AR005876A1 - Esteres azabiciclicos de acidos carbamicos utiles en terapia, composicion farmaceutica que incluye a dichos esteres, uso de dichos esteres, metodos parael tratamiento o profilaxis de varios desordenes, enfermedades y adicciones, procedimiento para la preparacion de dichos esteres, intermediarios utilizados - Google Patents

Esteres azabiciclicos de acidos carbamicos utiles en terapia, composicion farmaceutica que incluye a dichos esteres, uso de dichos esteres, metodos parael tratamiento o profilaxis de varios desordenes, enfermedades y adicciones, procedimiento para la preparacion de dichos esteres, intermediarios utilizados

Info

Publication number
AR005876A1
AR005876A1 ARP970100618A ARP970100618A AR005876A1 AR 005876 A1 AR005876 A1 AR 005876A1 AR P970100618 A ARP970100618 A AR P970100618A AR P970100618 A ARP970100618 A AR P970100618A AR 005876 A1 AR005876 A1 AR 005876A1
Authority
AR
Argentina
Prior art keywords
esters
alkyl
halogen
prophylaxis
therapy
Prior art date
Application number
ARP970100618A
Other languages
English (en)
Original Assignee
Astra Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astra Ab filed Critical Astra Ab
Publication of AR005876A1 publication Critical patent/AR005876A1/es

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/027—Organoboranes and organoborohydrides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Neurology (AREA)
  • Biomedical Technology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Veterinary Medicine (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Psychology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pain & Pain Management (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)

Abstract

Esteres azabicíclicos de ácidos carbámicos útiles en terapia, de fórmula (I), donde A es fórmula (II), (III),(IV) o (V); X es O o S; Y es O o S; G y Dson independientemente nitrógeno o carbono con la condición de que no más de G, D o E seanitr ógeno; E es N o C-R4; R1 es hidrógeno o metilo; R2 eshidrógeno o fluor; R3 es hidrógeno, halógeno, alquilo C1 a C3, -OR5, -CN, -CONH2, -CO2R5, -NR5R6 o fenilo opcionalmente sustituido con uno a tres de lossiguientes sustituyentes:halógeno, alq uilo C1 a C3, -NO2, -CN, o -OCH3; R4 es hidrógeno, halógeno, alquilo C1 a C3, -OR5, -CN, -CONH2, -CO2R5, -NR5R6 ofenilo opcionalmente sustituido con uno a tres de los siguientes sustituyentes: halógeno, alquilo C1 a C3, -NO2, -CN o-OCH3; o R2 y R3 o R3 y R4 pueden serconjuntamente un anillo fenilo fusionado opcionalmente sustituido con uno o dos de los siguientes sustituyentes: halógeno, alquilo C1-C3, -CN, o -OCH3; R5y R6 son independientemente hidrógeno o alquilo C1 aC3; o un enatiómero del mismo, y sus sales farmacéuticamente aceptables. Además, se dan a conocercomposiciones farmacéuticas que incluyen a dichos ésteres, usos de dichos ésteres, métodos para el tratamiento o profilaxis de desórdenespsicóticos ydesórdenes de deterioro intelectual, procedimientos para la preparación de dichos ésteres, intermediarios utilizados en la preparación de dichos ésteresy usos de dichos intermediarios. Los intermediarios tienen la fórmula (IX) y(VIII), donde A, X, Y, G, D, E, R1, R2, R3, R4, R5 y R6 son como se definenanteriormente.
ARP970100618A 1996-02-23 1997-02-17 Esteres azabiciclicos de acidos carbamicos utiles en terapia, composicion farmaceutica que incluye a dichos esteres, uso de dichos esteres, metodos parael tratamiento o profilaxis de varios desordenes, enfermedades y adicciones, procedimiento para la preparacion de dichos esteres, intermediarios utilizados AR005876A1 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SE9600683A SE9600683D0 (sv) 1996-02-23 1996-02-23 Azabicyclic esters of carbamic acids useful in therapy

Publications (1)

Publication Number Publication Date
AR005876A1 true AR005876A1 (es) 1999-07-21

Family

ID=20401517

Family Applications (1)

Application Number Title Priority Date Filing Date
ARP970100618A AR005876A1 (es) 1996-02-23 1997-02-17 Esteres azabiciclicos de acidos carbamicos utiles en terapia, composicion farmaceutica que incluye a dichos esteres, uso de dichos esteres, metodos parael tratamiento o profilaxis de varios desordenes, enfermedades y adicciones, procedimiento para la preparacion de dichos esteres, intermediarios utilizados

Country Status (27)

Country Link
US (2) US5998429A (es)
EP (1) EP0885221B1 (es)
JP (1) JP2000505452A (es)
KR (1) KR19990087184A (es)
CN (1) CN1063749C (es)
AR (1) AR005876A1 (es)
AT (1) ATE219081T1 (es)
AU (1) AU706944B2 (es)
BR (1) BR9707616A (es)
CA (1) CA2246051A1 (es)
CZ (1) CZ289110B6 (es)
DE (1) DE69713295T2 (es)
EE (1) EE9800250A (es)
HK (1) HK1017357A1 (es)
HU (1) HUP9901273A3 (es)
ID (1) ID15969A (es)
IL (2) IL125620A (es)
IS (1) IS4830A (es)
NO (1) NO983711D0 (es)
NZ (1) NZ331145A (es)
PL (1) PL328614A1 (es)
RU (1) RU2172739C2 (es)
SE (1) SE9600683D0 (es)
SK (1) SK102798A3 (es)
TR (1) TR199801642T2 (es)
WO (1) WO1997030998A1 (es)
ZA (1) ZA971082B (es)

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