SE9600683D0 - Azabicyclic esters of carbamic acids useful in therapy - Google Patents
Azabicyclic esters of carbamic acids useful in therapyInfo
- Publication number
- SE9600683D0 SE9600683D0 SE9600683A SE9600683A SE9600683D0 SE 9600683 D0 SE9600683 D0 SE 9600683D0 SE 9600683 A SE9600683 A SE 9600683A SE 9600683 A SE9600683 A SE 9600683A SE 9600683 D0 SE9600683 D0 SE 9600683D0
- Authority
- SE
- Sweden
- Prior art keywords
- alkyl
- halogen
- hydrogen
- therapy
- och3
- Prior art date
Links
- 238000002560 therapeutic procedure Methods 0.000 title abstract 2
- 150000001715 carbamic acids Chemical class 0.000 title 1
- 150000002148 esters Chemical class 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 abstract 6
- 125000004093 cyano group Chemical group *C#N 0.000 abstract 5
- 229910052736 halogen Inorganic materials 0.000 abstract 5
- 150000002367 halogens Chemical group 0.000 abstract 5
- 229910052739 hydrogen Inorganic materials 0.000 abstract 5
- 239000001257 hydrogen Substances 0.000 abstract 5
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 abstract 3
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 abstract 3
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 abstract 3
- 229910052757 nitrogen Inorganic materials 0.000 abstract 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 3
- 125000001424 substituent group Chemical group 0.000 abstract 3
- -1 -OR5 Chemical group 0.000 abstract 2
- 150000002431 hydrogen Chemical group 0.000 abstract 2
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
- 239000000543 intermediate Substances 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 229910052717 sulfur Inorganic materials 0.000 abstract 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- 208000028017 Psychotic disease Diseases 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 229910052799 carbon Inorganic materials 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000006735 deficit Effects 0.000 abstract 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract 1
- 125000001153 fluoro group Chemical group F* 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 238000003786 synthesis reaction Methods 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/34—Tobacco-abuse
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/027—Organoboranes and organoborohydrides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Animal Behavior & Ethology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Neurology (AREA)
- General Health & Medical Sciences (AREA)
- Psychiatry (AREA)
- Addiction (AREA)
- Psychology (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Hydrogenated Pyridines (AREA)
Priority Applications (29)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9600683A SE9600683D0 (sv) | 1996-02-23 | 1996-02-23 | Azabicyclic esters of carbamic acids useful in therapy |
ZA9701082A ZA971082B (en) | 1996-02-23 | 1997-02-10 | Azabicyclic esters of carbamic acids useful in therapy. |
ARP970100618A AR005876A1 (es) | 1996-02-23 | 1997-02-17 | Esteres azabiciclicos de acidos carbamicos utiles en terapia, composicion farmaceutica que incluye a dichos esteres, uso de dichos esteres, metodos parael tratamiento o profilaxis de varios desordenes, enfermedades y adicciones, procedimiento para la preparacion de dichos esteres, intermediarios utilizados |
IDP970487A ID15969A (id) | 1996-02-23 | 1997-02-20 | Ester azabisiklik asam karbamat yang berguna dalam terapi. |
DE69713295T DE69713295T2 (de) | 1996-02-23 | 1997-02-21 | Azabicyclishe carbaniumsaureester zur therapeutsichen verwendung |
JP9530075A JP2000505452A (ja) | 1996-02-23 | 1997-02-21 | 治療に有用なカルバミン酸のアザビシクロエステル |
IL12562097A IL125620A (en) | 1996-02-23 | 1997-02-21 | Azabicyclic esters of cereal phenylic and pyridylic acids, their preparations and medicinal preparations containing them |
EP97905544A EP0885221B1 (de) | 1996-02-23 | 1997-02-21 | Azabicyclishe carbaniumsaureester zur therapeutsichen verwendung |
PCT/SE1997/000294 WO1997030998A1 (en) | 1996-02-23 | 1997-02-21 | Azabicyclic esters of carbamic acids useful in therapy |
AU22387/97A AU706944B2 (en) | 1996-02-23 | 1997-02-21 | Azabicyclic esters of carbamic acids useful in therapy |
RU98117804A RU2172739C2 (ru) | 1996-02-23 | 1997-02-21 | Азабициклические сложные эфиры карбаминовых кислот, способы их получения, фармацевтическая композиция и промежуточные соединения |
US08/836,143 US5998429A (en) | 1996-02-23 | 1997-02-21 | Azabicyclic esters of carbamic acids useful in therapy |
BR9707616A BR9707616A (pt) | 1996-02-23 | 1997-02-21 | Composto composiç o farmacéutica utilização de um composto e processo para a preparação de um composto para o tratamento ou profilaxia de distúrbios de deficiéncia intelectual ou profilaxia da doença de parkinson doença de huntington síndrome de tourette esclerose amiotrófica lateral ou distúrbios neurodegenerativos |
SK1027-98A SK102798A3 (en) | 1996-02-23 | 1997-02-21 | Azabicyclic esters of carbamic acids useful in therapy |
EE9800250A EE9800250A (et) | 1996-02-23 | 1997-02-21 | Teraapias kasutatavad karbaamhapete asabitsüklilised estrid |
CN97192461A CN1063749C (zh) | 1996-02-23 | 1997-02-21 | 用于治疗的氨基甲酸的氮杂双环酯 |
CA002246051A CA2246051A1 (en) | 1996-02-23 | 1997-02-21 | Azabicyclic esters of carbamic acids useful in therapy |
NZ331145A NZ331145A (en) | 1996-02-23 | 1997-02-21 | Azabicyclic esters of carbamic acids useful in treating disorders involving reduced cholinergic function |
AT97905544T ATE219081T1 (de) | 1996-02-23 | 1997-02-21 | Azabicyclishe carbaniumsaureester zur therapeutsichen verwendung |
TR1998/01642T TR199801642T2 (xx) | 1996-02-23 | 1997-02-21 | Tedavide faydal� olan karbamik asitlerin azabisiklik esterleri. |
CZ19982659A CZ289110B6 (cs) | 1996-02-23 | 1997-02-21 | Azabicyklické estery pro léčení poruch psychotických nebo naruąení intelektu |
HU9901273A HUP9901273A3 (en) | 1996-02-23 | 1997-02-21 | Azabicyclic esters of carbamic acids useful in therapy |
PL97328614A PL328614A1 (en) | 1996-02-23 | 1997-02-21 | Azabicyclic carbaminic esters useful in therapy |
KR1019980706579A KR19990087184A (ko) | 1996-02-23 | 1997-02-21 | 치료에 유용한 카르밤산의 아자비시클릭 에스테르 |
NO983711A NO983711D0 (no) | 1996-02-23 | 1998-08-13 | Azabicykliske estere av karbaminsyrer som er nyttige i terapi |
IS4830A IS4830A (is) | 1996-02-23 | 1998-08-20 | Asabísýklískir esterar af karbamiksýrum sem eru gagnlegir við læknismeðferð |
US09/276,689 US6054464A (en) | 1996-02-23 | 1999-03-26 | Azabicyclic esters of carbamic acids useful in therapy |
HK99102514A HK1017357A1 (en) | 1996-02-23 | 1999-06-09 | Azabicyclic esters of carbamic acids useful in therapy |
IL13758500A IL137585A0 (en) | 1996-02-23 | 2000-07-30 | Azabicyclic esters of phenyl and pyridyl carbamic adics, their preparation and pharmaceutical compositions containing them |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
SE9600683A SE9600683D0 (sv) | 1996-02-23 | 1996-02-23 | Azabicyclic esters of carbamic acids useful in therapy |
Publications (1)
Publication Number | Publication Date |
---|---|
SE9600683D0 true SE9600683D0 (sv) | 1996-02-23 |
Family
ID=20401517
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
SE9600683A SE9600683D0 (sv) | 1996-02-23 | 1996-02-23 | Azabicyclic esters of carbamic acids useful in therapy |
Country Status (27)
Country | Link |
---|---|
US (2) | US5998429A (de) |
EP (1) | EP0885221B1 (de) |
JP (1) | JP2000505452A (de) |
KR (1) | KR19990087184A (de) |
CN (1) | CN1063749C (de) |
AR (1) | AR005876A1 (de) |
AT (1) | ATE219081T1 (de) |
AU (1) | AU706944B2 (de) |
BR (1) | BR9707616A (de) |
CA (1) | CA2246051A1 (de) |
CZ (1) | CZ289110B6 (de) |
DE (1) | DE69713295T2 (de) |
EE (1) | EE9800250A (de) |
HK (1) | HK1017357A1 (de) |
HU (1) | HUP9901273A3 (de) |
ID (1) | ID15969A (de) |
IL (2) | IL125620A (de) |
IS (1) | IS4830A (de) |
NO (1) | NO983711D0 (de) |
NZ (1) | NZ331145A (de) |
PL (1) | PL328614A1 (de) |
RU (1) | RU2172739C2 (de) |
SE (1) | SE9600683D0 (de) |
SK (1) | SK102798A3 (de) |
TR (1) | TR199801642T2 (de) |
WO (1) | WO1997030998A1 (de) |
ZA (1) | ZA971082B (de) |
Families Citing this family (122)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5977144A (en) * | 1992-08-31 | 1999-11-02 | University Of Florida | Methods of use and compositions for benzylidene- and cinnamylidene-anabaseines |
US7214686B2 (en) | 1997-06-30 | 2007-05-08 | Targacept, Inc. | Pharmaceutical compositions and methods for effecting dopamine release |
US6632823B1 (en) * | 1997-12-22 | 2003-10-14 | Merck & Co., Inc. | Substituted pyridine compounds useful as modulators of acetylcholine receptors |
US6277870B1 (en) | 1998-05-04 | 2001-08-21 | Astra Ab | Use |
FR2804430B1 (fr) * | 2000-01-28 | 2002-03-22 | Sanofi Synthelabo | Derives de 4-heteroaryl-1,4-diazabicyclo[3.2.2] nonane, leur preparation et leur application en therapeutique |
GB0010955D0 (en) | 2000-05-05 | 2000-06-28 | Novartis Ag | Organic compounds |
US8914114B2 (en) | 2000-05-23 | 2014-12-16 | The Feinstein Institute For Medical Research | Inhibition of inflammatory cytokine production by cholinergic agonists and vagus nerve stimulation |
WO2002016356A2 (en) * | 2000-08-18 | 2002-02-28 | Pharmacia & Upjohn Company | Quinuclidine-substituted aryl moieties for treatment of disease (nicotinic acetylcholine receptor ligands) |
US6492385B2 (en) | 2000-08-18 | 2002-12-10 | Pharmacia & Upjohn Company | Quinuclidine-substituted heteroaryl moieties for treatment of disease |
AU2001282873A1 (en) | 2000-08-18 | 2002-03-04 | Pharmacia And Upjohn Company | Quinuclidine-substituted aryl compounds for treatment of disease |
US6479510B2 (en) | 2000-08-18 | 2002-11-12 | Pharmacia & Upjohn Company | Quinuclidine-substituted aryl compounds for treatment of disease |
AU2001282875A1 (en) | 2000-08-21 | 2002-03-04 | Pharmacia And Upjohn Company | Quinuclidine-substituted heteroaryl moieties for treatment of disease |
WO2002015662A2 (en) * | 2000-08-21 | 2002-02-28 | Pharmacia & Upjohn Company | Quinuclidine-substituted heteroaryl moieties for treatment of disease (nicotinic acetylcholine receptor antagonists |
EP1311505A2 (de) * | 2000-08-21 | 2003-05-21 | PHARMACIA & UPJOHN COMPANY | Mit heteroaryl gruppen substituierte chinuklidine zur behandlung von krankheiten ( nikotin acetylcholin rezeptor liganden ) |
PE20021019A1 (es) | 2001-04-19 | 2002-11-13 | Upjohn Co | Grupos azabiciclicos sustituidos |
AR036040A1 (es) | 2001-06-12 | 2004-08-04 | Upjohn Co | Compuestos de heteroarilo multiciclicos sustituidos con quinuclidinas y composiciones farmaceuticas que los contienen |
AR036041A1 (es) * | 2001-06-12 | 2004-08-04 | Upjohn Co | Compuestos aromaticos heterociclicos sustituidos con quinuclidina y composiciones farmaceuticas que los contienen |
EP1419162A1 (de) * | 2001-08-24 | 2004-05-19 | Pharmacia & Upjohn Company | Substituierte aryl-7-aza 2,2,1 bicycloheptane zur behandlung von krankheiten |
JP2005504058A (ja) | 2001-08-24 | 2005-02-10 | ファルマシア アンド アップジョン カンパニー リミティド ライアビリティー カンパニー | 疾患の治療のための置換ヘテロアリール−7−アザ[2.2.1]ビシクロヘプタン |
CA2460075A1 (en) * | 2001-09-12 | 2003-03-20 | Donn Gregory Wishka | Substituted 7-aza[2.2.1] bicycloheptanes for the treatment of diseases |
IL160884A0 (en) * | 2001-10-02 | 2004-08-31 | Upjohn Co | Azabicyclic-substituted fused-heteroaryl compounds for the treatment of disease |
US6849620B2 (en) | 2001-10-26 | 2005-02-01 | Pfizer Inc | N-(azabicyclo moieties)-substituted hetero-bicyclic aromatic compounds for the treatment of disease |
MXPA04004464A (es) | 2001-11-08 | 2004-08-11 | Upjohn Co | Compuestos de heteroarilo sustituido con azabiciclo para el tratamiento de enfermedades. |
BR0214016A (pt) * | 2001-11-09 | 2004-10-13 | Upjohn Co | Compostos azabicìclico-fenil-fundido heterocìclicos e seu uso como ligandos alfa 7 nachr |
EP1463481A4 (de) | 2001-12-14 | 2008-06-25 | Targacept Inc | Verfahren und zusammensetzungen zur behandlung von erkrankungen des zentralen nervensystems |
DE10164139A1 (de) | 2001-12-27 | 2003-07-10 | Bayer Ag | 2-Heteroarylcarbonsäureamide |
BR0307714A (pt) | 2002-02-15 | 2005-02-09 | Upjohn Co | Benzoilamidas substituìdas com azabiciclo e tioamidas para tratamento de distúrbios relacionados ao cns |
AU2003217275A1 (en) * | 2002-02-19 | 2003-09-09 | Pharmacia And Upjohn Company | Azabicyclic compounds for the treatment of disease |
AU2003219690A1 (en) * | 2002-02-19 | 2003-09-09 | Pharmacia And Upjohn Company | Fused bicyclic-n-bridged-heteroaromatic carboxamides for the treatment of disease |
EP1478646A1 (de) * | 2002-02-20 | 2004-11-24 | PHARMACIA & UPJOHN COMPANY | Azabicyclische verbindungen mit activität an alfa7 nikotinischen acetylcholin rezeptoren |
DE10211416A1 (de) * | 2002-03-15 | 2003-09-25 | Bayer Ag | Essig- und Propionsäureamide |
DE10211415A1 (de) * | 2002-03-15 | 2003-09-25 | Bayer Ag | Bicyclische N-Biarylamide |
EP1542999A1 (de) | 2002-08-01 | 2005-06-22 | Pharmacia & Upjohn Company LLC | 1h-pyrazol- und 1h-pyrrol-azabicyclische verbindungen mit alpha-7-nachr-aktivität |
WO2004019943A1 (en) | 2002-08-30 | 2004-03-11 | Memory Pharmaceuticals Corporation | Anabaseine derivatives useful in the treatment of neurodegenerative diseases |
GB0220581D0 (en) | 2002-09-04 | 2002-10-09 | Novartis Ag | Organic Compound |
CA2499128C (en) | 2002-09-25 | 2012-07-31 | Memory Pharmaceuticals Corporation | Indazoles, benzothiazoles, and benzoisothiazoles, and preparation and uses thereof |
CA2503786A1 (en) * | 2002-11-01 | 2004-05-13 | Pharmacia & Upjohn Company Llc | Compounds having both alpha7 nicotinic agonist activity and 5ht, antagonist activity for treatment of cns diseases |
DK1949901T3 (da) * | 2002-12-06 | 2014-05-19 | The Feinstein Inst Medical Res | Fremgangsmåde til bestemmelse af en cholinerg agonist selektiv for en alfa-7-nikotinsk receptor |
US7238715B2 (en) * | 2002-12-06 | 2007-07-03 | The Feinstein Institute For Medical Research | Treatment of pancreatitis using alpha 7 receptor-binding cholinergic agonists |
CA2519265A1 (en) * | 2003-03-28 | 2004-10-07 | Pharmacia & Upjohn Company Llc | Positive allosteric modulators of the nicotinic acetylcholine receptor |
GB0310867D0 (en) | 2003-05-12 | 2003-06-18 | Novartis Ag | Organic compounds |
DE10334724A1 (de) | 2003-07-30 | 2005-02-24 | Bayer Healthcare Ag | N-Biarylamide |
CA2539811A1 (en) | 2003-10-15 | 2005-04-28 | Targacept, Inc. | Azabicycyclic compounds for relieving pain and treating central nervous system disorders |
RS20060391A (en) | 2003-12-22 | 2008-11-28 | Memory Pharmaceuticals Corporation, | Indoles, 1h-indazoles, 1,2-benzisoxazoles, and 1,2- benzisothiazoles, and preparation and uses thereof |
US20050137217A1 (en) * | 2003-12-22 | 2005-06-23 | Jianguo Ji | Spirocyclic quinuclidinic ether derivatives |
US10912712B2 (en) | 2004-03-25 | 2021-02-09 | The Feinstein Institutes For Medical Research | Treatment of bleeding by non-invasive stimulation |
MXPA06010852A (es) | 2004-03-25 | 2007-01-16 | Memory Pharm Corp | Indazoles, benzotiazoles, benzoisotiazoles, bencisoxazoles y preparacion y usos de los mismos. |
WO2006001894A1 (en) | 2004-04-22 | 2006-01-05 | Memory Pharmaceutical Corporation | Indoles, 1h-indazoles, 1,2-benzisoxazoles, 1,2-benzoisothiazoles, and preparation and uses thereof |
DE602005027452D1 (de) | 2004-05-07 | 2011-05-26 | Memory Pharm Corp | 1h-indazole, benzothiazole, 1,2-benzisoxazole, 1,2-benzisothiazole und chromone und deren herstellung und verwendungen |
PE20060437A1 (es) | 2004-06-18 | 2006-06-08 | Novartis Ag | COMPUESTOS AZA-BICICLONONANOS COMO LIGANDOS COLINERGICOS DE nAChR |
GB0415746D0 (en) | 2004-07-14 | 2004-08-18 | Novartis Ag | Organic compounds |
GB0424564D0 (en) * | 2004-11-05 | 2004-12-08 | Novartis Ag | Organic compounds |
PL1828179T3 (pl) | 2004-12-22 | 2010-08-31 | Memory Pharm Corp | Ligandy dla receptorów nikotynowych alfa-7 przeciwko chorobom związanym z OUN |
CN101124012B (zh) | 2004-12-27 | 2012-09-05 | 范因斯坦医学研究院 | 通过电刺激迷走神经治疗炎症性疾病的装置 |
US11207518B2 (en) | 2004-12-27 | 2021-12-28 | The Feinstein Institutes For Medical Research | Treating inflammatory disorders by stimulation of the cholinergic anti-inflammatory pathway |
CN101248073A (zh) | 2005-08-22 | 2008-08-20 | 塔加西普特公司 | 杂芳基-取代的二氮杂三环烷类、其制备方法及其应用 |
US8106066B2 (en) | 2005-09-23 | 2012-01-31 | Memory Pharmaceuticals Corporation | Indazoles, benzothiazoles, benzoisothiazoles, benzisoxazoles, pyrazolopyridines, isothiazolopyridines, and preparation and uses thereof |
GB0521508D0 (en) | 2005-10-21 | 2005-11-30 | Novartis Ag | Organic compounds |
US8316104B2 (en) | 2005-11-15 | 2012-11-20 | California Institute Of Technology | Method and apparatus for collaborative system |
GB0525672D0 (en) | 2005-12-16 | 2006-01-25 | Novartis Ag | Organic compounds |
GB0525673D0 (en) | 2005-12-16 | 2006-01-25 | Novartis Ag | Organic compounds |
TWI454262B (zh) * | 2006-11-02 | 2014-10-01 | Targacept Inc | 菸鹼乙醯膽鹼受體亞型選擇性之二氮雜雙環烷類醯胺 |
TW200901974A (en) | 2007-01-16 | 2009-01-16 | Wyeth Corp | Compounds, compositions, and methods of making and using them |
RU2441868C2 (ru) | 2007-02-09 | 2012-02-10 | Астеллас Фарма Инк. | Аза-кольцевое соединение с внутренним мостиком |
WO2009013535A1 (en) * | 2007-07-23 | 2009-01-29 | Astrazeneca Ab | 2-azabicyclo(2.2.2)octane derivatives as modulators of the glycine transporter i receptor |
SA08290475B1 (ar) | 2007-08-02 | 2013-06-22 | Targacept Inc | (2s، 3r)-n-(2-((3-بيردينيل)ميثيل)-1-آزا بيسيكلو[2، 2، 2]أوكت-3-يل)بنزو فيوران-2-كربوكساميد، وصور أملاحه الجديدة وطرق استخدامه |
US8391970B2 (en) | 2007-08-27 | 2013-03-05 | The Feinstein Institute For Medical Research | Devices and methods for inhibiting granulocyte activation by neural stimulation |
KR101565469B1 (ko) | 2007-10-01 | 2015-11-03 | 코멘티스, 인코포레이티드 | 알츠하이머병의 치료를 위한 알파 7 니코틴 아세틸콜린 수용체 리간드로서 퀴누클리딘-4-일메틸 1h-인돌-3-카르복실레이트 유도체 |
SI2254598T1 (sl) | 2008-02-13 | 2013-10-30 | Targacept, Inc. | Kombinacija alfa 7 nikotinskih agonistov in antipsihotikov |
US9662490B2 (en) | 2008-03-31 | 2017-05-30 | The Feinstein Institute For Medical Research | Methods and systems for reducing inflammation by neuromodulation and administration of an anti-inflammatory drug |
WO2009146030A1 (en) | 2008-03-31 | 2009-12-03 | The Feinstein Institute For Medical Research | Methods and systems for reducing inflammation by neuromodulation of t-cell activity |
DK2307389T3 (da) | 2008-06-20 | 2013-04-02 | Astrazeneca Ab | Dibenzothiazepinderivat og anvendelser deraf |
CN102215909B (zh) | 2008-11-18 | 2014-09-10 | 赛博恩特医疗器械公司 | 优化用于消炎刺激的电极放置的装置和方法 |
TW201031664A (en) | 2009-01-26 | 2010-09-01 | Targacept Inc | Preparation and therapeutic applications of (2S,3R)-N-2-((3-pyridinyl)methyl)-1-azabicyclo[2.2.2]oct-3-yl)-3,5-difluorobenzamide |
WO2010087762A1 (en) * | 2009-01-28 | 2010-08-05 | Astrazeneca Ab | 2-aza-bicyclo[2.2.1]heptane compounds and uses thereof |
US8996116B2 (en) | 2009-10-30 | 2015-03-31 | Setpoint Medical Corporation | Modulation of the cholinergic anti-inflammatory pathway to treat pain or addiction |
US9211410B2 (en) | 2009-05-01 | 2015-12-15 | Setpoint Medical Corporation | Extremely low duty-cycle activation of the cholinergic anti-inflammatory pathway to treat chronic inflammation |
US8788034B2 (en) | 2011-05-09 | 2014-07-22 | Setpoint Medical Corporation | Single-pulse activation of the cholinergic anti-inflammatory pathway to treat chronic inflammation |
WO2010144578A2 (en) | 2009-06-09 | 2010-12-16 | Setpoint Medical Corporation | Nerve cuff with pocket for leadless stimulator |
FR2948368B1 (fr) * | 2009-07-21 | 2011-07-22 | Servier Lab | Nouveaux composes piperidiniques, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
WO2014169145A1 (en) | 2013-04-10 | 2014-10-16 | Setpoint Medical Corporation | Closed-loop vagus nerve stimulation |
US9833621B2 (en) | 2011-09-23 | 2017-12-05 | Setpoint Medical Corporation | Modulation of sirtuins by vagus nerve stimulation |
WO2011079309A2 (en) | 2009-12-23 | 2011-06-30 | Setpoint Medical Corporation | Neural stimulation devices and systems for treatment of chronic inflammation |
CN103221411B (zh) | 2010-05-17 | 2016-05-11 | 富瑞姆制药公司 | (R)-7-氯-N-(奎宁环-3-基)苯并[b]噻吩-2-甲酰胺盐酸盐单水合物的晶型 |
DK2605655T3 (en) | 2010-08-19 | 2019-02-04 | Buck Institute For Age Res | METHODS OF TREATING SMALL COGNITIVE DISABILITY (MCI) AND RELATED DISORDERS |
GB201111704D0 (en) | 2011-07-07 | 2011-08-24 | Takeda Pharmaceutical | Novel compounds |
GB201111705D0 (en) | 2011-07-07 | 2011-08-24 | Takeda Pharmaceutical | Compounds and their use |
JO3115B1 (ar) | 2011-08-22 | 2017-09-20 | Takeda Pharmaceuticals Co | مركبات بيريدازينون واستخدامها كمثبطات daao |
US9572983B2 (en) | 2012-03-26 | 2017-02-21 | Setpoint Medical Corporation | Devices and methods for modulation of bone erosion |
AU2013259871A1 (en) | 2012-05-08 | 2014-11-20 | Forum Pharmaceuticals Inc. | Methods of maintaining, treating or improving cognitive function |
GB201209587D0 (en) | 2012-05-30 | 2012-07-11 | Takeda Pharmaceutical | Therapeutic compounds |
JOP20130273B1 (ar) * | 2012-09-11 | 2021-08-17 | Genzyme Corp | مثبطات انزيم (سينثاز) غلوكوسيل سيراميد |
WO2014122474A1 (en) | 2013-02-07 | 2014-08-14 | Takeda Pharmaceutical Company Limited | Piperidin-1 -yl and azepin-1 -yl carboxylates as muscarinic m4 receptor agonists |
CN108658970A (zh) * | 2013-03-15 | 2018-10-16 | 建新公司 | 制备葡萄糖基神经酰胺合酶抑制剂的方法 |
CA2914263C (en) | 2013-06-21 | 2021-05-18 | Takeda Pharmaceutical Company Limited | 1-sulfonyl piperidine derivatives as modulators of prokineticin receptors |
GB201314286D0 (en) | 2013-08-08 | 2013-09-25 | Takeda Pharmaceutical | Therapeutic Compounds |
GB201318222D0 (en) | 2013-10-15 | 2013-11-27 | Takeda Pharmaceutical | Novel compounds |
GB201320905D0 (en) | 2013-11-27 | 2014-01-08 | Takeda Pharmaceutical | Therapeutic compounds |
TW201613864A (en) | 2014-02-20 | 2016-04-16 | Takeda Pharmaceutical | Novel compounds |
WO2016007630A1 (en) | 2014-07-11 | 2016-01-14 | Alpharmagen, Llc | Quinuclidine compounds for modulating alpha7 -nicotinic acetylcholine receptor activity |
US11311725B2 (en) | 2014-10-24 | 2022-04-26 | Setpoint Medical Corporation | Systems and methods for stimulating and/or monitoring loci in the brain to treat inflammation and to enhance vagus nerve stimulation |
US11406833B2 (en) | 2015-02-03 | 2022-08-09 | Setpoint Medical Corporation | Apparatus and method for reminding, prompting, or alerting a patient with an implanted stimulator |
US9724340B2 (en) | 2015-07-31 | 2017-08-08 | Attenua, Inc. | Antitussive compositions and methods |
US10596367B2 (en) | 2016-01-13 | 2020-03-24 | Setpoint Medical Corporation | Systems and methods for establishing a nerve block |
EP3405255A4 (de) | 2016-01-20 | 2019-10-16 | Setpoint Medical Corporation | Implantierbare mikrostimulatoren und induktive ladesysteme |
EP3405107B1 (de) | 2016-01-20 | 2023-04-12 | Setpoint Medical Corporation | Steuerung der vagalstimulierung |
US11471681B2 (en) | 2016-01-20 | 2022-10-18 | Setpoint Medical Corporation | Batteryless implantable microstimulators |
US10583304B2 (en) | 2016-01-25 | 2020-03-10 | Setpoint Medical Corporation | Implantable neurostimulator having power control and thermal regulation and methods of use |
GB201616839D0 (en) | 2016-10-04 | 2016-11-16 | Takeda Pharmaceutical Company Limited | Therapeutic compounds |
GB201619514D0 (en) | 2016-11-18 | 2017-01-04 | Takeda Pharmaceuticals Co | Novel compounds |
DE102017210141A1 (de) | 2017-06-16 | 2018-12-20 | Henkel Ag & Co. Kgaa | Portion zur Bereitstellung tensidhaltiger Flotten |
EP3668402A4 (de) | 2017-08-14 | 2021-05-19 | Setpoint Medical Corporation | Vagusnervstimulationsvorscreening-test |
US11660443B2 (en) | 2018-04-20 | 2023-05-30 | The Feinstein Institutes For Medical Research | Methods and apparatuses for reducing bleeding via electrical trigeminal nerve stimulation |
US11260229B2 (en) | 2018-09-25 | 2022-03-01 | The Feinstein Institutes For Medical Research | Methods and apparatuses for reducing bleeding via coordinated trigeminal and vagal nerve stimulation |
JP2023503832A (ja) * | 2019-11-15 | 2023-02-01 | ユーハン・コーポレイション | 1,2,3,4-テトラヒドロナフタレン基を有する新規な誘導体またはその薬学的に許容可能な塩及びこれらを含む医薬組成物 |
CA3154313A1 (en) * | 2019-11-15 | 2021-05-20 | Dong-Hoon Kim | Novel derivatives having 2,3-dihydro-1h-indene or 2,3-dihydrobenzofuran moiety or pharmaceutically acceptable salt thereof and pharmaceutical compositions comprising the same |
JP2021138648A (ja) | 2020-03-04 | 2021-09-16 | 武田薬品工業株式会社 | 経口固形製剤 |
WO2021236977A1 (en) | 2020-05-21 | 2021-11-25 | The Feinstein Institutes For Medical Research | Systems and methods for vagus nerve stimulation |
CA3186766A1 (en) | 2020-07-24 | 2022-01-27 | Danielle Combessis | Pharmaceutical compositions comprising venglustat |
KR20220153511A (ko) * | 2021-05-11 | 2022-11-18 | 주식회사유한양행 | 글루코실세라마이드 합성효소에 대한 저해 활성을 갖는 신규의 화합물 또는 이의 약학적으로 허용가능한 염, 이의 제조방법, 및 이를 포함하는 약학 조성물 |
WO2024090919A1 (en) * | 2022-10-24 | 2024-05-02 | Yuhan Corporation | Improved processes for preparing dimethyl-2,3-dihydro-1h-indene derivatives |
KR20240057364A (ko) * | 2022-10-24 | 2024-05-02 | 주식회사유한양행 | 다이메틸-2,3-다이하이드로-1h-인덴 유도체의 신규 염 및 이의 제조방법 |
Family Cites Families (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE8817121U1 (de) * | 1988-11-22 | 1993-02-04 | Boehringer Ingelheim Kg, 55218 Ingelheim | Neue Quinuclidine |
JP3169188B2 (ja) * | 1991-01-31 | 2001-05-21 | 杏林製薬株式会社 | カルバミン酸誘導体及びその製造方法 |
US5468875A (en) * | 1994-12-22 | 1995-11-21 | American Home Products Corporation | 1-azabicycloheptane derivatives |
-
1996
- 1996-02-23 SE SE9600683A patent/SE9600683D0/xx unknown
-
1997
- 1997-02-10 ZA ZA9701082A patent/ZA971082B/xx unknown
- 1997-02-17 AR ARP970100618A patent/AR005876A1/es not_active Application Discontinuation
- 1997-02-20 ID IDP970487A patent/ID15969A/id unknown
- 1997-02-21 EE EE9800250A patent/EE9800250A/xx unknown
- 1997-02-21 WO PCT/SE1997/000294 patent/WO1997030998A1/en not_active Application Discontinuation
- 1997-02-21 JP JP9530075A patent/JP2000505452A/ja not_active Ceased
- 1997-02-21 CZ CZ19982659A patent/CZ289110B6/cs not_active IP Right Cessation
- 1997-02-21 AU AU22387/97A patent/AU706944B2/en not_active Ceased
- 1997-02-21 HU HU9901273A patent/HUP9901273A3/hu unknown
- 1997-02-21 RU RU98117804A patent/RU2172739C2/ru active
- 1997-02-21 SK SK1027-98A patent/SK102798A3/sk unknown
- 1997-02-21 KR KR1019980706579A patent/KR19990087184A/ko not_active Application Discontinuation
- 1997-02-21 DE DE69713295T patent/DE69713295T2/de not_active Expired - Fee Related
- 1997-02-21 TR TR1998/01642T patent/TR199801642T2/xx unknown
- 1997-02-21 AT AT97905544T patent/ATE219081T1/de active
- 1997-02-21 IL IL12562097A patent/IL125620A/en not_active IP Right Cessation
- 1997-02-21 EP EP97905544A patent/EP0885221B1/de not_active Expired - Lifetime
- 1997-02-21 CA CA002246051A patent/CA2246051A1/en not_active Abandoned
- 1997-02-21 CN CN97192461A patent/CN1063749C/zh not_active Expired - Fee Related
- 1997-02-21 NZ NZ331145A patent/NZ331145A/en unknown
- 1997-02-21 BR BR9707616A patent/BR9707616A/pt unknown
- 1997-02-21 PL PL97328614A patent/PL328614A1/xx unknown
- 1997-02-21 US US08/836,143 patent/US5998429A/en not_active Expired - Fee Related
-
1998
- 1998-08-13 NO NO983711A patent/NO983711D0/no not_active Application Discontinuation
- 1998-08-20 IS IS4830A patent/IS4830A/is unknown
-
1999
- 1999-03-26 US US09/276,689 patent/US6054464A/en not_active Expired - Fee Related
- 1999-06-09 HK HK99102514A patent/HK1017357A1/xx not_active IP Right Cessation
-
2000
- 2000-07-30 IL IL13758500A patent/IL137585A0/xx unknown
Also Published As
Similar Documents
Publication | Publication Date | Title |
---|---|---|
SE9600683D0 (sv) | Azabicyclic esters of carbamic acids useful in therapy | |
ATE63742T1 (de) | Chinazolinon-derivate. | |
ATE399753T1 (de) | Amide als pyruvatdehydrogenaseinhibitoren | |
TW370529B (en) | Pyrazolopyrimidines | |
EP1689233A4 (de) | Bicyclische mek-hemmer und verfahren zu ihrer verwendung | |
SE9701144D0 (sv) | Novel compounds, their use and preparation | |
SE0104334D0 (sv) | Therapeutic agents | |
HUP0001760A2 (hu) | Aril-acil-piridazin-származékok, ezeket a vegyületeket tartalmazó gyógyászati készítmények, eljárás előállításukra és a vegyületek alkalmazása gyógyszerkészítmények előállítására | |
HUP0100488A2 (hu) | Tieno-pirimidinek, eljárás az előállításukra és a vegyületeket tartalmazó gyógyászati készítmények | |
HUP0400370A2 (hu) | Antibakteriális hatású oxazolidinonszármazékok, előállításukra szolgáló eljárás, azokat hatóanyagként tartalmazó gyógyászati készítmények, alkalmazásuk és intermedierek | |
NO160995C (no) | Analogifremgangsmaate for fremstilling av terapeutisk aktive bis -(4-aminofenyl)-sulfoner. | |
ES8606337A1 (es) | Un procedimiento para preparar nuevas benzamidas con actividada antagonista de 5-ht. | |
HUP0001093A2 (hu) | 5-HT2A-antagonista oxazolidinon-származékok, az ezeket tartalmazó gyógyszerkészítmények és eljárás előállításukra | |
NO160783C (no) | Analogifremgangsmaate til fremstilling av terapeutisk aktive substituerte beta-karbolinderivater. | |
ES2000524A6 (es) | Procedimiento para la preparacion de nuevas benzamidas y benzoatos sustituidos. | |
HUP0000233A2 (hu) | Pirazolinon-származékok alkalmazása potenciazavarok kezelésére szolgáló gyógyszerkészítmények előállítására | |
HUP0003861A2 (hu) | Kinolin-4-il-származékok, eljárás előállításukra és a vegyületeket tartalmazó gyógyászati készítmények | |
HUP0203364A2 (hu) | Eljárás 3-helyettesített-4-arilkinolin-2-on származékok előállítására | |
EA200500738A1 (ru) | КРИСТАЛЛИЧЕСКИЕ ФУМАРАТНЫЕ СОЛИ 1-АЗАБИЦИКЛО [2.2.2]ОКТЗАМЕЩЕННОГО ФУРО [2,3-c] ПИРИДИНИЛКАРБОКСАМИДА И ИХ КОМПОЗИЦИИ И ПОЛУЧЕНИЕ | |
PT1430034E (pt) | Derivados de alquilaminopiridazinona substituida processo para sua preparacao e composicoes farmaceuticas que os contem | |
HUP0002826A2 (hu) | 6-Azauracil-származékok, eljárás előállításukra, alkalmazásuk gyulladások elleni gyógyszer előállítására és az ilyen kompozíciók | |
HUP9800889A1 (hu) | Új naftil-piperazin-származékok | |
ATE41770T1 (de) | Derivate von n-(2-pyrrolidinylmethyl)benzamid, verfahren zu ihrer herstellung, zwischenprodukte und pharmazeutische zubereitung. | |
ES2097093A1 (es) | Nuevos compuestos derivados de 5h-tiazolo (3,2-a) pirimidin-5-ona. |