SG46380A1 - New xanthine derivatives with adenosine- antagonistic activity - Google Patents

New xanthine derivatives with adenosine- antagonistic activity

Info

Publication number
SG46380A1
SG46380A1 SG1996003965A SG1996003965A SG46380A1 SG 46380 A1 SG46380 A1 SG 46380A1 SG 1996003965 A SG1996003965 A SG 1996003965A SG 1996003965 A SG1996003965 A SG 1996003965A SG 46380 A1 SG46380 A1 SG 46380A1
Authority
SG
Singapore
Prior art keywords
substd
opt
alkyl
cycloalkyl
alkenyl
Prior art date
Application number
SG1996003965A
Other languages
English (en)
Inventor
Ulrike Kufner-Muhl
Helmut Ensinger
Karl-Heinz Weber
Franz Josef Kuhn
Gerhard Walther
Erich Lehr
Werner Stransky
Gunther Schingnitz
Original Assignee
Boehringer Ingelheim Int
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Int filed Critical Boehringer Ingelheim Int
Publication of SG46380A1 publication Critical patent/SG46380A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • C07D473/08—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1 and 3, e.g. theophylline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/08—Bronchodilators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Psychiatry (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Pulmonology (AREA)
  • Hospice & Palliative Care (AREA)
  • Cardiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Steroid Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
SG1996003965A 1988-12-22 1989-12-19 New xanthine derivatives with adenosine- antagonistic activity SG46380A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE3843117A DE3843117A1 (de) 1988-12-22 1988-12-22 Neue xanthinderivate mit adenosin-antagonistischer wirkung

Publications (1)

Publication Number Publication Date
SG46380A1 true SG46380A1 (en) 1998-02-20

Family

ID=6369764

Family Applications (1)

Application Number Title Priority Date Filing Date
SG1996003965A SG46380A1 (en) 1988-12-22 1989-12-19 New xanthine derivatives with adenosine- antagonistic activity

Country Status (32)

Country Link
US (4) US5175291A (ru)
EP (1) EP0374808B1 (ru)
JP (1) JP2565576B2 (ru)
KR (1) KR0165666B1 (ru)
AT (1) ATE136897T1 (ru)
BG (1) BG61669B2 (ru)
BR (1) BR1100527A (ru)
CA (1) CA2006387C (ru)
CZ (1) CZ286230B6 (ru)
DD (1) DD290421A5 (ru)
DE (3) DE8817122U1 (ru)
DK (1) DK652689A (ru)
ES (1) ES2086313T3 (ru)
FI (1) FI96513C (ru)
GR (1) GR3019733T3 (ru)
HR (1) HRP940724A2 (ru)
HU (1) HU218674B (ru)
IE (1) IE74205B1 (ru)
IL (1) IL92829A (ru)
MX (1) MX9203618A (ru)
NO (1) NO173502C (ru)
NZ (1) NZ231901A (ru)
PH (2) PH31107A (ru)
PL (1) PL162877B1 (ru)
PT (1) PT92658B (ru)
RU (1) RU2057752C1 (ru)
SG (1) SG46380A1 (ru)
SI (1) SI8912423B (ru)
SK (1) SK279525B6 (ru)
UA (1) UA26427A (ru)
YU (1) YU47934B (ru)
ZA (1) ZA899881B (ru)

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DE8817122U1 (de) * 1988-12-22 1993-02-04 Boehringer Ingelheim Kg, 55218 Ingelheim Neue Xanthinderivate mit Adenosinantogenistischer Wirkung
US5290782A (en) * 1989-09-01 1994-03-01 Kyowa Hakko Kogyo Co., Ltd. Xanthine derivatives
JPH06102662B2 (ja) * 1989-09-01 1994-12-14 協和醗酵工業株式会社 キサンチン誘導体
US5047534A (en) * 1990-03-26 1991-09-10 Merrell Dow Pharmaceuticals Inc. Selective adenosine receptor agents
DE4019892A1 (de) * 1990-06-22 1992-01-02 Boehringer Ingelheim Kg Neue xanthinderivate
CA2061544A1 (en) * 1991-02-25 1992-08-26 Fumio Suzuki Xanthine compounds
GB9111131D0 (en) * 1991-05-23 1991-07-17 Ici Plc Heterocyclic compounds
GB9111130D0 (en) * 1991-05-23 1991-07-17 Ici Plc Azole derivatives
EP0541120B1 (en) * 1991-11-08 1999-05-26 Kyowa Hakko Kogyo Co., Ltd. Xanthine derivatives for the treatment of dementia
IT1260444B (it) * 1992-01-24 1996-04-09 Mario Brufani Derivati della 8-(1-amminocicloalchil)1,3-dialchilxantina, procedimenbto di preparazione e loro composizioni farmaceutiche antidepressive, nootropiche e psicostimolanti
EP0556778A3 (en) * 1992-02-17 1993-11-24 Kyowa Hakko Kogyo Kk Xanthine derivatives
CA2093403C (en) * 1992-04-08 1999-08-10 Fumio Suzuki Therapeutic agent for parkinson's disease
US5484920A (en) * 1992-04-08 1996-01-16 Kyowa Hakko Kogyo Co., Ltd. Therapeutic agent for Parkinson's disease
WO1994003173A1 (de) * 1992-08-01 1994-02-17 Boehringer Ingelheim Kg Verwendung von 8-(3-oxocyclopentyl)-1,3-dipropyl-7h-purin-2,6-dion zur symptomatischen behandlung der zystischen fibrose
TW252044B (ru) * 1992-08-10 1995-07-21 Boehringer Ingelheim Kg
US5288721A (en) * 1992-09-22 1994-02-22 Cell Therapeutics, Inc. Substituted epoxyalkyl xanthines
JP2613355B2 (ja) * 1992-09-28 1997-05-28 協和醗酵工業株式会社 パーキンソン氏病治療剤
US5877179A (en) * 1992-09-29 1999-03-02 The United States Of America As Represented By The Department Of Health And Human Services Xanthines for identifying CFTR--binding compounds useful for activating chloride conductance in animal cells
DE4236331A1 (de) * 1992-10-28 1994-05-05 Boehringer Ingelheim Kg Synergistische Kombination
WO1994015605A1 (en) * 1993-01-14 1994-07-21 Cell Therapeutics, Inc. Acetal or ketal substituted therapeutic compounds
JPH08512281A (ja) * 1993-02-26 1996-12-24 メレル ダウ ファーマス−ティカルズ インコーポレイテッド アデノシンａ▲下１▼受容体拮抗剤としてのキサンチン誘導体類
AU6781194A (en) * 1993-05-03 1994-11-21 United States Of America, Represented By The Secretary, Department Of Health And Human Services, The 8-substituted 1,3,7-trialkyl-xanthine derivatives as a2-selective adenosine receptor antagonists
DE4316576A1 (de) * 1993-05-18 1994-11-24 Boehringer Ingelheim Kg Verbessertes Verfahren zur Herstellung von 1,3-Dipropyl-8-(3-Oxocyclopentyl)-xanthin
US5446046A (en) * 1993-10-28 1995-08-29 University Of Florida Research Foundation A1 adenosine receptor agonists and antagonists as diuretics
US5736528A (en) * 1993-10-28 1998-04-07 University Of Florida Research Foundation, Inc. N6 -(epoxynorborn-2-yl) adenosines as A1 adenosine receptor agonists
JP3769737B2 (ja) * 1994-03-30 2006-04-26 味の素株式会社 シクロプロパン誘導体及びその製造法
US5591776A (en) * 1994-06-24 1997-01-07 Euro-Celtique, S.A. Pheynl or benzyl-substituted rolipram-based compounds for and method of inhibiting phosphodiesterase IV
JP2001523213A (ja) * 1994-12-13 2001-11-20 ユーロ−セルティーク，エス．エイ． 三置換チオキサンチン類
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US5864037A (en) * 1996-06-06 1999-01-26 Euro-Celtique, S.A. Methods for the synthesis of chemical compounds having PDE-IV inhibitory activity
US5789416B1 (en) * 1996-08-27 1999-10-05 Cv Therapeutics Inc N6 mono heterocyclic substituted adenosine derivatives
US5786360A (en) * 1996-11-19 1998-07-28 Link Technology Incorporated A1 adenosine receptor antagonists
US6727259B2 (en) * 1997-09-05 2004-04-27 Kyowa Hakko Kogyo Co., Ltd. Remedial agent for neural degeneration
US6248746B1 (en) 1998-01-07 2001-06-19 Euro-Celtique S.A. 3-(arylalkyl) xanthines
DE19816857A1 (de) * 1998-04-16 1999-10-21 Boehringer Ingelheim Pharma Neue unsymmetrisch substituierte Xanthin-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
ATE342734T1 (de) * 1998-06-01 2006-11-15 Astellas Pharma Inc Adenosin a1 antagonisten gegen männliche sterilität
AU4980999A (en) 1998-07-10 2000-02-01 United States Of America, Represented By The Secretary, Department Of Health And Human Services, The A3 adenosine receptor antagonists
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US6576619B2 (en) 1999-05-24 2003-06-10 Cv Therapeutics, Inc. Orally active A1 adenosine receptor agonists
US6545002B1 (en) * 1999-06-01 2003-04-08 University Of Virginia Patent Foundation Substituted 8-phenylxanthines useful as antagonists of A2B adenosine receptors
EA005211B1 (ru) * 1999-11-12 2004-12-30 Байоджен, Инк. Полициклоалкилпурины в качестве антагонистов аденозиновых рецепторов
NZ519427A (en) * 1999-11-12 2003-08-29 Biogen Inc Polycycloalkylpurine derivative useful as an adenosine receptor antagonist
DE60122285D1 (de) 2000-01-14 2006-09-28 Us Gov Health & Human Serv Methonocarbacycloalkylanaloga von nucleosiden
US20020115635A1 (en) * 2001-02-21 2002-08-22 Pnina Fishman Modulation of GSK-3beta activity and its different uses
IL161867A0 (en) 2001-11-09 2005-11-20 Cv Therapeutics Inc A2b adenosine receptor antagonists
US7125993B2 (en) * 2001-11-09 2006-10-24 Cv Therapeutics, Inc. A2B adenosine receptor antagonists
US7317017B2 (en) * 2002-11-08 2008-01-08 Cv Therapeutics, Inc. A2B adenosine receptor antagonists
US6977300B2 (en) * 2001-11-09 2005-12-20 Cv Therapeutics, Inc. A2B adenosine receptor antagonists
US20080318983A1 (en) * 2001-11-09 2008-12-25 Rao Kalla A2b adenosine receptor antagonists
US20040106797A1 (en) * 2002-07-19 2004-06-03 Pascal Druzgala Novel xanthines having adenosine A1-receptor antagonist properties
WO2004074247A2 (en) * 2003-02-19 2004-09-02 Endacea, Inc. A1 adenosine receptor antagonists
US20040229901A1 (en) * 2003-02-24 2004-11-18 Lauren Otsuki Method of treatment of disease using an adenosine A1 receptor antagonist
NZ543109A (en) * 2003-04-25 2008-06-30 Novacardia Inc Method of improved diuresis in individuals with impaired renal function
US20060293312A1 (en) * 2003-04-25 2006-12-28 Howard Dittrich Method of improved diuresis in individuals with impaired renal function
MXPA05011860A (es) * 2003-05-06 2006-02-17 Cv Therapeutics Inc Derivados de xantina como antagonistas del receptor de adenosina a2b.
WO2005009343A2 (en) * 2003-06-06 2005-02-03 Endacea, Inc. A1 adenosine receptor antogonists
US20090068101A9 (en) * 2003-06-09 2009-03-12 Endacea, Inc. A1 Adenosine Receptor Antagonists
TW200507882A (en) * 2003-07-17 2005-03-01 Kyowa Hakko Kogyo Kk Solid formulations
US6847249B1 (en) * 2003-10-09 2005-01-25 Analog Devices, Inc. Highest available voltage selector circuit
BRPI0509753A (pt) * 2004-04-16 2007-10-16 Novacardia Inc composição farmacêutica e método de tratamento de doença cardiovascular
RU2385322C2 (ru) * 2004-09-01 2010-03-27 Си Ви Терапьютикс, Инк. Способ заживления ран с применением антагонистов аденозинового рецептора a2b
CN101466383A (zh) * 2006-06-16 2009-06-24 美国诺华卡迪亚公司 包含低频率投与aa1ra的肾功能延长改善
US8193200B2 (en) 2007-01-04 2012-06-05 University Of Virginia Patent Foundation Antagonists of A2B adenosine receptors for treatment of inflammatory bowel disease
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US3624215A (en) * 1970-06-25 1971-11-30 Abbott Lab 8-substituted theophyllines as anti-anxiety agents
US3624216A (en) * 1970-06-25 1971-11-30 Abbott Lab 8-substituted theophyllines as anti-inflammatory agents
DE3028273A1 (de) * 1980-07-25 1982-02-25 Fa. Dr. Willmar Schwabe, 7500 Karlsruhe Durch purinbasen substituierte 1.4;3.6-dianhydro-hexit-nitrate
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US4593095A (en) * 1983-02-18 1986-06-03 The Johns Hopkins University Xanthine derivatives
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US4755517A (en) * 1986-07-31 1988-07-05 Warner-Lambert Company Derivatives of xanthine, pharmaceutical compositions and methods of use therefor
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DE8817122U1 (de) * 1988-12-22 1993-02-04 Boehringer Ingelheim Kg, 55218 Ingelheim Neue Xanthinderivate mit Adenosinantogenistischer Wirkung
US5290782A (en) * 1989-09-01 1994-03-01 Kyowa Hakko Kogyo Co., Ltd. Xanthine derivatives
JPH06102662B2 (ja) * 1989-09-01 1994-12-14 協和醗酵工業株式会社 キサンチン誘導体
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EP0541120B1 (en) * 1991-11-08 1999-05-26 Kyowa Hakko Kogyo Co., Ltd. Xanthine derivatives for the treatment of dementia

Also Published As

Publication number Publication date
FI96513C (fi) 1996-07-10
KR0165666B1 (ko) 1999-01-15
DE3843117A1 (de) 1990-06-28
US5532368A (en) 1996-07-02
CA2006387A1 (en) 1990-06-22
NO895168L (no) 1990-06-25
UA26427A (uk) 1999-08-30
SI8912423A (sl) 1998-04-30
CZ286230B6 (cs) 2000-02-16
BR1100527A (pt) 2000-08-01
PH31107A (en) 1998-02-23
DK652689A (da) 1990-06-23
ATE136897T1 (de) 1996-05-15
US5688802A (en) 1997-11-18
NO173502B (no) 1993-09-13
DE58909657D1 (de) 1996-05-23
SK719789A3 (en) 1998-12-02
PH31111A (en) 1998-02-23
PT92658A (pt) 1990-06-29
EP0374808B1 (de) 1996-04-17
SI8912423B (sl) 1998-12-31
EP0374808A3 (de) 1991-05-15
HU218674B (hu) 2000-10-28
AU4707289A (en) 1990-06-28
IE894147L (en) 1990-06-22
NZ231901A (en) 1993-12-23
NO895168D0 (no) 1989-12-21
EP0374808A2 (de) 1990-06-27
KR900009646A (ko) 1990-07-05
RU2057752C1 (ru) 1996-04-10
JPH02247180A (ja) 1990-10-02
FI96513B (fi) 1996-03-29
US5175291A (en) 1992-12-29
YU242389A (en) 1991-10-31
JP2565576B2 (ja) 1996-12-18
HUT52503A (en) 1990-07-28
NO173502C (no) 1993-12-22
IL92829A (en) 1995-12-31
YU47934B (sh) 1996-05-20
AU637990B2 (en) 1993-06-17
IE74205B1 (en) 1997-07-16
PL162877B1 (pl) 1994-01-31
HU896736D0 (en) 1990-02-28
PT92658B (pt) 1995-09-12
DD290421A5 (de) 1991-05-29
BG61669B2 (bg) 1998-02-27
ES2086313T3 (es) 1996-07-01
DE8817122U1 (de) 1993-02-04
SK279525B6 (sk) 1998-12-02
FI896117A0 (fi) 1989-12-20
DK652689D0 (da) 1989-12-21
HRP940724A2 (en) 1997-06-30
US5696124A (en) 1997-12-09
ZA899881B (en) 1991-08-28
PL282878A1 (en) 1992-03-09
CZ719789A3 (cs) 1999-10-13
IL92829A0 (en) 1990-09-17
MX9203618A (es) 1992-09-01
CA2006387C (en) 2000-02-08
GR3019733T3 (en) 1996-07-31

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