SG11201808085WA - Protease-activated t cell bispecific molecules - Google Patents
Protease-activated t cell bispecific moleculesInfo
- Publication number
- SG11201808085WA SG11201808085WA SG11201808085WA SG11201808085WA SG11201808085WA SG 11201808085W A SG11201808085W A SG 11201808085WA SG 11201808085W A SG11201808085W A SG 11201808085WA SG 11201808085W A SG11201808085W A SG 11201808085WA SG 11201808085W A SG11201808085W A SG 11201808085WA
- Authority
- SG
- Singapore
- Prior art keywords
- protease
- international
- idiotype
- activatable
- roche
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2809—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
- C07K16/4208—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/42—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins
- C07K16/4208—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig
- C07K16/4241—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig
- C07K16/4258—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against immunoglobulins against an idiotypic determinant on Ig against anti-human or anti-animal Ig against anti-receptor Ig
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/524—CH2 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/526—CH3 domain
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/64—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising a combination of variable region and constant region components
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/71—Decreased effector function due to an Fc-modification
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/50—Fusion polypeptide containing protease site
Abstract
FcKnob) PG LALA Fc(Hole) P329G LALA = (54) Title: PROTEASE-ACTIVATED T CELL BISPECIFIC MOLECULES FIG. 1A Protease site with GS linker Anti CD3 scFv 4.15.64 anti-CD3 V CH1 Common Light Chain 7859 W O 20 17 / 16 25 87 Al (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) (19) World Intellectual Property Organization International Bureau (10) International Publication Number (43) International Publication Date WO 2017/162587 Al 28 September 2017 (28.09.2017) WIPO I PCT IIIII111111110111011111111111$111110 011IIIIII0111111111110111111111111111 (51) International Patent Classification: C07K 16/46 (2006.01) C07K 16/30 (2006.01) C07K 16/42 (2006.01) C07K 16/32 (2006.01) C07K 16/28 (2006.01) (21) International Application Number: PCT/EP2017/056556 (22) International Filing Date: 20 March 2017 (20.03.2017) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 16161740.2 22 March 2016 (22.03.2016) EP 62/433,327 13 December 2016 (13.12.2016) US (71) Applicant (for all designated States except US): F. HOFF- MANN-LA ROCHE AG [CH/CH]; Grenzacherstrasse 124, 4070 Basel (CH). (71) Applicant US only): HOFFMANN-LA ROCHE INC. [US/US]; Overlook at Great Notch, 150 Clove Road, 8th Floor, Suite 8 - Legal Department, Little Falls, New Jersey 07424 (US). (72) Inventors: BRUENKER, Peter; Burgwiesenstrasse 3c, 8335 Hittnau (CH). CROASDALE-WOOD, Rebecca; 39 college close, Longridge, Preston Lancashire PR3 3AX (GB). KLEIN, Christian; Chapfstrasse 26B, 8906 Bon- stetten (CH). SCHANZER, Juergen Michael; Metzstr. 26, 81667 Mlinchen (DE). STUBENRAUCH, Kay-Gun- nar; Parkstrasse la, 82377 Penzberg (DE). UMANA, Pablo; Felsenrainstrasse 28, 8832 Wollerau (CH). GEI- GER, Martina; Muehlestrasse 4a, 8912 Obfelden (CH). SULLIVAN, Eric; c/o Roche Sequencing Solutions, Inc., 4300 Hacienda Drive, Pleasanton, California 94588 (US). PATEL, Jigar; c/o Roche Sequencing Solutions, Inc., 4300 Hacienda Drive, Pleasanton, California 94588 (US). (74) Agent: BRODBECK, Michel; Grenzacherstrasse 124, 4070 Basel (CH). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, [Continued on next page] (57) : The present invention generally relates to novel protease-activatable T cell activating bispecific molecules and idiotype-specific poly- peptides acting as masking moieties. The present in- vention also relates to polynucleotides encoding such protease-activatable T cell activating bispecific mo- lecules and idiotype-specific polypeptides, and vec- tors and host cells comprising such polynucleotides. The invention further relates to methods for produ- cing the protease-activatable T cell activating bispe- cific molecules and idiotype-specific polypeptides of the invention, and to methods of using these pro- tease-activatable T cell activating bispecific mo- lecules and idiotype-specific polypeptides in the treatment of disease. WO 2017/162587 Al MIDEDIMOMOIDEIRMEMOMOHEIHIONDERVOIMIE DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, DK, EE, ES, FI, FR, GB, GR, HR, HU, IE, IS, IT, LT, GT, HN, HR, HU, ID, IL, IN, IR, IS, JP, KE, KG, KH, LU, LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG, MK, MN, MW, MX, MY, MZ, NA, NG, NI, NO, NZ, OM, PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC, SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW. (84) Designated States (unless otherwise indicated, for every kind of regional protection available): ARIPO (BW, GH, GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ, TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ, TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, SI, SK, SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, KM, ML, MR, NE, SN, TD, TG). Declarations under Rule 4.17: — of inventorship (Rule 4.17(iv)) Published: with international search report (Art. 21(3)) with sequence listing part of description (Rule 5.2(a))
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP16161740 | 2016-03-22 | ||
US201662433327P | 2016-12-13 | 2016-12-13 | |
PCT/EP2017/056556 WO2017162587A1 (en) | 2016-03-22 | 2017-03-20 | Protease-activated t cell bispecific molecules |
Publications (1)
Publication Number | Publication Date |
---|---|
SG11201808085WA true SG11201808085WA (en) | 2018-10-30 |
Family
ID=55646332
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SG11201808085WA SG11201808085WA (en) | 2016-03-22 | 2017-03-20 | Protease-activated t cell bispecific molecules |
Country Status (14)
Country | Link |
---|---|
EP (1) | EP3433280B1 (en) |
KR (1) | KR102444614B1 (en) |
CN (1) | CN108884170A (en) |
AR (2) | AR107946A1 (en) |
AU (1) | AU2017237376B2 (en) |
BR (1) | BR112018016281A2 (en) |
CA (1) | CA3012422A1 (en) |
CO (1) | CO2018007556A2 (en) |
CR (1) | CR20180453A (en) |
MA (1) | MA43724B1 (en) |
PE (1) | PE20181891A1 (en) |
PT (1) | PT3433280T (en) |
SG (1) | SG11201808085WA (en) |
WO (1) | WO2017162587A1 (en) |
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2017
- 2017-03-20 SG SG11201808085WA patent/SG11201808085WA/en unknown
- 2017-03-20 KR KR1020187027293A patent/KR102444614B1/en active IP Right Grant
- 2017-03-20 CA CA3012422A patent/CA3012422A1/en active Pending
- 2017-03-20 MA MA43724A patent/MA43724B1/en unknown
- 2017-03-20 BR BR112018016281A patent/BR112018016281A2/en unknown
- 2017-03-20 CN CN201780018328.8A patent/CN108884170A/en active Pending
- 2017-03-20 AU AU2017237376A patent/AU2017237376B2/en active Active
- 2017-03-20 CR CR20180453A patent/CR20180453A/en unknown
- 2017-03-20 WO PCT/EP2017/056556 patent/WO2017162587A1/en active Application Filing
- 2017-03-20 PE PE2018001324A patent/PE20181891A1/en unknown
- 2017-03-20 PT PT177112232T patent/PT3433280T/en unknown
- 2017-03-20 EP EP17711223.2A patent/EP3433280B1/en active Active
- 2017-03-22 AR ARP170100708A patent/AR107946A1/en unknown
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2018
- 2018-07-18 CO CONC2018/0007556A patent/CO2018007556A2/en unknown
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2020
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PE20181891A1 (en) | 2018-12-11 |
MA43724B1 (en) | 2023-06-28 |
PT3433280T (en) | 2023-06-15 |
AR107946A1 (en) | 2018-06-28 |
MA43724A (en) | 2018-11-28 |
AU2017237376A1 (en) | 2018-08-02 |
WO2017162587A1 (en) | 2017-09-28 |
AU2017237376B2 (en) | 2024-03-07 |
KR102444614B1 (en) | 2022-09-21 |
BR112018016281A2 (en) | 2019-01-02 |
CN108884170A (en) | 2018-11-23 |
EP3433280B1 (en) | 2023-04-19 |
KR20180128407A (en) | 2018-12-03 |
AR120543A2 (en) | 2022-02-23 |
CO2018007556A2 (en) | 2018-07-31 |
EP3433280A1 (en) | 2019-01-30 |
CR20180453A (en) | 2018-12-05 |
CA3012422A1 (en) | 2017-09-28 |
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