SI2545939T1 - Tetrahidrobiopterin za zdravljenje stanj povezanih s povišanimi nivoji fenilalanina - Google Patents
Tetrahidrobiopterin za zdravljenje stanj povezanih s povišanimi nivoji fenilalaninaInfo
- Publication number
- SI2545939T1 SI2545939T1 SI200832155T SI200832155T SI2545939T1 SI 2545939 T1 SI2545939 T1 SI 2545939T1 SI 200832155 T SI200832155 T SI 200832155T SI 200832155 T SI200832155 T SI 200832155T SI 2545939 T1 SI2545939 T1 SI 2545939T1
- Authority
- SI
- Slovenia
- Prior art keywords
- tetrahydrobiopterin
- conditions associated
- treating conditions
- phenylalanine levels
- elevated phenylalanine
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
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- A—HUMAN NECESSITIES
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- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A61K9/0065—Forms with gastric retention, e.g. floating on gastric juice, adhering to gastric mucosa, expanding to prevent passage through the pylorus
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- A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
- A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
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- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
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- A61K9/2022—Organic macromolecular compounds
- A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
- A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B63/00—Purification; Separation; Stabilisation; Use of additives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- G—PHYSICS
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- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
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- G01N33/6848—Methods of protein analysis involving mass spectrometry
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- A61K9/1605—Excipients; Inactive ingredients
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- G01N30/02—Column chromatography
- G01N30/62—Detectors specially adapted therefor
- G01N30/72—Mass spectrometers
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- H—ELECTRICITY
- H01—ELECTRIC ELEMENTS
- H01J—ELECTRIC DISCHARGE TUBES OR DISCHARGE LAMPS
- H01J49/00—Particle spectrometers or separator tubes
- H01J49/004—Combinations of spectrometers, tandem spectrometers, e.g. MS/MS, MSn
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
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- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
- Y10T436/145555—Hetero-N
- Y10T436/147777—Plural nitrogen in the same ring [e.g., barbituates, creatinine, etc.]
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Nutrition Science (AREA)
- Hematology (AREA)
- Physiology (AREA)
- Molecular Biology (AREA)
- Physics & Mathematics (AREA)
- Dermatology (AREA)
- Urology & Nephrology (AREA)
- Diabetes (AREA)
- Psychiatry (AREA)
- Immunology (AREA)
- Bioinformatics & Computational Biology (AREA)
- Heart & Thoracic Surgery (AREA)
- Obesity (AREA)
- Pain & Pain Management (AREA)
- Cardiology (AREA)
- Biochemistry (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
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Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US92282107P | 2007-04-11 | 2007-04-11 | |
US1975308P | 2008-01-08 | 2008-01-08 | |
EP12005352.5A EP2545939B1 (en) | 2007-04-11 | 2008-04-11 | Tetrahydrobiopterin for treating conditions associated with elevated phenylalanine levels |
Publications (1)
Publication Number | Publication Date |
---|---|
SI2545939T1 true SI2545939T1 (sl) | 2021-04-30 |
Family
ID=39620159
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI200832155T SI2545939T1 (sl) | 2007-04-11 | 2008-04-11 | Tetrahidrobiopterin za zdravljenje stanj povezanih s povišanimi nivoji fenilalanina |
SI200832189T SI3461503T1 (sl) | 2007-04-11 | 2008-04-11 | Postopki za dajanje tetrahidrobiopterina, povezani sestavki in postopki merjenja |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SI200832189T SI3461503T1 (sl) | 2007-04-11 | 2008-04-11 | Postopki za dajanje tetrahidrobiopterina, povezani sestavki in postopki merjenja |
Country Status (23)
Country | Link |
---|---|
US (6) | US7612073B2 (sl) |
EP (4) | EP4029519A1 (sl) |
JP (2) | JP2010523708A (sl) |
KR (5) | KR101721198B1 (sl) |
CN (1) | CN101678025A (sl) |
AU (1) | AU2008240259C1 (sl) |
BR (1) | BRPI0809470A2 (sl) |
CA (1) | CA2682598C (sl) |
CY (3) | CY1113543T1 (sl) |
DE (1) | DE22154751T1 (sl) |
DK (3) | DK3461503T3 (sl) |
ES (3) | ES2906582T3 (sl) |
HK (1) | HK1139864A1 (sl) |
HR (3) | HRP20220188T3 (sl) |
HU (2) | HUE053107T2 (sl) |
IL (1) | IL201101A (sl) |
LT (2) | LT3461503T (sl) |
MX (1) | MX2009010977A (sl) |
PL (3) | PL2545939T3 (sl) |
PT (3) | PT2545939T (sl) |
RU (1) | RU2486899C2 (sl) |
SI (2) | SI2545939T1 (sl) |
WO (1) | WO2008128049A2 (sl) |
Families Citing this family (53)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BRPI0416566A (pt) | 2003-11-17 | 2007-01-23 | Biomarin Pharm Inc | tratamento de fenilcetonúrias com bh4 |
EP4029519A1 (en) | 2007-04-11 | 2022-07-20 | BioMarin Pharmaceutical Inc. | Tetrahydrobiopterin for treating conditions associated with elevated phenylalanine levels |
ES2736730T3 (es) * | 2008-08-12 | 2020-01-07 | Orpha Swiss Gmbh | Forma de administración farmacéutica que contiene tetrahidrobiopterina |
EP2456432B1 (en) | 2009-07-22 | 2024-02-28 | University of Massachusetts | Compositions to reduce oxidative stress |
US20130197000A1 (en) | 2010-04-22 | 2013-08-01 | Nihon University | Drug and food/drink for preventing or improving cerebral dysfunction |
EP2646031B9 (en) * | 2010-12-03 | 2018-01-10 | Orexigen Therapeutics, Inc. | Increasing drug bioavailability in naltrexone therapy |
CA2828685C (en) * | 2011-03-01 | 2018-05-29 | Rubicon Research Private Limited | Stable compositions of tetrahydrobiopterin |
US9549563B2 (en) | 2011-10-24 | 2017-01-24 | Kickass Candy Llc | Sweet tart energy tablet |
US9216178B2 (en) * | 2011-11-02 | 2015-12-22 | Biomarin Pharmaceutical Inc. | Dry blend formulation of tetrahydrobiopterin |
ES2758446T3 (es) | 2012-01-23 | 2020-05-05 | Sage Therapeutics Inc | Formulaciones de esteroides neuroactivos que comprenden un complejo de alopregnanolona y sulfobutil éter beta-ciclodextrina |
ES2897671T3 (es) | 2012-01-26 | 2022-03-02 | Vanda Pharmaceuticals Inc | Sincronización del ritmo circadiano desincrónico del cortisol |
US11918557B2 (en) | 2012-01-26 | 2024-03-05 | Vanda Pharmaceuticals Inc. | Treatment of circadian rhythm disorders |
CN102650621B (zh) * | 2012-05-02 | 2014-06-25 | 安徽农业大学 | 一种从蚕体提取的墨蝶呤的鉴定方法 |
WO2014124392A1 (en) * | 2013-02-08 | 2014-08-14 | University Of Iowa Research Foundation | Diagnostic tools to predict onset of preeclampsia |
US10376487B2 (en) | 2013-11-12 | 2019-08-13 | Vanda Pharmaceuticals Inc. | Method of treatment |
US11090285B2 (en) | 2013-11-12 | 2021-08-17 | Vanda Pharmaceuticals Inc | Treatment of circadian rhythm disorders |
US20150204834A1 (en) * | 2014-01-22 | 2015-07-23 | Sarfaraz K. Niazi | Thermodynamic equivalence surrogate test (test) for bioequivalence |
RS54973B1 (sr) * | 2014-03-31 | 2016-11-30 | Vasopharm Gmbh | Čvrste farmaceutske kompozicije koje uključuju derivate biopterina i upotreba takvih kompozicija |
MA41124A (fr) * | 2014-12-05 | 2017-10-10 | Sun Pharmaceutical Ind Ltd | Compositions en suspension à libération prolongée à rétention gastrique |
WO2017061663A1 (ko) | 2015-10-06 | 2017-04-13 | 주식회사 지트리비앤티 | 티모신 베타 4를 포함하는 안약의 제조방법 |
CA3017172C (en) | 2016-03-08 | 2023-03-14 | Sage Therapeutics, Inc. | Neuroactive steroids, compositions, and uses thereof |
US11072614B2 (en) * | 2016-11-29 | 2021-07-27 | Ptc Therapeutics Mp, Inc. | Polymorphs of sepiapterin and salts thereof |
CA3043499A1 (en) * | 2016-11-29 | 2018-06-07 | Censa Pharmaceuticals Inc. | Polymorphic form of sepiapterin |
CN108627576A (zh) * | 2017-03-17 | 2018-10-09 | 武汉宏韧生物医药科技有限公司 | 一种人血浆中他达拉非的定量分析方法 |
JP7414529B2 (ja) | 2017-06-07 | 2024-01-16 | シファメド・ホールディングス・エルエルシー | 血管内流体移動デバイス、システム、および使用方法 |
EP3648760A1 (en) * | 2017-07-06 | 2020-05-13 | Treeway TW001 B.V. | Use of edaravone in oral treatment of oxidative-stress mediated neurodegenerative disorders |
CA3079245A1 (en) * | 2017-07-13 | 2019-03-21 | Tab Protein, Llc | Supplement tablet and packaging |
JP2020532535A (ja) | 2017-09-01 | 2020-11-12 | ピーティーシー セラピューティクス エムピー,インコーポレイテッド | セピアプテリンを含む医薬組成物及びその使用 |
US11511103B2 (en) | 2017-11-13 | 2022-11-29 | Shifamed Holdings, Llc | Intravascular fluid movement devices, systems, and methods of use |
CN110461332A (zh) * | 2017-11-20 | 2019-11-15 | 麦迪贝肯有限公司 | 制备和分析血浆中的荧光化合物的方法 |
CN109946412B (zh) * | 2017-12-21 | 2021-10-15 | 上海产业技术研究院 | 一种体液蝶呤谱检测试剂盒及其使用 |
US10722631B2 (en) | 2018-02-01 | 2020-07-28 | Shifamed Holdings, Llc | Intravascular blood pumps and methods of use and manufacture |
CN110269099B (zh) * | 2018-03-16 | 2023-01-31 | 共生地球生物科技有限公司 | 多重pH缓冲配方与蛋白质消化助剂的组合物及其用途 |
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