SE8305390L - Seskviterpenderivat - Google Patents
SeskviterpenderivatInfo
- Publication number
- SE8305390L SE8305390L SE8305390A SE8305390A SE8305390L SE 8305390 L SE8305390 L SE 8305390L SE 8305390 A SE8305390 A SE 8305390A SE 8305390 A SE8305390 A SE 8305390A SE 8305390 L SE8305390 L SE 8305390L
- Authority
- SE
- Sweden
- Prior art keywords
- group
- general formula
- compound
- formula
- van
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/94—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom spiro-condensed with carbocyclic rings or ring systems, e.g. griseofulvins
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D493/00—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
- C07D493/02—Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system in which the condensed system contains two hetero rings
- C07D493/10—Spiro-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
- C12P17/04—Oxygen as only ring hetero atoms containing a five-membered hetero ring, e.g. griseofulvin, vitamin C
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Wood Science & Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Furan Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
Claims (5)
1. Forfarande for framstallning av en forening som har formeln (I) (I) van i Ri betecknar on vdteatom, en lagre alkylgrupp eller en lagre alkanoylgrupp; R2 och R3, som kan vara lika eller olika, vardera betecknar en formylgrupp, en hydroximetylgrupp, en hydroxylgrupp, en karboxylgrupp, en lagre alkanoy1oximetylgrupp eller en grupp som har formeln -CH.CR7R8, van i R7 och R8, som kan vara lika eller olika, vardera betecknar en vateatom, en cyanogrupp, en lggre alkoxikarbonylgrupp eller en karboxylgrupp, eller van i R2 och R3 kan kombineras och bilda R9 0 en laktonring som har formeln van i R9 betecknar en vateatom eller en hydroxylgrupp; R4 och R6, som kan vara lika eller olika, vardera betecknar en hydroxylgrupp eller en lagre alkanoyloxigrupp; 115 betecknar en vateatom; R4 och R5 tillsammans kan bilda en oxogrupp; och R4 och R6 kan kombineras till att bilda en lagre alkylidendioxigrupp; samt de farmaceutiskt godtagbara salterna darav,kannetecknat ddrav, att man (1) ear man framstaller en forening med den allmanna formeln (I), van i 112, R3 eller bada betecknar en hydroximetylgrupp, reducerar formylgrupperna i en forening, som har den allmanna formeln (I), van i R
2. , R3 eller bada betecknar en formylgrupp eller reducerar en fOrening, som har den allmanna formeln (I), van i 02 och R3 Or bundna till varandra till bild- R9 0 ning av en laktonring som has formeln van i R9 har den ovan angivna betydelsen; (2) vid framstallning av en fbrening som har den allmanna formeln (I), van i R2 och R3 Or bundna till varandra och 0 bildar en laktonring med formeln cykliserar man under frig-6ring av vatten en forening som har den allmanna formeln (I an endera • och R
3. Or en hydroximetylgrupp och den a en karboxyl (Aar man framstaller en fOrening som har den allmanna formeln (I), van i R2, R3 eller hada betecknar en grupp corn har formeln -CH=CR7R8, van i R7 och R8 har den ovan angivna betydelsen, dehydrokondenserar man en forening, som har den allmanna formeln (I), vari R2, R3 eller bada betecknar en formylgrupP, med en aktiv metylenforening, som har den allmanna formeln (II): R7 H 2 van i R7 och R8 har oven angiven betydelse, i narvaro av en kata/ysator:
4. nar man framstaller en fOrening scm har den all-manna formeln (I), van i R2, R3 eller bada betecknar en hydroxylgrupp, bringar man en forening, som har den allmanna formcln (I), van i R2, R3 eller bada betecknar en formylgrupp, att reagera med en peroxid i ett inert 18sningsmedel; eller
5. nar man framstaller en fOrening som her den all-manna formeln (T), vari 52, R3 eller bide betecknar en lagre alkanoyloximetylgrupp, acylerar man en forening, som her den allmanna formeln (I), van i R2, R3 eller bada betecknar en hydroximetylgrupp; och, em 58 Onskas, omvandlar man produkten i wart och ett av fallen (1) - (5) till de farmaceutiskt godtagbara salterna darav.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP52078641A JPS589114B2 (ja) | 1977-06-30 | 1977-06-30 | セスキテルペン類縁体、その製造法及び腎炎治療剤 |
| JP15895977A JPS5492680A (en) | 1977-12-29 | 1977-12-29 | Novel microorganism |
| JP53014674A JPS5936913B2 (ja) | 1978-02-10 | 1978-02-10 | セスキテルペン誘導体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| SE8305390L true SE8305390L (sv) | 1983-09-30 |
| SE8305390D0 SE8305390D0 (sv) | 1983-09-30 |
| SE452008B SE452008B (sv) | 1987-11-09 |
Family
ID=27280728
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE7805606A SE439322B (sv) | 1977-06-30 | 1978-05-16 | Forfarande for framstellning av seskviterpenderivat genom odling av en mikroorganism tillhorande slektet stachybotrys |
| SE8305390A SE452008B (sv) | 1977-06-30 | 1983-09-30 | Forfarande for framstellning av seskviterpenderivat |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SE7805606A SE439322B (sv) | 1977-06-30 | 1978-05-16 | Forfarande for framstellning av seskviterpenderivat genom odling av en mikroorganism tillhorande slektet stachybotrys |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US4229466A (sv) |
| AR (1) | AR228011A1 (sv) |
| CA (1) | CA1142106A (sv) |
| CH (1) | CH641452A5 (sv) |
| DE (1) | DE2821403C2 (sv) |
| DK (2) | DK154704C (sv) |
| ES (2) | ES469821A1 (sv) |
| FR (1) | FR2405941A1 (sv) |
| GB (1) | GB1601479A (sv) |
| IE (1) | IE46785B1 (sv) |
| IT (1) | IT1103138B (sv) |
| MX (1) | MX6053E (sv) |
| NL (1) | NL181804C (sv) |
| NO (2) | NO152220C (sv) |
| NZ (1) | NZ187243A (sv) |
| PT (1) | PT68035B (sv) |
| SE (2) | SE439322B (sv) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5630917A (en) * | 1979-08-22 | 1981-03-28 | Otsuka Pharmaceut Co Ltd | Preventive and remedy for hepatitis |
| US4423027A (en) * | 1982-12-22 | 1983-12-27 | Simon Lionel N | Pharmaceutical compositions of deglycyrrhizinated licorice (DGL) |
| JPS6193179A (ja) * | 1984-10-15 | 1986-05-12 | Takara Shuzo Co Ltd | グアニジルフンジン類の誘導体及びその製造方法 |
| JPS646214A (en) * | 1987-02-13 | 1989-01-10 | Otsuka Pharma Co Ltd | Remedy for ulcerative colonopathy |
| US5506247A (en) * | 1988-04-15 | 1996-04-09 | T Cell Sciences, Inc. | Compounds that inhibit complement and/or suppress immune activity |
| US5173499A (en) * | 1988-04-15 | 1992-12-22 | T Cell Sciences, Inc. | Compounds which inhibit complement and/or suppress immune activity |
| US5366986A (en) * | 1988-04-15 | 1994-11-22 | T Cell Sciences, Inc. | Compounds which inhibit complement and/or suppress immune activity |
| US4981980A (en) * | 1989-09-14 | 1991-01-01 | Merck & Co., Inc. | Drug for treating manic depression |
| EP0447813A1 (en) * | 1990-02-28 | 1991-09-25 | GRUPPO LEPETIT S.p.A. | Water soluble salts of purpuromycin and pharmaceutical formulations thereof |
| US5532416A (en) * | 1994-07-20 | 1996-07-02 | Monsanto Company | Benzoyl derivatives and synthesis thereof |
| DE69509643T2 (de) * | 1994-03-25 | 1999-10-14 | Gruppo Lepetit S.P.A. | Sesquiterpenderivate |
| US5869688A (en) * | 1994-07-20 | 1999-02-09 | Monsanto Company | Preparation of substituted 3-aryl-5-haloalkyl-pyrazoles having herbicidal activity |
| US5698708A (en) * | 1996-06-20 | 1997-12-16 | Monsanto Company | Preparation of substituted 3-aryl-5-haloalkyl-pyrazoles having herbicidal activity |
| JP4194196B2 (ja) * | 1999-02-22 | 2008-12-10 | 花王株式会社 | 浴用剤組成物 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3985896A (en) * | 1975-07-15 | 1976-10-12 | Smithkline Corporation | Benzophenalenofurans |
| US4046805A (en) * | 1976-05-10 | 1977-09-06 | American Cyanamid Company | Substituted-hydroxy-naphthalenedisulfonic acid compounds |
-
1978
- 1978-05-10 FR FR7813932A patent/FR2405941A1/fr active Granted
- 1978-05-11 NZ NZ187243A patent/NZ187243A/en unknown
- 1978-05-12 NL NLAANVRAGE7805160,A patent/NL181804C/xx not_active IP Right Cessation
- 1978-05-12 DK DK212778A patent/DK154704C/da not_active IP Right Cessation
- 1978-05-12 GB GB19140/78A patent/GB1601479A/en not_active Expired
- 1978-05-12 CH CH519378A patent/CH641452A5/de not_active IP Right Cessation
- 1978-05-12 NO NO781704A patent/NO152220C/no unknown
- 1978-05-12 PT PT68035A patent/PT68035B/pt unknown
- 1978-05-12 AR AR272175A patent/AR228011A1/es active
- 1978-05-12 ES ES469821A patent/ES469821A1/es not_active Expired
- 1978-05-15 IT IT49342/78A patent/IT1103138B/it active
- 1978-05-15 IE IE975/78A patent/IE46785B1/en not_active IP Right Cessation
- 1978-05-15 US US05/906,300 patent/US4229466A/en not_active Expired - Lifetime
- 1978-05-15 CA CA000303381A patent/CA1142106A/en not_active Expired
- 1978-05-16 SE SE7805606A patent/SE439322B/sv not_active IP Right Cessation
- 1978-05-16 DE DE2821403A patent/DE2821403C2/de not_active Expired
- 1978-06-02 MX MX787121U patent/MX6053E/es unknown
-
1979
- 1979-02-15 ES ES477771A patent/ES477771A1/es not_active Expired
-
1983
- 1983-09-30 SE SE8305390A patent/SE452008B/sv not_active IP Right Cessation
- 1983-11-28 NO NO834363A patent/NO154013C/no unknown
-
1987
- 1987-02-04 DK DK058487A patent/DK155670C/da not_active IP Right Cessation
Also Published As
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| NAL | Patent in force |
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| NUG | Patent has lapsed |
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