SG170620A1 - Novel compounds, pharmaceutical compositions containing same, and methods of use for same - Google Patents

Novel compounds, pharmaceutical compositions containing same, and methods of use for same

Info

Publication number
SG170620A1
SG170620A1 SG200806631-8A SG2008066318A SG170620A1 SG 170620 A1 SG170620 A1 SG 170620A1 SG 2008066318 A SG2008066318 A SG 2008066318A SG 170620 A1 SG170620 A1 SG 170620A1
Authority
SG
Singapore
Prior art keywords
group
cycloalkyl
alkenyl
alkyl
same
Prior art date
Application number
SG200806631-8A
Other languages
English (en)
Inventor
Francis P Kuhadja
Susan M Medghalchi
Jagan N Thupari
Craig A Townsend
Jill M Mcfadden
Original Assignee
Fasgen Llc
Univ Johns Hopkins
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fasgen Llc, Univ Johns Hopkins filed Critical Fasgen Llc
Publication of SG170620A1 publication Critical patent/SG170620A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/32—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/32—Oxygen atoms
    • C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/58—One oxygen atom, e.g. butenolide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Child & Adolescent Psychology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Furan Compounds (AREA)
SG200806631-8A 2002-07-01 2003-07-01 Novel compounds, pharmaceutical compositions containing same, and methods of use for same SG170620A1 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US39280902P 2002-07-01 2002-07-01

Publications (1)

Publication Number Publication Date
SG170620A1 true SG170620A1 (en) 2011-05-30

Family

ID=30115535

Family Applications (1)

Application Number Title Priority Date Filing Date
SG200806631-8A SG170620A1 (en) 2002-07-01 2003-07-01 Novel compounds, pharmaceutical compositions containing same, and methods of use for same

Country Status (15)

Country Link
US (1) US20060241177A1 (zh)
EP (1) EP1534263A4 (zh)
JP (1) JP2005533107A (zh)
KR (1) KR20050072670A (zh)
CN (2) CN101633650A (zh)
AU (1) AU2003248810B2 (zh)
BR (1) BRPI0312413A2 (zh)
CA (1) CA2491183A1 (zh)
EA (1) EA010484B1 (zh)
HK (1) HK1086485A1 (zh)
IL (1) IL166054A0 (zh)
MX (1) MXPA05000152A (zh)
SG (1) SG170620A1 (zh)
WO (1) WO2004006835A2 (zh)
ZA (1) ZA200500203B (zh)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9018737D0 (en) * 1990-08-28 1990-10-10 Goodfellow John W Phosphetic patellar components
EA007029B1 (ru) 2002-02-08 2006-06-30 Джон Хопкинс Юниверсити Скул Оф Медсин Стимуляция срт-1 как средство уменьшения веса
BRPI0312654A2 (pt) * 2002-07-09 2017-05-02 Fasgen Llc métodos de tratar infecções microbianas em seres humanos e animais
CN101007796A (zh) * 2006-01-27 2007-08-01 北京摩力克科技有限公司 新型五元杂环化合物及其制备方法和医疗用途
CN101190904A (zh) * 2006-11-23 2008-06-04 中国人民解放军军事医学科学院毒物药物研究所 脂肪酸合成酶抑制剂及其制药用途
JP5616220B2 (ja) 2007-06-01 2014-10-29 ザ トラスティーズ オブ プリンストン ユニバーシティ 宿主細胞代謝経路の調節によるウイルス感染治療
WO2010118324A2 (en) 2009-04-09 2010-10-14 Nuclea Biotechnologies, LLC Antibodies against fatty acid synthase
FR2957078B1 (fr) * 2010-03-05 2012-05-04 Centre Nat Rech Scient Acides paraconiques comme activateurs de pigmentation
WO2011140190A1 (en) 2010-05-05 2011-11-10 Infinity Pharmaceuticals Tetrazolones as inhibitors of fatty acid synthase
US8450350B2 (en) 2010-05-05 2013-05-28 Infinity Pharmaceuticals, Inc. Triazoles as inhibitors of fatty acid synthase
WO2014039769A1 (en) * 2012-09-07 2014-03-13 Janssen Pharmaceutica Nv Imidazolin-5-one derivatives useful as fatty acid snthase (fasn) inhibitors for|the treatment of cancer
CN103145662B (zh) * 2013-02-18 2014-07-16 深圳万和制药有限公司 N-取代的氨基丁内酯衍生物及其用途
CN103864731B (zh) * 2014-02-19 2016-01-20 成都中医药大学 含季碳手性中心的呋喃内酯环类化合物的合成方法
CN104530018B (zh) * 2014-12-12 2017-04-12 郑州大学 含α‑亚甲基‑γ‑丁内酯结构的吲哚类化合物、制备方法及其应用
EP3253742B1 (en) * 2015-02-05 2020-04-08 Dermira Inc. Synthetic process for preparing 2-((2-ethoxy-2-oxoethyl)(methyl)amino)-2-oxoethyl 5-tetradecyloxy)furan-2-carboxylate
KR102038971B1 (ko) * 2018-03-12 2019-11-26 주식회사 엔지켐생명과학 디아실글리세롤락톤 화합물, 그 제조방법 및 이를 유효성분으로 함유하는 면역증진제
KR20220159831A (ko) 2021-05-26 2022-12-05 울산과학기술원 미토콘드리아 표적화 뉴클레오펩티드 및 이를 포함하는 암의 예방 또는 치료용 약학적 조성물

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3496187A (en) * 1967-03-20 1970-02-17 American Home Prod N-(heterocyclyl)aconamides
US3472878A (en) * 1969-01-27 1969-10-14 American Home Prod N-(hydroxyaryl)aconamides
US4753871A (en) * 1986-12-12 1988-06-28 Eastman Kodak Company Cyan dye-forming couplers and photographic materials containing same
JPS63169848A (ja) * 1987-01-07 1988-07-13 Nec Corp デジタルデ−タ通信におけるデ−タ端末収容方式
JP2524760B2 (ja) * 1987-07-10 1996-08-14 テイカ株式会社 新規抗生物質
JPH04199148A (ja) * 1990-11-29 1992-07-20 Konica Corp ハロゲン化銀写真感光材料
JPH05246822A (ja) * 1992-03-07 1993-09-24 Nippon Paint Co Ltd 抗菌剤
JPH07112931A (ja) * 1993-08-27 1995-05-02 Nippon Paint Co Ltd エプスタイン−バーウイルス活性化抑制剤
ATE303144T1 (de) * 1995-11-17 2005-09-15 Univ Johns Hopkins Hemmung der fettsäuresynthase als mittel zur verminderung der adipozytenmenge
AU784495B2 (en) * 1999-11-12 2006-04-13 Johns Hopkins University School Of Medicine, The Treating cancer by increasing intracellular malonyl coa levels
AU2001238515A1 (en) * 2000-02-16 2001-08-27 The John Hopkins University School Of Medicine Weight loss induced by reduction in neuropeptide y level

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
SYNTHESIS AND ABSOLUTE STEREOCHEMISTRY OF (-)- PROTOLICHESTERINIC ACID, ANTITUMOR ANTIBIOTIC LACTONE FROM CETRARIA ISLANDICA *
SYNTHESIS AND ANTITUMOR ACTIVITY OF AN INHIBITOR OF FATTY ACID SYNTHASE *

Also Published As

Publication number Publication date
EP1534263A4 (en) 2006-10-11
WO2004006835A2 (en) 2004-01-22
MXPA05000152A (es) 2005-10-24
US20060241177A1 (en) 2006-10-26
CA2491183A1 (en) 2004-01-22
IL166054A0 (en) 2006-01-15
EA200500122A1 (ru) 2005-12-29
KR20050072670A (ko) 2005-07-12
AU2003248810A1 (en) 2004-02-02
CN100482219C (zh) 2009-04-29
JP2005533107A (ja) 2005-11-04
AU2003248810B2 (en) 2009-08-20
EP1534263A2 (en) 2005-06-01
WO2004006835A3 (en) 2004-07-22
ZA200500203B (en) 2009-09-30
BRPI0312413A2 (pt) 2016-08-02
HK1086485A1 (en) 2006-09-22
CN1705478A (zh) 2005-12-07
CN101633650A (zh) 2010-01-27
EA010484B1 (ru) 2008-10-30

Similar Documents

Publication Publication Date Title
SG170620A1 (en) Novel compounds, pharmaceutical compositions containing same, and methods of use for same
TW200716661A (en) A novel triterpenic acid derivative and the skin external preparation containing the same
EA200601620A1 (ru) 5,6-диалкил-7-аминотриазолопиримидины, способ их получения и их применение для борьбы с патогенными растениями, а также содержащие их средства
ATE396771T1 (de) Pflegezusammensetzung mit aminosilicon
EP1623985A3 (en) Analogs of indole-3-carbinol metabolites as chemotherapeutic and chemopreventative agents
GB1460515A (en) Chemical compositions
MXPA03011576A (es) Composiciones antitranspirantes o desodorantes.
BR0309710A (pt) Composição ácida espessada e usos da mesma
DE60035428D1 (de) Haarpflege- und antischuppenmittel
MA38865A1 (fr) Formulation comprenant un agent hypolipidémiant
JP2005533897A5 (zh)
MY150070A (en) Pharmaceutically active compounds, their manufacture, compositions containing them and their use
BRPI0508232A (pt) sìntese de epotilonas, intermediários das mesmas, análogos e usos das mesmas
ES8800841A1 (es) Procedimiento de preparacion de un nuevo cosmetico a base de un gel de aceite incluyendo al menos una sal metalica de un fosfato de dialquilo.
IL66853A (en) Pharmaceutical compositions comprising levallorphan derivatives
MX2013002620A (es) Novedosas n-hidroxi-benzamidas para el tratamiento del cancer.
PL1970372T3 (pl) Sole kwasu 9-oksoakrydyno-10-octowego z 1-alkiloamino-1-deoksypoliolami
MX2007002531A (es) Derivados novedosos de 3,5-seco-4-norcolestan y usos de los mismos.
ZA202309924B (en) Amarouciaxanthin a esters and uses thereof
WO2006100692A3 (en) A novel inter and intra multilamellar vesicular composition.
NO993489L (no) Lysfiltrerende blanding
DE60308171D1 (de) Haarpflegemittel, die phenolische haarformungsmittel enthalten
DK1663165T3 (da) Forbedret stearatsammensætning og fremgangsmåde til fremstilling deraf
MY170616A (en) Skin cleansing composition
MX2009005182A (es) Derivados de 2-hidroxi-1,3-diamino-propano.