US1009390A
(en)
|
1910-04-18 |
1911-11-21 |
Miehle Printing Press & Mfg |
Manufacture of printing-plates.
|
US1035847A
(en)
|
1910-05-23 |
1912-08-20 |
William P Bettendorf |
Means for cushioning the bodies of railway-cars.
|
US1020828A
(en)
|
1911-12-11 |
1912-03-19 |
William A Rees |
Electric washing-machine.
|
US1044284A
(en)
|
1912-04-29 |
1912-11-12 |
Gen Electric |
Heating device.
|
FR901228A
(fr)
|
1943-01-16 |
1945-07-20 |
Deutsche Edelstahlwerke Ag |
Système d'aimant à entrefer annulaire
|
US4816567A
(en)
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
US6548640B1
(en)
|
1986-03-27 |
2003-04-15 |
Btg International Limited |
Altered antibodies
|
US5225539A
(en)
|
1986-03-27 |
1993-07-06 |
Medical Research Council |
Recombinant altered antibodies and methods of making altered antibodies
|
GB8607679D0
(en)
|
1986-03-27 |
1986-04-30 |
Winter G P |
Recombinant dna product
|
US5906936A
(en)
*
|
1988-05-04 |
1999-05-25 |
Yeda Research And Development Co. Ltd. |
Endowing lymphocytes with antibody specificity
|
US6905680B2
(en)
|
1988-11-23 |
2005-06-14 |
Genetics Institute, Inc. |
Methods of treating HIV infected subjects
|
US5858358A
(en)
|
1992-04-07 |
1999-01-12 |
The United States Of America As Represented By The Secretary Of The Navy |
Methods for selectively stimulating proliferation of T cells
|
US6534055B1
(en)
|
1988-11-23 |
2003-03-18 |
Genetics Institute, Inc. |
Methods for selectively stimulating proliferation of T cells
|
US6352694B1
(en)
|
1994-06-03 |
2002-03-05 |
Genetics Institute, Inc. |
Methods for inducing a population of T cells to proliferate using agents which recognize TCR/CD3 and ligands which stimulate an accessory molecule on the surface of the T cells
|
US5530101A
(en)
|
1988-12-28 |
1996-06-25 |
Protein Design Labs, Inc. |
Humanized immunoglobulins
|
US5703055A
(en)
|
1989-03-21 |
1997-12-30 |
Wisconsin Alumni Research Foundation |
Generation of antibodies through lipid mediated DNA delivery
|
US5399346A
(en)
|
1989-06-14 |
1995-03-21 |
The United States Of America As Represented By The Department Of Health And Human Services |
Gene therapy
|
US5585362A
(en)
|
1989-08-22 |
1996-12-17 |
The Regents Of The University Of Michigan |
Adenovirus vectors for gene therapy
|
GB8928874D0
(en)
|
1989-12-21 |
1990-02-28 |
Celltech Ltd |
Humanised antibodies
|
DE69233482T2
(de)
|
1991-05-17 |
2006-01-12 |
Merck & Co., Inc. |
Verfahren zur Verminderung der Immunogenität der variablen Antikörperdomänen
|
US5199942A
(en)
|
1991-06-07 |
1993-04-06 |
Immunex Corporation |
Method for improving autologous transplantation
|
US6407213B1
(en)
|
1991-06-14 |
2002-06-18 |
Genentech, Inc. |
Method for making humanized antibodies
|
US5565332A
(en)
|
1991-09-23 |
1996-10-15 |
Medical Research Council |
Production of chimeric antibodies - a combinatorial approach
|
GB9125768D0
(en)
|
1991-12-04 |
1992-02-05 |
Hale Geoffrey |
Therapeutic method
|
CA2507749C
(en)
|
1991-12-13 |
2010-08-24 |
Xoma Corporation |
Methods and materials for preparation of modified antibody variable domains and therapeutic uses thereof
|
GB9203459D0
(en)
|
1992-02-19 |
1992-04-08 |
Scotgen Ltd |
Antibodies with germ-line variable regions
|
WO1993019163A1
(en)
†
|
1992-03-18 |
1993-09-30 |
Yeda Research And Development Co, Ltd. |
Chimeric receptor genes and cells transformed therewith
|
IL104570A0
(en)
*
|
1992-03-18 |
1993-05-13 |
Yeda Res & Dev |
Chimeric genes and cells transformed therewith
|
US5350674A
(en)
|
1992-09-04 |
1994-09-27 |
Becton, Dickinson And Company |
Intrinsic factor - horse peroxidase conjugates and a method for increasing the stability thereof
|
US5639641A
(en)
|
1992-09-09 |
1997-06-17 |
Immunogen Inc. |
Resurfacing of rodent antibodies
|
US7175843B2
(en)
|
1994-06-03 |
2007-02-13 |
Genetics Institute, Llc |
Methods for selectively stimulating proliferation of T cells
|
US5731168A
(en)
|
1995-03-01 |
1998-03-24 |
Genentech, Inc. |
Method for making heteromultimeric polypeptides
|
US6692964B1
(en)
|
1995-05-04 |
2004-02-17 |
The United States Of America As Represented By The Secretary Of The Navy |
Methods for transfecting T cells
|
US7067318B2
(en)
|
1995-06-07 |
2006-06-27 |
The Regents Of The University Of Michigan |
Methods for transfecting T cells
|
GB9809658D0
(en)
|
1998-05-06 |
1998-07-01 |
Celltech Therapeutics Ltd |
Biological products
|
DK1180123T3
(da)
|
1999-05-27 |
2008-10-13 |
Us Gov Health & Human Serv |
Immunkonjugater, der har höj bindingsaffinitet
|
IL147095A0
(en)
|
1999-06-16 |
2002-08-14 |
Myelos Corp |
Retro-inverso peptides derived from leukemia inhibitory factor
|
CA2386270A1
(en)
|
1999-10-15 |
2001-04-26 |
University Of Massachusetts |
Rna interference pathway genes as tools for targeted genetic interference
|
US6326193B1
(en)
|
1999-11-05 |
2001-12-04 |
Cambria Biosciences, Llc |
Insect control agent
|
US6797514B2
(en)
|
2000-02-24 |
2004-09-28 |
Xcyte Therapies, Inc. |
Simultaneous stimulation and concentration of cells
|
MXPA02008265A
(es)
|
2000-02-24 |
2004-09-10 |
Xcyte Therapies Inc |
Concentracion y estimulacion simultanea de calulas.
|
US6867041B2
(en)
|
2000-02-24 |
2005-03-15 |
Xcyte Therapies, Inc. |
Simultaneous stimulation and concentration of cells
|
US7572631B2
(en)
|
2000-02-24 |
2009-08-11 |
Invitrogen Corporation |
Activation and expansion of T cells
|
WO2001096584A2
(en)
|
2000-06-12 |
2001-12-20 |
Akkadix Corporation |
Materials and methods for the control of nematodes
|
AU2001271589A1
(en)
|
2000-06-30 |
2002-01-14 |
Zymogenetics Inc. |
Mammalian secreted proteins
|
AU2001297703B2
(en)
|
2000-11-07 |
2006-10-19 |
City Of Hope |
CD19-specific redirected immune cells
|
CN1294148C
(zh)
|
2001-04-11 |
2007-01-10 |
中国科学院遗传与发育生物学研究所 |
环状单链三特异抗体
|
JP4213586B2
(ja)
|
2001-09-13 |
2009-01-21 |
株式会社抗体研究所 |
ラクダ抗体ライブラリーの作製方法
|
US7323440B2
(en)
|
2002-02-13 |
2008-01-29 |
Micromet Ag |
De-immunized MOG (poly)peptide constructs
|
DE10244457A1
(de)
|
2002-09-24 |
2004-04-01 |
Johannes-Gutenberg-Universität Mainz |
Verfahren zur rationalen Mutagenese von alpha/beta T-Zell Rezeptoren und entsprechend mutierte MDM2-Protein spezifische alpha/beta T-Zell Rezeptoren
|
EP3299393A1
(en)
|
2002-11-08 |
2018-03-28 |
Ablynx N.V. |
Single domain antibodies directed against tumour necrosis factor-alpha and uses therefor
|
US20050129671A1
(en)
|
2003-03-11 |
2005-06-16 |
City Of Hope |
Mammalian antigen-presenting T cells and bi-specific T cells
|
US7251470B2
(en)
|
2003-06-25 |
2007-07-31 |
Nokia Corporation |
Emergency response system with personal emergency device
|
EP1638510B1
(en)
|
2003-07-01 |
2015-09-02 |
Immunomedics, Inc. |
Multivalent carriers of bi-specific antibodies
|
US7902338B2
(en)
|
2003-07-31 |
2011-03-08 |
Immunomedics, Inc. |
Anti-CD19 antibodies
|
JP4934426B2
(ja)
|
2003-08-18 |
2012-05-16 |
メディミューン,エルエルシー |
抗体のヒト化
|
CA2537055A1
(en)
|
2003-08-22 |
2005-04-21 |
Medimmune, Inc. |
Humanization of antibodies
|
KR20120125634A
(ko)
|
2003-10-16 |
2012-11-16 |
마이크로메트 에이지 |
다중특이적 탈면역화된 cd3-바인더
|
US20130266551A1
(en)
|
2003-11-05 |
2013-10-10 |
St. Jude Children's Research Hospital, Inc. |
Chimeric receptors with 4-1bb stimulatory signaling domain
|
AU2004293471C1
(en)
|
2003-11-25 |
2011-02-24 |
The Government Of The United States, As Represented By The Secretary Of Health And Human Services |
Mutated anti-CD22 antibodies and immunoconjugates
|
US20050238626A1
(en)
|
2004-04-01 |
2005-10-27 |
Lili Yang |
Antigen specific T cell therapy
|
WO2006020258A2
(en)
|
2004-07-17 |
2006-02-23 |
Imclone Systems Incorporated |
Novel tetravalent bispecific antibody
|
WO2006018833A2
(en)
|
2004-08-16 |
2006-02-23 |
Tadiran Spectralink Ltd. |
A wearable device, system and method for measuring a pulse while a user is in motion
|
US9707302B2
(en)
|
2013-07-23 |
2017-07-18 |
Immunomedics, Inc. |
Combining anti-HLA-DR or anti-Trop-2 antibodies with microtubule inhibitors, PARP inhibitors, bruton kinase inhibitors or phosphoinositide 3-kinase inhibitors significantly improves therapeutic outcome in cancer
|
WO2006099141A2
(en)
|
2005-03-10 |
2006-09-21 |
Morphotek, Inc. |
Anti-mesothelin antibodies
|
US20090047211A1
(en)
|
2005-05-12 |
2009-02-19 |
The Govt. Of The U.S. As Represented By The Sec. Of The Dept. Of Health And Human Services |
Anti-mesothelin antibodies useful for immunological assays
|
EP1928506A4
(en)
|
2005-08-19 |
2009-10-21 |
Abbott Lab |
IMMUNOGLOBULIN HAVING TWO VARIABLE DOMAINS AND USES THEREOF
|
AT503861B1
(de)
|
2006-07-05 |
2008-06-15 |
F Star Biotech Forsch & Entw |
Verfahren zur manipulation von t-zell-rezeptoren
|
WO2008121420A1
(en)
|
2007-03-30 |
2008-10-09 |
Memorial Sloan-Kettering Cancer Center |
Constitutive expression of costimulatory ligands on adoptively transferred t lymphocytes
|
GB0721686D0
(en)
|
2007-11-05 |
2007-12-12 |
Medinnova As |
Polypeptides
|
US9023351B2
(en)
|
2007-11-26 |
2015-05-05 |
Bayer Intellectual Property Gmbh |
Anti-mesothelin antibodies and uses thereof
|
US9308257B2
(en)
|
2007-11-28 |
2016-04-12 |
Medimmune, Llc |
Protein formulation
|
KR20090092900A
(ko)
|
2008-02-28 |
2009-09-02 |
신준호 |
어린이 및 노약자 안전보호시스템
|
US20090322513A1
(en)
|
2008-06-27 |
2009-12-31 |
Franklin Dun-Jen Hwang |
Medical emergency alert system and method
|
ES2961498T3
(es)
|
2008-08-26 |
2024-03-12 |
Hope City |
Método y composiciones para el funcionamiento mejorado del efecto antitumoral de las células T
|
JP5794917B2
(ja)
|
2008-09-12 |
2015-10-14 |
アイシス・イノベーション・リミテッドIsis Innovationlimited |
Pd−1特異抗体およびその使用
|
CN102164961B
(zh)
|
2008-10-01 |
2014-04-16 |
安进研发(慕尼黑)股份有限公司 |
种间特异性PSCAxCD3、CD19xCD3、C-METxCD3、内皮唾液酸蛋白xCD3、EpCAMxCD3、IGF-1RxCD3或FAPαxCD3双特异性单链抗体
|
LT2982696T
(lt)
*
|
2008-11-07 |
2019-06-10 |
Amgen Research (Munich) Gmbh |
Ūmios limfoblastinės leukemijos gydymas
|
KR20110122859A
(ko)
|
2009-02-23 |
2011-11-11 |
그렌마크 파머수티칼스 에스. 아. |
Cd19에 결합하는 인간화된 항체 및 그것의 용도
|
PT2406284T
(pt)
*
|
2009-03-10 |
2016-09-29 |
Biogen Ma Inc |
Anticorpos anti-bcma
|
CA2759733C
(en)
|
2009-04-23 |
2019-09-03 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Anti-human ror1 antibodies
|
EP2258719A1
(en)
*
|
2009-05-19 |
2010-12-08 |
Max-Delbrück-Centrum für Molekulare Medizin (MDC) |
Multiple target T cell receptor
|
ES2649890T3
(es)
|
2009-10-23 |
2018-01-16 |
Nexisvision, Inc. |
Enervación corneal para el tratamiento de dolor ocular
|
US9181527B2
(en)
|
2009-10-29 |
2015-11-10 |
The Trustees Of Dartmouth College |
T cell receptor-deficient T cell compositions
|
PT2361936T
(pt)
|
2010-02-25 |
2016-07-15 |
Affimed Gmbh |
Molécula que se liga a antigénio e utilizações desta
|
PT2552959T
(pt)
|
2010-03-26 |
2017-04-21 |
Memorial Sloan Kettering Cancer Center |
Anticorpos para muc16 e métodos de utilização dos mesmos
|
US10357577B2
(en)
|
2010-07-16 |
2019-07-23 |
Auckland Uniservices Limited |
Bacterial nitroreductase enzymes and methods relating thereto
|
US9493740B2
(en)
|
2010-09-08 |
2016-11-15 |
Baylor College Of Medicine |
Immunotherapy of cancer using genetically engineered GD2-specific T cells
|
SG189869A1
(en)
|
2010-10-27 |
2013-06-28 |
Amgen Res Munich Gmbh |
Means and methods for treating dlbcl
|
JP6109741B2
(ja)
|
2010-10-27 |
2017-04-05 |
ベイラー カレッジ オブ メディスンBaylor College Of Medicine |
T細胞をcd70陽性悪性腫瘍に仕向けるためのキメラなcd27受容体
|
AU2011336650B2
(en)
|
2010-12-01 |
2016-12-08 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Chimeric rabbit/human ROR1 antibodies
|
BR122021026169B1
(pt)
*
|
2010-12-09 |
2023-12-12 |
The Trustees Of The University Of Pennsylvania |
Uso de uma célula
|
GB201020995D0
(en)
|
2010-12-10 |
2011-01-26 |
Bioinvent Int Ab |
Biological materials and uses thereof
|
AU2011349443B2
(en)
|
2010-12-20 |
2015-12-24 |
Genentech, Inc. |
Anti-mesothelin antibodies and immunoconjugates
|
DK3252076T3
(da)
|
2011-01-14 |
2019-12-02 |
Univ California |
Diagnostisk anvendelse af antistoffer mod ror-1-protein
|
EA201391059A1
(ru)
|
2011-01-18 |
2014-05-30 |
Дзе Трастиз Оф Дзе Юниверсити Оф Пенсильвания |
Композиции для лечения рака и способы их применения
|
EP2686417B1
(de)
|
2011-03-17 |
2016-06-08 |
Miltenyi Biotec GmbH |
Tcralpha/beta-depletierte zellpräparationen
|
CA2832540C
(en)
|
2011-04-08 |
2020-09-15 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Anti-epidermal growth factor receptor variant iii chimeric antigen receptors and use of same for the treatment of cancer
|
AU2012308205A1
(en)
|
2011-09-16 |
2014-03-13 |
The Trustees Of The University Of Pennsylvania |
RNA engineered T cells for the treatment of cancer
|
KR101471647B1
(ko)
|
2011-10-26 |
2014-12-11 |
국립암센터 |
변이 ctla4 유전자 이입 t 세포 및 이를 포함하는 항암 면역치료용 조성물
|
WO2013063419A2
(en)
|
2011-10-28 |
2013-05-02 |
The Trustees Of The University Of Pennsylvania |
A fully human, anti-mesothelin specific chimeric immune receptor for redirected mesothelin-expressing cell targeting
|
ES2861435T3
(es)
|
2011-11-03 |
2021-10-06 |
Univ Pennsylvania |
Composiciones específicas de B7-H4 aisladas y métodos de uso de las mismas
|
WO2013070468A1
(en)
|
2011-11-08 |
2013-05-16 |
The Trustees Of The University Of Pennsylvania |
Glypican-3-specific antibody and uses thereof
|
TWI679212B
(zh)
|
2011-11-15 |
2019-12-11 |
美商安進股份有限公司 |
針對bcma之e3以及cd3的結合分子
|
UY34504A
(es)
|
2011-12-09 |
2013-06-28 |
Amgen Res Munich Gmbh |
Prevención de los efectos adversos causados por los anticuerpos biespecíficos EpCAMxCD3
|
EP2814846B1
(en)
|
2012-02-13 |
2020-01-08 |
Seattle Children's Hospital d/b/a Seattle Children's Research Institute |
Bispecific chimeric antigen receptors and therapeutic uses thereof
|
ES2959443T3
(es)
|
2012-02-22 |
2024-02-26 |
Univ Pennsylvania |
Uso del dominio de señalización de CD2 en receptores de antígenos quiméricos de segunda generación
|
WO2013126712A1
(en)
|
2012-02-22 |
2013-08-29 |
The Trustees Of The University Of Pennsylvania |
Compositions and methods for generating a persisting population of t cells useful for the treatment of cancer
|
EP2828290B1
(en)
|
2012-03-23 |
2018-08-15 |
The United States of America, represented by the Secretary, Department of Health and Human Services |
Anti-mesothelin chimeric antigen receptors
|
EP3689383A1
(en)
|
2012-04-11 |
2020-08-05 |
The U.S.A. As Represented By The Secretary, Department Of Health And Human Services |
Chimeric antigen receptors targeting b-cell maturation antigen
|
US20130280220A1
(en)
|
2012-04-20 |
2013-10-24 |
Nabil Ahmed |
Chimeric antigen receptor for bispecific activation and targeting of t lymphocytes
|
US9127081B2
(en)
|
2012-05-10 |
2015-09-08 |
Washington University |
Tumor targeted TNF-related apoptosis inducing ligand fusion polypeptide and nucleic acids encoding the same
|
WO2013176916A1
(en)
|
2012-05-25 |
2013-11-28 |
Roman Galetto |
Use of pre t alpha or functional variant thereof for expanding tcr alpha deficient t cells
|
CA2878862C
(en)
|
2012-07-13 |
2023-01-10 |
The Trustees Of The University Of Pennsylvania |
Methods of assessing the suitability of transduced t cells for administration
|
BR112015000638A2
(pt)
|
2012-07-13 |
2017-08-08 |
Univ Pennsylvania |
sequência de ácido nucleico isolada, célula, métodos para estimular uma resposta imune mediada pela célula t e uma população de célula alvo ou tecido em um mamífero, para provimento de imunidade antitumor em um mamífero, para tratamento de um mamífero que tenha uma doença, distúrbio ou condição associado com uma expressão elevada de um antígeno de tumor
|
EP2872617A4
(en)
|
2012-07-13 |
2015-12-09 |
Univ Pennsylvania |
EXTENSION OF EPITOPES IN RELATION TO T CAR LYMPHOCYTES
|
WO2014031687A1
(en)
|
2012-08-20 |
2014-02-27 |
Jensen, Michael |
Method and compositions for cellular immunotherapy
|
CA2885761C
(en)
|
2012-09-27 |
2021-09-21 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Mesothelin antibodies and methods for eliciting potent antitumor activity
|
US9365641B2
(en)
|
2012-10-01 |
2016-06-14 |
The Trustees Of The University Of Pennsylvania |
Compositions and methods for targeting stromal cells for the treatment of cancer
|
CN112430580A
(zh)
|
2012-10-02 |
2021-03-02 |
纪念斯隆-凯特琳癌症中心 |
用于免疫疗法的组合物和方法
|
WO2014055657A1
(en)
|
2012-10-05 |
2014-04-10 |
The Trustees Of The University Of Pennsylvania |
Use of a trans-signaling approach in chimeric antigen receptors
|
JP6571527B2
(ja)
|
2012-11-21 |
2019-09-04 |
ウーハン ワイゼットワイ バイオファルマ カンパニー リミテッドWuhan Yzy Biopharma Co., Ltd. |
二重特異性抗体
|
US8697359B1
(en)
|
2012-12-12 |
2014-04-15 |
The Broad Institute, Inc. |
CRISPR-Cas systems and methods for altering expression of gene products
|
WO2014099671A1
(en)
|
2012-12-20 |
2014-06-26 |
Bluebird Bio, Inc. |
Chimeric antigen receptors and immune cells targeting b cell malignancies
|
EP2953972B1
(en)
|
2013-02-05 |
2020-07-08 |
EngMab Sàrl |
Method for the selection of antibodies against bcma
|
CA2904014C
(en)
|
2013-02-06 |
2021-06-15 |
Anthrogenesis Corporation |
Modified t lymphocytes having improved specificity
|
JP6450690B2
(ja)
|
2013-02-15 |
2019-01-09 |
ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア |
キメラ抗原受容体及びその使用方法
|
ES2814962T3
(es)
*
|
2013-02-20 |
2021-03-29 |
Novartis Ag |
Fijación eficaz como objetivo de la leucemia humana primaria utilizando células T modificadas con receptor de antígeno quimérico anti-CD123
|
CN113684185A
(zh)
|
2013-02-26 |
2021-11-23 |
纪念斯隆-凯特琳癌症中心 |
用于免疫疗法的组合物和方法
|
EP3444278A1
(en)
|
2013-02-26 |
2019-02-20 |
Roche Glycart AG |
Bispecific t cell activating antigen binding molecules
|
WO2014134412A1
(en)
|
2013-03-01 |
2014-09-04 |
Regents Of The University Of Minnesota |
Talen-based gene correction
|
WO2014138306A1
(en)
|
2013-03-05 |
2014-09-12 |
Baylor College Of Medicine |
Engager cells for immunotherapy
|
US10150800B2
(en)
|
2013-03-15 |
2018-12-11 |
Zyngenia, Inc. |
EGFR-binding modular recognition domains
|
CA2907397C
(en)
|
2013-03-15 |
2022-11-22 |
Anthrogenesis Corporation |
Modified t lymphocytes
|
NZ712693A
(en)
|
2013-03-15 |
2021-07-30 |
Memorial Sloan Kettering Cancer Center |
Compositions and methods for immunotherapy
|
US9446105B2
(en)
|
2013-03-15 |
2016-09-20 |
The Trustees Of The University Of Pennsylvania |
Chimeric antigen receptor specific for folate receptor β
|
AR095374A1
(es)
|
2013-03-15 |
2015-10-14 |
Amgen Res (Munich) Gmbh |
Moléculas de unión para bcma y cd3
|
TWI654206B
(zh)
|
2013-03-16 |
2019-03-21 |
諾華公司 |
使用人類化抗-cd19嵌合抗原受體治療癌症
|
AU2014248119B2
(en)
|
2013-04-03 |
2019-06-20 |
Memorial Sloan-Kettering Cancer Center |
Effective generation of tumor-targeted T-cells derived from pluripotent stem cells
|
EP4364809A2
(en)
|
2013-05-13 |
2024-05-08 |
Cellectis |
Cd19 specific chimeric antigen receptor and uses thereof
|
US11311575B2
(en)
|
2013-05-13 |
2022-04-26 |
Cellectis |
Methods for engineering highly active T cell for immunotherapy
|
CA2913052A1
(en)
|
2013-05-24 |
2014-11-27 |
Board Of Regents, The University Of Texas System |
Chimeric antigen receptor-targeting monoclonal antibodies
|
EP3004337B1
(en)
|
2013-05-29 |
2017-08-02 |
Cellectis |
Methods for engineering t cells for immunotherapy by using rna-guided cas nuclease system
|
ES2883131T3
(es)
|
2013-05-29 |
2021-12-07 |
Cellectis |
Métodos para la modificación de células T para inmunoterapia utilizando el sistema de nucleasa CAS guiado por ARN
|
EP3019622A4
(en)
|
2013-07-12 |
2017-06-14 |
Zymeworks Inc. |
Bispecific cd3 and cd19 antigen binding contructs
|
US9951118B2
(en)
|
2013-08-02 |
2018-04-24 |
The Regents Of The University Of California |
Engineering antiviral T cell immunity through stem cells and chimeric antigen receptors
|
AU2014324884B2
(en)
|
2013-09-25 |
2020-03-26 |
Cytomx Therapeutics, Inc |
Matrix metalloproteinase substrates and other cleavable moieties and methods of use thereof
|
GB201317929D0
(en)
|
2013-10-10 |
2013-11-27 |
Ucl Business Plc |
Chimeric antigen receptor
|
ES2741308T3
(es)
|
2013-10-15 |
2020-02-10 |
Scripps Research Inst |
Interruptores de células T con receptores de antígenos quiméricos y usos de los mismos
|
KR102339240B1
(ko)
|
2013-10-15 |
2021-12-15 |
더 스크립스 리서치 인스티튜트 |
펩타이드 키메라 항원 수용체 t 세포 스위치 및 이의 용도
|
US10239948B2
(en)
|
2013-12-20 |
2019-03-26 |
Cellectis |
Method of engineering multi-input signal sensitive T cell for immunotherapy
|
JP6793902B2
(ja)
|
2013-12-20 |
2020-12-02 |
ノバルティス アーゲー |
調節可能キメラ抗原受容体
|
SG10201804439PA
(en)
|
2013-12-20 |
2018-06-28 |
Hutchinson Fred Cancer Res |
Tagged chimeric effector molecules and receptors thereof
|
CN106459182B
(zh)
|
2013-12-30 |
2021-09-03 |
岸迈生物科技有限公司 |
串联fab免疫球蛋白及其用途
|
CA2936693C
(en)
|
2014-01-14 |
2020-07-21 |
Cellectis |
Chimeric antigen receptor using antigen recognition domains derived from cartilaginous fish
|
US11028143B2
(en)
*
|
2014-01-21 |
2021-06-08 |
Novartis Ag |
Enhanced antigen presenting ability of RNA CAR T cells by co-introduction of costimulatory molecules
|
TWI681969B
(zh)
|
2014-01-23 |
2020-01-11 |
美商再生元醫藥公司 |
針對pd-1的人類抗體
|
CA2936984A1
(en)
|
2014-01-24 |
2015-07-30 |
The United States Of America, As Represented By The Secretary, Department Of Health And Human Services |
Anti-ny-br-1 polypeptides, proteins, and chimeric antigen receptors
|
EP3102609A4
(en)
|
2014-02-04 |
2017-08-23 |
The United States of America, as represented by The Secretary, Department of Health and Human Services |
Methods for producing autologous t cells useful to treat b cell malignancies and other cancers and compositions thereof
|
CA2938887C
(en)
|
2014-02-14 |
2023-04-11 |
Laurence J. N. Cooper |
Chimeric antigen receptors and methods of making
|
EP3505623A1
(en)
|
2014-02-14 |
2019-07-03 |
Cellectis |
Cells for immunotherapy engineered for targeting antigen present both on immune cells and pathological cells
|
EP3107552B1
(en)
|
2014-02-21 |
2018-03-28 |
Cellectis |
Method for in situ inhibition of regulatory t cells
|
EP3110445A4
(en)
|
2014-02-25 |
2017-09-27 |
Immunomedics, Inc. |
Humanized rfb4 anti-cd22 antibody
|
KR101605421B1
(ko)
|
2014-03-05 |
2016-03-23 |
국립암센터 |
B 세포 림프종 세포를 특이적으로 인지하는 단일클론항체 및 이의 용도
|
EP3593812A3
(en)
|
2014-03-15 |
2020-05-27 |
Novartis AG |
Treatment of cancer using chimeric antigen receptor
|
WO2015142661A1
(en)
|
2014-03-15 |
2015-09-24 |
Novartis Ag |
Regulatable chimeric antigen receptor
|
CN113150109A
(zh)
|
2014-04-01 |
2021-07-23 |
拜恩科技细胞&基因治疗有限公司 |
密封蛋白-6特异性免疫受体和t细胞表位
|
EP3131927B8
(en)
|
2014-04-14 |
2020-12-23 |
Cellectis |
Bcma (cd269) specific chimeric antigen receptors for cancer immunotherapy
|
EP3998278A1
(en)
|
2014-04-25 |
2022-05-18 |
2seventy bio, Inc. |
Mnd promoter chimeric antigen receptors
|
RU2741899C2
(ru)
|
2014-04-25 |
2021-01-29 |
Блубёрд Био, Инк. |
Улучшенные способы производства средств адоптивной клеточной терапии
|
US10301370B2
(en)
|
2014-05-02 |
2019-05-28 |
The Trustees Of The University Of Pennsylvania |
Compositions and methods of chimeric autoantibody receptor T cells
|
CN106535925A
(zh)
|
2014-05-23 |
2017-03-22 |
佛罗里达大学研究基金会有限公司 |
基于car的免疫治疗
|
EP3145954A1
(en)
|
2014-05-23 |
2017-03-29 |
Institut National de la Santé et de la Recherche Médicale (INSERM) |
Anti- egfr conformational single domain antibodies and uses thereof
|
ES2928000T3
(es)
|
2014-06-06 |
2022-11-14 |
Memorial Sloan Kettering Cancer Center |
Receptores de antígeno quimérico dirigidos a mesotelina y usos de los mismos
|
JP7113618B2
(ja)
|
2014-07-15 |
2022-08-05 |
ジュノー セラピューティクス インコーポレイテッド |
養子細胞療法用の操作された細胞
|
MX2017001011A
(es)
|
2014-07-21 |
2018-05-28 |
Novartis Ag |
Tratamiento de cancer de usando un receptor quimerico de antigeno anti-bcma.
|
CA2956002C
(en)
|
2014-07-24 |
2023-06-27 |
Bluebird Bio, Inc. |
Bcma chimeric antigen receptors
|
CN106922148B
(zh)
|
2014-07-29 |
2021-10-15 |
瑟勒提斯公司 |
用于癌症免疫疗法的ror1(ntrkr1)特异性的嵌合抗原受体
|
EP2982692A1
(en)
|
2014-08-04 |
2016-02-10 |
EngMab AG |
Bispecific antibodies against CD3epsilon and BCMA
|
WO2016022900A1
(en)
|
2014-08-07 |
2016-02-11 |
Northwestern University |
Use of ligands for the programmed cell death receptor conjugated to solid supports for the expansion of human regulatory t cells
|
US9546206B2
(en)
|
2014-08-08 |
2017-01-17 |
The Board Of Trustees Of The Leland Stanford Junior University |
High affinity PD-1 agents and methods of use
|
WO2016019969A1
(en)
|
2014-08-08 |
2016-02-11 |
Ludwig-Maximilians-Universität München |
Subcutaneously administered bispecific antibodies for use in the treatment of cancer
|
EP3828267A3
(en)
|
2014-08-12 |
2021-08-11 |
Celgene Corporation |
Car-t lymphocytes engineered to home to lymph node b cell zone, skin, or gastrointestinal tract
|
US20170260261A1
(en)
|
2014-08-28 |
2017-09-14 |
Bioatla, Llc |
Conditionally Active Chimeric Antigen Receptors for Modified T-Cells
|
GB201415347D0
(en)
|
2014-08-29 |
2014-10-15 |
Ucl Business Plc |
Signalling system
|
WO2016036678A1
(en)
|
2014-09-02 |
2016-03-10 |
Medimmune, Llc |
Formulations of bispecific antibodies
|
BR112017004675A2
(pt)
|
2014-09-09 |
2017-12-05 |
Unum Therapeutics |
receptores quiméricos e usos dos mesmos em terapia imunológica
|
WO2016044811A1
(en)
|
2014-09-19 |
2016-03-24 |
City Of Hope |
COSTIMULATORY CHIMERIC ANTIGEN RECEPTOR T CELLS TARGETING IL13Rα2
|
WO2016054520A2
(en)
*
|
2014-10-03 |
2016-04-07 |
The California Institute For Biomedical Research |
Engineered cell surface proteins and uses thereof
|
BR112017007003A2
(pt)
|
2014-10-07 |
2017-12-19 |
Cellectis |
método para modulação de atividade de células imunes induzidas por car
|
JP7057669B2
(ja)
|
2014-10-20 |
2022-04-20 |
ジュノー セラピューティクス インコーポレイテッド |
養子細胞療法において投薬するための方法および組成物
|
AU2015338984A1
(en)
†
|
2014-10-31 |
2017-04-27 |
The Trustees Of The University Of Pennsylvania |
Methods and compositions for modified T cells
|
WO2016073381A1
(en)
|
2014-11-03 |
2016-05-12 |
Cerus Corporation |
Compositions and methods for improved car-t cell therapies
|
AU2015343121B2
(en)
|
2014-11-05 |
2020-06-18 |
Juno Therapeutics, Inc. |
Methods for transduction and cell processing
|
EP3023437A1
(en)
|
2014-11-20 |
2016-05-25 |
EngMab AG |
Bispecific antibodies against CD3epsilon and BCMA
|
PT3221357T
(pt)
|
2014-11-20 |
2020-07-28 |
Hoffmann La Roche |
Cadeias leves comuns e métodos de utilização
|
US10201606B2
(en)
|
2014-11-26 |
2019-02-12 |
Miltenyi Biotec Gmbh |
Combination immunotherapy of antigen-recognizing receptors and hematopoietic cells for the treatment of diseases
|
EP3029067A1
(en)
|
2014-12-01 |
2016-06-08 |
Deutsches Krebsforschungszentrum |
Use of blocking-reagents for reducing unspecific T cell-activation
|
JP7068820B2
(ja)
|
2014-12-03 |
2022-05-17 |
ジュノー セラピューティクス インコーポレイテッド |
養子細胞療法のための方法および組成物
|
EP3029068A1
(en)
|
2014-12-03 |
2016-06-08 |
EngMab AG |
Bispecific antibodies against CD3epsilon and BCMA for use in the treatment of diseases
|
US20180334490A1
(en)
|
2014-12-03 |
2018-11-22 |
Qilong H. Wu |
Methods for b cell preconditioning in car therapy
|
RS61781B1
(sr)
|
2014-12-05 |
2021-06-30 |
Memorial Sloan Kettering Cancer Center |
Antitela koja ciljaju antigen za sazrevanje b-ćelija i postupci upotrebe
|
SI3227339T1
(sl)
|
2014-12-05 |
2022-02-28 |
Memorial Sloan-Kettering Cancer Center |
Himerni antigenski receptorji, ki ciljajo na receptor, povezan z G-proteinom, in njihova uporaba
|
SG11201704549UA
(en)
|
2014-12-05 |
2017-07-28 |
Memorial Sloan Kettering Cancer Center |
Chimeric antigen receptors targeting b-cell maturation antigen and uses thereof
|
WO2016097231A2
(en)
|
2014-12-17 |
2016-06-23 |
Cellectis |
INHIBITORY CHIMERIC ANTIGEN RECEPTOR (iCAR OR N-CAR) EXPRESSING NON-T CELL TRANSDUCTION DOMAIN
|
EP3037170A1
(en)
|
2014-12-27 |
2016-06-29 |
Miltenyi Biotec GmbH |
Multisort cell separation method
|
IL303247A
(en)
|
2014-12-29 |
2023-07-01 |
Novartis Ag |
Methods for preparing cells expressing a chimeric receptor antigen
|
CN107614522A
(zh)
|
2015-01-14 |
2018-01-19 |
指南针制药有限责任公司 |
多特异性免疫调节性抗原结合构建体
|
WO2016115482A1
(en)
|
2015-01-16 |
2016-07-21 |
Novartis Pharma Ag |
Phosphoglycerate kinase 1 (pgk) promoters and methods of use for expressing chimeric antigen receptor
|
WO2016115559A1
(en)
|
2015-01-16 |
2016-07-21 |
Juno Therapeutics, Inc. |
Antibodies and chimeric antigen receptors specific for ror1
|
GB201501175D0
(en)
|
2015-01-23 |
2015-03-11 |
Univ Oslo Hf |
A universal T-cell for personalised medicine
|
WO2016123143A1
(en)
|
2015-01-26 |
2016-08-04 |
The University Of Chicago |
CAR T-CELLS RECOGNIZING CANCER-SPECIFIC IL 13Rα2
|
WO2016126608A1
(en)
|
2015-02-02 |
2016-08-11 |
Novartis Ag |
Car-expressing cells against multiple tumor antigens and uses thereof
|
WO2016127043A1
(en)
|
2015-02-05 |
2016-08-11 |
Stc.Unm |
Anti-pre-bcr antagonists and methods
|
EP3253414A4
(en)
|
2015-02-05 |
2018-07-11 |
The University Of Queensland |
Targeting constructs for delivery of payloads
|
US20160228547A1
(en)
|
2015-02-06 |
2016-08-11 |
Batu Biologics, Inc. |
Chimeric antigen receptor targeting of tumor endothelium
|
WO2016130598A1
(en)
|
2015-02-09 |
2016-08-18 |
University Of Florida Research Foundation, Inc. |
Bi-specific chimeric antigen receptor and uses thereof
|
ES2857998T3
(es)
|
2015-02-12 |
2021-09-29 |
Univ Health Network |
Receptores de antígenos quiméricos
|
US20160237407A1
(en)
|
2015-02-17 |
2016-08-18 |
Batu Biologics, Inc. |
Universal donor chimeric antigen receptor cells
|
IL284985B2
(en)
|
2015-02-18 |
2023-03-01 |
Enlivex Therapeutics R& D Ltd |
Combined immunotherapy and cytokine control therapy for cancer treatment
|
CN108064283B
(zh)
|
2015-02-24 |
2024-01-09 |
加利福尼亚大学董事会 |
结合触发的转录开关及其使用方法
|
BR112017018770A2
(pt)
|
2015-03-02 |
2018-04-17 |
Innovative Cellular Therapeutics CO., LTD. |
redução da tolerância imunológica induzida por pd-l1
|
JP6917896B2
(ja)
|
2015-03-05 |
2021-08-18 |
フレッド ハッチンソン キャンサー リサーチ センター |
免疫調節性融合タンパク質およびその使用
|
GB201504840D0
(en)
|
2015-03-23 |
2015-05-06 |
Ucl Business Plc |
Chimeric antigen receptor
|
AU2016243043B2
(en)
|
2015-04-02 |
2021-12-09 |
Memorial Sloan Kettering Cancer Center |
TNFRSF14/ HVEM proteins and methods of use thereof
|
EP3466967A1
(en)
|
2015-05-18 |
2019-04-10 |
TCR2 Therapeutics Inc. |
Compositions and methods for tcr reprogramming using fusion proteins
|
HUE054201T2
(hu)
|
2015-06-19 |
2021-08-30 |
Endres Stefan Prof Dr |
PD-1-CD28 fúziós fehérjék és gyógyászatban való alkalmazásuk
|
CN108337890B
(zh)
|
2015-06-23 |
2021-10-15 |
纪念斯隆-凯特琳癌症中心 |
新型pd-1免疫调节剂
|
JP2018520679A
(ja)
|
2015-06-29 |
2018-08-02 |
ザ・ジョンズ・ホプキンス・ユニバーシティー |
免疫チェックポイントキメラ抗原受容体療法
|
WO2017040945A1
(en)
|
2015-09-04 |
2017-03-09 |
Memorial Sloan Kettering Cancer Center |
Immune cell compositions and methods of use
|
CN106519037B
(zh)
|
2015-09-11 |
2019-07-23 |
科济生物医药(上海)有限公司 |
可活化的嵌合受体
|
CN108601821B
(zh)
|
2015-10-05 |
2023-09-19 |
精密生物科学公司 |
包含经修饰的人T细胞受体α恒定区基因的经遗传修饰的细胞
|
EP3842450A1
(en)
|
2015-10-23 |
2021-06-30 |
Eureka Therapeutics, Inc. |
Antibody/t-cell receptor chimeric constructs and uses thereof
|
US11020429B2
(en)
|
2015-11-05 |
2021-06-01 |
Juno Therapeutics, Inc. |
Vectors and genetically engineered immune cells expressing metabolic pathway modulators and uses in adoptive cell therapy
|
CN105331585A
(zh)
|
2015-11-13 |
2016-02-17 |
科济生物医药(上海)有限公司 |
携带pd-l1阻断剂的嵌合抗原受体修饰的免疫效应细胞
|
US11648268B2
(en)
|
2015-12-09 |
2023-05-16 |
Memorial Sloan Kettering Cancer Center |
Immune cell compositions and methods of using same
|
CN109069597A
(zh)
|
2015-12-22 |
2018-12-21 |
诺华股份有限公司 |
间皮素嵌合抗原受体(car)和抗pd-l1抗体抑制剂联用于抗癌治疗
|
US20170224837A1
(en)
|
2016-02-10 |
2017-08-10 |
Immunomedics, Inc. |
Combination of abcg2 inhibitors with sacituzumab govitecan (immu-132) overcomes resistance to sn-38 in trop-2 expressing cancers
|
SG11201808085WA
(en)
|
2016-03-22 |
2018-10-30 |
Hoffmann La Roche |
Protease-activated t cell bispecific molecules
|
US11365237B2
(en)
|
2016-03-23 |
2022-06-21 |
Helmholtz Zentrum Muenchen—Deutsches Forschungszentrum Fuer Gesundheit Und Umwelt (Gmbh) |
Fusion proteins of PD-1 and 4-1BB
|
KR102584280B1
(ko)
|
2016-04-01 |
2023-10-04 |
카이트 파마 인코포레이티드 |
키메라 항원 및 t 세포 수용체 및 사용 방법
|
HUE064454T2
(hu)
|
2016-06-08 |
2024-03-28 |
Xencor Inc |
IgG4-gyel kapcsolatos betegségek kezelése CD32B-vel keresztkötõ, CD-19 elleni ellenanyagokkal
|
CN109715668A
(zh)
|
2016-08-02 |
2019-05-03 |
T细胞受体治疗公司 |
用于使用融合蛋白进行tcr重编程的组合物和方法
|
JP2019528699A
(ja)
|
2016-08-30 |
2019-10-17 |
メモリアル スローン ケタリング キャンサー センター |
ウイルスおよびその他の感染を処置するための免疫細胞組成物および使用の方法
|
PT3445787T
(pt)
|
2016-10-07 |
2021-03-15 |
Tcr2 Therapeutics Inc |
Composições e métodos para reprogramação de recetores de célula t com o uso de proteínas de fusão
|
CN110177803A
(zh)
|
2016-11-22 |
2019-08-27 |
T细胞受体治疗公司 |
用于使用融合蛋白进行tcr重新编程的组合物和方法
|
JP2020513754A
(ja)
|
2016-12-21 |
2020-05-21 |
ティーシーアール2 セラピューティクス インク. |
がん治療用に操作されたt細胞
|
CA3038150A1
(en)
|
2016-12-22 |
2018-06-28 |
Windmil Therapeutics, Inc. |
Compositions and methods for modulating the immune system
|
IL268206B2
(en)
|
2017-01-23 |
2024-05-01 |
Carsgen Therapeutics Co Ltd |
Antibodies directed against BCMA and their use
|
AU2018251150B2
(en)
|
2017-04-13 |
2024-05-09 |
Albert-Ludwigs-Universität Freiburg |
New sequence specific reagents targeting CCR5 in primary hematopoietic cells
|
CA3059755A1
(en)
|
2017-04-26 |
2018-11-01 |
Eureka Therapeutics, Inc. |
Cells expressing chimeric activating receptors and chimeric stimulating receptors and uses thereof
|
WO2018232020A1
(en)
|
2017-06-13 |
2018-12-20 |
TCR2 Therapeutics Inc. |
Compositions and methods for tcr reprogramming using fusion proteins
|
MX2020004185A
(es)
|
2017-09-27 |
2021-01-08 |
Univ Southern California |
Nuevas plataformas para coestimulacion, nuevos diseños car y otras mejoras para terapia celular adoptiva.
|
GB201800298D0
(en)
|
2018-01-09 |
2018-02-21 |
Autolus Ltd |
Method
|
KR20200128018A
(ko)
|
2018-02-01 |
2020-11-11 |
화이자 인코포레이티드 |
Cd70을 표적으로 하는 키메라 항원 수용체
|
AU2019231792A1
(en)
|
2018-03-09 |
2020-10-22 |
TCR2 Therapeutics Inc. |
Compositions and methods for TCR reprogramming using fusion proteins
|
WO2019222275A2
(en)
|
2018-05-14 |
2019-11-21 |
TCR2 Therapeutics Inc. |
Compositions and methods for tcr reprogramming using inducible fusion proteins
|
SG11202100838QA
(en)
|
2018-07-26 |
2021-02-25 |
Tcr2 Therapeutics Inc |
Compositions and methods for tcr reprogramming using target specific fusion proteins
|
CN112639102B
(zh)
|
2018-08-29 |
2024-03-01 |
南京传奇生物科技有限公司 |
抗间皮素嵌合抗原受体(car)构建体及其用途
|
AU2019327569A1
(en)
|
2018-08-30 |
2021-04-29 |
TCR2 Therapeutics Inc. |
Compositions and methods for TCR reprogramming using fusion proteins
|
US20220347214A1
(en)
|
2019-03-22 |
2022-11-03 |
TCR2 Therapeutics Inc. |
Compositions and methods for tcr reprogramming using fusion proteins
|
WO2020219563A1
(en)
|
2019-04-22 |
2020-10-29 |
TCR2 Therapeutics Inc. |
Compositions and methods for tcr reprogramming using fusion proteins
|
US20210130438A1
(en)
|
2019-10-28 |
2021-05-06 |
The Broad Institute, Inc. |
Pan-cancer t cell exhaustion genes
|
WO2021142302A1
(en)
|
2020-01-10 |
2021-07-15 |
TCR2 Therapeutics Inc. |
Compositions and methods for autoimmunity regulation
|
WO2021155034A1
(en)
|
2020-01-29 |
2021-08-05 |
TCR2 Therapeutics Inc. |
Compositions and methods for tcr reprogramming using muc16 specific fusion proteins
|
JP2023524811A
(ja)
|
2020-05-05 |
2023-06-13 |
ティーシーアール2 セラピューティクス インク. |
Cd70特異的融合タンパク質を使用したtcrリプログラミングのための組成物及び方法
|
EP4185326A1
(en)
|
2020-07-24 |
2023-05-31 |
TCR2 Therapeutics Inc. |
Compositions and methods for treating cancer
|
WO2022056321A1
(en)
|
2020-09-10 |
2022-03-17 |
TCR2 Therapeutics Inc. |
Compositions and methods for tcr reprogramming using gpc3 specific fusion proteins
|
WO2022177966A1
(en)
|
2021-02-16 |
2022-08-25 |
TCR2 Therapeutics Inc. |
Compositions and methods for the treatment of hiv
|
US20230065936A1
(en)
|
2021-04-09 |
2023-03-02 |
Tcr2 Therapeutics Inc |
Compositions and methods for treating cancer
|
WO2023044039A1
(en)
|
2021-09-16 |
2023-03-23 |
TCR2 Therapeutics Inc. |
Compositions and methods for treating cancer
|