MEP62008A - Crystalline anticholinergic, method for its production, and use thereof in the production of a drug - Google Patents

Crystalline anticholinergic, method for its production, and use thereof in the production of a drug

Info

Publication number
MEP62008A
MEP62008A MEP-620/08A MEP62008A MEP62008A ME P62008 A MEP62008 A ME P62008A ME P62008 A MEP62008 A ME P62008A ME P62008 A MEP62008 A ME P62008A
Authority
ME
Montenegro
Prior art keywords
production
drug
crystalline
anticholinergic
medicament
Prior art date
Application number
MEP-620/08A
Other languages
Bosnian (bs)
Inventor
Peter Sieger
Ulrike Werthmann
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Publication of MEP62008A publication Critical patent/MEP62008A/en
Publication of ME00412B publication Critical patent/ME00412B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
    • C07D451/06—Oxygen atoms
    • C07D451/10—Oxygen atoms acylated by aliphatic or araliphatic carboxylic acids, e.g. atropine, scopolamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/46—8-Azabicyclo [3.2.1] octane; Derivatives thereof, e.g. atropine, ***e
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics

Abstract

Pronalazak se odnosi na kristalni, bezvodni (1α,2β,4β,5α,7β)-7-[(hidroksidi-2-tienil-acetil)oksi]-9,9-dimetil-3-oksa-9-azoniatriciklo[3.3.1.02,4] nonan-bromid, na postupak za njegovo pripremanje, kao i na njegovu primjenu za pripremanje lijeka, naročito za proizvodnju lijeka sa antiholinergijskim dejstvom.The invention relates to crystalline, anhydrous (1α, 2β, 4β, 5α, 7β) -7 - [(hydroxides-2-thienyl-acetyl) oxy] -9,9-dimethyl-3-oxa-9-azoniatricyclo [3.3. 1.02,4] nonan-bromide, to a process for its preparation as well as to its use for the preparation of a medicament, in particular for the manufacture of a medicament having an anticholinergic action.

MEP-2008-620A 2001-06-22 2002-06-08 Crystalline anticholinergic, method for its production, and use thereof in the production of a drug ME00412B (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE10129710 2001-06-22
DE10215436 2002-04-08
YUP-997/03A RS50441B (en) 2001-06-22 2002-06-08 Crystalline anticholinergic, method for its production, and use thereof in the production of a drug
PCT/EP2002/006291 WO2003000265A1 (en) 2001-06-22 2002-06-08 Crystalline anticholinergic, method for its production, and use thereof in the production of a drug

Publications (2)

Publication Number Publication Date
MEP62008A true MEP62008A (en) 2011-05-10
ME00412B ME00412B (en) 2011-10-10

Family

ID=26009556

Family Applications (1)

Application Number Title Priority Date Filing Date
MEP-2008-620A ME00412B (en) 2001-06-22 2002-06-08 Crystalline anticholinergic, method for its production, and use thereof in the production of a drug

Country Status (38)

Country Link
EP (1) EP1401445B1 (en)
JP (1) JP2005504015A (en)
KR (2) KR101011353B1 (en)
CN (1) CN100586948C (en)
AR (1) AR037491A1 (en)
AT (1) ATE337006T1 (en)
AU (1) AU2002345016B2 (en)
BG (1) BG66303B1 (en)
BR (1) BR0210537A (en)
CA (1) CA2450961C (en)
CO (1) CO5550423A2 (en)
CY (1) CY1105223T1 (en)
CZ (1) CZ302786B6 (en)
DE (1) DE50207943D1 (en)
DK (1) DK1401445T3 (en)
EA (1) EA005813B1 (en)
EE (1) EE05316B1 (en)
EG (1) EG24851A (en)
ES (1) ES2271280T3 (en)
HK (1) HK1068540A1 (en)
HR (1) HRP20031066B1 (en)
HU (1) HUP0400333A3 (en)
IL (2) IL159238A0 (en)
ME (1) ME00412B (en)
MX (1) MXPA03011718A (en)
MY (1) MY122779A (en)
NO (1) NO334301B1 (en)
NZ (1) NZ530690A (en)
PE (2) PE20030130A1 (en)
PL (1) PL208137B1 (en)
PT (1) PT1401445E (en)
RS (1) RS50441B (en)
SA (1) SA02230255B1 (en)
SI (1) SI1401445T1 (en)
SK (1) SK287262B6 (en)
TW (2) TW200617007A (en)
UY (1) UY27342A1 (en)
WO (1) WO2003000265A1 (en)

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GB0716026D0 (en) 2007-08-16 2007-09-26 Norton Healthcare Ltd An inhalable medicament
BRPI0818006B8 (en) 2007-10-19 2021-05-25 Boehringer Ingelheim Int Substituted-Piperidino-dihydrothienopyrimidine Compounds, Use thereof, and Pharmaceutical Formulations
EP2093219A1 (en) 2008-02-22 2009-08-26 Boehringer Ingelheim International Gmbh Crystalline enantiomer free salt form of a betamimetic and its use as medicine
PE20120061A1 (en) 2008-12-19 2012-02-19 Boehringer Ingelheim Int PYRIMIDINE DERIVATIVES AS ANTAGONISTS OF THE CCR2 RECEPTOR
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PT3091012T (en) 2009-12-17 2018-06-27 Centrexion Therapeutics Corp Ccr2 receptor antagonists and uses thereof
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Also Published As

Publication number Publication date
TWI261589B (en) 2006-09-11
KR101011353B1 (en) 2011-01-28
SA02230255B1 (en) 2006-10-31
BG66303B1 (en) 2013-03-29
AR037491A1 (en) 2004-11-17
ES2271280T3 (en) 2007-04-16
EA005813B1 (en) 2005-06-30
MY122779A (en) 2006-05-31
EA200301293A1 (en) 2004-08-26
AU2002345016B2 (en) 2008-04-17
KR20040018285A (en) 2004-03-02
HUP0400333A3 (en) 2012-10-29
ME00412B (en) 2011-10-10
EE200400029A (en) 2004-04-15
YU99703A (en) 2006-05-25
NZ530690A (en) 2005-05-27
PE20030130A1 (en) 2003-04-02
SK287262B6 (en) 2010-04-07
CZ2004120A3 (en) 2004-05-12
EG24851A (en) 2010-10-27
PL208137B1 (en) 2011-03-31
EE05316B1 (en) 2010-08-16
PL364489A1 (en) 2004-12-13
WO2003000265A1 (en) 2003-01-03
CA2450961A1 (en) 2003-01-03
SK522004A3 (en) 2004-06-08
IL159238A (en) 2010-04-15
HRP20031066B1 (en) 2011-10-31
PT1401445E (en) 2006-10-31
NO20035696D0 (en) 2003-12-19
DE50207943D1 (en) 2006-10-05
KR100971616B1 (en) 2010-07-22
UY27342A1 (en) 2003-02-28
CY1105223T1 (en) 2010-03-03
RS50441B (en) 2010-03-02
CO5550423A2 (en) 2005-08-31
NO334301B1 (en) 2014-02-03
TW200617007A (en) 2006-06-01
HK1068540A1 (en) 2005-04-29
CN100586948C (en) 2010-02-03
KR20090031638A (en) 2009-03-26
DK1401445T3 (en) 2006-11-27
CZ302786B6 (en) 2011-11-09
EP1401445A1 (en) 2004-03-31
IL159238A0 (en) 2004-06-01
BG108440A (en) 2004-08-31
SI1401445T1 (en) 2007-02-28
HUP0400333A2 (en) 2004-12-28
EP1401445B1 (en) 2006-08-23
CA2450961C (en) 2010-03-30
HRP20031066A2 (en) 2004-04-30
JP2005504015A (en) 2005-02-10
PE20081305A1 (en) 2008-10-01
BR0210537A (en) 2004-06-22
ATE337006T1 (en) 2006-09-15
MXPA03011718A (en) 2004-12-06
CN1520294A (en) 2004-08-11

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