SG10201913032TA - Treating refractory migraine - Google Patents
Treating refractory migraineInfo
- Publication number
- SG10201913032TA SG10201913032TA SG10201913032TA SG10201913032TA SG10201913032TA SG 10201913032T A SG10201913032T A SG 10201913032TA SG 10201913032T A SG10201913032T A SG 10201913032TA SG 10201913032T A SG10201913032T A SG 10201913032TA SG 10201913032T A SG10201913032T A SG 10201913032TA
- Authority
- SG
- Singapore
- Prior art keywords
- treating refractory
- refractory migraine
- migraine
- treating
- refractory
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/06—Antimigraine agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662399180P | 2016-09-23 | 2016-09-23 | |
| US201762558557P | 2017-09-14 | 2017-09-14 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SG10201913032TA true SG10201913032TA (en) | 2020-02-27 |
Family
ID=60120094
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SG10201913032TA SG10201913032TA (en) | 2016-09-23 | 2017-09-22 | Treating refractory migraine |
Country Status (15)
| Country | Link |
|---|---|
| US (6) | US10392434B2 (es) |
| EP (1) | EP3515937A1 (es) |
| JP (3) | JP6937368B2 (es) |
| KR (2) | KR20190066607A (es) |
| CN (1) | CN109952314A (es) |
| AU (2) | AU2017331593B2 (es) |
| BR (1) | BR112019005823A2 (es) |
| CA (1) | CA3036632A1 (es) |
| CL (1) | CL2019000760A1 (es) |
| IL (1) | IL265343A (es) |
| MX (1) | MX2019003337A (es) |
| PE (1) | PE20191148A1 (es) |
| SG (1) | SG10201913032TA (es) |
| WO (1) | WO2018055574A1 (es) |
| ZA (1) | ZA201901531B (es) |
Families Citing this family (58)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US11951139B2 (en) | 2015-11-30 | 2024-04-09 | Seed Health, Inc. | Method and system for reducing the likelihood of osteoporosis |
| US11951140B2 (en) | 2011-02-04 | 2024-04-09 | Seed Health, Inc. | Modulation of an individual's gut microbiome to address osteoporosis and bone disease |
| US11844720B2 (en) | 2011-02-04 | 2023-12-19 | Seed Health, Inc. | Method and system to reduce the likelihood of dental caries and halitosis |
| US11839632B2 (en) | 2013-12-20 | 2023-12-12 | Seed Health, Inc. | Topical application of CRISPR-modified bacteria to treat acne vulgaris |
| US11969445B2 (en) | 2013-12-20 | 2024-04-30 | Seed Health, Inc. | Probiotic composition and method for controlling excess weight, obesity, NAFLD and NASH |
| US11833177B2 (en) | 2013-12-20 | 2023-12-05 | Seed Health, Inc. | Probiotic to enhance an individual's skin microbiome |
| US11826388B2 (en) | 2013-12-20 | 2023-11-28 | Seed Health, Inc. | Topical application of Lactobacillus crispatus to ameliorate barrier damage and inflammation |
| UA123759C2 (uk) | 2014-03-21 | 2021-06-02 | Тева Фармасьютікалз Інтернешнл Гмбх | Застосування моноклонального антитіла, яке інгібує шлях пов'язаного з геном кальциноніну пептиду (cgrp), для лікування або зниження частоти випадків мігренозного головного болю у суб'єкта |
| US10933136B2 (en) | 2015-02-10 | 2021-03-02 | Axsome Therapeutics, Inc. | Pharmaceutical compositions comprising meloxicam |
| US10780165B2 (en) | 2015-02-10 | 2020-09-22 | Axsome Therapeutics, Inc. | Pharmaceutical compositions comprising meloxicam |
| US10780166B2 (en) | 2015-02-10 | 2020-09-22 | Axsome Therapeutics, Inc. | Pharmaceutical compositions comprising meloxicam |
| US10758618B2 (en) | 2015-02-10 | 2020-09-01 | Axsome Therapeutics, Inc. | Pharmaceutical compositions comprising meloxicam |
| US11045549B2 (en) | 2015-02-10 | 2021-06-29 | Axsome Therapeutics, Inc. | Pharmaceutical compositions comprising meloxicam |
| US10799588B2 (en) | 2015-02-10 | 2020-10-13 | Axsome Therapeutics, Inc. | Pharmaceutical compositions comprising meloxicam |
| US11013806B2 (en) | 2015-02-10 | 2021-05-25 | Axsome Therapeutics, Inc. | Pharmaceutical compositions comprising meloxicam |
| US11738085B2 (en) | 2015-02-10 | 2023-08-29 | Axsome Therapeutics, Inc. | Pharmaceutical compositions comprising meloxicam |
| US10821181B2 (en) | 2015-02-10 | 2020-11-03 | Axsome Therapeutics, Inc. | Pharmaceutical compositions comprising meloxicam |
| US10933137B2 (en) | 2015-02-10 | 2021-03-02 | Axsome Therapeutics, Inc. | Pharmaceutical compositions comprising meloxicam |
| US11602563B2 (en) | 2015-02-10 | 2023-03-14 | Axsome Therapeutics, Inc. | Pharmaceutical compositions comprising meloxicam |
| US11110173B2 (en) | 2015-02-10 | 2021-09-07 | Axsome Therapeutics, Inc | Pharmaceutical compositions comprising meloxicam |
| US11013805B2 (en) | 2015-02-10 | 2021-05-25 | Axsome Therapeutics, Inc. | Pharmaceutical compositions comprising meloxicam |
| US10729774B1 (en) | 2015-02-10 | 2020-08-04 | Axsome Therapeutics, Inc. | Pharmaceutical compositions comprising meloxicam |
| US11607456B2 (en) | 2015-02-10 | 2023-03-21 | Axsome Therapeutics, Inc. | Pharmaceutical compositions comprising meloxicam |
| US10392434B2 (en) * | 2016-09-23 | 2019-08-27 | Teva Pharmaceuticals International Gmbh | Treating refractory migraine |
| US10894053B2 (en) | 2017-01-04 | 2021-01-19 | Axsome Therapeutics, Inc. | Pharmaceutical compositions comprising meloxicam |
| US10821182B2 (en) | 2017-06-29 | 2020-11-03 | Axsome Therapeutics, Inc. | Pharmaceutical compositions comprising meloxicam |
| US11433078B2 (en) | 2017-01-04 | 2022-09-06 | Axsome Therapeutics, Inc. | Pharmaceutical compositions comprising meloxicam |
| US10905693B2 (en) | 2017-01-04 | 2021-02-02 | Axsome Therapeutics, Inc. | Pharmaceutical compositions comprising meloxicam |
| US11433079B2 (en) | 2017-01-04 | 2022-09-06 | Axsome Therapeutics, Inc. | Pharmaceutical compositions comprising meloxicam |
| US11617755B2 (en) | 2017-01-04 | 2023-04-04 | Axsome Therapeutics, Inc. | Pharmaceutical compositions comprising meloxicam |
| US11471465B2 (en) | 2017-01-04 | 2022-10-18 | Axsome Therapeutics, Inc. | Pharmaceutical compositions comprising meloxicam |
| US10729696B2 (en) | 2017-01-04 | 2020-08-04 | Axsome Therapeutics, Inc. | Pharmaceutical compositions comprising meloxicam |
| US10940153B2 (en) | 2017-01-04 | 2021-03-09 | Axsome Therapeutics, Inc. | Pharmaceutical compositions comprising meloxicam |
| US11207327B2 (en) | 2017-01-04 | 2021-12-28 | Axsome Therapeutics, Inc. | Pharmaceutical compositions comprising meloxicam |
| US11806354B2 (en) | 2017-01-04 | 2023-11-07 | Axsome Therapeutics, Inc. | Pharmaceutical compositions comprising meloxicam |
| US11801250B2 (en) | 2017-01-04 | 2023-10-31 | Axsome Therapeutics, Inc. | Pharmaceutical compositions comprising meloxicam |
| US11266657B2 (en) | 2017-01-04 | 2022-03-08 | Axsome Therapeutics, Inc. | Pharmaceutical compositions comprising meloxicam |
| US11219626B2 (en) | 2017-06-29 | 2022-01-11 | Axsome Therapeutics, Inc. | Pharmaceutical compositions comprising meloxicam |
| US10987358B2 (en) | 2017-06-29 | 2021-04-27 | Axsome Therapeutics, Inc. | Pharmaceutical compositions comprising meloxicam |
| US10758617B2 (en) | 2017-06-29 | 2020-09-01 | Axsome Therapeutics, Inc. | Pharmaceutical compositions comprising meloxicam |
| US11759522B2 (en) | 2017-06-29 | 2023-09-19 | Axsome Therapeutics, Inc. | Pharmaceutical compositions comprising meloxicam |
| US11865117B2 (en) | 2017-06-29 | 2024-01-09 | Axsome Therapeutics, Inc | Pharmaceutical compositions comprising meloxicam |
| US11510927B2 (en) | 2017-06-29 | 2022-11-29 | Axsome Therapeutics, Inc. | Pharmaceutical compositions comprising meloxicam |
| US11617791B2 (en) | 2017-06-29 | 2023-04-04 | Axsome Therapeutics, Inc. | Pharmaceutical compositions comprising meloxicam |
| US11185550B2 (en) | 2017-06-29 | 2021-11-30 | Axsome Therapeutics, Inc. | Pharmaceutical compositions comprising meloxicam |
| US11617756B2 (en) | 2017-06-29 | 2023-04-04 | Axsome Therapeutics, Inc. | Pharmaceutical compositions comprising meloxicam |
| US10918722B2 (en) | 2017-06-29 | 2021-02-16 | Axsome Therapeutics, Inc. | Pharmaceutical compositions comprising meloxicam |
| TWI754772B (zh) * | 2017-09-06 | 2022-02-11 | 美商美國禮來大藥廠 | 用於治療偏頭痛之拉米迪坦(lasmiditan)與cgrp拮抗劑之組合療法 |
| US20190275270A1 (en) * | 2018-03-07 | 2019-09-12 | Richard Postrel | System and method for arresting debilitating migraine events |
| JP2021534197A (ja) * | 2018-08-22 | 2021-12-09 | イーライ リリー アンド カンパニー | 治療抵抗性患者のための抗ｃｇｒｐ抗体 |
| US10899826B1 (en) | 2018-09-13 | 2021-01-26 | Teva Pharmaceuticals International Gmbh | Pharmaceutical compositions for an anti-CGRP antagonist antibody |
| US20210322679A1 (en) | 2018-09-20 | 2021-10-21 | Teva Pharmaceuticals International Gmbh | Injection spring for aged prefilled syringe and auto injector |
| AU2020206241A1 (en) * | 2019-01-08 | 2021-08-26 | H. Lundbeck A/S | Acute treatment and rapid treatment of headache using anti-CGRP antibodies |
| PE20211708A1 (es) * | 2019-01-08 | 2021-09-01 | H Lundbeck As | Tratamiento de cefalea por uso excesivo de medicamentos usando anticuerpos anticgrp o anti-cgrp-r |
| AU2020210024A1 (en) * | 2019-01-20 | 2021-07-01 | Biohaven Pharmaceutical Holding Company Ltd. | CGRP antagonists for treating migraine breakthrough |
| EP3920909A4 (en) * | 2019-02-06 | 2022-11-30 | Axsome Therapeutics, Inc. | PHARMACEUTICAL COMPOSITIONS COMPRISING MELOXICAM |
| US20210236485A1 (en) * | 2020-01-14 | 2021-08-05 | Impel Neuropharma, Inc. | Repeated administration of dihydroergotamine for treatment of frequent migraine headaches |
| WO2023177823A1 (en) * | 2022-03-17 | 2023-09-21 | Vasoceuticals, Inc. | Combined use of individual compounds for treatment of chronic pain disorders |
Family Cites Families (127)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3773919A (en) | 1969-10-23 | 1973-11-20 | Du Pont | Polylactide-drug mixtures |
| US3662333A (en) | 1970-09-08 | 1972-05-09 | Bendix Corp | Hydraulic accumulator charge detector and indicating system |
| FR2413974A1 (fr) | 1978-01-06 | 1979-08-03 | David Bernard | Sechoir pour feuilles imprimees par serigraphie |
| US4485045A (en) | 1981-07-06 | 1984-11-27 | Research Corporation | Synthetic phosphatidyl cholines useful in forming liposomes |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US4544545A (en) | 1983-06-20 | 1985-10-01 | Trustees University Of Massachusetts | Liposomes containing modified cholesterol for organ targeting |
| US5807715A (en) | 1984-08-27 | 1998-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin |
| JPS62129297A (ja) | 1985-08-09 | 1987-06-11 | Toyo Jozo Co Ltd | カルシトニン遺伝子関連ペプチド誘導体 |
| US4676980A (en) | 1985-09-23 | 1987-06-30 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Target specific cross-linked heteroantibodies |
| IL85035A0 (en) | 1987-01-08 | 1988-06-30 | Int Genetic Eng | Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same |
| GB8823869D0 (en) | 1988-10-12 | 1988-11-16 | Medical Res Council | Production of antibodies |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| US5116964A (en) | 1989-02-23 | 1992-05-26 | Genentech, Inc. | Hybrid immunoglobulins |
| WO1991000360A1 (en) | 1989-06-29 | 1991-01-10 | Medarex, Inc. | Bispecific reagents for aids therapy |
| AU620727B2 (en) | 1989-07-10 | 1992-02-20 | Amylin Pharmaceuticals, Inc. | Treatment of obesity and essential hypertension and related disorders |
| US5013556A (en) | 1989-10-20 | 1991-05-07 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
| US5661016A (en) | 1990-08-29 | 1997-08-26 | Genpharm International Inc. | Transgenic non-human animals capable of producing heterologous antibodies of various isotypes |
| ES2108048T3 (es) | 1990-08-29 | 1997-12-16 | Genpharm Int | Produccion y utilizacion de animales inferiores transgenicos capaces de producir anticuerpos heterologos. |
| US5545806A (en) | 1990-08-29 | 1996-08-13 | Genpharm International, Inc. | Ransgenic non-human animals for producing heterologous antibodies |
| US5633425A (en) | 1990-08-29 | 1997-05-27 | Genpharm International, Inc. | Transgenic non-human animals capable of producing heterologous antibodies |
| US5625126A (en) | 1990-08-29 | 1997-04-29 | Genpharm International, Inc. | Transgenic non-human animals for producing heterologous antibodies |
| EP0564531B1 (en) | 1990-12-03 | 1998-03-25 | Genentech, Inc. | Enrichment method for variant proteins with altered binding properties |
| JPH06507398A (ja) | 1991-05-14 | 1994-08-25 | リプリジェン コーポレーション | Ｈｉｖ感染治療のための異種複合抗体 |
| JP4124480B2 (ja) | 1991-06-14 | 2008-07-23 | ジェネンテック・インコーポレーテッド | 免疫グロブリン変異体 |
| EP0656064B1 (en) | 1992-08-17 | 1997-03-05 | Genentech, Inc. | Bispecific immunoadhesins |
| US5981568A (en) | 1993-01-28 | 1999-11-09 | Neorx Corporation | Therapeutic inhibitor of vascular smooth muscle cells |
| AU6524794A (en) | 1993-03-24 | 1994-10-11 | Amylin Pharmaceuticals, Inc. | Cloned receptors and methods for screening |
| GB9316989D0 (en) | 1993-08-16 | 1993-09-29 | Lynxvale Ltd | Binding molecules |
| JPH07196700A (ja) | 1994-01-06 | 1995-08-01 | Sando Yakuhin Kk | 抗カルシトニン抗体及びその作製方法、並びに該抗体を用いたカルシトニンの測定方法 |
| WO1996005221A1 (en) | 1994-08-16 | 1996-02-22 | Human Genome Sciences, Inc. | Calcitonin receptor |
| FR2732221B1 (fr) | 1995-03-28 | 1997-04-25 | Oreal | Utilisation d'un antagoniste de cgrp pour traiter les rougeurs cutanees d'origine neurogene et composition obtenue |
| FR2732220B1 (fr) | 1995-03-28 | 1997-04-25 | Oreal | Utilisation d'un antagoniste de cgrp pour traiter les lichens et les prurits et composition obtenue |
| FR2732222B1 (fr) | 1995-03-28 | 1997-04-25 | Oreal | Utilisation d'un antagoniste de cgrp pour le traitement des prurits et des dysesthesies oculaires et palpebraux |
| EP0737471A3 (fr) | 1995-04-10 | 2000-12-06 | L'oreal | Utilisation d'un sel d'une métal alcalino-terreux comme inhibiteur de TNF-alpha dans une composition unique et composition obtenue |
| FR2732598B1 (fr) | 1995-04-10 | 1997-05-09 | Oreal | Utilisation de sel de metaux alcalino-terreux pour le traitement des prurits et des dysesthesies oculaires ou palpebraux |
| CA2219361C (en) | 1995-04-27 | 2012-02-28 | Abgenix, Inc. | Human antibodies derived from immunized xenomice |
| EP0851759A4 (en) | 1995-09-05 | 2000-12-06 | Smithkline Beecham Corp | COMPOUNDS AND RELATED METHODS |
| AU2731797A (en) | 1996-04-15 | 1997-11-19 | University Of Miami | Molecular clone of cgrp receptor component protein and uses thereof |
| US5746694A (en) | 1996-05-16 | 1998-05-05 | Wilk; Peter J. | Endoscope biopsy channel liner and associated method |
| WO1998003534A1 (en) | 1996-07-23 | 1998-01-29 | Smithkline Beecham Corporation | Calcitonin gene-related peptide receptor component factor (houdc44) |
| US6586458B1 (en) | 1996-08-16 | 2003-07-01 | Pozen Inc. | Methods of treating headaches using 5-HT agonists in combination with long-acting NSAIDs |
| JP3734315B2 (ja) | 1996-08-26 | 2006-01-11 | 株式会社小松製作所 | 曲げ加工方法および曲げ加工装置 |
| AU4261697A (en) | 1996-09-09 | 1998-03-26 | Smithkline Beecham Corporation | Compounds and methods |
| BR9712023A (pt) | 1996-09-10 | 1999-08-31 | Thomae Gmbh Dr K | Aminoácidos derivados, medicamentos contendo esses compostos e processos para a sua preparação. |
| WO1998056779A1 (en) | 1997-06-13 | 1998-12-17 | Smithkline Beecham Corporation | 4-sulfinyl benzamides as calcitonin gene-related peptide receptor antagonists |
| US20030069231A1 (en) | 1999-10-12 | 2003-04-10 | Klaus Rudolf | Modified aminoacids, pharmaceuticals containing these compounds and method for their production |
| SE9704770D0 (sv) | 1997-12-19 | 1997-12-19 | Astra Ab | New use |
| GB9809951D0 (en) | 1998-05-08 | 1998-07-08 | Univ Cambridge Tech | Binding molecules |
| GB9809839D0 (en) | 1998-05-09 | 1998-07-08 | Glaxo Group Ltd | Antibody |
| CA2345357A1 (en) | 1998-09-30 | 2000-04-06 | Merck Sharp & Dohme Limited | Benzimidazolinyl piperidines as cgrp ligands |
| US6737056B1 (en) | 1999-01-15 | 2004-05-18 | Genentech, Inc. | Polypeptide variants with altered effector function |
| EP1031350A1 (en) | 1999-02-23 | 2000-08-30 | Warner-Lambert Company | Use of a gabapentin-analog for the manufacture of a medicament for preventing and treating visceral pain |
| US6313097B1 (en) | 1999-03-02 | 2001-11-06 | Boehringer Ingelheim Pharma Kg | Antagonists of calcitonin gene-related peptide |
| WO2000053211A2 (en) | 1999-03-09 | 2000-09-14 | University Of Southern California | Method of promoting myocyte proliferation and myocardial tissue repair |
| AU6836200A (en) | 1999-08-10 | 2001-03-05 | Glaxo Group Limited | Use of ep4 receptor ligands in the treatment of, inter alia, neuropathic pain and colon cancer |
| US6521609B1 (en) | 1999-08-10 | 2003-02-18 | Boehringer Ingelheim Pharma Kg | Use of CGRP antagonists and CGRP release inhibitors for combating menopausal hot flushes |
| US6849425B1 (en) | 1999-10-14 | 2005-02-01 | Ixsys, Inc. | Methods of optimizing antibody variable region binding affinity |
| GB0027537D0 (en) | 2000-11-10 | 2000-12-27 | Glaxo Group Ltd | New polypeptide |
| US20020162125A1 (en) | 2001-03-06 | 2002-10-31 | Anne-Marie Salmon | Methods and compositions for the modulation of neurogenic inflammatory pain and physical opiate withdrawal |
| WO2004003019A2 (en) | 2002-06-28 | 2004-01-08 | Domantis Limited | Immunoglobin single variant antigen-binding domains and dual-specific constructs |
| JP4603261B2 (ja) | 2001-09-27 | 2010-12-22 | メルク・シャープ・エンド・ドーム・コーポレイション | ヒト化カルシトニン遺伝子関連ペプチド受容体をコードする単離ｄｎａ分子、関連する非ヒトトランスジェニック動物及びアッセイ方法 |
| US6767056B2 (en) | 2002-01-14 | 2004-07-27 | Shin Yeh Enterprise Co., Ltd. | Settee with a foldable tray-support unit |
| TWI263497B (en) | 2002-03-29 | 2006-10-11 | Lilly Co Eli | Pyridinoylpiperidines as 5-HT1F agonists |
| ATE435239T1 (de) | 2002-03-29 | 2009-07-15 | Schering Corp | Menschliche monoklonale antikörper gegen interleukin-5 sowie diese umfassende verfahren und zusammensetzungen |
| EP1501929B1 (de) | 2002-05-06 | 2013-03-27 | Noxxon Pharma AG | Cgrp bindende nukleinsäuren |
| US20040110170A1 (en) | 2002-05-18 | 2004-06-10 | The Regents Of The University Of California | Cloning and characterization of calcitonin gene related peptide receptors |
| US7345065B2 (en) | 2002-05-21 | 2008-03-18 | Allergan, Inc. | Methods and compositions for alleviating pain |
| US7097467B2 (en) | 2002-06-03 | 2006-08-29 | Wan-Tien Chen | Dustproof plate fixture for an electrical connector |
| KR20120004541A (ko) | 2002-06-05 | 2012-01-12 | 브리스톨-마이어스 스큅 컴퍼니 | 칼시토닌 유전자 관련 펩티드 수용체 길항제 |
| DE60326370D1 (de) | 2002-08-12 | 2009-04-09 | Actavis Group Hf | Verwendung von cgrp-antagonisten-verbindungen zur behandlung von psoriasis |
| ES2347239T3 (es) | 2002-12-02 | 2010-10-27 | Amgen Fremont Inc. | Anticuerpos dirigidos al factor de necrosis tumoral y usos de los mismos. |
| NZ540730A (en) | 2002-12-24 | 2010-09-30 | Rinat Neuroscience Corp | Anti-NGF antibodies and methods using same |
| CA2519515A1 (en) | 2003-03-14 | 2004-10-14 | Merck & Co., Inc. | Benodiazepine spirohydantoin cgrp receptor antagonists |
| JP4673295B2 (ja) | 2003-03-14 | 2011-04-20 | メルク・シャープ・エンド・ドーム・コーポレイション | 単環式アニリドスピロヒダントインｃｇｒｐ受容体拮抗物質 |
| ATE535514T1 (de) | 2003-03-14 | 2011-12-15 | Merck Sharp & Dohme | Carboxamid-spirohydantoin-cgrp-rezeptor- antagonisten |
| CA2519475A1 (en) | 2003-03-14 | 2004-09-30 | Merck & Co., Inc. | Bicyclic anilide spirohydantoin cgrp receptor antagonists |
| AU2004222328B2 (en) | 2003-03-14 | 2009-10-08 | Merck Sharp & Dohme Corp. | Aryl spirohydantoin CGRP receptor antagonists |
| CA2522024A1 (en) | 2003-04-15 | 2004-10-28 | Merck & Co., Inc. | Cgrp receptor antagonists |
| JO2355B1 (en) | 2003-04-15 | 2006-12-12 | ميرك شارب اند دوم كوربوريشن | Hereditary calcitonin polypeptide receptor antagonists |
| WO2004097421A2 (en) | 2003-04-29 | 2004-11-11 | Bayer Healthcare Ag | Diagnostics and therapeutics for diseases associated with calcitonin receptor-like receptor (calcrl) |
| EP1646611A1 (en) | 2003-07-15 | 2006-04-19 | Merck & Co., Inc. | Hydroxypyridine cgrp receptor antagonists |
| WO2005041757A2 (en) | 2003-10-29 | 2005-05-12 | University Of Rochester | Detection of neuropeptides associated with pelvic pain disorders and uses thereof |
| DE102004015723A1 (de) | 2004-03-29 | 2005-10-20 | Boehringer Ingelheim Pharma | Ausgewählte CGRP-Antagonisten, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel |
| US7279471B2 (en) | 2004-04-15 | 2007-10-09 | Boehringer Ingelheim International Gmbh | Selected CGRP-antagonists, process for preparing them and their use as pharmaceutical compositions |
| DE102004018794A1 (de) | 2004-04-15 | 2005-10-27 | Boehringer Ingelheim Pharma Gmbh & Co. Kg | Ausgewählte CGRP-Antagonisten, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel |
| EP1740175A1 (de) | 2004-04-20 | 2007-01-10 | Boehringer Ingelheim International Gmbh | Verwendung eines cgrp-antagonisten in kombination mit einem serotonin-wiederaufnahme-hemmer zur behandlung von migräne |
| DE102004027912A1 (de) | 2004-06-09 | 2005-12-29 | Grünenthal GmbH | Substituierte Cyclopenten-Verbindungen |
| US7384930B2 (en) | 2004-11-03 | 2008-06-10 | Bristol-Myers Squibb Company | Constrained compounds as CGRP-receptor antagonists |
| TWI432196B (zh) | 2005-01-18 | 2014-04-01 | Euro Celtique Sa | 內臟痛的治療 |
| EP1770091A1 (de) | 2005-09-29 | 2007-04-04 | Boehringer Ingelheim Pharma GmbH & Co. KG | CGRP-Antagonisten, Verfahren zu deren Herstellung sowie deren Verwendung als Arzneimittel |
| EP1928452A4 (en) | 2005-08-25 | 2010-09-01 | Wex Medical Ltd | USE OF SODIUM CHANNEL BLOCKS FOR THE TREATMENT OF VISCERAL PAIN OR PAIN THROUGH CANCER TREATMENT |
| EP1928484B1 (en) | 2005-08-26 | 2010-02-24 | The Board Of Trustees Of The Leland Stanford Junior University | Methods for treatment of headaches by administration of oxytocin |
| EP1933714B1 (en) | 2005-09-21 | 2020-03-18 | The Regents of The University of California | Systems and compositions for local imaging and treatment of pain |
| US8168592B2 (en) | 2005-10-21 | 2012-05-01 | Amgen Inc. | CGRP peptide antagonists and conjugates |
| ES2433251T5 (es) | 2005-11-14 | 2020-03-13 | Teva Pharmaceuticals Int Gmbh | Anticuerpos antagonistas dirigidos contra un péptido relacionado con el gen de la calcitonina y procedimientos que utilizan los mismos |
| JP2009515971A (ja) | 2005-11-18 | 2009-04-16 | メルク エンド カムパニー インコーポレーテッド | スピロヒダントインアリールｃｇｒｐ受容体アンタゴニスト |
| WO2007076336A1 (en) | 2005-12-22 | 2007-07-05 | Eli Lilly And Company | Treatment of migraine with anti-cgrp antibodies |
| DE602007006961D1 (de) | 2006-07-21 | 2010-07-15 | Vertex Pharma | Cgrp-rezeptorantagonisten |
| US8945505B2 (en) | 2007-02-02 | 2015-02-03 | Panaphix, Inc. | Use of arsenic compounds for treatment of pain and inflammation |
| MX2010004488A (es) | 2007-10-23 | 2010-06-17 | Allergan Inc | Metodos para tratar inflamacion neurogenica cronica usando toxinas clostridiales modificadas. |
| CA2716799C (en) | 2008-03-04 | 2018-05-22 | Pfizer Limited | Methods of treating inflammatory pain |
| NZ587292A (en) | 2008-03-04 | 2012-09-28 | Pfizer Ltd | Use of anti-CGRP (calcitonin gene-related peptide) antagonists to treat chronic pain |
| CA2721950A1 (en) | 2008-04-25 | 2009-10-29 | Nellix, Inc. | Stent graft delivery system |
| WO2010006168A2 (en) | 2008-07-09 | 2010-01-14 | University Of Rochester | Methods of treating cancer using and agent that modulates activity of the calcitonin-gene related peptide ("cgrp") receptor |
| JO3382B1 (ar) | 2008-12-23 | 2019-03-13 | Amgen Inc | أجسام مضادة ترتبط مع مستقبل cgrp بشري |
| WO2011024113A1 (en) | 2009-08-28 | 2011-03-03 | Rinat Neuroscience Corporation | Methods for treating visceral pain by administering antagonist antibodies directed against calcitonin gene-related peptide |
| AR081434A1 (es) | 2010-06-10 | 2012-08-29 | Lilly Co Eli | Anticuerpo del peptido relacionado con el gen calcitonina (cgrp), composicion farmaceutica que lo comprende, uso de dicho anticuerpo para preparar un medicamento util para tratar dolor de osteoartritis o migranas y fragmento de union a antigeno de dicho anticuerpo |
| US8669368B2 (en) | 2010-10-12 | 2014-03-11 | Bristol-Myers Squibb Company | Process for the preparation of cycloheptapyridine CGRP receptor antagonists |
| AR086515A1 (es) | 2011-05-20 | 2013-12-18 | Alderbio Holdings Llc | Uso de anticuerpos o fragmentos de anticuerpos anti-cgrp o anti-cgrp-r para tratar o prevenir las formas cronicas y agudas de la diarrea |
| SI3495392T1 (sl) | 2011-05-20 | 2021-11-30 | H. Lundbeck A/S | Sestavki proti CGRP in uporaba le-teh |
| CN107827982B (zh) | 2011-05-20 | 2021-07-06 | H.伦德贝克公司 | 抗cgrp抗体和抗体片段用于在有需要的受试者中预防或抑制畏光或厌光的用途 |
| MX355890B (es) | 2011-08-19 | 2018-05-03 | Alderbio Holdings Llc | Estrategia de múltiples copias para producción de alto título y alta pureza de proteínas de multi-subunidades tales como anticuerpos en microbios transformados tal como pichia pastoris. |
| MX2014008456A (es) | 2012-01-10 | 2014-11-25 | Noxxon Pharma Ag | Acidos nucleicos que enlazan especificamente a cgrp. |
| US8722060B2 (en) | 2012-05-23 | 2014-05-13 | William J. Binder | Method of treating vertigo |
| WO2014067911A1 (en) | 2012-10-29 | 2014-05-08 | Net Entertainment Ne Ab | Architecture for multi-player, multi-game, multi- table, multi-operator & multi-jurisdiction live casino gaming |
| US10138294B2 (en) | 2013-03-15 | 2018-11-27 | Alderbio Holdings Llc | Temperature shift for high yield expression of polypeptides in yeast and other transformed cells |
| WO2014146074A2 (en) | 2013-03-15 | 2014-09-18 | Alder Biopharmaceuticals, Inc. | Protocol for identifying and isolating antigen-specific b cells and producing antibodies to desired antigens |
| CA2916980C (en) | 2013-07-03 | 2023-02-21 | Alder Biopharmaceuticals, Inc. | Regulation of glucose metabolism using anti-cgrp antibodies |
| UA123759C2 (uk) * | 2014-03-21 | 2021-06-02 | Тева Фармасьютікалз Інтернешнл Гмбх | Застосування моноклонального антитіла, яке інгібує шлях пов'язаного з геном кальциноніну пептиду (cgrp), для лікування або зниження частоти випадків мігренозного головного болю у суб'єкта |
| US10556945B2 (en) | 2014-03-21 | 2020-02-11 | Teva Pharmaceuticals International Gmbh | Antagonist antibodies directed against calcitonin gene-related peptide and methods using same |
| EP3194435A1 (en) | 2014-09-15 | 2017-07-26 | Amgen Inc. | Bi-specific anti-cgrp receptor/pac1 receptor antigen binding proteins and uses thereof |
| JOP20200116A1 (ar) | 2015-04-24 | 2017-06-16 | Amgen Inc | طرق لعلاج أو الوقاية من الصداع النصفي |
| AR104847A1 (es) | 2015-06-17 | 2017-08-16 | Lilly Co Eli | Formulación de anticuerpo anti-cgrp |
| ES2846878T3 (es) | 2015-09-24 | 2021-07-30 | Teva Pharmaceuticals Int Gmbh | Prevenir, tratar y reducir el dolor de cabeza post-traumático (persistente) |
| US10392434B2 (en) | 2016-09-23 | 2019-08-27 | Teva Pharmaceuticals International Gmbh | Treating refractory migraine |
| MX2019003338A (es) | 2016-09-23 | 2019-09-26 | Teva Pharmaceuticals Int Gmbh | Tratamiento de cefalea en racimos. |
| JP2021534197A (ja) | 2018-08-22 | 2021-12-09 | イーライ リリー アンド カンパニー | 治療抵抗性患者のための抗ｃｇｒｐ抗体 |
-
2017
- 2017-09-22 US US15/712,444 patent/US10392434B2/en active Active
- 2017-09-22 SG SG10201913032TA patent/SG10201913032TA/en unknown
- 2017-09-22 BR BR112019005823A patent/BR112019005823A2/pt unknown
- 2017-09-22 PE PE2019000710A patent/PE20191148A1/es unknown
- 2017-09-22 CN CN201780066786.9A patent/CN109952314A/zh active Pending
- 2017-09-22 KR KR1020197011124A patent/KR20190066607A/ko not_active Application Discontinuation
- 2017-09-22 AU AU2017331593A patent/AU2017331593B2/en active Active
- 2017-09-22 CA CA3036632A patent/CA3036632A1/en active Pending
- 2017-09-22 MX MX2019003337A patent/MX2019003337A/es unknown
- 2017-09-22 JP JP2019515926A patent/JP6937368B2/ja active Active
- 2017-09-22 EP EP17785013.8A patent/EP3515937A1/en active Pending
- 2017-09-22 WO PCT/IB2017/055777 patent/WO2018055574A1/en unknown
- 2017-09-22 KR KR1020227007092A patent/KR20220031944A/ko not_active Application Discontinuation
-
2019
- 2019-03-12 ZA ZA2019/01531A patent/ZA201901531B/en unknown
- 2019-03-13 IL IL265343A patent/IL265343A/en unknown
- 2019-03-22 CL CL2019000760A patent/CL2019000760A1/es unknown
- 2019-07-11 US US16/508,574 patent/US20200223911A1/en not_active Abandoned
-
2020
- 2020-10-21 US US17/076,772 patent/US11028161B2/en active Active
- 2020-10-21 US US17/076,759 patent/US11028160B2/en active Active
-
2021
- 2021-05-05 US US17/308,580 patent/US20220098287A1/en active Pending
- 2021-08-30 JP JP2021139774A patent/JP2021185180A/ja active Pending
-
2022
- 2022-07-21 AU AU2022206792A patent/AU2022206792A1/en active Pending
-
2023
- 2023-02-17 US US18/111,172 patent/US20230242631A1/en active Pending
- 2023-03-07 JP JP2023034438A patent/JP2023065647A/ja active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| MX2019003337A (es) | 2019-09-26 |
| US20200223911A1 (en) | 2020-07-16 |
| AU2017331593B2 (en) | 2022-04-28 |
| US20220098287A1 (en) | 2022-03-31 |
| JP2019530683A (ja) | 2019-10-24 |
| PE20191148A1 (es) | 2019-09-02 |
| US20180127490A1 (en) | 2018-05-10 |
| JP2023065647A (ja) | 2023-05-12 |
| US20210040191A1 (en) | 2021-02-11 |
| US10392434B2 (en) | 2019-08-27 |
| JP6937368B2 (ja) | 2021-09-22 |
| CA3036632A1 (en) | 2018-03-29 |
| KR20190066607A (ko) | 2019-06-13 |
| US11028161B2 (en) | 2021-06-08 |
| ZA201901531B (en) | 2022-01-26 |
| KR20220031944A (ko) | 2022-03-14 |
| JP2021185180A (ja) | 2021-12-09 |
| WO2018055574A1 (en) | 2018-03-29 |
| CL2019000760A1 (es) | 2019-12-27 |
| BR112019005823A2 (pt) | 2019-06-25 |
| CN109952314A (zh) | 2019-06-28 |
| US11028160B2 (en) | 2021-06-08 |
| US20210040190A1 (en) | 2021-02-11 |
| IL265343A (en) | 2019-05-30 |
| AU2022206792A1 (en) | 2022-10-06 |
| US20230242631A1 (en) | 2023-08-03 |
| EP3515937A1 (en) | 2019-07-31 |
| AU2017331593A1 (en) | 2019-04-11 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| IL265343A (en) | Treatment of persistent migraine | |
| IL291153A (en) | Methods for treating or preventing migraine headaches | |
| IL249600A0 (en) | Bone marrow cell transplant treatment | |
| IL265335A (en) | Treating cluster headache | |
| HK1244217A1 (zh) | 用於治療蛋白質病的方法 | |
| GB201608885D0 (en) | Treatment | |
| HK1246655A1 (zh) | 治療不育的方法 | |
| HUE051924T2 (hu) | Hõkezelési eljárás | |
| HK1255871A1 (zh) | 用於治療骨髓瘤的賽度替尼 | |
| IL259393B (en) | Furnace apparatus | |
| HK1255481A1 (zh) | 用於治療hcv的方法 | |
| EP3507838C0 (fr) | Dispositif de traitement de pièces | |
| IL271211A (en) | Migraine treatment | |
| ZA201607068B (en) | Methods for treating hypersomnia | |
| PT3250218T (pt) | Péptido natkide para o tratamento da obesidade | |
| IL262916A (en) | Treatment of side effects resulting from chemo-nervous disorder | |
| IL249616A0 (en) | Methods for treating inflammation | |
| PT2965754T (pt) | Método de tratamento de deficiência de ferro | |
| HK1256371A1 (zh) | 用於治療腫瘤的方法 | |
| GB201617107D0 (en) | Treatment | |
| GB201612260D0 (en) | Treatment | |
| GB201612193D0 (en) | Treatment | |
| SG10201601492TA (en) | Furnace | |
| GB201609683D0 (en) | Treatment | |
| PT3261661T (pt) | Menotropina para tratar a infertilidade |