2 (ru) | 2001-09-25 | 2007-08-27 | Джуридикэл Фаундейшн Дзе Чемо-Серо-Терапьютик Рисерч Инститьют | Рекомбинантное антитело против остеопонтина и его применение |
GB0124317D0 (en) | 2001-10-10 | 2001-11-28 | Celltech R&D Ltd | Biological products |
US20030190705A1 (en) * | 2001-10-29 | 2003-10-09 | Sunol Molecular Corporation | Method of humanizing immune system molecules |
ATE469176T1 (de) * | 2001-11-12 | 2010-06-15 | Merck Patent Gmbh | Modifizierter anti-tnf antikörper |
BR0214350A (pt) | 2001-11-21 | 2005-05-10 | Univ Pennsylvania | Sequências de ácido nucleico e aminoácido de adenovìrus de sìmio, vetores contendo as mesmas e métodos de uso |
EP1944043A1 (en) | 2001-11-21 | 2008-07-16 | The Trustees of the University of Pennsylvania | Simian adenovirus nucleic acid and amino acid sequences, vectors containing same, and methods of use |
DK1461300T3 (da) | 2001-11-30 | 2011-10-24 | Biogen Idec Inc | Antistoffer mod kemotaktiske monocytproteiner |
US7393648B2 (en) | 2001-12-03 | 2008-07-01 | Alexion Pharmaceuticals, Inc. | Hybrid antibodies |
JP4723810B2 (ja) | 2001-12-03 | 2011-07-13 | アレクシオン ファーマシューティカルズ, インコーポレイテッド | ハイブリッド抗体 |
GB0129105D0 (en) | 2001-12-05 | 2002-01-23 | Celltech R&D Ltd | Expression control using variable intergenic sequences |
CN100522999C (zh) * | 2002-02-14 | 2009-08-05 | 免疫医疗公司 | 抗cd20抗体及其融合蛋白和使用方法 |
PT1478738E (pt) * | 2002-02-22 | 2009-02-16 | Progenics Pharm Inc | Anticorpo anti-ccr5 |
EP3173426A1 (en) | 2002-02-25 | 2017-05-31 | Biogen MA Inc. | Administration of agents for the treatment of inflammation |
MY139983A (en) | 2002-03-12 | 2009-11-30 | Janssen Alzheimer Immunotherap | Humanized antibodies that recognize beta amyloid peptide |
CN104805090A (zh) | 2002-03-13 | 2015-07-29 | 生物基因Ma公司 | 抗αvβ6抗体 |
US20060171940A1 (en) | 2002-03-20 | 2006-08-03 | Celltech R&D Limited | Antibody disulfide isomers, use thereof, and methods of analyzing same |
JP4432031B2 (ja) * | 2002-03-22 | 2010-03-17 | ズィナイス オペレーションズ ピーティーワイ.エルティーディー. | インターロイキン13受容体α1(IL−13Rα1)に対するモノクローナル抗体 |
GB0210121D0 (en) | 2002-05-02 | 2002-06-12 | Celltech R&D Ltd | Biological products |
ATE473284T1 (de) | 2002-05-14 | 2010-07-15 | Martek Biosciences Corp | Carotinsynthase-gen und dessen verwendung |
AU2003240790A1 (en) | 2002-05-28 | 2003-12-12 | Pharmacia Corporation | Antibody peg positional isomers, compositions comprising same, and use thereof |
ATE483472T1 (de) * | 2002-05-30 | 2010-10-15 | Macrogenics Inc | Cd16a bindungsproteine und verwendung zur behandlung von immunkrankheiten |
GB0213745D0 (en) | 2002-06-14 | 2002-07-24 | Univ Edinburgh | Enzyme |
AU2002319236A1 (en) | 2002-06-14 | 2003-12-31 | Monier Tadros | Method for the production of protamine |
US7132100B2 (en) | 2002-06-14 | 2006-11-07 | Medimmune, Inc. | Stabilized liquid anti-RSV antibody formulations |
AU2002368055B2 (en) * | 2002-06-28 | 2008-09-18 | The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Method of treating autoimmune diseases with interferon-beta and IL-2R antagonist |
WO2010011999A2 (en) | 2008-07-25 | 2010-01-28 | The Regents Of The University Of California | Methods and compositions for eliciting an amyloid-selective immune response |
US7432351B1 (en) | 2002-10-04 | 2008-10-07 | Mayo Foundation For Medical Education And Research | B7-H1 variants |
GB0228832D0 (en) | 2002-12-10 | 2003-01-15 | Novartis Ag | Organic compound |
US8506959B2 (en) | 2002-11-01 | 2013-08-13 | Neotope Biosciences Limited | Prevention and treatment of synucleinopathic and amyloidogenic disease |
TW200509968A (en) | 2002-11-01 | 2005-03-16 | Elan Pharm Inc | Prevention and treatment of synucleinopathic disease |
NZ540555A (en) | 2002-11-15 | 2008-04-30 | Genmab As | Antibody therapeutics for treatingand/or preventing diseases associated with cells expressing CD25, including autoimmune diseases, inflammatory and hyperproliferative skin disorders |
JP2007531505A (ja) | 2002-11-27 | 2007-11-08 | ミネルバ バイオオテクノロジーズ コーポレーション | 癌(muc1)の診断および治療のための技術および組成物 |
KR20070055625A (ko) | 2002-12-16 | 2007-05-30 | 제넨테크, 인크. | 이뮤노글로불린 변이체 및 이들의 용도 |
CA2513113A1 (en) | 2003-01-23 | 2004-08-05 | Genentech, Inc. | Methods for producing humanized antibodies and improving yield of antibodies or antigen binding fragments in cell culture |
AU2004207535A1 (en) | 2003-01-24 | 2004-08-12 | Elan Pharmaceuticals Inc. | Composition for and treatment of demyelinating diseases and paralysis by administration of remyelinating agents |
EP1460088A1 (en) | 2003-03-21 | 2004-09-22 | Biotest AG | Humanized anti-CD4 antibody with immunosuppressive properties |
US7321065B2 (en) | 2003-04-18 | 2008-01-22 | The Regents Of The University Of California | Thyronamine derivatives and analogs and methods of use thereof |
US7619070B2 (en) | 2003-04-23 | 2009-11-17 | Medarex, Inc. | Humanized antibodies to interferon alpha receptor-1 (IFNAR-1) |
AU2004232362C1 (en) | 2003-04-23 | 2008-05-29 | E. R. Squibb & Sons, L.L.C. | Compositions and methods for the therapy of inflammatory bowel disease |
PL2361928T3 (pl) | 2003-05-19 | 2017-09-29 | Prothena Biosciences Limited | Skrócone fragmenty alfa-synukleiny w chorobie z ciałami Lewy'ego |
US7358331B2 (en) | 2003-05-19 | 2008-04-15 | Elan Pharmaceuticals, Inc. | Truncated fragments of alpha-synuclein in Lewy body disease |
DK1639014T3 (da) | 2003-06-13 | 2011-01-17 | Biogen Idec Inc | Aglycosyl-anti-CD154 (CD40-ligand)-antistoffer og anvendelser deraf |
US8153410B2 (en) | 2003-07-07 | 2012-04-10 | Fox Chase Cancer Center | Alternate morpheein forms of allosteric proteins as a target for the development of bioactive molecules |
US20060162014A1 (en) | 2003-07-07 | 2006-07-20 | Jaffe Eileen K | Alternate morpheeins of allosteric proteins as a target for the development of bioactive molecules |
PT2784084T (pt) | 2003-07-08 | 2019-10-01 | Genentech Inc | Anticorpos antagonistas contra polipéptidos heterólogos il-17a/f |
EP1648998B1 (en) | 2003-07-18 | 2014-10-01 | Amgen Inc. | Specific binding agents to hepatocyte growth factor |
US7834155B2 (en) | 2003-07-21 | 2010-11-16 | Immunogen Inc. | CA6 antigen-specific cytotoxic conjugate and methods of using the same |
US20060228350A1 (en) * | 2003-08-18 | 2006-10-12 | Medimmune, Inc. | Framework-shuffling of antibodies |
GB0321997D0 (en) | 2003-09-19 | 2003-10-22 | Novartis Ag | Organic compound |
EP1693385A4 (en) * | 2003-11-11 | 2009-11-04 | Chugai Pharmaceutical Co Ltd | ANTI-CD47 ANTIBODIES HUMANIZED |
AU2004290059A1 (en) | 2003-11-12 | 2005-05-26 | Albert Einstein College Of Medicine Of Yeshiva University | Novel sequences encoding hepatitis C virus glycoproteins |
EP2070947B1 (en) | 2003-12-05 | 2014-06-11 | multimmune GmbH | Therapeutic and diagnostic anti-Hsp70 antibodies |
EP1692177A2 (en) | 2003-12-08 | 2006-08-23 | Morphotek, Inc. | Antibodies that specifically bind pms2 |
US20080025913A1 (en) | 2003-12-15 | 2008-01-31 | Bowdish Katherine S | Novel Anti-Dc-Sign Antibodies |
ITRM20030601A1 (it) * | 2003-12-24 | 2005-06-25 | Lay Line Genomics Spa | Metodo per l'umanizzazione di anticorpi e anticorpi umanizzati con esso ottenuti. |
MXPA06007856A (es) | 2004-01-07 | 2007-03-23 | Chiron Corp | Anticuerpo monoclonal especifico de factor de estimulacion de colonias de macrofagos (m-csf) y usos del mismo. |
US20070280950A1 (en) | 2004-01-19 | 2007-12-06 | Medical And Biological Laboratories Co., Ltd. | Inflammatory Cytokine Inhibitors |
WO2005081783A2 (en) | 2004-01-30 | 2005-09-09 | Dana Farber Cancer Institute | Method for determination and quantification of radiation or genotoxin exposure |
AU2005212369B2 (en) | 2004-02-10 | 2011-06-23 | Musc Foundation For Research Development | Inhibition of factor B, the alternative complement pathway and methods related thereto |
TWI359026B (en) | 2004-02-12 | 2012-03-01 | Sankyo Co | Pharmaceutical composition for the osteoclast rela |
WO2005080431A2 (en) | 2004-02-12 | 2005-09-01 | Morphotek, Inc. | Monoclonal antibodies that specifically bind to folate receptor alpha |
EP1717250A4 (en) | 2004-02-20 | 2008-10-01 | Immuno Biological Lab Co Ltd | MONOCLONAL ANTIBODY AND ITS USE |
AU2005224081B2 (en) | 2004-03-12 | 2011-06-30 | Vasgene Therapeutics, Inc. | Polypeptide compounds for inhibiting angiogenesis and tumor growth |
US7625549B2 (en) | 2004-03-19 | 2009-12-01 | Amgen Fremont Inc. | Determining the risk of human anti-human antibodies in transgenic mice |
JP2008507257A (ja) | 2004-03-19 | 2008-03-13 | アムゲン・インコーポレーテッド | V遺伝子の操作を介したヒト抗ヒト抗体の危険性の低減 |
MY162179A (en) | 2004-04-01 | 2017-05-31 | Elan Pharm Inc | Steroid sparing agents and methods of using same |
DK1734996T3 (da) | 2004-04-02 | 2013-06-10 | Univ California | Fremgangsmåder og sammensætninger til behandling og forebyggelse af sygdom, der er associeret med alfa v beta 5-integrin |
CA2568201C (en) | 2004-05-24 | 2013-07-30 | Universitat Zu Koln | Identification of ergothioneine transporter and therapeutic uses thereof |
EP1602926A1 (en) | 2004-06-04 | 2005-12-07 | University of Geneva | Novel means and methods for the treatment of hearing loss and phantom hearing |
PL2662390T3 (pl) | 2004-06-21 | 2017-12-29 | E. R. Squibb & Sons, L.L.C. | Antyciała receptora interferonu alfa I oraz ich zastosowania |
GB0414054D0 (en) | 2004-06-23 | 2004-07-28 | Owen Mumford Ltd | Improvements relating to automatic injection devices |
GEP20105059B (en) | 2004-07-26 | 2010-08-10 | Biogen Idec Inc | Anti-cd154 antibodies |
GB0417487D0 (en) | 2004-08-05 | 2004-09-08 | Novartis Ag | Organic compound |
MX2007001679A (es) | 2004-08-09 | 2007-05-23 | Elan Pharm Inc | Prevencion y tratamiento de la enfermedad sinucleinopatica y amiloidogenica. |
CA2478458A1 (en) | 2004-08-20 | 2006-02-20 | Michael Panzara | Treatment of pediatric multiple sclerosis |
FI20041204A0 (fi) | 2004-09-16 | 2004-09-16 | Riikka Lund | Menetelmät immuunivälitteisiin sairauksiin liittyvien uusien kohdegeenien hyödyntämiseksi |
AU2005291486A1 (en) | 2004-10-01 | 2006-04-13 | Max-Planck-Gesellschaft Zur Forderung Der Wissenschaften E.V. | Novel antibodies directed to the mammalian EAG1 ion channel protein |
CA2943949C (en) | 2004-10-06 | 2020-03-31 | Mayo Foundation For Medical Education And Research | B7-h1 and methods of diagnosis, prognosis, and treatment of cancer |
EA012162B1 (ru) | 2004-10-22 | 2009-08-28 | Эмджен Инк. | Способ рефолдинга рекомбинантных антител |
CA2584859C (en) | 2004-10-25 | 2017-11-07 | Merck & Co., Inc. | Anti-addl antibodies and uses thereof |
JP2008520717A (ja) | 2004-11-19 | 2008-06-19 | バイオジェン・アイデック・エムエイ・インコーポレイテッド | 多発性硬化症についての処置 |
WO2006066089A1 (en) | 2004-12-15 | 2006-06-22 | Neuralab Limited | Humanized amyloid beta antibodies for use in improving cognition |
EP2028193B1 (en) | 2005-01-05 | 2012-03-07 | f-star Biotechnologische Forschungs- und Entwicklungsges.m.b.H. | Synthetic immunoglobulin domains with binding properties engineered in regions of the molecule different from the complementarity determining regions |
NZ555937A (en) | 2005-01-27 | 2009-05-31 | Childrens Hosp & Res Ct Oak | GNA1870-based vesicle vaccines for broad spectrum protection against diseases caused by Neisseria meningitidis |
US8088579B2 (en) | 2005-02-14 | 2012-01-03 | University Of Iowa Research Foundation | Complement factor H for diagnosis of age-related macular degeneration |
US20090124993A1 (en) | 2005-02-17 | 2009-05-14 | Burkly Linda C | Treating neurological disorders |
EP1860119B1 (en) | 2005-02-28 | 2011-08-03 | Institute for Antibodies Co., Ltd. | ANTI-IgSF4 ANTIBODY AND UTILIZATION OF THE SAME |
WO2006094134A2 (en) | 2005-03-02 | 2006-09-08 | Biogen Idec Ma Inc. | Kim-1 antibodies for treatment of th2-mediated conditions |
AU2006223301B2 (en) | 2005-03-10 | 2010-11-04 | Eisai, Inc. | Anti-mesothelin antibodies |
AU2006226192A1 (en) | 2005-03-19 | 2006-09-28 | Medical Research Council | Improvements in or relating to treatment and prevention of viral infections |
PT2343320T (pt) | 2005-03-25 | 2018-01-23 | Gitr Inc | Anticorpos anti-gitr e as suas utilizações |
CA2610292C (en) | 2005-03-30 | 2015-06-02 | Minerva Biotechnologies Corporation | Proliferation of muc1 expressing cells |
ES2720288T3 (es) | 2005-03-30 | 2019-07-19 | Minerva Biotechnologies Corp | Proliferación de células que expresan MUC1 |
CN102989012B (zh) | 2005-03-31 | 2015-05-13 | 通用医疗公司 | 监测和调制hgf/hgfr活性 |
US8124350B2 (en) | 2005-04-04 | 2012-02-28 | Biogen Idec Ma Inc. | Methods and products for evaluating an immune response to a therapeutic protein |
CA2607444C (en) | 2005-04-22 | 2015-03-10 | Morphotek, Inc. | Antibodies with immune effector activity and that internalize in folate receptor alpha-positive cells |
JP2008538700A (ja) | 2005-04-22 | 2008-11-06 | モルフォテック、インク. | 免疫エフェクター活性を有するエンドシアリン細胞に内部移行する抗体 |
US20090041783A1 (en) | 2005-04-28 | 2009-02-12 | Mochida Pharmaceutical Co., Ltd. | Anti-platelet membrane glycoprotein vi monoclonal antibody |
WO2006117782A2 (en) | 2005-05-04 | 2006-11-09 | Quark Pharmaceuticals, Inc. | Recombinant antibodies against cd55 and cd59 and uses thereof |
BRPI0608604B8 (pt) | 2005-05-10 | 2021-05-25 | Incyte Corp | moduladores de 2,3-dioxigenase de indolamina e composição farmacêutica |
AU2006247188A1 (en) | 2005-05-18 | 2006-11-23 | Children's Hospital & Research Center At Oakland | Methods and compositions for immunizing against chlamydia infection |
WO2006125207A2 (en) | 2005-05-19 | 2006-11-23 | Amgen Inc. | Compositions and methods for increasing the stability of antibodies |
CA2610340C (en) | 2005-05-26 | 2016-02-16 | Vernon Michael Holers | Inhibition of the alternative complement pathway for treatment of traumatic brain injury, spinal cord injury and related conditions |
ES2605945T3 (es) | 2005-05-27 | 2017-03-17 | Biogen Ma Inc. | Anticuerpos de unión a Tweak |
EP1899376A2 (en) | 2005-06-16 | 2008-03-19 | The Feinstein Institute for Medical Research | Antibodies against hmgb1 and fragments thereof |
CA2611519A1 (en) | 2005-06-17 | 2006-12-28 | Tolerx, Inc. | Ilt3 binding molecules and uses therefor |
ATE446972T1 (de) * | 2005-06-21 | 2009-11-15 | Xoma Technology Ltd | Il-1 bindende antikörper und fragmente davon |
CN102875681A (zh) | 2005-07-08 | 2013-01-16 | 拜奥根Idec马萨诸塞公司 | 抗-αvβ6抗体及其用途 |
FR2888850B1 (fr) | 2005-07-22 | 2013-01-11 | Pf Medicament | Nouveaux anticorps anti-igf-ir et leurs applications |
KR20080035653A (ko) | 2005-07-22 | 2008-04-23 | 프로제닉스 파머슈티컬스, 인코포레이티드 | Hiv―1 감염 환자에서 바이러스 부하를 감소시키는방법 |
JP5457671B2 (ja) | 2005-07-28 | 2014-04-02 | ノバルティス アーゲー | M−csf特異的モノクローナル抗体およびその使用 |
US8193328B2 (en) | 2005-09-08 | 2012-06-05 | Philadelphia Health & Education Corporation | Identification of modulators of serine protease inhibitor Kazal and their use as anti-cancer and anti-viral agents |
EP1934605B1 (en) | 2005-09-22 | 2014-03-26 | Prosci Incorporated | Glycosylated polypeptides produced in yeast mutants and methods of use thereof |
CA2627309A1 (en) | 2005-10-28 | 2007-05-03 | Meiji Seika Kaisha, Ltd. | Pseudomonas aeruginosa outer membrane protein pa5158 |
WO2007051077A2 (en) | 2005-10-28 | 2007-05-03 | The Regents Of The University Of California | Methods and compounds for lymphoma cell detection and isolation |
NZ608431A (en) | 2005-11-01 | 2014-11-28 | Abbvie Biotechnology Ltd | Methods and compositions for diagnosing ankylosing spondylitis using biomarkers |
EP1957541A2 (en) | 2005-11-21 | 2008-08-20 | Laboratoires Serono SA | Compositions and methods of producing hybrid antigen binding molecules and uses thereof |
KR20140087058A (ko) | 2005-11-30 | 2014-07-08 | 애브비 인코포레이티드 | 아밀로이드 베타 단백질에 대한 모노클로날 항체 및 이의 용도 |
DOP2006000277A (es) | 2005-12-12 | 2007-08-31 | Bayer Pharmaceuticals Corp | Anticuerpos anti mn y métodos para su utilización |
CN103638522A (zh) | 2006-01-18 | 2014-03-19 | 通用医疗公司 | 增强淋巴功能的方法 |
WO2007096396A2 (en) | 2006-02-22 | 2007-08-30 | University Of Zurich | Methods for treating autoimmune or demyelinating diseases |
JP2009534297A (ja) | 2006-03-10 | 2009-09-24 | ザイモジェネティクス, インコーポレイテッド | Il−17aおよびil−17fの両方に結合する抗体ならびにその使用方法 |
EP2006379B1 (en) | 2006-03-23 | 2016-08-31 | Tohoku University | High functional bispecific antibody |
WO2007114340A1 (ja) | 2006-03-30 | 2007-10-11 | Meiji Seika Kaisha, Ltd. | 緑膿菌の外膜タンパク質pa0427 |
NZ610566A (en) | 2006-04-05 | 2014-09-26 | Abbvie Biotechnology Ltd | Antibody purification |
EP2708242A3 (en) | 2006-04-10 | 2014-03-26 | Abbott Biotechnology Ltd | Uses and compositions for treatment of ankylosing spondylitis |
CA2564435A1 (en) | 2006-04-10 | 2007-10-10 | Abbott Biotechnology Ltd. | Methods for monitoring and treating intestinal disorders |
EP2666472A3 (en) | 2006-04-10 | 2014-04-02 | Abbott Biotechnology Ltd | Uses and compositions for treatment of psoriatic arthritis |
CN101494978A (zh) | 2006-05-25 | 2009-07-29 | 比奥根艾迪克Ma公司 | 治疗中风的方法 |
ATE553130T1 (de) | 2006-05-31 | 2012-04-15 | Astellas Pharma Inc | Humanisierter anti-human-osteopontin-antikörper |
JP2009538924A (ja) | 2006-06-01 | 2009-11-12 | エラン ファーマシューティカルズ,インコーポレイテッド | Appの神経活性断片 |
US8101721B2 (en) | 2006-06-15 | 2012-01-24 | Fibron Ltd. | Antibodies blocking fibroblast growth factor receptor activation and methods of use thereof |
US7777008B2 (en) | 2006-06-19 | 2010-08-17 | Tolerx, Inc. | ILT3 binding molecules and uses therefor |
TWI527603B (zh) | 2006-06-30 | 2016-04-01 | 艾伯維生物技術有限責任公司 | 自動注射裝置 |
AT503889B1 (de) | 2006-07-05 | 2011-12-15 | Star Biotechnologische Forschungs Und Entwicklungsges M B H F | Multivalente immunglobuline |
US8529911B2 (en) | 2006-07-07 | 2013-09-10 | Intercell Austria Ag | Small Streptococcus pyogenes antigens and their use |
CA2662905A1 (en) | 2006-07-10 | 2008-01-17 | Biogen Idec Ma Inc. | Compositions and methods for inhibiting growth of smad4-deficient cancers |
WO2008007648A1 (fr) | 2006-07-10 | 2008-01-17 | Institute For Antibodies Co., Ltd. | Procédé de classification d'antigène, procédé d'identification d'antigène, procédé d'obtention d' un ensemble d'antigènes ou d'anticorps, procédés de construction d'un panel d'anticorps, anticorps et ens |
EP2420252A1 (en) | 2006-08-04 | 2012-02-22 | Novartis AG | EPHB3-specific antibody and uses thereof |
JP2010502573A (ja) | 2006-08-11 | 2010-01-28 | ユニヴァーシティ オブ メディスン アンド デンティストリー オブ ニュー ジャージー | 二重増感剤含有ルミネッセンス化合物および結合体、ならびにその使用 |
TWI454480B (zh) | 2006-08-18 | 2014-10-01 | Novartis Ag | 催乳激素受體(prlr)之專一性抗體及其用途 |
TW201516149A (zh) | 2006-09-13 | 2015-05-01 | Abbvie Inc | 細胞培養改良 |
EP2500414A1 (en) | 2006-09-13 | 2012-09-19 | Abbott Laboratories | Cell culture improvements |
EP2083017A4 (en) | 2006-09-14 | 2011-01-12 | Med & Biological Lab Co Ltd | ANTIBODIES HAVING INCREASED ADCC ACTIVITY AND METHOD FOR PRODUCING THE SAME |
FR2906533B1 (fr) | 2006-09-28 | 2013-02-22 | Pf Medicament | Procede de generation d'anticorps actifs contre un antigene de resistance,anticorps obtenus par ledit procede et leurs utilisations |
WO2008052796A1 (en) | 2006-11-03 | 2008-05-08 | U3 Pharma Gmbh | Fgfr4 antibodies |
CA2669731C (en) | 2006-11-10 | 2016-01-19 | Livtech Inc. | Anti-human dlk-1 antibody showing anti-tumor activity in vivo |
JP5647414B2 (ja) | 2006-11-17 | 2014-12-24 | ノバルティス アーゲー | Lingo結合分子およびその医薬用使用 |
EP1923069A1 (en) | 2006-11-20 | 2008-05-21 | Intercell AG | Peptides protective against S. pneumoniae and compositions, methods and uses relating thereto |
US8288110B2 (en) | 2006-12-04 | 2012-10-16 | Perkinelmer Health Sciences, Inc. | Biomarkers for detecting cancer |
EP2101816B1 (en) | 2006-12-07 | 2013-08-14 | Novartis AG | Antagonist antibodies against ephb3 |
WO2008073914A2 (en) | 2006-12-10 | 2008-06-19 | Dyadic International Inc. | Expression and high-throughput screening of complex expressed dna libraries in filamentous fungi |
WO2008083169A2 (en) | 2006-12-26 | 2008-07-10 | The Johns Hopkins University | Compositions and methods for the treatment of immunologic disorders |
US7989173B2 (en) | 2006-12-27 | 2011-08-02 | The Johns Hopkins University | Detection and diagnosis of inflammatory disorders |
AU2007339762B2 (en) | 2006-12-27 | 2011-03-31 | The Johns Hopkins University | Compositions and methods for treating inflammation and auto-immune diseases |
ES2533566T3 (es) | 2006-12-29 | 2015-04-13 | The Regents Of The University Of Colorado, A Body Corporate | Diana diagnóstica y terapéutica para enfermedades autoinmunitarias y sus usos |
PL2099826T3 (pl) | 2007-01-05 | 2014-04-30 | Univ Zuerich | Przeciwciało przeciwko beta-amyloidowi i jego zastosowania |
WO2008084072A2 (en) | 2007-01-12 | 2008-07-17 | Intercell Ag | Protective proteins of s. agalactiae, combinations thereof and methods of using the same |
WO2008098139A2 (en) | 2007-02-07 | 2008-08-14 | The Regents Of The University Of Colorado | Axl tyrosine kinase inhibitors and methods of making and using the same |
HUE031421T2 (hu) | 2007-02-16 | 2017-07-28 | Genzyme Corp | Eljárások pajzsmirigy rendellenességek kockázatának azonosítására |
PL3067066T3 (pl) | 2007-02-23 | 2019-09-30 | Prothena Biosciences Limited | Zapobieganie i leczenie choroby synukleinopatycznej i amyloidogennej |
EP2118300B1 (en) | 2007-02-23 | 2015-05-27 | Prothena Biosciences Limited | Prevention and treatment of synucleinopathic and amyloidogenic disease |
JP2010519256A (ja) | 2007-02-23 | 2010-06-03 | ザ・トラスティーズ・オブ・コランビア・ユニバーシティー・イン・ザ・シティー・オブ・ニューヨーク | 免疫疾患を治療するために、HLA−E/Qa−1拘束性CD8+T細胞制御性経路を活性化または遮断する方法 |
WO2008110372A1 (en) | 2007-03-13 | 2008-09-18 | University Of Zurich | Monoclonal human tumor-specific antibody |
EP3524626A1 (en) | 2007-03-22 | 2019-08-14 | Biogen MA Inc. | Binding proteins, including antibodies, antibody derivatives and antibody fragments, that specifically bind cd154 and uses thereof |
HUE031269T2 (en) | 2007-04-05 | 2017-06-28 | Morphotek Inc | Methods for inhibiting the binding of endosial ligands |
CA2683145C (en) | 2007-04-27 | 2018-06-12 | Katherine E. Lewis | Antagonists to il-17a, il-17f, and il-23p19 and methods of use |
CA2685805A1 (en) | 2007-05-02 | 2008-11-13 | Intercell Ag | Klebsiella antigens |
WO2008143797A1 (en) | 2007-05-11 | 2008-11-27 | Genzyme Corporation | Methods of producing a secreted protein |
US7709215B2 (en) | 2007-06-01 | 2010-05-04 | Cytonics Corporation | Method for diagnosing and treating acute joint injury |
EP1997830A1 (en) | 2007-06-01 | 2008-12-03 | AIMM Therapeutics B.V. | RSV specific binding molecules and means for producing them |
US8999337B2 (en) | 2007-06-11 | 2015-04-07 | Abbvie Biotechnology Ltd. | Methods for treating juvenile idiopathic arthritis by inhibition of TNFα |
US8048420B2 (en) | 2007-06-12 | 2011-11-01 | Ac Immune S.A. | Monoclonal antibody |
US8613923B2 (en) | 2007-06-12 | 2013-12-24 | Ac Immune S.A. | Monoclonal antibody |
LT2170390T (lt) | 2007-06-14 | 2019-01-10 | Biogen Ma Inc. | Natalizumabo antikūnų kompozicijos |
CA2690271A1 (en) | 2007-06-18 | 2008-12-24 | Intercell Ag | Chlamydia antigens |
WO2009000006A1 (en) | 2007-06-26 | 2008-12-31 | F-Star Biotechnologische Forschungs- Und Entwicklungsges.M.B.H. | Display of binding agents |
KR101560843B1 (ko) | 2007-06-27 | 2015-10-15 | 고꾸리쯔 다이가꾸 호우징 오사까 다이가꾸 | 페리오스틴의 Exon-17 부위에 의해 코드되는 펩티드에 대한 항체를 함유하는 암 치료제 |
AU2008275589B2 (en) | 2007-07-12 | 2013-11-21 | Gitr, Inc. | Combination therapies employing GITR binding molecules |
EP2014681A1 (en) | 2007-07-12 | 2009-01-14 | Pierre Fabre Medicament | Novel antibodies inhibiting c-met dimerization, and uses thereof |
EP2514762B1 (en) | 2007-07-13 | 2015-04-08 | The Johns Hopkins University | B7-DC variants |
ES2534490T3 (es) | 2007-08-02 | 2015-04-23 | Gilead Biologics, Inc. | Inhibidores de LOX y LOXL2 y usos de los mismos |
RU2525133C2 (ru) | 2007-08-30 | 2014-08-10 | Дайити Санкио Компани, Лимитед | Антитело к epha2 |
EP2186892A1 (en) * | 2007-09-06 | 2010-05-19 | Osaka University | Anti-cd20 monoclonal antibodies |
CA2736661A1 (en) | 2007-09-07 | 2009-03-12 | Dyadic International, Inc. | Novel fungal enzymes |
EP2185592B1 (en) | 2007-09-13 | 2013-01-23 | University Of Zurich Prorektorat Forschung | Monoclonal amyloid beta (abeta)-specific antibody and uses thereof |
MX2010002683A (es) | 2007-09-14 | 2010-03-26 | Amgen Inc | Poblaciones de anticuerpos homogeneos. |
RU2482876C2 (ru) | 2007-10-05 | 2013-05-27 | Дженентек, Инк. | Применение антитела против амилоида-бета при глазных заболеваниях |
SG187523A1 (en) | 2007-10-11 | 2013-02-28 | Daiichi Sankyo Co Ltd | Antibody targeting osteoclast-related protein siglec-15 |
JO3076B1 (ar) | 2007-10-17 | 2017-03-15 | Janssen Alzheimer Immunotherap | نظم العلاج المناعي المعتمد على حالة apoe |
WO2009051220A1 (ja) | 2007-10-19 | 2009-04-23 | Immunas Pharma, Inc. | Aβオリゴマーに特異的に結合する抗体およびその利用 |
US20100330097A1 (en) | 2007-11-01 | 2010-12-30 | Hageman Gregory S | Predicting amd with snps within or near c2, factor b, plekha1, htra1, prelp, or loc387715 |
MY149546A (en) | 2007-11-02 | 2013-09-13 | Novartis Ag | Improved nogo-a binding molecules and pharmaceutical use tereof |
CA2703519C (en) | 2007-11-09 | 2017-04-18 | The Salk Institute For Biological Studies | Use of tam receptor inhibitors as immunoenhancers and tam activators as immunosuppressors |
EP2918605A1 (en) | 2007-11-12 | 2015-09-16 | U3 Pharma GmbH | Axl antibodies |
EP2220217A2 (en) | 2007-11-28 | 2010-08-25 | The Trustees of the University of Pennsylvania | Simian subfamily c adenoviruses sadv-40, -31, and-34 and uses thereof |
PL2220241T3 (pl) | 2007-11-28 | 2017-06-30 | The Trustees Of The University Of Pennsylvania | Adenowirus zawierający kapsydowe białko heksonu SAdV-39 małpiego adenowirusa E oraz jego zastosowanie |
WO2009079242A2 (en) | 2007-12-05 | 2009-06-25 | Massachusetts Institute Of Technology | Aglycosylated immunoglobulin mutants |
WO2009078799A1 (en) | 2007-12-17 | 2009-06-25 | Marfl Ab | New vaccine for the treatment of mycobacterium related disorders |
CN101970468A (zh) | 2007-12-25 | 2011-02-09 | 明治制果株式会社 | 绿脓杆菌的ⅲ型分泌***构成蛋白质pa1698 |
PL2237803T3 (pl) | 2007-12-28 | 2015-12-31 | Prothena Therapeutics Ltd | Leczenie i profilaktyka amyloidozy |
US8591888B2 (en) | 2008-01-11 | 2013-11-26 | Synovex Corporation | Cadherin-11 EC1 domain antagonists for treating inflammatory joint disorders |
AU2009203350B2 (en) * | 2008-01-11 | 2014-03-13 | Gene Techno Science Co., Ltd. | Humanized anti-alpha9 integrin antibodies and the uses thereof |
KR101634636B1 (ko) | 2008-01-11 | 2016-06-29 | 아스텔라스세이야쿠 가부시키가이샤 | 개량형 인간화 항-인간 α9 인테그린 항체 |
ES2617604T3 (es) | 2008-02-08 | 2017-06-19 | Immunas Pharma, Inc. | Anticuerpos capaces de unirse específicamente a oligómeros de beta amiloides, y su utilización |
EP2250255A2 (en) | 2008-03-04 | 2010-11-17 | The Trustees of the University of Pennsylvania | Simian adenoviruses sadv-36,-42.1, -42.2, and -44 and uses thereof |
AU2009224690B2 (en) | 2008-03-13 | 2014-10-09 | Biotest Ag | Agent for treating disease |
BRPI0909048A2 (pt) | 2008-03-13 | 2015-11-24 | Biotest Ag | composição farmacêutica, e, método de tratamento de uma doença autoimune |
AU2009235622C9 (en) | 2008-03-13 | 2015-07-02 | Biotest Ag | Agent for treating disease |
CA2718473A1 (en) | 2008-03-17 | 2009-09-24 | Intercell Ag | Peptides protective against s. pneumoniae and compositions, methods and uses relating thereto |
WO2009116670A1 (ja) | 2008-03-17 | 2009-09-24 | 株式会社リブテック | in vivoで抗腫瘍活性を有する抗ヒトDlk-1抗体 |
US8840901B2 (en) | 2008-03-17 | 2014-09-23 | Universitaetsklinikum Muenster | YopM as delivery vehicle for cargo molecules and as biological therapeutic for immunomodulation of inflammatory reactions |
WO2009119794A1 (ja) | 2008-03-27 | 2009-10-01 | タカラバイオ株式会社 | 感染症予防、治療剤 |
BRPI0906903B8 (pt) | 2008-04-11 | 2021-05-25 | Seattle Genetics Inc | anticorpo monoclonal e método de detecção da expressão de cd70 |
EP2113255A1 (en) | 2008-05-02 | 2009-11-04 | f-star Biotechnologische Forschungs- und Entwicklungsges.m.b.H. | Cytotoxic immunoglobulin |
CA2723197C (en) | 2008-05-02 | 2017-09-19 | Seattle Genetics, Inc. | Methods and compositions for making antibodies and antibody derivatives with reduced core fucosylation |
EP3384919A1 (en) | 2008-06-02 | 2018-10-10 | Dana Farber Cancer Institute, Inc. | Cs1 peptides |
KR20110038047A (ko) | 2008-06-20 | 2011-04-13 | 고꾸리츠 다이가꾸 호우징 오까야마 다이가꾸 | 산화 LDL/β2GPI복합체에 대한 항체 및 그 용도 |
CA2728004C (en) | 2008-06-25 | 2022-05-24 | Esbatech, An Alcon Biomedical Research Unit Llc | Humanization of rabbit antibodies using a universal antibody framework |
PL2307458T3 (pl) | 2008-06-25 | 2018-08-31 | Esbatech, An Alcon Biomedical Research Unit Llc | Humanizacja przeciwciał króliczych z zastosowaniem uniwersalnego zrębu przeciwciała |
BRPI0914319B8 (pt) | 2008-06-25 | 2021-05-25 | Esbatech Alcon Biomed Res Unit | imunoligante que se liga especificamente ao tnf alfa humano e composição |
PT2824100T (pt) | 2008-07-08 | 2018-05-10 | Incyte Holdings Corp | 1,2,5-oxadiazoles como inibidores da indoleamina 2,3-dioxigenase |
JP5773650B2 (ja) | 2008-07-16 | 2015-09-02 | 株式会社医学生物学研究所 | 抗ヒトclcp1抗体とその用途 |
CA2732715C (en) | 2008-08-01 | 2015-04-07 | Kusuki Nishioka | Treatment agent or preventative agent for osteoarthritis |
US8795981B2 (en) | 2008-08-08 | 2014-08-05 | Molecular Devices, Llc | Cell detection |
US8417011B2 (en) | 2008-09-18 | 2013-04-09 | Molecular Devices (New Milton) Ltd. | Colony detection |
EP2172485A1 (en) | 2008-10-01 | 2010-04-07 | Pierre Fabre Medicament | Novel anti CXCR4 antibodies and their use for the treatment of cancer |
WO2010040029A1 (en) | 2008-10-02 | 2010-04-08 | Celtaxsys, Inc. | Methods of modulating the negative chemotaxis of immune cells |
KR20140101876A (ko) | 2008-10-09 | 2014-08-20 | 미네르바 바이오테크놀로지 코포레이션 | 세포내에서 다능성을 유도하기 위한 방법 |
DK3199553T3 (da) | 2008-10-29 | 2019-07-22 | Circular Commitment Company | Fremgangsmåder og midler til diagnosticering og behandling af hepatocellulært carcinom |
US9067981B1 (en) | 2008-10-30 | 2015-06-30 | Janssen Sciences Ireland Uc | Hybrid amyloid-beta antibodies |
US8940290B2 (en) | 2008-10-31 | 2015-01-27 | The Trustees Of The University Of Pennsylvania | Simian adenoviruses SAdV-43, -45, -46, -47, -48, -49, and -50 and uses thereof |
US8545839B2 (en) | 2008-12-02 | 2013-10-01 | Pierre Fabre Medicament | Anti-c-Met antibody |
US9469691B2 (en) | 2008-12-02 | 2016-10-18 | Pierre Fabre Medicament | Anti-cMET antibody |
AR074439A1 (es) | 2008-12-02 | 2011-01-19 | Pf Medicament | Anticuerpo anti-cmet (receptor c-met) |
MX2011006422A (es) | 2008-12-19 | 2011-09-15 | Panima Pharmaceuticals Ag | Autoanticuerpos humanos anti-alfa-sinucleina. |
US8313915B2 (en) | 2009-01-21 | 2012-11-20 | Gundersen Lutheran Medical Foundation, Inc. | Early detection of canine lyme disease by specific peptides and antibodies |
WO2010085590A1 (en) | 2009-01-23 | 2010-07-29 | Biosynexus Incorporated | Opsonic and protective antibodies specific for lipoteichoic acid gram positive bacteria |
EP2424882A2 (en) | 2009-02-05 | 2012-03-07 | Intercell AG | Peptides protective against e. faecalis, methods and uses relating thereto |
WO2010092176A2 (en) | 2009-02-13 | 2010-08-19 | Intercell Ag | Nontypable haemophilus influenzae antigens |
US20110306069A1 (en) | 2009-02-19 | 2011-12-15 | Qingyu Wu | Corin As A Marker For Heart Failure |
CN105837691B (zh) | 2009-03-10 | 2021-06-29 | 贝勒研究院 | 靶向抗原呈递细胞的癌症疫苗 |
MX2011009438A (es) | 2009-03-10 | 2012-04-02 | Baylor Res Inst | Anticuerpos anti-cd40 y usos de los mismos. |
DK2406290T3 (da) | 2009-03-10 | 2017-09-11 | Baylor Res Inst | Cancervacciner, som er målrettet mod antigenpræsenterende celler |
JP5725508B2 (ja) | 2009-03-25 | 2015-05-27 | 国立大学法人東北大学 | Lh型二重特異性抗体 |
KR101690340B1 (ko) | 2009-04-09 | 2016-12-27 | 다이이찌 산쿄 가부시키가이샤 | 항 Siglec-15 항체 |
EP3061460A1 (en) | 2009-04-10 | 2016-08-31 | Tufts Medical Center, Inc. | Par-1 activation by metalloproteinase-1 (mmp-1) |
DK2419447T3 (da) | 2009-04-17 | 2017-09-25 | Immunas Pharma Inc | Antistoffer, der specifikt binder til a beta-oligomerer og anvendelse deraf |
SG175279A1 (en) | 2009-04-29 | 2011-11-28 | Abbott Biotech Ltd | Automatic injection device |
EP2246364A1 (en) | 2009-04-29 | 2010-11-03 | Pierre Fabre Médicament | Anti CXCR4 antibodies for the treatment of HIV |
EP2270053A1 (en) | 2009-05-11 | 2011-01-05 | U3 Pharma GmbH | Humanized AXL antibodies |
CN102575232B (zh) | 2009-05-29 | 2015-07-22 | 宾夕法尼亚大学托管会 | 猿腺病毒41及其应用 |
EP2260864A1 (en) | 2009-06-10 | 2010-12-15 | University of Melbourne | Therapeutic applications |
TWI513465B (zh) | 2009-06-25 | 2015-12-21 | Regeneron Pharma | 以dll4拮抗劑與化學治療劑治療癌症之方法 |
IN2012DN00303A (da) | 2009-07-24 | 2015-05-08 | Univ California | |
CN102548466A (zh) | 2009-07-28 | 2012-07-04 | 霍夫曼-拉罗奇有限公司 | 非侵入性体内光学成像方法 |
US20120164659A1 (en) | 2009-08-05 | 2012-06-28 | Nexigen Gmbh | Human hcv-interacting proteins and methods of use |
WO2011024114A1 (en) | 2009-08-25 | 2011-03-03 | Ecole Polytechnique Federale De Lausanne (Epfl) | Targeting extracellular matrix molecules for the treatment of cancer |
TWI412375B (zh) | 2009-08-28 | 2013-10-21 | Roche Glycart Ag | 人類化抗cdcp1抗體 |
CA2772199A1 (en) | 2009-08-31 | 2011-03-03 | Amplimmune, Inc. | B7-h4 fusion proteins and methods of use thereof |
AU2010291985B2 (en) | 2009-09-14 | 2016-05-05 | The Regents Of The University Of Colorado | Modulation of yeast-based immunotherapy products and responses |
EP2305285A1 (en) | 2009-09-29 | 2011-04-06 | Julius-Maximilians-Universität Würzburg | Means and methods for treating ischemic conditions |
US8568726B2 (en) | 2009-10-06 | 2013-10-29 | Medimmune Limited | RSV specific binding molecule |
EP2308897A1 (en) | 2009-10-09 | 2011-04-13 | Pierre Fabre Medicament | Chimeric antibodies specific for CD151 and use thereof in the treatment of cancer |
EP3349010A1 (en) | 2009-10-11 | 2018-07-18 | Biogen MA Inc. | Anti-vla-4 related assays |
US8921525B2 (en) | 2009-11-18 | 2014-12-30 | Tohoku University | Highly-functional mutant of humanized anti-EGFR antibody variable region |
EP2332929A1 (en) | 2009-11-25 | 2011-06-15 | ArisGen SA | Orthoester derivatives of crown ethers as carriers for pharmaceutical and diagnostic compositions |
GB0920944D0 (en) | 2009-11-30 | 2010-01-13 | Biotest Ag | Agents for treating disease |
US9872905B2 (en) | 2009-12-01 | 2018-01-23 | President And Fellows Of Harvard College | Modulation of NK cell antigen specific effector activity by modulation of CXCR6 (CD186) |
AU2010330907A1 (en) | 2009-12-16 | 2012-06-14 | Bosch, Phillip | Methods of treating interstitial cystitis |
US9221759B2 (en) | 2010-01-13 | 2015-12-29 | Rutgers, The State University Of New Jersey | Fluorophore chelated lanthanide luminescent probes with improved quantum efficiency |
WO2011091181A1 (en) | 2010-01-20 | 2011-07-28 | Tolerx, Inc. | Immunoregulation by anti-ilt5 antibodies and ilt5-binding antibody fragments |
EP2525813B1 (en) | 2010-01-20 | 2017-01-04 | Merck Sharp & Dohme Corp. | Anti-ilt5 antibodies and ilt5-binding antibody fragments |
CA2788527A1 (en) | 2010-01-29 | 2011-08-04 | Axis Inc. | Pharmaceutical composition for osteoarthritis treatment or prevention and manufacturing method therefor |
CN102821786B (zh) | 2010-01-29 | 2016-01-13 | 阿克西斯股份有限公司 | 含有骨关节炎治疗剂的注射液 |
JP2012246222A (ja) | 2010-01-29 | 2012-12-13 | Axis Inc | 変形性関節症治療剤または予防剤を製造するための使用 |
EP2531613A2 (en) | 2010-02-02 | 2012-12-12 | Abbott Biotechnology Ltd. | Methods and compositions for predicting responsiveness to treatment with tnf-alpha inhibitor |
BR112012019780A2 (pt) | 2010-02-08 | 2020-09-01 | Agensys, Inc. | conjugados de fármaco e anticorpo (adc) que ligam a proteínas 161p2f10b |
SG183356A1 (en) | 2010-02-18 | 2012-09-27 | Univ California | INTEGRIN aVß8 NEUTRALIZING ANTIBODY |
US20130058915A1 (en) | 2010-03-02 | 2013-03-07 | Children's Medica Center Corporation | Methods and compositions for treatment of angelman syndrome and autism spectrum disorders |
CA2791538C (en) * | 2010-03-03 | 2019-04-16 | Neil R. Cashman | Oligomer-specific amyloid beta epitope and antibodies |
WO2011117392A2 (en) | 2010-03-26 | 2011-09-29 | Universitaetsklinikum Muenster | Substitute therapy for glucocorticoids |
EP2371863A1 (en) | 2010-03-30 | 2011-10-05 | Pierre Fabre Médicament | Humanized anti CXCR4 antibodies for the treatment of cancer |
EP3434694B1 (en) | 2010-04-09 | 2020-12-30 | Critical Care Diagnostics, Inc. | Soluble human st-2 antibodies and assays |
SG184318A1 (en) | 2010-04-16 | 2012-11-29 | Biogen Idec Inc | Anti-vla-4 antibodies |
CA2796186C (en) | 2010-04-21 | 2019-04-09 | Abbott Biotechnology Ltd. | Wearable automatic injection device for controlled delivery of therapeutic agents |
RU2012148816A (ru) | 2010-05-07 | 2014-06-20 | Ф. Хоффманн-Ля Рош Аг | Метод диагностики для определения клеток ex vivo |
NZ702053A (en) | 2010-05-17 | 2016-01-29 | Livtech Inc | Anti-human trop-2 antibody having antitumor activity in vivo |
WO2011146727A1 (en) | 2010-05-19 | 2011-11-24 | Philip Bosch | Methods of treating interstitial cystitis |
EP2592161B1 (en) | 2010-07-08 | 2016-02-03 | Honda Motor Co., Ltd. | High frequency heating coil |
JP5934203B2 (ja) | 2010-07-14 | 2016-06-15 | メルク・シャープ・エンド・ドーム・コーポレイション | 抗addlモノクローナル抗体およびこの使用 |
SI2593128T1 (en) | 2010-07-15 | 2018-08-31 | Adheron Therapeutics, Inc. | Humanized antibodies targeting the EC1 Kaderina-11 domain and associated compositions and procedures |
US8853150B2 (en) | 2010-07-29 | 2014-10-07 | Eleven Biotherapeutics, Inc. | Chimeric IL-1 receptor type I antagonists |
WO2012016173A2 (en) | 2010-07-30 | 2012-02-02 | Ac Immune S.A. | Safe and functional humanized antibodies |
JP2012034668A (ja) | 2010-08-12 | 2012-02-23 | Tohoku Univ | ヒト型化抗egfr抗体リジン置換可変領域断片及びその利用 |
WO2012027494A1 (en) | 2010-08-24 | 2012-03-01 | Regents Of The University Of Minnesota | Bispecific targeting reagents |
EP2609431B1 (en) | 2010-08-27 | 2017-05-10 | University of Zurich | Method for target and drug validation in inflammatory and/or cardiovascular diseases |
JP2013540991A (ja) | 2010-08-27 | 2013-11-07 | ユニバーシティ・オブ・チューリッヒ | 炎症および/または心血管疾患における新規診断および治療標的 |
WO2012028697A1 (en) | 2010-09-01 | 2012-03-08 | Eth Zürich, Institute Of Molecular Biology And Biophysics | Affinity purification system based on donor strand complementation |
US20120244141A1 (en) | 2010-09-28 | 2012-09-27 | Boehringer Ingelheim International Gmbh | Stratification of cancer patients for susceptibility to therapy with PTK2 inhibitors |
WO2012043747A1 (ja) | 2010-09-30 | 2012-04-05 | 独立行政法人理化学研究所 | グリオーマの治療方法、グリオーマの検査方法、所望の物質をグリオーマに送達させる方法、及びそれらの方法に用いられる薬剤 |
US8497138B2 (en) | 2010-09-30 | 2013-07-30 | Genetix Limited | Method for cell selection |
NZ609984A (en) | 2010-10-11 | 2015-05-29 | Biogen Idec Internat Neuroscience Gmbh | Human anti-tau antibodies |
CN103261223B (zh) | 2010-10-13 | 2017-03-29 | 詹森生物科技公司 | 人制瘤素m抗体及使用方法 |
ES2632486T3 (es) | 2010-10-18 | 2017-09-13 | Mediapharma S.R.L. | Anticuerpo de unión a ErbB3 |
JP6121906B2 (ja) | 2010-10-22 | 2017-04-26 | シアトル ジェネティクス,インコーポレーテッド | アウリスタチン系抗体薬物複合体とPI3K−AKTmTOR経路インヒビターの間の相乗効果 |
AR083495A1 (es) | 2010-10-22 | 2013-02-27 | Esbatech Alcon Biomed Res Unit | Anticuerpos estables y solubles |
RS60565B1 (sr) | 2010-10-25 | 2020-08-31 | Biogen Ma Inc | Postupci za određivanje razlika u aktivnosti alfa-4 integrina putem uspostavljanja korelacije sa razlikama u nivoima svcam i/ili smadcam |
EP2632953A1 (en) | 2010-10-27 | 2013-09-04 | Pierre Fabre Medicament | Antibodies for the treatment of hiv |
AU2011321374B2 (en) | 2010-10-29 | 2016-04-28 | Daiichi Sankyo Company,Limited | Novel anti-DR5 antibody |
EP2640425A2 (en) | 2010-11-18 | 2013-09-25 | Beth Israel Deaconess Medical Center, Inc. | Methods of treating obesity by inhibiting nicotinamide n-methyl transferase (nnmt) |
KR101919170B1 (ko) | 2010-11-19 | 2018-11-15 | 에자이 알앤드디 매니지먼트 가부시키가이샤 | 중화 항-ccl20 항체 |
EP3075860A1 (en) | 2010-11-23 | 2016-10-05 | The Trustees of the University of Pennsylvania | Subfamily e simian adenovirus a1295 and uses thereof |
JP6067575B2 (ja) | 2010-12-17 | 2017-01-25 | ニューリミューン ホールディング エイジー | ヒト抗sod1抗体 |
WO2012090939A1 (ja) | 2010-12-27 | 2012-07-05 | 国立大学法人名古屋大学 | 受容体型チロシンキナーゼが仲介する癌細胞の生存促進性シグナルを抑制する方法 |
DK2663580T3 (da) | 2011-01-10 | 2017-03-13 | Ct Atlantic Ltd | Kombinationsterapi omfattende tumorassocierede antigenbindende antistoffer |
CA2858350A1 (en) | 2011-01-14 | 2013-07-19 | The Regents Of The University Of California | Therapeutic antibodies against ror-1 protein and methods for use of same |
WO2012103141A1 (en) | 2011-01-24 | 2012-08-02 | Abbott Biotechnology Ltd. | Automatic injection devices having overmolded gripping surfaces |
WO2012104824A1 (en) | 2011-02-04 | 2012-08-09 | Ecole polytechnique fédérale de Lausanne (EPFL) | Therapeutic antibodies targeting app-c99 |
WO2012107589A1 (en) | 2011-02-11 | 2012-08-16 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment and prevention of hcv infections |
WO2012110843A1 (en) | 2011-02-18 | 2012-08-23 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for promoting fibrinolysis and thrombolysis |
US20140044644A1 (en) | 2011-02-21 | 2014-02-13 | University Of Zurich | Ankyrin g and modulators thereof for the treatment of neurodegenerative disorders |
WO2012119999A1 (en) | 2011-03-07 | 2012-09-13 | F. Hoffmann-La Roche Ag | Means and methods for in vivo testing of therapeutic antibodies |
WO2012120004A1 (en) | 2011-03-07 | 2012-09-13 | F. Hoffmann-La Roche Ag | In vivo selection of therapeutically active antibodies |
US10139420B2 (en) | 2011-03-09 | 2018-11-27 | ISNERM (Institut National de la Sante et de la Recherche Medicale) | Methods for treating vaso-occlusive crisis using non-modified annexin V |
WO2012125680A1 (en) | 2011-03-16 | 2012-09-20 | Novartis Ag | Methods of treating vasculitis using an il-17 binding molecule |
WO2012123590A1 (de) | 2011-03-17 | 2012-09-20 | Miltenyi Biotec Gmbh | Tcralpha/beta-depletierte zellpräparationen |
WO2012135132A1 (en) | 2011-03-25 | 2012-10-04 | Baylor Research Institute | Compositions and methods to immunize against hepatitis c virus |
TW201249867A (en) | 2011-04-01 | 2012-12-16 | Astellas Pharma Inc | Novel anti-human il-23 receptor antibody |
EP3020428A1 (en) | 2011-04-21 | 2016-05-18 | AbbVie Inc. | Wearable automatic injection device for controlled administration of therapeutic agents |
TWI561531B (en) | 2011-04-25 | 2016-12-11 | Daiichi Sankyo Co Ltd | Anti b7-h3 antibody |
DK2704742T3 (da) | 2011-05-02 | 2017-10-23 | Millennium Pharm Inc | Formulering til anti-4-7-antistof |
UA116189C2 (uk) | 2011-05-02 | 2018-02-26 | Мілленніум Фармасьютікалз, Інк. | КОМПОЗИЦІЯ АНТИ-α4β7 АНТИТІЛА |
UA117218C2 (uk) | 2011-05-05 | 2018-07-10 | Мерк Патент Гмбх | Поліпептид, спрямований проти il-17a, il-17f та/або il17-a/f |
WO2012154889A1 (en) | 2011-05-09 | 2012-11-15 | The Cleveland Clinic Foundation | Serum s100b and uses thereof |
WO2012163848A1 (en) | 2011-05-27 | 2012-12-06 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of crohn's disease |
EP2530088A1 (en) | 2011-05-30 | 2012-12-05 | Klinikum rechts der Isar der Technischen Universität München | Means and methods for diagnosing and treating multiple sclerosis |
US20140093514A1 (en) | 2011-06-03 | 2014-04-03 | University Of Zurich | Magea3 binding antibodies |
JP2014524891A (ja) | 2011-06-03 | 2014-09-25 | シーティー アトランティック リミテッド | Magea3結合抗体 |
JP6305919B2 (ja) | 2011-06-06 | 2018-04-04 | プロセナ バイオサイエンシーズ リミテッド | Mcamアンタゴニスト及び治療の方法 |
WO2012172449A1 (en) | 2011-06-13 | 2012-12-20 | Pfizer Inc. | Lactams as beta secretase inhibitors |
US20140120555A1 (en) | 2011-06-20 | 2014-05-01 | Pierre Fabre Medicament | Anti-cxcr4 antibody with effector functions and its use for the treatment of cancer |
HUE041391T2 (hu) | 2011-06-23 | 2019-05-28 | Biogen Int Neuroscience Gmbh | Anti-alfa-szinukleinkötõ molekulák |
DE202011103324U1 (de) | 2011-07-12 | 2012-01-02 | Nekonal S.A.R.L. | Therapeutische anti-TIRC7 Antikörper für die Verwendung in Immun und anderen Krankheiten |
GB201112056D0 (en) | 2011-07-14 | 2011-08-31 | Univ Leuven Kath | Antibodies |
US20140308275A1 (en) | 2011-07-27 | 2014-10-16 | Inserm (Institut National De La Sante Et De La Recherche Medicale | Methods for diagnosing and treating myhre syndrome |
CN103748222B (zh) | 2011-08-11 | 2015-07-22 | 安斯泰来制药株式会社 | 新型抗人ngf抗体 |
US20140271680A1 (en) | 2011-08-12 | 2014-09-18 | Universite Paris-Est Creteil Val De Marne | Methods and pharmaceutical compositions for treatment of pulmonary hypertension |
EP2743699A4 (en) | 2011-08-12 | 2015-04-08 | Nat Inst Infectious Diseases | METHOD FOR THE TEST, PREVENTION AND TREATMENT OF ASPERGILLUS FUMIGATUS INFECTIOUS DISEASE, AND COMPOSITION |
GB201116092D0 (en) | 2011-09-16 | 2011-11-02 | Bioceros B V | Antibodies and uses thereof |
AU2012311234B2 (en) | 2011-09-19 | 2017-09-28 | Axon Neuroscience Se | Protein-based therapy and diagnosis of tau-mediated pathology in Alzheimer's disease |
GB2495115A (en) * | 2011-09-29 | 2013-04-03 | Oxford Plastic Sys Ltd | Base for supporting temporary fence panels or posts. |
TW201329105A (zh) | 2011-10-04 | 2013-07-16 | Thr Trustees Of Columbia University In The City Of New York | 人類notch1引誘物 |
EP2764118A1 (en) | 2011-10-05 | 2014-08-13 | University of Bremen | Wnt4 and med12 for use in the diagnosis and treatment of tumor diseases |
WO2013050441A1 (en) | 2011-10-05 | 2013-04-11 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical composition for inhibiting or preventing platelet aggregation |
WO2013054320A1 (en) | 2011-10-11 | 2013-04-18 | Tel Hashomer Medical Research Infrastructure And Services Ltd. | Antibodies to carcinoembryonic antigen-related cell adhesion molecule (ceacam) |
WO2013055911A1 (en) | 2011-10-14 | 2013-04-18 | Dana-Farber Cancer Institute, Inc. | Znf365/zfp365 biomarker predictive of anti-cancer response |
CN103998598A (zh) | 2011-10-17 | 2014-08-20 | 米纳瓦生物技术公司 | 用于干细胞增殖和诱导的培养基 |
WO2013057313A1 (en) | 2011-10-20 | 2013-04-25 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for the detection and the treatment of cardiac remodeling |
EP2589609A1 (en) | 2011-11-03 | 2013-05-08 | Pierre Fabre Medicament | Antigen binding protein and its use as addressing product for the treatment of cancer |
US9427464B2 (en) | 2011-11-22 | 2016-08-30 | Chiome Bioscience Inc. | Anti-human TROP-2 antibody having an antitumor activity in vivo |
EP2782933A1 (en) | 2011-11-22 | 2014-10-01 | Institut National de la Santé et de la Recherche Médicale (INSERM) | Methods and pharmaceutical compositions for reducing airway hyperresponse |
US9381229B2 (en) | 2011-11-28 | 2016-07-05 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Pharmaceutical composition for use in the treatment of dysfunction associated with aging |
EP2602621A1 (en) | 2011-12-08 | 2013-06-12 | Julius-Maximilians-Universität Würzburg | LASP-1, a novel urinary marker for transitional cell carcinoma detection |
SG11201403134PA (en) * | 2011-12-13 | 2014-07-30 | Nordic Nanovector As | Chimeric therapeutic anti - cd37 antibodie hh1 |
FR2984750B1 (fr) | 2011-12-23 | 2014-01-10 | Lfb Biotechnologies | Nouvelles compositions pharmaceutiques comprenant un anticorps liant le recepteur humain de l'hormone anti-mullerienne de type ii |
US20150030602A1 (en) | 2011-12-23 | 2015-01-29 | Phenoquest Ag | Antibodies for the treatment and diagnosis of affective and anxiety disorders |
WO2013098419A1 (en) | 2011-12-28 | 2013-07-04 | Immunoqure Ag | Method of providing monoclonal auto-antibodies with desired specificity |
WO2013098813A1 (en) | 2012-01-01 | 2013-07-04 | Qbi Enterprises Ltd. | Endo180-targeted particles for selective delivery of therapeutic and diagnostic agents |
AU2013216863B2 (en) | 2012-02-10 | 2018-09-06 | Seagen Inc. | Detection and treatment of CD30+ cancers |
WO2013123114A2 (en) | 2012-02-16 | 2013-08-22 | Santarus, Inc. | Antibody formulations |
WO2013124419A1 (en) | 2012-02-23 | 2013-08-29 | U3 Pharma Gmbh | Her3 inhibitor for modulating radiosensitivity |
WO2013129454A1 (ja) | 2012-02-28 | 2013-09-06 | アステラス製薬株式会社 | 新規抗ヒトil-23受容体抗体 |
JO3787B1 (ar) | 2012-03-15 | 2021-01-31 | Janssen Biotech Inc | أجسام مضادة بشرية ضد cd27 و طرق و استخداماتها |
EP2828284B1 (en) | 2012-03-20 | 2019-05-08 | Biogen MA Inc. | Jcv neutralizing antibodies |
JP6059205B2 (ja) | 2012-03-30 | 2017-01-11 | 第一三共株式会社 | CDR改変抗Siglec−15抗体 |
CA2868965A1 (en) | 2012-03-30 | 2013-10-03 | Daiichi Sankyo Company, Limited | Anti-siglec-15 antibody |
EP2833900B1 (en) | 2012-04-01 | 2018-09-19 | Technion Research & Development Foundation Limited | Extracellular matrix metalloproteinase inducer (emmprin) peptides and binding antibodies |
CN103382223B (zh) | 2012-04-01 | 2015-06-10 | 上海益杰生物技术有限公司 | 针对表皮生长因子受体隐蔽表位和t细胞抗原的多功能抗体多肽 |
CA2869394A1 (en) | 2012-04-02 | 2013-10-10 | Gundersen Lutheran Health System, Inc. | Reagents, methods, and kits for the classification of cancer |
WO2013154206A1 (ja) | 2012-04-09 | 2013-10-17 | 第一三共株式会社 | 抗fgfr2抗体 |
CN104768973B (zh) | 2012-04-27 | 2019-01-22 | 第一三共株式会社 | 抗robo4抗体 |
US9062120B2 (en) | 2012-05-02 | 2015-06-23 | Janssen Biotech, Inc. | Binding proteins having tethered light chains |
EP2848633B1 (en) | 2012-05-11 | 2019-02-06 | Microbial Chemistry Research Foundation | Anti-cxadr antibody |
JP6122948B2 (ja) | 2012-05-15 | 2017-04-26 | モルフォテック, インコーポレイテッド | 胃癌の治療のための方法 |
BR112014028684A2 (pt) | 2012-05-18 | 2017-07-25 | Univ Pennsylvania | subfamília e adenovírus de símio a1302, a1320, a1331 e a1337 e usos dos mesmos |
WO2013174834A1 (en) | 2012-05-22 | 2013-11-28 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for diagnosing and treating focal segmental glomerulosclerosis |
IN2014KN02831A (da) | 2012-05-24 | 2015-05-08 | Mountgate Group Ltd | |
EP4019041B1 (en) | 2012-07-13 | 2022-12-28 | The Trustees of the University of Pennsylvania | Toxicity management for anti-tumor activity of cars |
PL2875049T3 (pl) | 2012-07-18 | 2019-07-31 | Institut National De La Santé Et De La Recherche Médicale (Inserm) | Sposoby zapobiegania i leczenia przewlekłej choroby nerek (ckd) |
CN104582717B (zh) | 2012-07-19 | 2018-03-13 | 雷德伍德生物科技股份有限公司 | 对cd22有特异性的抗体及其使用方法 |
AU2013297478B2 (en) | 2012-07-30 | 2018-12-20 | Medical & Biological Laboratories Co., Ltd. | Monoclonal antibody against human midkine |
PL3489261T3 (pl) | 2012-08-24 | 2021-08-16 | The Regents Of The University Of California | Przeciwciała i szczepionki do stosowania w leczeniu nowotworów z ekspresją ROR1 i w hamowaniu przerzutu |
TWI660972B (zh) | 2012-09-10 | 2019-06-01 | 愛爾蘭商尼歐托普生物科學公司 | 抗mcam抗體及相關使用方法 |
SG11201501924UA (en) | 2012-09-13 | 2015-05-28 | Chugai Pharmaceutical Co Ltd | Gene knock-in non-human animal |
EP2711016A1 (en) | 2012-09-21 | 2014-03-26 | Covagen AG | Novel IL-17A binding molecules and medical uses thereof |
RS57120B1 (sr) | 2012-10-03 | 2018-06-29 | Chiome Bioscience Inc | Anti-humano dlk-1 antitelo koje ima in vivo aktivnost protiv tumora |
EP3677310A1 (en) | 2012-10-08 | 2020-07-08 | St. Jude Children's Research Hospital | Therapies based on control of regulatory t cell stability and function via a neuropilin-1:semaphorin axis |
SI2907824T1 (en) | 2012-10-11 | 2018-06-29 | Daiichi Sankyo Company, Limited | THE HEALTHY KJUBIER OF THE PROTITEL |
DE102012020496A1 (de) | 2012-10-18 | 2014-04-24 | Charité - Universitätsmedizin Berlin | Biomarker zur Diagnostik und Behandlung von Neurofibromatose Typ 1 |
US9872924B2 (en) | 2012-10-19 | 2018-01-23 | Daiichi Sankyo Company, Limited | Antibody-drug conjugate produced by binding through linker having hydrophilic structure |
WO2014064203A1 (en) | 2012-10-26 | 2014-05-01 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Lyve-1 antagonists for preventing or treating a pathological condition associated with lymphangiogenesis |
JP6694712B2 (ja) | 2012-11-01 | 2020-05-20 | マックス−デルブルック−セントラム フアー モレキュラーレ メデジン | Cd269(bcma)に対する抗体 |
WO2014068139A1 (en) | 2012-11-05 | 2014-05-08 | Pierre Fabre Medicament | Novel antigen binding proteins and their use as addressing product for the treatment of cancer |
EP2917347B1 (en) | 2012-11-08 | 2019-01-02 | Institut National de la Sante et de la Recherche Medicale (INSERM) | Methods and pharmaceutical compositions for the treatment of bone metastases |
AR093445A1 (es) | 2012-11-14 | 2015-06-10 | Regeneron Pharma | Metodos para tratar el cancer de ovario con antagonistas de dll4 |
WO2014093396A1 (en) | 2012-12-10 | 2014-06-19 | Biogen Idec Ma Inc. | Anti-blood dendritic cell antigen 2 antibodies and uses thereof |
US20160185847A1 (en) | 2012-12-17 | 2016-06-30 | Laboratoire Francais Du Fractionnement Et Des Biotechnologies | Use of monoclonal antibodies for the treatment of inflammation and bacterial infections |
WO2014100602A1 (en) | 2012-12-20 | 2014-06-26 | Hospital For Special Surgery | Treatment of egf-receptor dependent pathologies |
LT2935326T (lt) | 2012-12-21 | 2020-12-10 | Biogen Ma Inc. | Žmogaus antikūnai prieš tau baltymą |
JP6407165B2 (ja) | 2012-12-31 | 2018-10-17 | ニューリミューン ホールディング エイジー | ポリオーマウイルス関連疾患の治療および防止のための組換えヒト抗体 |
EP2752426A1 (en) | 2013-01-03 | 2014-07-09 | Covagen AG | Human serum albumin binding compounds and fusion proteins thereof |
MX2015009547A (es) | 2013-01-28 | 2015-11-25 | Evec Inc | Anticuerpo anti-hmgb1 humanizado o fragmento de union al antigeno del mismo. |
US20150377888A1 (en) | 2013-02-01 | 2015-12-31 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for Predicting and Preventing Metastasis in Triple Negative Breast Cancers |
JP6357113B2 (ja) | 2013-02-08 | 2018-07-11 | 株式会社医学生物学研究所 | ヒトnrg1タンパク質に対する抗体 |
WO2014124677A1 (en) | 2013-02-15 | 2014-08-21 | Esbatech - A Novartis Company Llc | Acceptor framework for cdr grafting |
EP2958939A1 (en) | 2013-02-20 | 2015-12-30 | ESBATech - a Novartis Company LLC | Acceptor framework for cdr grafting |
FR3004184B1 (fr) | 2013-02-26 | 2016-03-18 | Agronomique Inst Nat Rech | Anticorps anti-gluten desamide et utilisations. |
US9429584B2 (en) | 2013-02-28 | 2016-08-30 | National Cancer Center | Antibody against insoluble fibrin |
ES2811060T3 (es) | 2013-03-08 | 2021-03-10 | Univ Osaka | Anticuerpo contra péptido codificado por exón-21 de periostina y composición farmacéutica para prevenir o tratar enfermedades asociadas a inflamación que contienen el mismo |
AU2014243839B2 (en) | 2013-03-13 | 2019-01-03 | Buzzard Pharmaceuticals AB | Chimeric cytokine formulations for ocular delivery |
US10023608B1 (en) | 2013-03-13 | 2018-07-17 | Amgen Inc. | Protein purification methods to remove impurities |
US10081673B2 (en) | 2013-03-14 | 2018-09-25 | Ffe Therapeutics Llc | Compositions and methods for treating angiogenesis-related disorders |
US9302005B2 (en) | 2013-03-14 | 2016-04-05 | Mayo Foundation For Medical Education And Research | Methods and materials for treating cancer |
WO2014144466A1 (en) | 2013-03-15 | 2014-09-18 | Biogen Idec Ma Inc. | Anti-alpha v beta 6 antibodies and uses thereof |
JP2016515120A (ja) | 2013-03-15 | 2016-05-26 | バイオジェン・エムエイ・インコーポレイテッドBiogen MA Inc. | 抗アルファvベータ5抗体を用いた急性腎損傷の治療及び予防 |
US10035860B2 (en) | 2013-03-15 | 2018-07-31 | Biogen Ma Inc. | Anti-alpha V beta 6 antibodies and uses thereof |
PE20160690A1 (es) | 2013-03-18 | 2016-08-14 | Biocerox Prod Bv | Anticuerpos anti-cd134 (ox40) humanizados y usos de los mismos |
US9969804B2 (en) | 2013-04-01 | 2018-05-15 | The Regents Of The University Of California | Methods and compositions for treating and preventing disease associated with alpha-V beta-8 integrin |
WO2014174596A1 (ja) | 2013-04-23 | 2014-10-30 | 株式会社医学生物学研究所 | ヘパリン結合上皮増殖因子様増殖因子に対する機能性モノクローナル抗体 |
US9717648B2 (en) | 2013-04-24 | 2017-08-01 | Corning Incorporated | Delamination resistant pharmaceutical glass containers containing active pharmaceutical ingredients |
CN104140974B (zh) | 2013-05-08 | 2017-09-29 | 科济生物医药(上海)有限公司 | 编码gpc‑3嵌合抗原受体蛋白的核酸及表达gpc‑3嵌合抗原受体蛋白的t淋巴细胞 |
CA2952390A1 (en) | 2013-06-20 | 2014-12-24 | The Trustees Of The University Of Pennsylvania | Methods for diagnosing pancreatic cancer |
CN112358548A (zh) | 2013-07-03 | 2021-02-12 | 因美诺克股份公司 | 人抗IFN-α抗体、IFN-α结合片段、多核苷酸、组合物、试剂盒及应用和制备方法 |
WO2015003114A1 (en) | 2013-07-05 | 2015-01-08 | University Of Washington Through Its Center For Commercialization | Soluble mic neutralizing monoclonal antibody for treating cancer |
WO2015001082A1 (en) | 2013-07-05 | 2015-01-08 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Novel alternative splice transcripts for mhc class i related chain alpha (mica) and uses thereof |
TR201906969T4 (tr) | 2013-08-09 | 2019-06-21 | Astellas Pharma Inc | Yeni anti-insan tslp reseptör antikoru. |
US20160216262A1 (en) | 2013-09-12 | 2016-07-28 | Institut National De La Sante Et De La Recherche Medicale | Method for In Vitro Quantifying Allo-Antibodies, Auto-Antibodies and/or Therapeutic Antibodies |
AU2014322988B2 (en) | 2013-09-20 | 2018-12-06 | Westfaelische Wilhelms-Universitaet Muenster | Cell-penetrating bacterial E3-ubiqitin-ligases for use in immunotherapy |
EP3049438B1 (en) | 2013-09-24 | 2018-07-25 | The Feinstein Institute for Medical Research | Peptides inhibiting cold-inducible rna binding protein activity |
US9974788B2 (en) | 2013-09-26 | 2018-05-22 | Beth Israel Deaconess Medical Center, Inc. | Inhibition of SGK1 in the treatment of heart conditions |
MX2016003643A (es) | 2013-09-30 | 2016-12-20 | Daiichi Sankyo Co Ltd | Anticuerpo anti-lps o11. |
EP3052131B1 (en) | 2013-10-01 | 2018-12-05 | Mayo Foundation for Medical Education and Research | Methods for treating cancer in patients with elevated levels of bim |
EP3056215B1 (en) | 2013-10-08 | 2019-11-20 | Daiichi Sankyo Company, Limited | Combination of anti-fgfr2 antibody and other agent |
MA39090B2 (fr) | 2013-11-06 | 2021-10-29 | Janssen Biotech Inc | Anticorps anti-ccl17 |
WO2015068781A1 (ja) | 2013-11-06 | 2015-05-14 | 国立大学法人大阪大学 | インフルエンザウイルスa型のグループ1に対して広域な中和活性を有する抗体 |
JP2016538286A (ja) | 2013-11-15 | 2016-12-08 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | 膵臓癌を処置するための方法及び医薬組成物 |
WO2015082446A1 (en) | 2013-12-02 | 2015-06-11 | F. Hoffmann-La Roche Ag | Treatment of cancer using an anti-cdcp1 antibody and a taxane |
MX2016008520A (es) | 2013-12-24 | 2016-11-30 | Astellas Pharma Inc | Anticuerpo bdca-2 antihumano novedoso. |
KR102088169B1 (ko) | 2013-12-25 | 2020-03-12 | 다이이찌 산쿄 가부시키가이샤 | 항 trop2 항체-약물 컨쥬게이트 |
AU2015205327B2 (en) | 2014-01-09 | 2019-02-14 | Hadasit Medical Research Services And Development Ltd. | Improved cell compositions and methods for cancer therapy |
JP7037884B2 (ja) | 2014-01-13 | 2022-03-17 | ベイラー リサーチ インスティテュート | Hpv及びhpv関連疾患に対する新規のワクチン |
CN104774264B (zh) | 2014-01-15 | 2018-09-14 | 上海易乐生物技术有限公司 | 抗人proBDNF单克隆抗体及其在疼痛中的作用 |
KR102190548B1 (ko) | 2014-01-31 | 2020-12-14 | 다이이찌 산쿄 가부시키가이샤 | 항-her2 항체-약물 접합체 |
WO2015124588A1 (en) | 2014-02-18 | 2015-08-27 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of diseases mediated by the nrp-1/obr complex signaling pathway |
WO2015124570A1 (en) | 2014-02-18 | 2015-08-27 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical composition for the treatment of influenza a virus infection |
EP3415160B1 (en) | 2014-03-04 | 2021-08-18 | Klinikum der Universität München | Polypeptides derived from enterococcus and their use for vaccination and the generation of therapeutic antibodies |
WO2015140351A1 (en) | 2014-03-21 | 2015-09-24 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for enhancing myelination |
EP3122768A2 (en) | 2014-03-27 | 2017-02-01 | Yeda Research and Development Co. Ltd. | T-cell receptor cdr3 peptides and antibodies |
KR20240008415A (ko) | 2014-04-10 | 2024-01-18 | 다이이찌 산쿄 가부시키가이샤 | 항her3 항체-약물 콘주게이트 |
WO2015164743A2 (en) | 2014-04-24 | 2015-10-29 | Dana-Farber Cancer Institute, Inc. | Tumor suppressor and oncogene biomarkers predictive of anti-immune checkpoint inhibitor response |
LT3134124T (lt) | 2014-04-25 | 2019-05-27 | Pierre Fabre Médicament | Igf-1r antikūno ir vaisto konjugatas, ir jo panaudojimas vėžio gydymui |
MA53069B1 (fr) | 2014-04-25 | 2022-04-29 | Pf Medicament | Anticorps igf-1r et son utilisation comme véhicule d'adressage pour le traitement du cancer |
SI3134125T1 (sl) | 2014-04-25 | 2020-02-28 | Pierre Fabre Medicament | Konjugat zdravila s protitelesom in uporaba le-tega za zdravljenje raka |
US11427647B2 (en) | 2014-04-27 | 2022-08-30 | Famewave Ltd. | Polynucleotides encoding humanized antibodies against CEACAM1 |
AP2016009564A0 (en) | 2014-04-27 | 2016-11-30 | Ccam Biotherapeutics Ltd | Humanized antibodies against ceacam1 |
WO2015179654A1 (en) | 2014-05-22 | 2015-11-26 | Mayo Foundation For Medical Education And Research | Distinguishing antagonistic and agonistic anti b7-h1 antibodies |
TWI713453B (zh) | 2014-06-23 | 2020-12-21 | 美商健生生物科技公司 | 干擾素α及ω抗體拮抗劑 |
EP3160493A4 (en) | 2014-06-26 | 2018-04-11 | Yale University | Compositions and methods to regulate renalase in the treatment of diseases and disorders |
CN105315375B (zh) | 2014-07-17 | 2021-04-23 | 恺兴生命科技(上海)有限公司 | 靶向cld18a2的t淋巴细胞及其制备方法和应用 |
ES2825708T3 (es) | 2014-07-17 | 2021-05-17 | Univ Pennsylvania | Métodos para usar exosomas para monitorizar el estado de órgano trasplantado |
WO2016014148A1 (en) | 2014-07-23 | 2016-01-28 | Mayo Foundation For Medical Education And Research | Targeting dna-pkcs and b7-h1 to treat cancer |
SG10201902850TA (en) | 2014-09-30 | 2019-04-29 | Neurimmune Holding Ag | Human-derived anti-dipeptide repeats (dprs) antibody |
JP2017531642A (ja) | 2014-10-03 | 2017-10-26 | マサチューセッツ インスティテュート オブ テクノロジー | エボラ糖タンパク質に結合する抗体およびその使用 |
WO2016057367A1 (en) | 2014-10-06 | 2016-04-14 | Dana-Farber Cancer Institute, Inc. | Angiopoietin-2 biomarkers predictive of anti-immune checkpoint response |
AU2015328163B2 (en) | 2014-10-09 | 2020-10-15 | Dana-Farber Cancer Institute, Inc. | Multiple-variable IL-2 dose regimen for treating immune disorders |
WO2016081835A2 (en) | 2014-11-21 | 2016-05-26 | University Of Maryland, Baltimore | Targeted structure-specific particulate delivery systems |
US20170319661A1 (en) | 2014-12-03 | 2017-11-09 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Methods and Pharmaceutical Compositions Using Orexins (OXA, OXB) for the Treatment of Prostate Cancers |
US20180031579A1 (en) | 2015-02-12 | 2018-02-01 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for predicting the responsiveness of a patient affected with malignant hematological disease to chemotherapy treatment and methods of treatment of such disease |
AU2016229238B2 (en) | 2015-03-06 | 2022-06-02 | Dana-Farber Cancer Institute, Inc. | PD-L2 biomarkers predictive of PD-1 pathway inhibitor responses in esophagogastric cancers |
EP3067062A1 (en) | 2015-03-13 | 2016-09-14 | Ipsen Pharma S.A.S. | Combination of tasquinimod or a pharmaceutically acceptable salt thereof and a pd1 and/or pdl1 inhibitor, for use as a medicament |
EP3271397B1 (en) | 2015-03-18 | 2021-03-03 | The Johns Hopkins University | Inhibitory monoclonal antibody targeting potassium channel kcnk9 |
EP3273981B1 (en) | 2015-03-24 | 2020-04-29 | INSERM - Institut National de la Santé et de la Recherche Médicale | Method and pharmaceutical composition for use in the treatment of diabetes |
US10214591B1 (en) | 2015-04-03 | 2019-02-26 | Alienor Farma | Monoclonal antibody to human line-1 ORF2 protein and method for early detection of transforming cells in pre-neoplastic tissues of a human subject |
EP3283108B1 (en) | 2015-04-13 | 2020-10-14 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for treatment of haemorrhagic diseases |
JP2018519248A (ja) | 2015-04-22 | 2018-07-19 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | Th17媒介性疾患の処置のための方法及び医薬組成物 |
CA2987877A1 (en) | 2015-06-01 | 2016-12-08 | Medigene Immunotherapies Gmbh | T-cell receptor specific antibodies |
US10858760B2 (en) | 2015-06-01 | 2020-12-08 | Medigene Immunotherapies Gmbh | T cell receptor library |
EA201792661A1 (ru) | 2015-06-01 | 2018-05-31 | Медиджин Иммьюнотерапиз Гмбх | Способ получения антител против т-клеточного рецептора |
US11384104B2 (en) | 2015-06-19 | 2022-07-12 | Centurion Biopharma Corporation | Delivery systems for controlled drug release |
CN108139375A (zh) | 2015-06-26 | 2018-06-08 | 贝斯以色列女执事医疗中心股份有限公司 | 靶向髓样衍生的抑制细胞中的四跨膜蛋白33(tspan33)的癌症疗法 |
BR112017027690A2 (pt) | 2015-06-29 | 2018-10-09 | Daiichi Sankyo Co Ltd | método para produção de uma composição de conjugado anticorpo-fármaco, e, composição de conjugado anticorpo-fármaco |
ES2944982T3 (es) | 2015-08-05 | 2023-06-27 | Janssen Biotech Inc | Anticuerpos anti-CD154 y métodos para utilizarlos |
US11078251B2 (en) | 2015-09-18 | 2021-08-03 | INSERM (Institut National de la Santé et de la Recherche Médicale) | T cell receptors (TCR) and uses thereof for the diagnosis and treatment of diabetes |
DK3353196T3 (da) | 2015-09-22 | 2023-02-20 | Inst Nat Sante Rech Med | Polypeptider, der er i stand til at inhibere bindingen mellem leptin og neuropilin-1 |
FI3354729T3 (fi) | 2015-09-24 | 2024-04-23 | Daiichi Sankyo Co Ltd | Anti-garp-vasta-aine |
EA037882B1 (ru) | 2015-09-30 | 2021-05-31 | Янссен Байотек, Инк. | Агонистические антитела, специфически связывающие человеческий cd40, и способы их применения |
WO2017061615A1 (ja) | 2015-10-08 | 2017-04-13 | 国立大学法人名古屋大学 | キメラ抗原受容体を発現する遺伝子改変t細胞の調製方法 |
EP3362093A4 (en) | 2015-10-13 | 2019-05-08 | Technion Research & Development Foundation Limited | MONOCLONAL ANTIBODIES NEUTRALIZING HEPARANASE |
US20180305458A1 (en) | 2015-10-16 | 2018-10-25 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of autoimmune inflammatory diseases |
WO2017072196A1 (en) | 2015-10-26 | 2017-05-04 | Pierre Fabre Medicament | Composition for the treatment of igf-1r expressing cancer |
WO2017075045A2 (en) | 2015-10-30 | 2017-05-04 | Mayo Foundation For Medical Education And Research | Antibodies to b7-h1 |
ITUB20155272A1 (it) | 2015-11-02 | 2017-05-02 | Scuola Normale Superiore | Intracellular antibody |
WO2017079112A1 (en) | 2015-11-03 | 2017-05-11 | Janssen Biotech, Inc. | Antibodies specifically binding pd-1 and their uses |
CA3002880A1 (en) | 2015-11-03 | 2017-05-11 | Glycomimetics, Inc. | Methods and compositions for the production of monoclonal antibodies, hematopoietic stem cells, and methods of using the same |
ITUB20155097A1 (it) | 2015-11-05 | 2017-05-05 | Biouniversa Srl | Anticorpi umanizzati anti-BAG3 |
WO2017097889A1 (en) | 2015-12-10 | 2017-06-15 | Katholieke Universiteit Leuven | Anti adamts13 antibodies and their use for treatment or prevention of haemorrhagic disorders due to ventricular assist device |
CN108713027A (zh) | 2015-12-17 | 2018-10-26 | 詹森生物科技公司 | 特异性结合hla-dr的抗体及其用途 |
GB201522394D0 (en) | 2015-12-18 | 2016-02-03 | Ucb Biopharma Sprl | Antibodies |
ES2863733T3 (es) | 2015-12-23 | 2021-10-11 | Medigene Immunotherapies Gmbh | Generación novedosa de TCR específicos de antígeno |
WO2017114976A1 (en) | 2015-12-31 | 2017-07-06 | Progastrine Et Cancers S.À R.L. | Compositions and methods for detecting and treating esophageal cancer |
JP6962920B2 (ja) | 2015-12-31 | 2021-11-05 | プロガストリン、エ、カンセル、エス、アー エル、エルProgastrine Et Cancers S.A R.L. | 卵巣癌の検出および治療のための組成物および方法 |
AU2017204685B2 (en) | 2015-12-31 | 2022-10-13 | Progastrine Et Cancers S.À R.L. | Compositions and methods for detecting and treating gastric cancer |
EP3202788A1 (en) | 2016-02-05 | 2017-08-09 | MediaPharma S.r.l. | Endosialin-binding antibody |
JP7063813B2 (ja) | 2016-02-15 | 2022-05-09 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | 術後認知機能障害の処置のための方法及び医薬組成物 |
EP3205663A1 (en) | 2016-02-15 | 2017-08-16 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Means and methods for inhibiting gene expression |
MX2018010445A (es) | 2016-03-01 | 2019-10-17 | Yissum Res Dev Co Of Hebrew Univ Jerusalem Ltd | Anticuerpos especificos del receptor de poliovirus humano (rvp). |
US11340233B2 (en) | 2016-03-07 | 2022-05-24 | Pierre Fabre Medicament | Universal method to capture and analyze ADCs for characterization of drug distribution and the drug-to-antibody ratio in biological samples |
US11921116B2 (en) | 2016-03-09 | 2024-03-05 | Memorial Sloan Kettering Cancer Center | Enigma and CDH18 as companion diagnostics for CDK4 inhibitors |
ES2911038T3 (es) | 2016-03-15 | 2022-05-17 | Inst Nat Sante Rech Med | Procedimiento temprano y no invasivo para evaluar el riesgo de un sujeto de tener adenocarcinoma ductal pancreático y procedimientos de tratamiento de dicha enfermedad |
WO2017158396A1 (en) | 2016-03-16 | 2017-09-21 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Cytidine deaminase inhibitors for the treatment of pancreatic cancer |
US20190086392A1 (en) | 2016-03-21 | 2019-03-21 | Inserm (Institut National De La Sante Et De La Recherch Medicale) | Methods for diagnosis and treatment of solar lentigo |
CN111363041B (zh) | 2016-03-23 | 2022-02-22 | 苏州创胜医药集团有限公司 | 新型抗-pd-l1抗体 |
CA3019145A1 (en) | 2016-03-28 | 2017-10-05 | Incyte Corporation | Pyrrolotriazine compounds as tam inhibitors |
ITUA20162242A1 (it) | 2016-04-01 | 2017-10-01 | St Biochimico Italiano Giovanni Lorenzini Spa | Un nuovo anticorpo anti-erbb2 |
WO2017182705A1 (en) | 2016-04-18 | 2017-10-26 | Faron Pharmaceuticals Oy | Humanized anti clever-1 antibodies and their use |
WO2017191100A1 (en) | 2016-05-03 | 2017-11-09 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of tissue lesions |
BR112018073316A2 (pt) | 2016-05-11 | 2019-06-04 | Amgen Inc | seleção direta de células que expressam altos níveis de proteínas heteroméricas usando vetores de complementação intragênica da glutamina sintetase |
EP3458093A1 (de) | 2016-05-20 | 2019-03-27 | Christoph Karl | Pharmazeutische zusammensetzungen mit anti-rankl-antikörpern, kalzium und vitamin d, geeignet zur behandlung und/oder prophylaxe von erkrankungen des knochenstoffwechsels und von therapiebedingten nebenwirkungen wie hypokalzämien |
WO2017202814A1 (en) | 2016-05-24 | 2017-11-30 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of neuropathological disorders characterized by a loss of cortical neurons |
EP3464357A1 (en) | 2016-05-24 | 2019-04-10 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of pulmonary bacterial infections |
SG11201810697QA (en) | 2016-06-07 | 2018-12-28 | Max Delbrueck Centrum Fuer Molekulare Medizin Helmholtz Gemeinschaft | Chimeric antigen receptor and car-t cells that bind bcma |
GB201610198D0 (en) | 2016-06-10 | 2016-07-27 | Ucb Biopharma Sprl | Anti-ige antibodies |
ES2883182T3 (es) | 2016-07-06 | 2021-12-07 | Prothena Biosciences Ltd | Ensayo para la detección de alfa-sinucleína total y fosforilada en S129 |
JP2018035137A (ja) | 2016-07-13 | 2018-03-08 | マブイミューン ダイアグノスティックス エイジーMabimmune Diagnostics Ag | 新規な抗線維芽細胞活性化タンパク質(fap)結合薬剤およびその使用 |
US20190330318A1 (en) | 2016-07-25 | 2019-10-31 | Biogen Ma Inc. | Anti-hspa5 (grp78) antibodies and uses thereof |
JP2019528437A (ja) | 2016-07-28 | 2019-10-10 | アンスティチュ ナショナル ドゥ ラ サンテ エ ドゥ ラ ルシェルシュ メディカル | 腫瘍関連マクロファージをターゲティングすることによるガン疾患の処置方法 |
CN109843916B (zh) | 2016-08-12 | 2023-10-31 | 詹森生物科技公司 | 具有增强的激动活性的Fc工程化抗TNFR超家族成员抗体及其使用方法 |
US10669344B2 (en) | 2016-08-12 | 2020-06-02 | Janssen Biotech, Inc. | Engineered antibodies and other Fc-domain containing molecules with enhanced agonism and effector functions |
AU2017332721B2 (en) | 2016-09-20 | 2023-11-09 | Sara BUHRLAGE | Compositions and methods for identification, assessment, prevention, and treatment of AML using USP10 biomarkers and modulators |
CN109789211A (zh) | 2016-10-07 | 2019-05-21 | 第一三共株式会社 | 基于抗her2抗体-药物偶联物施予的耐性癌的治疗 |
US20190300607A1 (en) | 2016-10-12 | 2019-10-03 | Daiichi Sankyo Company, Limited | Composition containing anti-robo4 antibody and other agents |
CU20200105A7 (es) | 2016-10-13 | 2021-08-06 | Massachusetts Inst Technology | Anticuerpos que se unen a la proteína de envoltura del virus zika |
IT201600111877A1 (it) | 2016-11-07 | 2018-05-07 | Biouniversa Srl | Anti-BAG3 antibodies in combination with inhibitors of immune check-point for therapeutic use |
UA126388C2 (uk) | 2016-11-18 | 2022-09-28 | Астеллас Фарма Інк. | Fab-фрагмент антитіла до muc1 людини |
EP3552626A4 (en) | 2016-12-12 | 2020-06-10 | Daiichi Sankyo Company, Limited | ASSOCIATION OF AN ANTIBODY DRUG CONJUGATE AND AN IMMUNE CONTROL POINT INHIBITOR |
BR112019011988A2 (pt) | 2016-12-13 | 2019-11-05 | Astellas Pharma Inc | anticorpo anti-cd73 humana |
CN110300761B (zh) | 2016-12-15 | 2023-05-09 | 国家生物技术研究所公司 | 抗pcna单克隆抗体及其用途 |
JP7202185B2 (ja) | 2016-12-22 | 2023-01-11 | 第一三共株式会社 | 抗cd3抗体及び該抗体を含む分子 |
US20180179490A1 (en) | 2016-12-27 | 2018-06-28 | Miltenyi Biotec Gmbh | CELL COMPOSITION DEPLETED FROM TCRab and CD45RA POSITIVE CELLS |
US11773182B2 (en) | 2017-01-05 | 2023-10-03 | The Johns Hopkins University | Development of new monoclonal antibodies recognizing human prostate-specific membrane antigen (PSMA) |
CN110382535A (zh) | 2017-01-17 | 2019-10-25 | 第一三共株式会社 | 抗-gpr20抗体以及抗-gpr20抗体-药物缀合物 |
WO2018140510A1 (en) | 2017-01-25 | 2018-08-02 | Biogen Ma Inc. | Compositions and methods for treatment of stroke and other cns disorders |
KR20190133160A (ko) | 2017-02-07 | 2019-12-02 | 다이이찌 산쿄 가부시키가이샤 | 항-gprc5d 항체 및 항-gprc5d 항체를 포함하는 분자 |
EP3363459A1 (en) | 2017-02-17 | 2018-08-22 | Alexander Klimka | Polypeptide epitopes of s. aureus and respective monoclonal antibodies for the treatment of infections and immune-diagnosis |
CA3092434A1 (en) | 2017-02-27 | 2018-08-30 | Caerus Therapeutics, Inc. | Compositions of a novel anti-human ceacam6 antibody and uses thereof |
KR20190120764A (ko) | 2017-02-28 | 2019-10-24 | 갓코 호진 긴키 다이가쿠 | 항 her3 항체-약물 콘주게이트 투여에 의한 egfr-tki 저항성의 비소세포 폐암의 치료 방법 |
EP4095161A1 (en) | 2017-03-15 | 2022-11-30 | Tsinghua University | Novel anti-trkb antibodies |
JOP20180021A1 (ar) | 2017-03-16 | 2019-01-30 | Janssen Biotech Inc | الأجسام المضادة لتكتلات خيوط بروتين تاو (tau) الحلزونية المزدوجة واستخداماتها |
WO2018167283A1 (en) | 2017-03-17 | 2018-09-20 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for the diagnosis and treatment of pancreatic ductal adenocarcinoma associated neural remodeling |
US11879014B2 (en) | 2017-03-17 | 2024-01-23 | Tusk Therapeutics Ltd. | Method of treating cancer or depleting regulatory T cells in a subject by administering a human IGG1 anti-CD25 antibody |
TWI782000B (zh) | 2017-03-30 | 2022-11-01 | 日商第一三共股份有限公司 | 抗gpr20抗體、其製造方法及其應用 |
CN110662967A (zh) | 2017-03-30 | 2020-01-07 | Ecs前胃泌素股份有限公司 | 用于检测肺癌的组合物和方法 |
CN110945025B (zh) | 2017-03-30 | 2023-11-03 | Ecs前胃泌素股份有限公司 | 用于检测***癌的组合物和方法 |
US10722589B2 (en) | 2017-04-03 | 2020-07-28 | Covagen Ag | FGFR3 binding molecules |
WO2018185516A1 (en) | 2017-04-05 | 2018-10-11 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for treating cardiovascular toxicity induced by anti-cancer therapy |
EP3610264A1 (en) | 2017-04-13 | 2020-02-19 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for the diagnosis and treatment of pancreatic ductal adenocarcinoma |
WO2018189403A1 (en) | 2017-04-14 | 2018-10-18 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for the treatment of cancer |
CN111201034A (zh) | 2017-05-11 | 2020-05-26 | 西托戴恩股份有限公司 | 涉及施用抗ccr5受体试剂的治疗或预防移植物抗宿主病的方法 |
TWI794230B (zh) | 2017-05-15 | 2023-03-01 | 日商第一三共股份有限公司 | 抗cdh6抗體及抗cdh6抗體-藥物結合物、以及其製造方法 |
MA52459A (fr) | 2017-06-05 | 2021-03-10 | Janssen Biotech Inc | Anticorps se liant spécifiquement à pd-1 et leurs méthodes d'utilisation |
US11820822B2 (en) | 2017-06-06 | 2023-11-21 | Dana-Farber Cancer Institute, Inc. | Methods for sensitizing cancer cells to T cell-mediated killing by modulating molecular pathways |
US20210145828A1 (en) | 2017-06-29 | 2021-05-20 | Rutgers, The State University Of New Jersey | Compositions And Methods Targeting G12 Signaling For Bronchodilator Therapy |
EP3646885A4 (en) | 2017-06-30 | 2021-04-28 | National University Corporation Hokkaido University | MEDICINAL PRODUCTS AGAINST OSTEOPOROSIS IN CHILDREN WITHOUT CAUSING GROWTH DISORDERS |
TWI795415B (zh) | 2017-07-07 | 2023-03-11 | 日商安斯泰來製藥股份有限公司 | 新穎的抗人類CEACAM5抗體Fab片段 |
BR112020001255A2 (pt) | 2017-07-21 | 2020-07-28 | The United States Of America, As Represented By The Secretary, Department Of Health And Human Services | composições imunogênicas de neisseria meningitidis |
EP3660155A4 (en) | 2017-07-27 | 2021-04-07 | Daiichi Sankyo Company, Limited | ANTI-CD147 ANTIBODY |
EP3658582A1 (en) | 2017-07-28 | 2020-06-03 | Intrepida Bio, Inc. | Anti-bag3 antibodies as therapeutic reagent in cardiovascular diseases |
CN110945023B (zh) | 2017-07-31 | 2023-08-18 | 豪夫迈·罗氏有限公司 | 基于三维结构的人源化方法 |
EP3444272A1 (en) | 2017-08-17 | 2019-02-20 | International-Drug-Development-Biotech | Treatment of ck8 positive cancers in relation with k-ras gene status |
JP7395465B2 (ja) | 2017-08-23 | 2023-12-11 | マックス-デルブリュック-セントルム フュール モレキュラー メディツィン イン デア ヘルムホルツ-ゲマインシャフト | キメラ抗原受容体と、cxcr5に結合するcar-t細胞 |
MA49987A (fr) | 2017-08-23 | 2020-07-01 | Daiichi Sankyo Co Ltd | Préparation de conjugué anticorps-médicament et lyophilisation associée |
SG11202000997YA (en) | 2017-08-31 | 2020-03-30 | Daiichi Sankyo Co Ltd | Improved method for producing antibody-drug conjugate |
CN111065621B (zh) | 2017-08-31 | 2024-01-26 | 第一三共株式会社 | 制备抗体-药物缀合物的新方法 |
US10610585B2 (en) | 2017-09-26 | 2020-04-07 | Inserm (Institut National De La Sante Et De La Recherche Medicale) | Methods and compositions for treating and preventing HIV |
IL301638B1 (en) | 2017-09-29 | 2024-05-01 | Daiichi Sankyo Co Ltd | Conjugation of an antibody with a pyrrolobenzodiazepine derivative |
WO2019069561A1 (ja) | 2017-10-03 | 2019-04-11 | 公益財団法人東京都医学総合研究所 | インフルエンザに対する医薬 |
CA3078436A1 (en) | 2017-10-05 | 2019-04-11 | Daiichi Sankyo Company, Limited | Composition for cytotoxic t cell depletion |
KR101966362B1 (ko) | 2017-10-20 | 2019-04-05 | 주식회사 녹십자 | 항-msln 항체 및 이를 포함하는 암 치료용 약학적 조성물 |
US11591385B2 (en) | 2017-11-09 | 2023-02-28 | Pinteon Therapeutics Inc. | Methods and compositions for the generation and use of humanized conformation-specific phosphorylated tau antibodies |
EP3717018A1 (en) | 2017-11-30 | 2020-10-07 | Centurion BioPharma Corporation | Maytansinoid-based drug delivery systems |
PT3717503T (pt) | 2017-11-30 | 2024-01-16 | Ladrx Corp | Profármacos de ligação a albumina de derivados de auristatina e |
WO2019106126A1 (en) | 2017-12-01 | 2019-06-06 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Mdm2 modulators for the diagnosis and treatment of liposarcoma |
CN111670197A (zh) | 2017-12-05 | 2020-09-15 | 普莱戈斯瑞恩癌症有限责任公司 | 治疗癌症的抗前胃泌激素抗体与免疫疗法的组合疗法 |
WO2019121872A1 (en) | 2017-12-20 | 2019-06-27 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for the diagnosis and treatment of liver cancer |
US20190225689A1 (en) | 2018-01-22 | 2019-07-25 | Janssen Biotech, Inc. | Methods of treating cancers with antagonistic anti-pd-1 antibodies |
TW201940881A (zh) | 2018-01-26 | 2019-10-16 | 瑞士商Ecs前胃泌激素公司 | 在癌症診斷中結合前胃泌激素檢測與其他癌症生物標記的技術 |
EP3752252A4 (en) | 2018-02-12 | 2021-11-17 | Hadasit Medical Research Services and Development Ltd. | MODULATION OF SLAMF6 SPLICE VARIANTS FOR CANCER THERAPY |
WO2019158512A1 (en) | 2018-02-13 | 2019-08-22 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for the prognosis and the treatment of glioblastoma |
SG11202008271QA (en) | 2018-02-27 | 2020-09-29 | Ecs Progastrin Sa | Progastrin as a biomarker for immunotherapy |
CN117903140A (zh) | 2018-02-27 | 2024-04-19 | 因赛特公司 | 作为a2a/a2b抑制剂的咪唑并嘧啶和***并嘧啶 |
CN111836643A (zh) | 2018-03-05 | 2020-10-27 | 学校法人埼玉医科大学 | 用于治疗或预防异位骨化的药物组合物 |
US20210047696A1 (en) | 2018-03-28 | 2021-02-18 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for treating cancer |
US20210164984A1 (en) | 2018-04-13 | 2021-06-03 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for predicting outcome and treatment of patients suffering from prostate cancer or breast cancer |
EP3781590A1 (en) | 2018-04-20 | 2021-02-24 | Medizinische Hochschule Hannover | Chimeric antigen receptor and car-t cells that bind a herpes virus antigen |
WO2019207066A1 (en) | 2018-04-26 | 2019-10-31 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and compositions for the treatment of sjögren's syndrome |
WO2019211369A1 (en) | 2018-05-03 | 2019-11-07 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for treating cancer |
WO2019211370A1 (en) | 2018-05-03 | 2019-11-07 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and pharmaceutical compositions for treating cancer |
US20210130459A1 (en) | 2018-05-09 | 2021-05-06 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Antibodies specific to human nectin4 |
AU2019268022A1 (en) | 2018-05-11 | 2020-11-26 | Astellas Pharma Inc. | Nucleic acid for treating mite allergy |
SG11202011166UA (en) | 2018-05-11 | 2020-12-30 | Astellas Pharma Inc | Nucleic acid for treating crustacean allergy |
JP7360766B2 (ja) | 2018-05-17 | 2023-10-13 | アステラス製薬株式会社 | 抗ヒトMUC1抗体Fabフラグメント、ペプチドリンカー及び/又は配位子を含む複合体 |
MA52940A (fr) | 2018-05-18 | 2021-04-28 | Incyte Corp | Dérivés de pyrimidine fusionnés utilisés en tant qu'inhibiteurs de a2a/a2b |
MA52773A (fr) | 2018-05-24 | 2021-04-14 | Janssen Biotech Inc | Anticorps anti-cd3 et leurs utilisations |
JOP20200303A1 (ar) | 2018-05-24 | 2020-11-23 | Janssen Biotech Inc | عوامل ربط psma واستخداماتها |
JOP20200295A1 (ar) | 2018-05-24 | 2020-11-22 | Janssen Biotech Inc | أجسام أحادية النوعية ومتعددة النوعية مضادة لـ tmeff2 المضاد واستخداماتها |
KR20210014660A (ko) | 2018-05-28 | 2021-02-09 | 다이이찌 산쿄 가부시키가이샤 | 항 her2 항체-약물 콘쥬게이트 투여에 의한 her2 변이암의 치료 |
UY38247A (es) | 2018-05-30 | 2019-12-31 | Novartis Ag | Anticuerpos frente a entpd2, terapias de combinación y métodos de uso de los anticuerpos y las terapias de combinación |
KR20210018192A (ko) | 2018-05-31 | 2021-02-17 | 다이이찌 산쿄 가부시키가이샤 | 항인간 tlr7 항체 |
EP3802611A2 (en) | 2018-06-01 | 2021-04-14 | Novartis AG | Binding molecules against bcma and uses thereof |
WO2019234099A1 (en) | 2018-06-06 | 2019-12-12 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for diagnosing, predicting the outcome and treating a patient suffering from heart failure with preserved ejection fraction |
WO2019234221A1 (en) | 2018-06-08 | 2019-12-12 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for stratification and treatment of a patient suffering from chronic lymphocytic leukemia |
US20200095322A1 (en) | 2018-06-20 | 2020-03-26 | Incyte Corporation | Anti-pd-1 antibodies and uses thereof |
US20210277118A1 (en) | 2018-06-21 | 2021-09-09 | Daiichi Sankyo Company, Limited | Compositions including cd3 antigen binding fragments and uses thereof |
AR117600A1 (es) | 2018-06-29 | 2021-08-18 | Incyte Corp | Formulaciones de un inhibidor de axl / mer |
WO2020007898A1 (en) | 2018-07-04 | 2020-01-09 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and compositions for treating brain injury or neurodegenerative disease |
JP7490631B2 (ja) | 2018-07-05 | 2024-05-27 | インサイト・コーポレイション | A2a/a2b阻害剤としての縮合ピラジン誘導体 |
KR20210038904A (ko) | 2018-07-25 | 2021-04-08 | 다이이찌 산쿄 가부시키가이샤 | 항체-약물 콘쥬게이트의 효과적인 제조 방법 |
CN112512584A (zh) | 2018-07-27 | 2021-03-16 | 国立大学法人大阪大学 | 用于抑制衰老、预防、改善或治疗衰老相关疾病或症状、或者延长寿命的组合物 |
EP3831853A4 (en) | 2018-07-27 | 2022-06-01 | Daiichi Sankyo Company, Limited | ANTIBODY-DRUG CONJUGATE PROTEIN-RECOGNIZING DRUG UNIT |
AU2019315177A1 (en) | 2018-07-31 | 2021-02-25 | Daiichi Sankyo Company, Limited | Treatment of metastatic brain tumor by administration of antibody-drug conjugate |
BR112021001750A2 (pt) | 2018-08-06 | 2021-04-27 | Daiichi Sankyo Company, Limited | composição farmacêutica |
CN112714649A (zh) | 2018-09-06 | 2021-04-27 | 第一三共株式会社 | 新型环状二核苷酸衍生物及其抗体药物偶联物 |
BR112021005246A2 (pt) | 2018-09-20 | 2021-06-15 | Daiichi Sankyo Company, Limited | agente terapêutico, e, método de tratamento para câncer |
US20230038521A1 (en) | 2018-09-21 | 2023-02-09 | National University Corporation Tokyo Medical An D Dental University | Human Monoclonal Antibody Binding Specifically to Human Hmgb1, and Pharmaceutical Composition for Treating or Preventing Alzheimer's Disease Containing Said Human Monoclonal Antibody |
JP2022502431A (ja) | 2018-09-27 | 2022-01-11 | ピエール、ファーブル、メディカマン | スルホマレイミドに基づくリンカーおよび対応する複合体 |
US20220048966A1 (en) | 2018-09-28 | 2022-02-17 | Pierre Fabre Medicament | New immunocytokines for the treatment of cancer |
CN112839683B (zh) | 2018-10-10 | 2023-11-14 | 安斯泰来制药株式会社 | 含有标记部-抗人抗体Fab片段复合物的药物组合物 |
UY38407A (es) | 2018-10-15 | 2020-05-29 | Novartis Ag | Anticuerpos estabilizadores de trem2 |
US20210340240A1 (en) | 2018-10-18 | 2021-11-04 | INSERM (Institut National de la Santé et de la Recherche Médicale | Combination of a big-h3 antagonist and an immune checkpoint inhibitor for the treatment of solid tumor |
AU2019369771A1 (en) | 2018-10-31 | 2021-06-03 | Astellas Pharma Inc. | Anti-human Fn14 antibody |
EP3880706A1 (en) | 2018-11-12 | 2021-09-22 | MediaPharma S.r.l. | Bispecific antibodies directed against human 90k and either endosialin or her3 |
CA3119956A1 (en) | 2018-11-14 | 2020-05-22 | Daiichi Sankyo Company, Limited | Anti-cdh6 antibody-pyrrolobenzodiazepine derivative conjugate |
CN113271942A (zh) | 2018-12-11 | 2021-08-17 | 第一三共株式会社 | 抗体-药物缀合物与parp抑制剂的组合 |
AU2019407426A1 (en) | 2018-12-21 | 2021-07-22 | Daiichi Sankyo Company, Limited | Combination of antibody-drug conjugate and kinase inhibitor |
BR112021012103A2 (pt) | 2018-12-21 | 2021-09-08 | Aim Immunotech Inc. | Composições e métodos para terapia de câncer |
WO2020145228A1 (ja) | 2019-01-07 | 2020-07-16 | アステラス製薬株式会社 | 配位子及びCEACAM5抗体Fabフラグメントからなる複合体 |
TW202043256A (zh) | 2019-01-10 | 2020-12-01 | 美商健生生物科技公司 | ***新抗原及其用途 |
KR20210117277A (ko) | 2019-01-13 | 2021-09-28 | 이슘 리서치 디벨롭먼트 컴퍼니 오브 더 히브루 유니버시티 오브 예루살렘 엘티디. | 인간 넥틴-2에 특이적인 항체 |
TWI829857B (zh) | 2019-01-29 | 2024-01-21 | 美商英塞特公司 | 作為a2a / a2b抑制劑之吡唑并吡啶及***并吡啶 |
CA3125697A1 (en) | 2019-01-29 | 2020-08-06 | Helmholtz Zentrum Munchen - Deutsches Forschungszentrum Fur Gesundheit Und Umwelt (Gmbh) | Treating the causative agent in adhesiogenesis |
JP2022520088A (ja) | 2019-02-13 | 2022-03-28 | ザ ブリガム アンド ウィメンズ ホスピタル インコーポレイテッド | 抗末梢リンパ節アドレッシン抗体およびその使用 |
WO2020178193A1 (en) | 2019-03-01 | 2020-09-10 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Method of treatment of sarcoidosis |
WO2020193441A1 (en) | 2019-03-22 | 2020-10-01 | Université de Paris | New inhibitors of lrrk2/pp1 interaction |
AU2020246448A1 (en) | 2019-03-25 | 2021-10-14 | Daiichi Sankyo Company, Limited | Anti-HER2 antibody-pyrrolobenzodiazepine derivative conjugate |
EP3950061A4 (en) | 2019-03-25 | 2022-11-16 | Daiichi Sankyo Company, Limited | ANTIBODY PYRROLOBENZODIAZEPINE DERIVATIVE CONJUGATE |
AU2020247119A1 (en) | 2019-03-25 | 2021-09-23 | Max-Delbrück-Centrum Für Molekulare Medizin In Der Helmholtz-Gemeinschaft | Enhancement of cytolytic T-cell activity by inhibiting EBAG9 |
US20220168438A1 (en) | 2019-03-27 | 2022-06-02 | Daiichi Sankyo Company, Limited | Combination of antibody-pyrrolobenzodiazepine derivative conjugate and parp inhibitor |
US20220193064A1 (en) | 2019-04-01 | 2022-06-23 | Chiome Bioscience Inc. | Medicament for treating cancer |
WO2020206033A1 (en) | 2019-04-02 | 2020-10-08 | Kenjockety Biotechnology, Inc. | Efflux pump-cancer antigen multi-specific antibodies and compositions, reagents, kits and methods related thereto |
MA55717A (fr) | 2019-04-19 | 2022-02-23 | Janssen Biotech Inc | Méthodes de traitement du cancer de la prostate avec un anticorps anti-psma/cd3 |
EP3962529A4 (en) | 2019-04-30 | 2023-11-01 | Dana-Farber Cancer Institute, Inc. | METHOD FOR CANCER TREATMENT USING ANTI-CX3CR1 AND IMMUNE CHECKPOINT BLOCKING REAGENTS COMBINATIONS |
CA3133333A1 (en) | 2019-04-30 | 2020-04-30 | Brian Scott GARRISON | Chimeric receptors and methods of use thereof |
EP3969569A1 (en) | 2019-05-14 | 2022-03-23 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Regulatory t cells targeted by lymphotoxin alpha blocking agent and uses thereof |
AU2020285681A1 (en) | 2019-05-29 | 2022-01-27 | Daiichi Sankyo Company, Limited | Dosage of an antibody-drug conjugate |
JP2022538237A (ja) | 2019-06-24 | 2022-09-01 | ノバルティス アーゲー | B細胞成熟抗原を標的にする多重特異性抗体のための投与計画及び組み合わせ治療 |
EP4008350A4 (en) | 2019-07-26 | 2023-06-14 | Saitama Medical University | ANTIBODY RECOGNIZING THE EXTRACELLULAR REGION OF ALK2/ACVR1 |
CN114375302A (zh) | 2019-07-26 | 2022-04-19 | 詹森生物科技公司 | 包含激肽释放酶相关肽酶2抗原结合结构域的蛋白质及其用途 |
WO2021019706A1 (ja) | 2019-07-31 | 2021-02-04 | 国立大学法人信州大学 | Car発現免疫細胞を含む細胞集団の製造方法 |
CN114502196A (zh) | 2019-08-01 | 2022-05-13 | 因赛特公司 | Ido抑制剂的给药方案 |
EP4007603A1 (en) | 2019-08-02 | 2022-06-08 | CytoDyn Inc. | Methods for treating or preventing cancers involving the administration of anti-ccr5 receptor agents |
CA3150428A1 (en) | 2019-08-12 | 2021-02-18 | Biond Biologics Ltd. | Antibodies against ilt2 and use thereof |
EP3792632A1 (en) | 2019-09-16 | 2021-03-17 | Vito NV | Immunotherapy markers |
TW202124446A (zh) | 2019-09-18 | 2021-07-01 | 瑞士商諾華公司 | 與entpd2抗體之組合療法 |
US20220348651A1 (en) | 2019-09-18 | 2022-11-03 | Novartis Ag | Entpd2 antibodies, combination therapies, and methods of using the antibodies and combination therapies |
WO2021058744A1 (en) | 2019-09-27 | 2021-04-01 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Use of müllerian inhibiting substance inhibitors for treating cancer |
WO2021059075A1 (en) | 2019-09-27 | 2021-04-01 | Janssen Biotech, Inc. | Anti-ceacam antibodies and uses thereof |
TW202128761A (zh) | 2019-10-25 | 2021-08-01 | 日商第一三共股份有限公司 | 抗garp抗體與免疫調節劑之組合 |
PE20221462A1 (es) | 2019-11-15 | 2022-09-21 | Pliant Therapeutics Inc | Composiciones y metodos para la activacion de integrinas |
BR112022009598A2 (pt) | 2019-11-18 | 2022-08-16 | Janssen Biotech Inc | Vacinas baseadas em calr e jak2 mutantes e uso dos mesmos |
CN112500483B (zh) * | 2019-12-10 | 2022-11-29 | 西西欧艾(杭州)生物医药有限责任公司 | 抗血小板膜糖蛋白ib alpha人源化抗体及其应用 |
CN115135671A (zh) | 2019-12-20 | 2022-09-30 | 新石生物制药有限公司 | 抗白介素-23 p19的抗体及其使用方法 |
TW202135824A (zh) | 2020-01-03 | 2021-10-01 | 美商英塞特公司 | 包含a2a/a2b及pd-1/pd-l1抑制劑之組合療法 |
WO2021140173A1 (en) | 2020-01-10 | 2021-07-15 | Biouniversa S.R.L. | Methods and uses for treating fibrotic solid tumors with bags inhibitors |
EP4100525A1 (en) | 2020-02-05 | 2022-12-14 | Institut National de la Santé et de la Recherche Médicale (INSERM) | Methods of treatment of cancer disease by targeting an epigenetic factor |
TW202140012A (zh) | 2020-02-12 | 2021-11-01 | 比利時商健生藥品公司 | 用於治療尿路上皮癌的fgfr酪胺酸激酶抑制劑和抗pd1藥劑 |
TW202144388A (zh) | 2020-02-14 | 2021-12-01 | 美商健生生物科技公司 | 在卵巢癌中表現之新抗原及其用途 |
TW202144389A (zh) | 2020-02-14 | 2021-12-01 | 美商健生生物科技公司 | 在多發性骨髓瘤中表現之新抗原及其用途 |
JP2023519153A (ja) | 2020-03-03 | 2023-05-10 | アクティブ バイオテック エイビー | 組合せ療法における使用のためのタスキニモドまたはその薬学的に許容される塩 |
BR112022015283A2 (pt) | 2020-03-06 | 2022-09-20 | Daiichi Sankyo Co Ltd | Conjugado anticorpo-fármaco incluindo derivados de dinucleotídeos cíclicos |
KR20230017165A (ko) | 2020-03-06 | 2023-02-03 | 인사이트 코포레이션 | Axl/mer 및 pd-1/pd-l1 억제제를 포함하는 병행 요법 |
WO2021183207A1 (en) | 2020-03-10 | 2021-09-16 | Massachusetts Institute Of Technology | COMPOSITIONS AND METHODS FOR IMMUNOTHERAPY OF NPM1c-POSITIVE CANCER |
EP4233893A3 (en) | 2020-03-13 | 2023-09-27 | Janssen Biotech, Inc. | Materials and methods for binding siglec-3/cd33 |
US11045546B1 (en) | 2020-03-30 | 2021-06-29 | Cytodyn Inc. | Methods of treating coronavirus infection |
JPWO2021200131A1 (da) | 2020-03-30 | 2021-10-07 | ||
EP3889183A1 (en) | 2020-04-01 | 2021-10-06 | Pierre Fabre Medicament | A protein complex comprising an immunocytokine |
CA3179348A1 (en) | 2020-04-06 | 2021-10-14 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Antibodies to nkp46 and constructs thereof for treatment of cancers and infections |
CN115397860A (zh) | 2020-05-14 | 2022-11-25 | 江苏恒瑞医药股份有限公司 | 抗cd25抗体、其抗原结合片段及其医药用途 |
US20230192879A1 (en) | 2020-05-19 | 2023-06-22 | Institut Curie | Methods for the diagnosis and treatment of cytokine release syndrome |
MX2022014938A (es) | 2020-05-27 | 2023-03-06 | Janssen Biotech Inc | Proteínas que comprenden dominios de unión al antígeno de cd3 y usos de éstas. |
BR112022023931A2 (pt) | 2020-05-27 | 2023-04-11 | Arialys Therapeutics Inc | Derivado de anticorpo nr1 anti-humano |
JP2023528417A (ja) | 2020-06-04 | 2023-07-04 | ケンジョッケティ バイオテクノロジー,インク. | Abcg2排出ポンプ-がん抗原多重特異性抗体並びにそれらに関連する組成物、試薬、キット、及び方法 |
TW202216208A (zh) | 2020-06-24 | 2022-05-01 | 英商阿斯特捷利康英國股份有限公司 | 抗體-藥物結合物及atr抑制劑之組合 |
TW202216207A (zh) | 2020-06-24 | 2022-05-01 | 英商阿斯特捷利康英國股份有限公司 | 抗體-藥物結合物及cdk9抑制劑之組合 |
WO2021260583A1 (en) | 2020-06-24 | 2021-12-30 | Astrazeneca Uk Limited | Combination of antibody-drug conjugate and dna-pk inhibitor |
WO2021260582A1 (en) | 2020-06-24 | 2021-12-30 | Astrazeneca Uk Limited | Combination of antibody-drug conjugate and aurora b inhibitor |
JP2023539715A (ja) | 2020-06-24 | 2023-09-19 | アストラゼネカ ユーケー リミテッド | 抗体-薬物コンジュゲートとatm阻害剤との組合わせ |
EP4171527A1 (en) | 2020-06-25 | 2023-05-03 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods of treatment and diagnostic of pathological conditions associated with intense stress |
BR112023000711A2 (pt) | 2020-07-17 | 2023-01-31 | Daiichi Sankyo Co Ltd | Método para produzir uma composição de conjugado de anticorpo-fármaco, e, composição de conjugado de anticorpo-fármaco |
US20230293714A1 (en) | 2020-07-20 | 2023-09-21 | Daiichi Sankyo Company, Limited | Combination of anti-her2 antibody-drug conjugate with her dimerization inhibitor |
CN116209681A (zh) | 2020-07-29 | 2023-06-02 | 詹森生物科技公司 | 包含hla-g抗原结合结构域的蛋白质及其用途 |
RU2764216C1 (ru) * | 2020-08-10 | 2022-01-14 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Чувашский государственный университет имени И.Н. Ульянова" | Способ лечения гломерулонефритов с нефротическим синдромом рецидивирующего течения |
EP4196227A2 (en) | 2020-08-12 | 2023-06-21 | Biond Biologics Ltd. | Antibodies against ilt2 and use thereof |
EP4199958A1 (en) | 2020-08-24 | 2023-06-28 | Charité - Universitätsmedizin Berlin | Chimeric antigen receptor (car)-expressing cells recognizing cea |
WO2022043315A1 (en) | 2020-08-24 | 2022-03-03 | Charité - Universitätsmedizin Berlin | A CHIMERIC ANTIGEN RECEPTOR CONSTRUCT ENCODING A CHECKPOINT INHIBITORY MOLECULE AND AN IMMUNE STIMULATORY CYTOKINE AND CAR-EXPRESSING CELLS RECOGNIZING CD44v6 |
EP4208259A2 (en) | 2020-09-04 | 2023-07-12 | NovaRock Biotherapeutics, Ltd. | Nectin-4 antibodies and uses thereof |
EP4210722A1 (en) | 2020-09-07 | 2023-07-19 | Institut National de la Santé et de la Recherche Médicale (INSERM) | Methods of treatment of inflammatory bowel diseases |
JP2023545359A (ja) | 2020-09-12 | 2023-10-30 | アストラゼネカ・ユーケイ・リミテッド | 抗her2抗体-薬物複合体治療のためのスコアリング方法 |
CA3198077A1 (en) | 2020-10-05 | 2022-04-14 | Chiome Bioscience Inc. | Medicine for treating cancer |
IL301921A (en) | 2020-10-09 | 2023-06-01 | Daiichi Sankyo Co Ltd | Combining an antibody-drug conjugate and a selective 1PARP inhibitor |
UY39467A (es) | 2020-10-13 | 2022-04-29 | Janssen Biotech Inc | Inmunidad mediada por células t de bioingeniería, materiales y otros métodos para modular el grupo de diferenciación iv y / o viii |
US20230416346A1 (en) | 2020-10-21 | 2023-12-28 | INSERM (Institut National de la Santé et de la Recherche Médicale) | C-terminal sparc fragments for treating cancer |
TW202233672A (zh) | 2020-10-22 | 2022-09-01 | 美商健生生物科技公司 | 包括類δ配體3(DLL3)抗原結合區之蛋白質及其用途 |
WO2022097090A1 (en) | 2020-11-05 | 2022-05-12 | Novartis Ag | Dosing regimen for combination therapies with multispecific antibodies targeting b-cell maturation antigen and gamma secretase inhibitors |
KR20230113564A (ko) | 2020-11-06 | 2023-07-31 | 인쎄름 (엥스띠뛰 나씨오날 드 라 쌍떼 에 드 라 흐쉐르슈 메디깔) | 다낭성 난소 증후군(pcos)의 진단 및 치료 방법 |
KR20230106645A (ko) | 2020-11-11 | 2023-07-13 | 다이이찌 산쿄 가부시키가이샤 | 항체-약물 콘주게이트와 항 SIRPα 항체의 조합 |
US20230398230A1 (en) | 2020-11-12 | 2023-12-14 | Daiichi Sankyo Company, Limited | Treatment of mesothelioma by administration of anti-b7-h3 antibody-drug conjugate |
CR20230244A (es) | 2020-11-16 | 2023-07-12 | Astellas Pharma Inc | Anticuerpo biespecífico anti-tspan8/anti-cd3 y anticuerpo anti-tspan8 |
WO2022112469A1 (en) | 2020-11-27 | 2022-06-02 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for diagnosis and monitoring of toxic epidermal necrolysis |
TW202241436A (zh) | 2020-11-30 | 2022-11-01 | 美商英塞特公司 | 抗cd19抗體及帕薩昔布(parsaclisib)之組合療法 |
WO2022115120A1 (en) | 2020-11-30 | 2022-06-02 | Incyte Corporation | Combination therapy with an anti-cd19 antibody and parsaclisib |
JPWO2022124247A1 (da) | 2020-12-09 | 2022-06-16 | ||
CN117500503A (zh) | 2020-12-29 | 2024-02-02 | 因赛特公司 | 包含a2a/a2b抑制剂、pd-1/pd-l1抑制剂和抗cd73抗体的组合疗法 |
EP4277664A1 (en) | 2021-01-13 | 2023-11-22 | Memorial Sloan Kettering Cancer Center | Antibody-pyrrolobenzodiazepine derivative conjugate |
TW202245844A (zh) | 2021-01-13 | 2022-12-01 | 紀念斯隆凱特琳癌症中心 | 抗dll3抗體-藥物結合物 |
WO2022153212A1 (en) | 2021-01-13 | 2022-07-21 | Axon Neuroscience Se | Antibodies neutralizing sars-cov-2 |
WO2022162518A2 (en) | 2021-01-28 | 2022-08-04 | Janssen Biotech, Inc. | Psma binding proteins and uses thereof |
US20240141060A1 (en) | 2021-01-29 | 2024-05-02 | Novartis Ag | Dosage regimes for anti-cd73 and anti-entpd2 antibodies and uses thereof |
TW202241454A (zh) | 2021-02-01 | 2022-11-01 | 日商第一三共股份有限公司 | 抗體-免疫賦活化劑共軛物之新穎製造方法 |
AU2022219681A1 (en) | 2021-02-11 | 2023-09-21 | Nectin Therapeutics Ltd. | Antibodies against cd112r and uses thereof |
CA3208905A1 (en) | 2021-02-12 | 2022-08-18 | Boehringer Ingelheim International Gmbh | Complement c3 antigen binding proteins |
US20220378929A1 (en) | 2021-02-25 | 2022-12-01 | MediBoston Limted | Anti-her2 antibody-drug conjugates and uses thereof |
AU2022229805A1 (en) | 2021-03-02 | 2023-09-21 | Dana-Farber Cancer Institute, Inc. | Methods of treating red blood cell disorders |
EP4305064A1 (en) | 2021-03-12 | 2024-01-17 | Fibrosys S.r.l. | Monoclonal antibodies for the treatment of viral infections |
IL305816A (en) | 2021-03-12 | 2023-11-01 | Daiichi Sankyo Co Ltd | Glycan and a method for preparing a medicine containing it |
EP4314055A1 (en) | 2021-03-24 | 2024-02-07 | Janssen Biotech, Inc. | Antibody targeting cd22 and cd79b |
IL307168A (en) | 2021-03-26 | 2023-11-01 | Janssen Biotech Inc | Humanized antibodies against paired helical strands of TAU protein and their uses |
WO2022218998A1 (en) | 2021-04-13 | 2022-10-20 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods for treating hepatitis b and d virus infection |
KR20230170672A (ko) | 2021-04-14 | 2023-12-19 | 빌라리스 테라퓨틱스 인코포레이티드 | 항-cd122 항체 및 이의 용도 |
AR125398A1 (es) | 2021-04-22 | 2023-07-12 | Astellas Pharma Inc | Anticuerpo biespecífico anti-cldn4 / anti-cd137 |
WO2022261183A2 (en) | 2021-06-08 | 2022-12-15 | Dana-Farber Cancer Institute, Inc. | Compositions and methods for treating and/or identifying an agent for treating intestinal cancers |
CN113361141B (zh) * | 2021-07-11 | 2022-02-18 | 西南石油大学 | 一种dna图谱算法的改进试验方法 |
CN118176213A (zh) | 2021-08-27 | 2024-06-11 | 詹森生物科技公司 | 抗psma抗体及其用途 |
AU2022347380A1 (en) | 2021-09-15 | 2024-04-11 | Daiichi Sankyo Company, Limited | Antibody-drug conjugate for use in methods of treating chemotherapy-resistant cancer |
WO2023041744A1 (en) | 2021-09-17 | 2023-03-23 | Institut Curie | Bet inhibitors for treating pab1 deficient cancer |
WO2023046322A1 (en) | 2021-09-24 | 2023-03-30 | Janssen Pharmaceutica Nv | Proteins comprising cd20 binding domains, and uses thereof |
WO2023052541A1 (en) | 2021-09-30 | 2023-04-06 | Imcheck Therapeutics | Combination of an anti-btn3a activating antibody and an il-2 agonist for use in therapy |
TW202330041A (zh) | 2021-10-18 | 2023-08-01 | 日商第一三共股份有限公司 | 抗cd37抗體-藥物結合物 |
AU2022378932A1 (en) | 2021-10-27 | 2024-05-02 | Assistance Publique Hopitaux De Marseille | Butyrophilin (btn) 3a activating antibodies for use in methods for treating infectious disorders |
EP4177266A1 (en) | 2021-11-05 | 2023-05-10 | Katholieke Universiteit Leuven | Neutralizing anti-sars-cov-2 human antibodies |
WO2023089527A1 (en) | 2021-11-18 | 2023-05-25 | Astrazeneca Uk Limited | Combination of antibody-drug conjugate and parp1 selective inhibitor |
WO2023089032A1 (en) | 2021-11-19 | 2023-05-25 | Institut Curie | Methods for the treatment of hrd cancer and brca-associated cancer |
WO2023097119A2 (en) | 2021-11-29 | 2023-06-01 | Dana-Farber Cancer Institute, Inc. | Methods and compositions to modulate riok2 |
WO2023099763A1 (en) | 2021-12-03 | 2023-06-08 | Institut Curie | Sirt6 inhibitors for use in treating resistant hrd cancer |
WO2023105528A1 (en) | 2021-12-12 | 2023-06-15 | Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. | Antibodies specific to ceacam1 |
US20230357392A1 (en) | 2021-12-22 | 2023-11-09 | Morphosys Ag | Treatment Paradigm for an Anti-CD19 Antibody Therapy |
CA3240724A1 (en) | 2021-12-28 | 2023-07-06 | Astrazeneca Uk Limited | Combination of antibody-drug conjugate and atr inhibitor |
TW202333800A (zh) | 2021-12-28 | 2023-09-01 | 英商阿斯特捷利康英國股份有限公司 | 抗體-藥物結合物及rasg12c抑制劑之組合 |
WO2023152581A1 (en) | 2022-02-09 | 2023-08-17 | Janssen Biotech, Inc. | Method of treating cancer with psmaxcd3 antibody |
WO2023166081A1 (en) | 2022-03-02 | 2023-09-07 | Heidelberg Immunotherapeutics Gmbh | Vaccine comprising an antibody or an fc-containing fusion protein comprising an fc part of an antibody |
WO2023175614A1 (en) | 2022-03-15 | 2023-09-21 | Yeda Research And Development Co. Ltd. | Anti glucocorticoid-induced tnfr-related (gitr) protein antibodies and uses thereof |
WO2023175483A1 (en) | 2022-03-16 | 2023-09-21 | Astrazeneca Uk Limited | A scoring method for an anti-trop2 antibody‑drug conjugate therapy |
TW202400140A (zh) | 2022-04-27 | 2024-01-01 | 日商第一三共股份有限公司 | 抗體-藥物結合物與ezh1及/或ezh2抑制劑之組合 |
TW202400650A (zh) | 2022-05-11 | 2024-01-01 | 日商第一三共股份有限公司 | 抗體與cd47抑制劑之組合 |
WO2023228095A1 (en) | 2022-05-24 | 2023-11-30 | Daiichi Sankyo Company, Limited | Dosage regimen of an anti-cdh6 antibody-drug conjugate |
WO2024013723A1 (en) | 2022-07-15 | 2024-01-18 | Pheon Therapeutics Ltd | Antibody drug conjugates that bind cdcp1 and uses thereof |
WO2024023750A1 (en) | 2022-07-28 | 2024-02-01 | Astrazeneca Uk Limited | Combination of antibody-drug conjugate and bispecific checkpoint inhibitor |
US20240101718A1 (en) | 2022-09-28 | 2024-03-28 | Incyte Corporation | Anti-pd-1/lag-3 bispecific antibodies and uses thereof |
WO2024074498A1 (en) | 2022-10-04 | 2024-04-11 | Imcheck Therapeutics | Combination of a btn3a activating antibody, a bcl2 inhibitor and hypomethylating agent for use in treating cancer |
WO2024116094A1 (en) | 2022-11-30 | 2024-06-06 | Daiichi Sankyo Company, Limited | Combination of antibody-drug conjugates and dnmt inhibitors |
WO2024121380A1 (en) | 2022-12-08 | 2024-06-13 | Pierre Fabre Medicament | Vaccinal composition and adjuvant |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4704362A (en) | 1977-11-08 | 1987-11-03 | Genentech, Inc. | Recombinant cloning vehicle microbial polypeptide expression |
JPS6033453B2 (ja) * | 1978-08-17 | 1985-08-02 | 富士電機株式会社 | 魚切断加工自動化装置 |
US4816567A (en) * | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
JPS6014678A (ja) * | 1983-07-04 | 1985-01-25 | Taiheiyo Kogyo Kk | 電磁弁 |
GB8607679D0 (en) | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
GB2188941B (en) * | 1986-04-14 | 1990-06-06 | Bayer Ag | Monoclonal antibodies recognizing human interleukin-2-receptor |
DK554986A (da) * | 1986-11-19 | 1988-07-18 | Novo Industri As | Human-human hybride cellelinier samt dermed producerede monoklonale cancerantistoffer |
GB8720833D0 (en) * | 1987-09-04 | 1987-10-14 | Celltech Ltd | Recombinant dna product |
GB2216126B (en) * | 1988-02-12 | 1992-06-03 | Medical Res Council | Antibodies to the antigen campath-1 |
EP0362371A4 (en) * | 1988-04-15 | 1990-10-24 | Protein Design Labs, Inc. | Il-2 receptor-specific chimeric antibodies |
JP5598363B2 (ja) | 2011-02-15 | 2014-10-01 | ソニー株式会社 | 記憶装置およびその動作方法 |
-
1989
- 1989-11-27 IL IL162181A patent/IL162181A/en not_active IP Right Cessation
- 1989-12-27 IL IL92904A patent/IL92904A0/xx not_active IP Right Cessation
- 1989-12-28 DE DE04076439.1T patent/DE04076439T1/de active Pending
- 1989-12-28 EP EP04076438.3A patent/EP1491556B1/en not_active Expired - Lifetime
- 1989-12-28 ES ES95105609T patent/ES2136760T3/es not_active Expired - Lifetime
- 1989-12-28 DE DE2000175038 patent/DE10075038I2/de active Active
- 1989-12-28 PT PT92758A patent/PT92758B/pt active IP Right Grant
- 1989-12-28 EP EP04076439.1A patent/EP1477497B1/en not_active Expired - Lifetime
- 1989-12-28 DE DE200712000037 patent/DE122007000037I1/de active Pending
- 1989-12-28 CA CA002006865A patent/CA2006865C/en not_active Expired - Lifetime
- 1989-12-28 CN CN89109618A patent/CN1057013C/zh not_active Expired - Lifetime
- 1989-12-28 DE DE68925536A patent/DE68925536D1/de not_active Expired - Lifetime
- 1989-12-28 CA CA002328851A patent/CA2328851C/en not_active Expired - Lifetime
- 1989-12-28 DE DE122005000057C patent/DE122005000057I2/de active Active
- 1989-12-28 DE DE68929061T patent/DE68929061T2/de not_active Expired - Lifetime
- 1989-12-28 DE DE122009000071C patent/DE122009000071I1/de active Pending
- 1989-12-28 IE IE20000331A patent/IE20000331A1/en unknown
- 1989-12-28 DE DE122005000007C patent/DE122005000007I2/de active Active
- 1989-12-28 AU AU51532/90A patent/AU647383B2/en not_active Expired
- 1989-12-28 MC MC@@@@D patent/MC2146A1/xx unknown
- 1989-12-28 ES ES90903576T patent/ES2081974T5/es not_active Expired - Lifetime
- 1989-12-28 YU YU248989A patent/YU48700B/sh unknown
- 1989-12-28 EP EP98204240.0A patent/EP0939127B1/en not_active Expired - Lifetime
- 1989-12-28 RU SU4895847/13A patent/RU2126046C1/ru active
- 1989-12-28 DE DE04076438.3T patent/DE04076438T1/de active Pending
- 1989-12-28 EP EP10185689A patent/EP2341080A1/en not_active Withdrawn
- 1989-12-28 DE DE98204240.0T patent/DE98204240T1/de active Pending
- 1989-12-28 DE DE68925536T patent/DE68925536T3/de not_active Expired - Lifetime
- 1989-12-28 KR KR1019900701939A patent/KR0178385B1/ko not_active IP Right Cessation
- 1989-12-28 ES ES98204240.0T patent/ES2492815T3/es not_active Expired - Lifetime
- 1989-12-28 DE DE1989625536 patent/DE122006000036I1/de active Pending
- 1989-12-28 DE DE19975047C patent/DE19975047I2/de active Active
- 1989-12-28 AT AT90903576T patent/ATE133452T1/de active
- 1989-12-28 DE DE2000175005 patent/DE10075005I2/de active Active
- 1989-12-28 WO PCT/US1989/005857 patent/WO1990007861A1/en active IP Right Grant
- 1989-12-28 ZA ZA899956A patent/ZA899956B/xx unknown
- 1989-12-28 ES ES04076439.1T patent/ES2523810T3/es not_active Expired - Lifetime
- 1989-12-28 AT AT95105609T patent/ATE183753T1/de not_active IP Right Cessation
- 1989-12-28 SI SI8912489A patent/SI8912489B/sl unknown
- 1989-12-28 EP EP90903576A patent/EP0451216B9/en not_active Expired - Lifetime
- 1989-12-28 ES ES04076438.3T patent/ES2440825T3/es not_active Expired - Lifetime
- 1989-12-28 JP JP2503677A patent/JP2828340B2/ja not_active Ceased
- 1989-12-28 EP EP95105609A patent/EP0682040B1/en not_active Revoked
-
1990
- 1990-01-04 NZ NZ231984A patent/NZ231984A/en unknown
- 1990-01-04 NZ NZ314793A patent/NZ314793A/xx unknown
- 1990-01-17 DD DD90337159A patent/DD296964A5/de unknown
-
1991
- 1991-05-20 FI FI912436A patent/FI108797B/fi active Protection Beyond IP Right Term
- 1991-06-19 DK DK911191A patent/DK119191D0/da not_active Application Discontinuation
- 1991-06-19 NO NO19912385A patent/NO310473B1/no not_active IP Right Cessation
- 1991-12-31 CZ CS914186A patent/CZ418691A3/cs unknown
-
1992
- 1992-01-20 BG BG95784A patent/BG61095B2/xx unknown
- 1992-09-26 HR HRP-2489/89A patent/HRP920500B1/xx not_active IP Right Cessation
-
1995
- 1995-06-16 HU HU95P/P00236P patent/HU211174A9/hu active Protection Beyond IP Right Term
-
1996
- 1996-04-13 SG SG1996007855A patent/SG78258A1/en unknown
-
1998
- 1998-01-12 JP JP00433498A patent/JP3604058B2/ja not_active Expired - Lifetime
- 1998-07-16 DK DK199800941A patent/DK174317B1/da not_active IP Right Cessation
- 1998-12-28 HK HK98115967A patent/HK1014718A1/xx not_active IP Right Cessation
-
1999
- 1999-07-02 LU LU90411C patent/LU90411I2/fr unknown
- 1999-07-14 NL NL990020C patent/NL990020I2/nl unknown
-
2000
- 2000-02-11 LU LU90528C patent/LU90528I2/fr unknown
- 2000-02-11 NL NL300005C patent/NL300005I2/nl unknown
- 2000-11-03 NL NL300023C patent/NL300023I2/nl unknown
- 2000-11-09 LU LU90676C patent/LU90676I2/fr unknown
-
2001
- 2001-12-17 NO NO2001024C patent/NO2001024I1/no unknown
- 2001-12-17 NO NO2001026C patent/NO2001026I2/no unknown
- 2001-12-17 NO NO2001025C patent/NO2001025I2/no unknown
-
2003
- 2003-01-20 JP JP2003011706A patent/JP2003245091A/ja not_active Withdrawn
- 2003-01-20 JP JP2003011705A patent/JP2003245090A/ja not_active Withdrawn
-
2005
- 2005-02-04 LU LU91139C patent/LU91139I2/fr unknown
- 2005-02-10 NL NL300173C patent/NL300173I2/nl unknown
- 2005-02-18 NO NO2005005C patent/NO2005005I2/no unknown
- 2005-12-02 LU LU91208C patent/LU91208I2/fr unknown
- 2005-12-07 NO NO2005026C patent/NO2005026I2/no unknown
- 2005-12-12 NL NL300213C patent/NL300213I2/nl unknown
-
2006
- 2006-08-07 NO NO2006009C patent/NO2006009I2/no unknown
- 2006-08-07 NL NL300239C patent/NL300239I2/nl unknown
- 2006-08-07 LU LU91272C patent/LU91272I2/fr unknown
-
2007
- 2007-03-02 JP JP2007053539A patent/JP2007145863A/ja not_active Withdrawn
- 2007-04-11 LU LU91333C patent/LU91333I2/fr unknown
- 2007-04-18 NO NO2007006C patent/NO2007006I2/no unknown
- 2007-04-18 NL NL300279C patent/NL300279I2/nl unknown
-
2009
- 2009-04-21 JP JP2009103471A patent/JP2009165488A/ja not_active Withdrawn
- 2009-11-12 NO NO2009026C patent/NO2009026I1/no unknown
- 2009-11-19 NL NL300426C patent/NL300426I1/nl unknown
- 2009-12-09 LU LU91627C patent/LU91627I2/fr unknown
-
2014
- 2014-09-17 FR FR14C0070C patent/FR14C0070I1/fr active Active
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
SI8912489B (sl) | Novi IL-2 receptor specifični humani imunoglobulini | |
US10400040B2 (en) | Anti-GITR antibodies | |
DE4193302C2 (de) | Verwendung rekombinanter Antikörper spezifisch für TNF-alpha | |
Presta et al. | Humanization of an antibody directed against IgE. | |
FI108777B (fi) | Menetelmä CDR-siirteellä muokatun vasta-ainemolekyylin tuottamiseksi | |
DE69530975T2 (de) | Rekombinante humanisierte antikörper gegen lewis y | |
US7807160B2 (en) | Engineered anti-IL-23 antibodies | |
KR101562580B1 (ko) | 사람 프로그램된 사멸 수용체 pd-1에 대한 항체 | |
CN101198624B (zh) | Il-31单克隆抗体及使用方法 | |
JP5238723B2 (ja) | 操作された抗il−23r抗体 | |
KR920702425A (ko) | Cdr 이식된 항-cea 항체 및 그의 제조 | |
MX2009002242A (es) | Secuencias de region variable de anticuerpos monoclonales contra il-31 y metodos de uso. | |
CN102083859B (zh) | 人源化抗人干扰素-α抗体 | |
RS51334B (en) | CD20 Antibodies with Increased Binding Affinity for FC RECEPTOR AND EFFECTORY FUNCTION | |
CN108367075A (zh) | 4-1bb结合蛋白及其用途 | |
CN103068848A (zh) | 抗N3pGlu淀粉样蛋白BETA肽抗体及其用途 | |
WO1993016184A1 (en) | Design, cloning and expression of humanized monoclonal antibodies against human interleukin-5 | |
KR20130080058A (ko) | Il-12/p40 결합 단백질 | |
AU2008218968A1 (en) | Engineered anti-IL-23p19 antibodies | |
RU2007132020A (ru) | Партнеры специфического связывания с ngf | |
KR20100014869A (ko) | Cxcr3에 대한 인간화 항체 | |
Te Wu et al. | Possible use of similar framework region amino acid sequences between human and mouse immunoglobulins for humanizing mouse antibodies | |
Tempest et al. | A humanized anti-tumor necrosis factor-α monoclonal antibody that acts as a partial, competitive antagonist of the template antibody | |
Couto et al. | Engineering of antibodies for breast cancer therapy: construction of chimeric and humanized versions of the murine monoclonal antibody BrE-3 | |
USRE39548E1 (en) | Interleukin-5 specific recombinant antibodies |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
IF | Valid on the event date | ||
SP73 | Change of data on owner |
Owner name: PROTEIN DESIGN LABS, INC.; US Effective date: 20051207 |
|
SP73 | Change of data on owner |
Owner name: PDL BIOPHARMA, INC.; US Effective date: 20061207 |
|
SP73 | Change of data on owner |
Owner name: PDL BIOPHARMA, INC.; US Effective date: 20081022 |
|
SP73 | Change of data on owner |
Owner name: PDL BIOPHARMA, INC.; US Effective date: 20090806 |