SG11201506479TA - Substituted xanthines and methods of use thereof - Google Patents
Substituted xanthines and methods of use thereofInfo
- Publication number
- SG11201506479TA SG11201506479TA SG11201506479TA SG11201506479TA SG11201506479TA SG 11201506479T A SG11201506479T A SG 11201506479TA SG 11201506479T A SG11201506479T A SG 11201506479TA SG 11201506479T A SG11201506479T A SG 11201506479TA SG 11201506479T A SG11201506479T A SG 11201506479TA
- Authority
- SG
- Singapore
- Prior art keywords
- methods
- substituted xanthines
- xanthines
- substituted
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
- C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201361789724P | 2013-03-15 | 2013-03-15 | |
PCT/US2014/027920 WO2014143799A2 (en) | 2013-03-15 | 2014-03-14 | Substituted xanthines and methods of use thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201506479TA true SG11201506479TA (en) | 2015-09-29 |
Family
ID=50680155
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201506479TA SG11201506479TA (en) | 2013-03-15 | 2014-03-14 | Substituted xanthines and methods of use thereof |
Country Status (32)
Country | Link |
---|---|
US (6) | US9359359B2 (hr) |
EP (1) | EP2970303B3 (hr) |
JP (1) | JP6360149B2 (hr) |
KR (1) | KR102227629B1 (hr) |
CN (2) | CN105143229B (hr) |
AU (1) | AU2014228206C1 (hr) |
CA (1) | CA2899646C (hr) |
CL (1) | CL2015002738A1 (hr) |
CY (1) | CY1119042T1 (hr) |
DK (1) | DK2970303T6 (hr) |
EA (1) | EA028815B1 (hr) |
ES (1) | ES2636835T7 (hr) |
HK (1) | HK1217329A1 (hr) |
HR (1) | HRP20170840T4 (hr) |
HU (1) | HUE033528T4 (hr) |
IL (1) | IL240216B (hr) |
LT (1) | LT2970303T (hr) |
MX (1) | MX370372B (hr) |
MY (1) | MY189912A (hr) |
NZ (1) | NZ711718A (hr) |
PE (1) | PE20151779A1 (hr) |
PH (1) | PH12015502141B1 (hr) |
PL (1) | PL2970303T6 (hr) |
PT (1) | PT2970303T (hr) |
RS (1) | RS56066B2 (hr) |
SG (1) | SG11201506479TA (hr) |
SI (1) | SI2970303T1 (hr) |
TW (1) | TWI609867B (hr) |
UA (1) | UA117470C2 (hr) |
UY (1) | UY35488A (hr) |
WO (1) | WO2014143799A2 (hr) |
ZA (1) | ZA201505414B (hr) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8173750B2 (en) | 2009-04-23 | 2012-05-08 | ATRP Solutions, Inc. | Star macromolecules for personal and home care |
JP6360149B2 (ja) | 2013-03-15 | 2018-07-18 | ハイドラ バイオサイエンシズ インコーポレイテッドHydra Biosciences,Inc. | 置換キサンチンおよびその使用方法 |
WO2016023831A1 (en) * | 2014-08-11 | 2016-02-18 | Hydra Biosciences, Inc. | Pyrrolo[3,2-d]pyrimidine-2,4(3h,5h)-dione derivatives |
WO2016159746A1 (en) | 2015-03-27 | 2016-10-06 | Latvian Institute Of Organic Synthesis | Novel ethynylxanthines, their preparation and use as inhibitors of matrix metalloproteinases and angiogenesis |
GB2553686B (en) | 2015-03-27 | 2020-06-03 | Latvian Inst Organic Synthesis | Ethynylxanthines, preparation and use as calcium ion channel modulators |
GB2553684B (en) | 2015-03-27 | 2020-06-03 | Latvian Inst Organic Synthesis | Ethynylxanthines, preparation and use for cancer treatment |
PL3280417T3 (pl) * | 2015-04-08 | 2020-12-28 | Lewis And Clark Pharmaceuticals, Inc. | Podstawione ksantyną karbaminiany alkinylu/odwrócone karbaminiany jako antagoniści A<sub>2B</sub> |
CN107118586A (zh) * | 2016-02-24 | 2017-09-01 | 中国科学技术大学 | 含氮杂环基取代的烯类化合物的用途 |
GB201702160D0 (en) * | 2017-02-09 | 2017-03-29 | Univ Leeds Innovations Ltd | Inhibitors for use in therapy |
US11666577B2 (en) * | 2017-02-28 | 2023-06-06 | National Institute Of Biological Sciences, Beijing | MLKL inhibitors |
CN110573509B (zh) * | 2017-02-28 | 2023-05-26 | 北京生命科学研究所 | Mlkl抑制剂 |
SI3652176T1 (sl) * | 2017-07-11 | 2022-04-29 | Boehringer Ingelheim International Gmbh | Substituirani ksantinski derivati |
CA3093084A1 (en) | 2018-03-05 | 2019-09-12 | Goldfinch Bio, Inc. | Imidazodiazepinediones and methods of use thereof |
CN113166150B (zh) * | 2018-12-12 | 2023-12-01 | 勃林格殷格翰国际有限公司 | 经取代的黄嘌呤衍生物 |
KR20210102955A (ko) | 2018-12-12 | 2021-08-20 | 베링거 인겔하임 인터내셔날 게엠베하 | 치환된 크산틴 유도체 |
CN112979651B (zh) * | 2021-04-09 | 2022-02-01 | 南京纽邦生物科技有限公司 | 一种副黄嘌呤的制备方法 |
CN113354646B (zh) * | 2021-07-06 | 2022-11-15 | 南开大学 | 8-芳氧基烷氧基取代黄嘌呤衍生物及其制备方法和应用 |
CN115636831A (zh) * | 2022-10-27 | 2023-01-24 | 中国药科大学 | 稠合嘧啶二酮类化合物、其用途以及药物组合物 |
Family Cites Families (30)
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DE4304650A1 (de) * | 1993-02-16 | 1994-08-18 | Thomae Gmbh Dr K | Kondensierte 5-gliedrige Heterocyclen, Verfahren zu ihrer Herstellung und diese Verbindungen enthaltende Arzneimittel |
US6878715B1 (en) * | 1994-02-18 | 2005-04-12 | Cell Therapeutics, Inc. | Therapeutic compounds for inhibiting interleukin-12 signals and method for using same |
JP4191269B2 (ja) | 1996-05-17 | 2008-12-03 | 興和株式会社 | 新規なアニリド化合物及びこれを含有する医薬 |
JPH10318487A (ja) | 1997-05-16 | 1998-12-04 | Mitsubishi Gas Chem Co Inc | 真空断熱材用ゲッタ |
US6075029A (en) * | 1998-01-02 | 2000-06-13 | Cell Therapeutics, Inc. | Xanthine modulators of metabolism of cellular P-450 |
US6187780B1 (en) * | 1998-04-16 | 2001-02-13 | Boehringer Ingelheim Pharma Kg | Assymetrically substituted xanthine derivatives having adenosine A1 antagonistic activity |
CA2369981A1 (en) * | 1999-04-09 | 2000-10-19 | Cell Therapeutics, Inc. | Therapeutic compounds for inhibiting interleukin-12 signaling and methods for using same |
IL153182A0 (en) * | 2000-07-04 | 2003-06-24 | Novo Nordisk As | Heterocyclic compounds, which are inhibitors of the enzyme dpp-iv |
CA2430951A1 (en) | 2000-12-07 | 2002-06-13 | Cv Therapeutics, Inc. | Substituted 1, 3, 5-triazines and pyrimidines as abca-1 elevating compounds against coronary artery disease or atherosclerosis |
NZ528216A (en) * | 2001-02-24 | 2006-12-22 | Boehringer Ingelheim Pharma | Xanthine derivatives, the preparation thereof and their use as pharmaceutical compositions |
AU2002359365B2 (en) * | 2001-11-09 | 2008-07-10 | Gilead Sciences, Inc. | A2B adenosine receptor antagonists |
DE60322748D1 (de) * | 2003-05-06 | 2008-09-18 | Cv Therapeutics Inc | Xanthinderivate als a2b-adenosinrezeptorantagonisten |
CA2545944A1 (en) | 2003-11-13 | 2005-06-02 | Board Of Regents, The University Of Texas System | Inhibition of trp channels as a treatment for cardiac hypertrophy and heart failure |
WO2006074051A2 (en) | 2004-12-30 | 2006-07-13 | Diakine Therapeutics, Inc. | PHARMACEUTICAL COMPOSITIONS AND METHODS FOR RESTORING β-CELL MASS AND FUNCTION |
WO2006089168A2 (en) | 2005-02-18 | 2006-08-24 | Cornell Research Foundation, Inc. | Methods for modulating ion channels |
NZ565494A (en) * | 2005-08-10 | 2011-06-30 | Glaxosmithkline Llc | Xanthine derivatives as selective HM74A agonists |
WO2007030359A1 (en) | 2005-09-06 | 2007-03-15 | Smithkline Beecham Corporation | Benzimidazole thiophene compounds as plk modulators |
JP2009518333A (ja) * | 2005-12-07 | 2009-05-07 | ユセベ ファルマ ソシエテ アノニム | キサンチン誘導体、その調製方法及びその使用 |
TWI423819B (zh) * | 2005-12-22 | 2014-01-21 | Hydra Biosciences Inc | 用於調節trpa1功能之化合物 |
EP1983992A4 (en) | 2006-01-19 | 2010-08-18 | Abbott Lab | 2-IMINO-BENZIMIDAZOLES |
WO2007101213A2 (en) | 2006-02-28 | 2007-09-07 | Kalypsys, Inc. | Novel 2-oxo-1,2,3,4-tetrahydropyrimidines, bicyclic pyrimidine diones and imidazolidine-2,4-diones useful as inducible nitric oxide synthase inhibitors |
WO2008011518A2 (en) * | 2006-07-19 | 2008-01-24 | Diakine Therapeutics, Inc. | Encapsulation system |
WO2009157938A1 (en) * | 2008-06-26 | 2009-12-30 | Cv Therapeutics, Inc. | A2b adenosine receptor antagonists for treating cancer |
WO2011022638A1 (en) | 2009-08-20 | 2011-02-24 | Transposagen Biopharmaceuticals, Inc. | Trp inhibitors and uses thereof |
WO2011114184A1 (en) * | 2010-03-15 | 2011-09-22 | Glenmark Pharmaceuticals S.A. | Amides of heterocyclic compounds as trpa1 inhibitors |
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JP2013023102A (ja) * | 2011-07-22 | 2013-02-04 | Panasonic Corp | 列車情報提供システム |
TW201311690A (zh) * | 2011-08-09 | 2013-03-16 | Hydra Biosciences Inc | 抑制暫態受體電位離子通道trpa1 |
CN103121970B (zh) | 2012-12-04 | 2015-04-29 | 中国科学院昆明植物研究所 | 苯并咪唑及其衍生物,其药物组合物及其在制备抗抑郁药物中的应用 |
JP6360149B2 (ja) | 2013-03-15 | 2018-07-18 | ハイドラ バイオサイエンシズ インコーポレイテッドHydra Biosciences,Inc. | 置換キサンチンおよびその使用方法 |
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2014
- 2014-03-14 JP JP2016502662A patent/JP6360149B2/ja active Active
- 2014-03-14 CA CA2899646A patent/CA2899646C/en active Active
- 2014-03-14 PL PL14722452T patent/PL2970303T6/pl unknown
- 2014-03-14 MY MYPI2015702631A patent/MY189912A/en unknown
- 2014-03-14 TW TW103109651A patent/TWI609867B/zh active
- 2014-03-14 CN CN201480023267.0A patent/CN105143229B/zh active Active
- 2014-03-14 EP EP14722452.1A patent/EP2970303B3/en active Active
- 2014-03-14 NZ NZ711718A patent/NZ711718A/en unknown
- 2014-03-14 SG SG11201506479TA patent/SG11201506479TA/en unknown
- 2014-03-14 LT LTEP14722452.1T patent/LT2970303T/lt unknown
- 2014-03-14 PT PT147224521T patent/PT2970303T/pt unknown
- 2014-03-14 EA EA201591615A patent/EA028815B1/ru not_active IP Right Cessation
- 2014-03-14 AU AU2014228206A patent/AU2014228206C1/en active Active
- 2014-03-14 DK DK14722452.1T patent/DK2970303T6/en active
- 2014-03-14 MX MX2015011617A patent/MX370372B/es active IP Right Grant
- 2014-03-14 US US14/210,781 patent/US9359359B2/en active Active
- 2014-03-14 WO PCT/US2014/027920 patent/WO2014143799A2/en active Application Filing
- 2014-03-14 KR KR1020157029667A patent/KR102227629B1/ko active IP Right Grant
- 2014-03-14 UA UAA201507774A patent/UA117470C2/uk unknown
- 2014-03-14 SI SI201430241T patent/SI2970303T1/sl unknown
- 2014-03-14 PE PE2015001829A patent/PE20151779A1/es active IP Right Grant
- 2014-03-14 RS RS20170566A patent/RS56066B2/sr unknown
- 2014-03-14 HU HUE14722452A patent/HUE033528T4/en unknown
- 2014-03-14 CN CN201710063554.XA patent/CN107082782B/zh active Active
- 2014-03-14 ES ES14722452.1T patent/ES2636835T7/es active Active
- 2014-03-17 UY UY0001035488A patent/UY35488A/es active IP Right Grant
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2015
- 2015-07-28 ZA ZA2015/05414A patent/ZA201505414B/en unknown
- 2015-07-29 IL IL240216A patent/IL240216B/en active IP Right Grant
- 2015-09-15 CL CL2015002738A patent/CL2015002738A1/es unknown
- 2015-09-15 PH PH12015502141A patent/PH12015502141B1/en unknown
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2016
- 2016-04-25 US US15/137,327 patent/US20160237089A1/en not_active Abandoned
- 2016-05-10 HK HK16105298.0A patent/HK1217329A1/zh unknown
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2017
- 2017-06-01 HR HRP20170840TT patent/HRP20170840T4/hr unknown
- 2017-06-14 US US15/622,838 patent/US9969736B2/en active Active
- 2017-06-20 CY CY20171100647T patent/CY1119042T1/el unknown
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2018
- 2018-05-02 US US15/968,941 patent/US10399982B2/en active Active
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2019
- 2019-04-29 US US16/397,697 patent/US11208409B2/en active Active
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2021
- 2021-11-10 US US17/523,838 patent/US11958854B2/en active Active
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