EP3237452A4 - Fusion proteins and methods thereof - Google Patents

Fusion proteins and methods thereof Download PDF

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Publication number
EP3237452A4
EP3237452A4 EP15873797.3A EP15873797A EP3237452A4 EP 3237452 A4 EP3237452 A4 EP 3237452A4 EP 15873797 A EP15873797 A EP 15873797A EP 3237452 A4 EP3237452 A4 EP 3237452A4
Authority
EP
European Patent Office
Prior art keywords
methods
fusion proteins
fusion
proteins
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
EP15873797.3A
Other languages
German (de)
French (fr)
Other versions
EP3237452A1 (en
Inventor
Anna Lasorella
Antonio Iavarone
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Columbia University of New York
Original Assignee
Columbia University of New York
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Columbia University of New York filed Critical Columbia University of New York
Priority to EP20197862.4A priority Critical patent/EP3778644A3/en
Priority to EP21173909.9A priority patent/EP3925979A3/en
Publication of EP3237452A1 publication Critical patent/EP3237452A1/en
Publication of EP3237452A4 publication Critical patent/EP3237452A4/en
Ceased legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
    • G01N33/57484—Immunoassay; Biospecific binding assay; Materials therefor for cancer involving compounds serving as markers for tumor, cancer, neoplasia, e.g. cellular determinants, receptors, heat shock/stress proteins, A-protein, oligosaccharides, metabolites
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use
    • C12Q2600/156—Polymorphic or mutational markers
EP15873797.3A 2014-12-23 2015-12-23 Fusion proteins and methods thereof Ceased EP3237452A4 (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
EP20197862.4A EP3778644A3 (en) 2014-12-23 2015-12-23 Fgfr-tacc fusion proteins and methods thereof
EP21173909.9A EP3925979A3 (en) 2014-12-23 2015-12-23 Fgfr-tacc fusion proteins and methods thereof

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201462096311P 2014-12-23 2014-12-23
PCT/US2015/000270 WO2016105517A1 (en) 2014-12-23 2015-12-23 Fusion proteins and methods thereof

Related Child Applications (2)

Application Number Title Priority Date Filing Date
EP20197862.4A Division EP3778644A3 (en) 2014-12-23 2015-12-23 Fgfr-tacc fusion proteins and methods thereof
EP21173909.9A Division EP3925979A3 (en) 2014-12-23 2015-12-23 Fgfr-tacc fusion proteins and methods thereof

Publications (2)

Publication Number Publication Date
EP3237452A1 EP3237452A1 (en) 2017-11-01
EP3237452A4 true EP3237452A4 (en) 2018-12-05

Family

ID=56151260

Family Applications (3)

Application Number Title Priority Date Filing Date
EP21173909.9A Pending EP3925979A3 (en) 2014-12-23 2015-12-23 Fgfr-tacc fusion proteins and methods thereof
EP20197862.4A Pending EP3778644A3 (en) 2014-12-23 2015-12-23 Fgfr-tacc fusion proteins and methods thereof
EP15873797.3A Ceased EP3237452A4 (en) 2014-12-23 2015-12-23 Fusion proteins and methods thereof

Family Applications Before (2)

Application Number Title Priority Date Filing Date
EP21173909.9A Pending EP3925979A3 (en) 2014-12-23 2015-12-23 Fgfr-tacc fusion proteins and methods thereof
EP20197862.4A Pending EP3778644A3 (en) 2014-12-23 2015-12-23 Fgfr-tacc fusion proteins and methods thereof

Country Status (2)

Country Link
EP (3) EP3925979A3 (en)
WO (1) WO2016105517A1 (en)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20150203589A1 (en) 2012-07-24 2015-07-23 The Trustees Of Columbia University In The City Of New York Fusion proteins and methods thereof
KR20150129847A (en) 2013-03-15 2015-11-20 더 트러스티스 오브 컬럼비아 유니버시티 인 더 시티 오브 뉴욕 Fusion proteins and methods thereof
WO2023230444A2 (en) * 2022-05-23 2023-11-30 Foundation Medicine, Inc. Abl1 fusions and uses thereof

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WO2014130890A1 (en) * 2013-02-21 2014-08-28 Toma Biosciences, Inc. Methods, compositions, and kits for nucleic acid analysis

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See also references of WO2016105517A1 *

Also Published As

Publication number Publication date
EP3778644A2 (en) 2021-02-17
EP3778644A3 (en) 2021-06-02
EP3925979A2 (en) 2021-12-22
EP3237452A1 (en) 2017-11-01
EP3925979A3 (en) 2022-03-23
WO2016105517A1 (en) 2016-06-30

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