MXPA05000152A - Nuevos compuestos, composiciones farmaceuticas que contienen a los mismos, y metodos de uso para los mismos. - Google Patents

Nuevos compuestos, composiciones farmaceuticas que contienen a los mismos, y metodos de uso para los mismos.

Info

Publication number
MXPA05000152A
MXPA05000152A MXPA05000152A MXPA05000152A MXPA05000152A MX PA05000152 A MXPA05000152 A MX PA05000152A MX PA05000152 A MXPA05000152 A MX PA05000152A MX PA05000152 A MXPA05000152 A MX PA05000152A MX PA05000152 A MXPA05000152 A MX PA05000152A
Authority
MX
Mexico
Prior art keywords
group
cycloalkyl
alkenyl
alkyl
same
Prior art date
Application number
MXPA05000152A
Other languages
English (en)
Inventor
Jill M Mcfadden
Original Assignee
Fasgen Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fasgen Llc filed Critical Fasgen Llc
Publication of MXPA05000152A publication Critical patent/MXPA05000152A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/32—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/26—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D307/30—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/32—Oxygen atoms
    • C07D307/33—Oxygen atoms in position 2, the oxygen atom being in its keto or unsubstituted enol form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/58—One oxygen atom, e.g. butenolide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen

Abstract

La presente invencion se refiere a una composicion farmaceutica que comprende un diluyente farmaceutico y un compuesto de formula (IX): R29 = H, o alquilo, cicloalquilo, alquenilo, arilo, arilalquilo o alquilarilo de C1-C20, CHR31, -C(O)0R31, -C(O)R31, -CH2C(O)0R31, -CH2C(O)NHR31, en donde R31 es E o alquilo, cicloalquilo o alquenilo de C1-C10 ; R30 = = alquilo, cicloalquilo, alquenilo, arilo, arilalquilo o alquilarilo de C1-C20; X5 = 0R32 o -NHR32, en donde R32 es E, alquilo, cicloalquilo, alquenilo, arilo, arilalquilo o alquilarilo de C1-C20, el grupo R32 opcionalmente contiene un grupo carbonilo, un grupo carboxilo, un grupo carboxiamida, un grupo alcohol, o un grupo eter, el grupo R32 ademas contiene opcionalmente uno o mas atomos de halogeno; con la condicion de que cuando R29 es =CH2, entonces X5 no es -OH. Tambien se describen compuestos dentro del ambito de la formula (IX), asi como tambien usos de las composiciones farmaceuticas para aplicaciones en perdida de peso, anti-microbianas y anti-cancerigenas, inhibicion del acido graso sintasa y neuropeptido Y, y la estimulacion de la actividad de carnitina palmitoiltransferasa-l.
MXPA05000152A 2002-07-01 2003-07-01 Nuevos compuestos, composiciones farmaceuticas que contienen a los mismos, y metodos de uso para los mismos. MXPA05000152A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US39280902P 2002-07-01 2002-07-01
PCT/US2003/020960 WO2004006835A2 (en) 2002-07-01 2003-07-01 Novel compounds, pharmaceutical compositions containing same, and methods of use for same

Publications (1)

Publication Number Publication Date
MXPA05000152A true MXPA05000152A (es) 2005-10-24

Family

ID=30115535

Family Applications (1)

Application Number Title Priority Date Filing Date
MXPA05000152A MXPA05000152A (es) 2002-07-01 2003-07-01 Nuevos compuestos, composiciones farmaceuticas que contienen a los mismos, y metodos de uso para los mismos.

Country Status (15)

Country Link
US (1) US20060241177A1 (es)
EP (1) EP1534263A4 (es)
JP (1) JP2005533107A (es)
KR (1) KR20050072670A (es)
CN (2) CN101633650A (es)
AU (1) AU2003248810B2 (es)
BR (1) BRPI0312413A2 (es)
CA (1) CA2491183A1 (es)
EA (1) EA010484B1 (es)
HK (1) HK1086485A1 (es)
IL (1) IL166054A0 (es)
MX (1) MXPA05000152A (es)
SG (1) SG170620A1 (es)
WO (1) WO2004006835A2 (es)
ZA (1) ZA200500203B (es)

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* Cited by examiner, † Cited by third party
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GB9018737D0 (en) * 1990-08-28 1990-10-10 Goodfellow John W Phosphetic patellar components
KR20040082417A (ko) 2002-02-08 2004-09-24 존스 홉킨스 유니버시티 스쿨 오브 메디슨 체중 감량을 위한 수단으로서의 ｃｐｔ-1의 자극
JP4493494B2 (ja) * 2002-07-09 2010-06-30 ファスゲン，インク． ヒトおよび動物における微生物感染症の治療方法
CN101007796A (zh) * 2006-01-27 2007-08-01 北京摩力克科技有限公司 新型五元杂环化合物及其制备方法和医疗用途
CN101190904A (zh) * 2006-11-23 2008-06-04 中国人民解放军军事医学科学院毒物药物研究所 脂肪酸合成酶抑制剂及其制药用途
EP2581081A3 (en) 2007-06-01 2013-07-31 The Trustees Of Princeton University Treatment of viral infections by modulation of host cell metabolic pathways
US8729239B2 (en) 2009-04-09 2014-05-20 Nuclea Biotechnologies, Inc. Antibodies against fatty acid synthase
FR2957078B1 (fr) * 2010-03-05 2012-05-04 Centre Nat Rech Scient Acides paraconiques comme activateurs de pigmentation
US8450350B2 (en) 2010-05-05 2013-05-28 Infinity Pharmaceuticals, Inc. Triazoles as inhibitors of fatty acid synthase
EP3159331A1 (en) 2010-05-05 2017-04-26 Infinity Pharmaceuticals, Inc. Tetrazolones as inhibitors of fatty acid synthase
WO2014039769A1 (en) * 2012-09-07 2014-03-13 Janssen Pharmaceutica Nv Imidazolin-5-one derivatives useful as fatty acid snthase (fasn) inhibitors for|the treatment of cancer
CN103145662B (zh) * 2013-02-18 2014-07-16 深圳万和制药有限公司 N-取代的氨基丁内酯衍生物及其用途
CN103880789B (zh) * 2014-02-19 2016-02-03 成都中医药大学 呋喃内酯环类衍生物及其用途
CN104530018B (zh) * 2014-12-12 2017-04-12 郑州大学 含α‑亚甲基‑γ‑丁内酯结构的吲哚类化合物、制备方法及其应用
US9487497B2 (en) * 2015-02-05 2016-11-08 Dermira Inc. Synthetic process for preparing 2-((2-ethoxy-2-oxoethyl)(methyl)amino)-2-oxoethyl 5-tetradecyloxy)furan-2-carboxylate
KR102038971B1 (ko) * 2018-03-12 2019-11-26 주식회사 엔지켐생명과학 디아실글리세롤락톤 화합물, 그 제조방법 및 이를 유효성분으로 함유하는 면역증진제
KR20220159831A (ko) 2021-05-26 2022-12-05 울산과학기술원 미토콘드리아 표적화 뉴클레오펩티드 및 이를 포함하는 암의 예방 또는 치료용 약학적 조성물

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US3496187A (en) * 1967-03-20 1970-02-17 American Home Prod N-(heterocyclyl)aconamides
US3472878A (en) * 1969-01-27 1969-10-14 American Home Prod N-(hydroxyaryl)aconamides
US4753871A (en) * 1986-12-12 1988-06-28 Eastman Kodak Company Cyan dye-forming couplers and photographic materials containing same
JPS63169848A (ja) * 1987-01-07 1988-07-13 Nec Corp デジタルデ−タ通信におけるデ−タ端末収容方式
JP2524760B2 (ja) * 1987-07-10 1996-08-14 テイカ株式会社 新規抗生物質
JPH04199148A (ja) * 1990-11-29 1992-07-20 Konica Corp ハロゲン化銀写真感光材料
JPH05246822A (ja) * 1992-03-07 1993-09-24 Nippon Paint Co Ltd 抗菌剤
JPH07112931A (ja) * 1993-08-27 1995-05-02 Nippon Paint Co Ltd エプスタイン−バーウイルス活性化抑制剤
DK0869784T3 (da) * 1995-11-17 2006-01-16 Univ Johns Hopkins Hæmning af fedtsyresyntase som middel til formindskelse af adipocytmængden
CA2391277A1 (en) * 1999-11-12 2001-05-17 The Johns Hopkins University School Of Medicine Treating cancer by increasing intracellular malonyl coa levels
JP2003528051A (ja) * 2000-02-16 2003-09-24 ザ ジョンズ ホプキンス ユニバーシティー スクール オブ メディシン ニューロペプチドｙレベルの減少によって誘導される体重減少

Also Published As

Publication number Publication date
AU2003248810A1 (en) 2004-02-02
JP2005533107A (ja) 2005-11-04
US20060241177A1 (en) 2006-10-26
CN1705478A (zh) 2005-12-07
CN101633650A (zh) 2010-01-27
AU2003248810B2 (en) 2009-08-20
EA200500122A1 (ru) 2005-12-29
CA2491183A1 (en) 2004-01-22
WO2004006835A3 (en) 2004-07-22
BRPI0312413A2 (pt) 2016-08-02
EP1534263A4 (en) 2006-10-11
ZA200500203B (en) 2009-09-30
CN100482219C (zh) 2009-04-29
EP1534263A2 (en) 2005-06-01
EA010484B1 (ru) 2008-10-30
HK1086485A1 (en) 2006-09-22
IL166054A0 (en) 2006-01-15
KR20050072670A (ko) 2005-07-12
WO2004006835A2 (en) 2004-01-22
SG170620A1 (en) 2011-05-30

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