SA515370014B1 - (صيغ صيدلانية، عمليات، صور صلبة، وطرق استخدام تتعلق بالمركب 1-إيثيل-7-(2-ميثيل-6-(1H-1، 2، 4-ترايازول-3-يل)بيريدين-3-يل)-3 ،4-داي هيدرو بيرازينو[2، 3-b]بيرازين-2-(1H)-أون - Google Patents

(صيغ صيدلانية، عمليات، صور صلبة، وطرق استخدام تتعلق بالمركب 1-إيثيل-7-(2-ميثيل-6-(1H-1، 2، 4-ترايازول-3-يل)بيريدين-3-يل)-3 ،4-داي هيدرو بيرازينو[2، 3-b]بيرازين-2-(1H)-أون

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Publication number
SA515370014B1
SA515370014B1 SA515370014A SA515370014A SA515370014B1 SA 515370014 B1 SA515370014 B1 SA 515370014B1 SA 515370014 A SA515370014 A SA 515370014A SA 515370014 A SA515370014 A SA 515370014A SA 515370014 B1 SA515370014 B1 SA 515370014B1
Authority
SA
Saudi Arabia
Prior art keywords
dihydropyrazino
pyrazin
triazol
pyridin
ethyl
Prior art date
Application number
SA515370014A
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English (en)
Inventor
مينون انيل
كوهين بينجامين
لي توماس
زو جين
كي.باريكه دارشان
فيسكي دورا
ليانج زياوزهانج
مايكل كريلين ماتيو
بويرسين ناثان
وي-هوا ليونج ويليام
لي ينج
Original Assignee
سيجنال فارماسيتوكالز، ال ال سي
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by سيجنال فارماسيتوكالز، ال ال سي filed Critical سيجنال فارماسيتوكالز، ال ال سي
Publication of SA515370014B1 publication Critical patent/SA515370014B1/ar

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4985—Pyrazines or piperazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4858—Organic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

يتعلق الاختراع الحالي بصيغ صيدلانية، عمليات، صور صلبة، وطرق استخدام تتعلق بالمركب 1-إيثيل-7-(2-ميثيل-6-(1H-1، 2، 4-ترايازول-3-يل)بيريدين-3-يل)-3 ،4-داي هيدرو بيرازينو[2، 3-b] بيرازين-2-(1H)-أون 1-ethyl-7-(2-methyl-6-(1H-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1H)-one.
SA515370014A 2013-04-17 2015-10-17 (صيغ صيدلانية، عمليات، صور صلبة، وطرق استخدام تتعلق بالمركب 1-إيثيل-7-(2-ميثيل-6-(1H-1، 2، 4-ترايازول-3-يل)بيريدين-3-يل)-3 ،4-داي هيدرو بيرازينو[2، 3-b]بيرازين-2-(1H)-أون SA515370014B1 (ar)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201361813064P 2013-04-17 2013-04-17
US201361911201P 2013-12-03 2013-12-03
PCT/US2014/034301 WO2014172423A1 (en) 2013-04-17 2014-04-16 Pharmaceutical formulations, processes, solid forms and methods of use relating to 1-ethyl-7-(2-methyl-6-(1h-1,2,4-triazol-3-yl) pyridin-3-yl) -3,4-dihydropyrazino[2,3-b]pyrazin-2(1h)-one

Publications (1)

Publication Number Publication Date
SA515370014B1 true SA515370014B1 (ar) 2018-06-27

Family

ID=50792565

Family Applications (1)

Application Number Title Priority Date Filing Date
SA515370014A SA515370014B1 (ar) 2013-04-17 2015-10-17 (صيغ صيدلانية، عمليات، صور صلبة، وطرق استخدام تتعلق بالمركب 1-إيثيل-7-(2-ميثيل-6-(1H-1، 2، 4-ترايازول-3-يل)بيريدين-3-يل)-3 ،4-داي هيدرو بيرازينو[2، 3-b]بيرازين-2-(1H)-أون

Country Status (24)

Country Link
US (3) US9359364B2 (ar)
EP (2) EP2986609B1 (ar)
JP (2) JP2016516815A (ar)
KR (2) KR102459285B1 (ar)
CN (2) CN111166751A (ar)
AU (1) AU2014254050B2 (ar)
BR (1) BR112015026300A2 (ar)
CA (1) CA2909629C (ar)
CL (1) CL2015003068A1 (ar)
CR (1) CR20150577A (ar)
EA (2) EA030726B1 (ar)
ES (1) ES2744198T3 (ar)
HK (1) HK1221951A1 (ar)
IL (1) IL242102B (ar)
MX (1) MX2015014677A (ar)
NI (1) NI201500152A (ar)
NZ (2) NZ730189A (ar)
PE (1) PE20160041A1 (ar)
PH (2) PH12015502394A1 (ar)
SA (1) SA515370014B1 (ar)
SG (1) SG11201508527VA (ar)
TW (1) TW201527300A (ar)
WO (1) WO2014172423A1 (ar)
ZA (1) ZA201507737B (ar)

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KR102221005B1 (ko) 2013-04-17 2021-02-26 시그날 파마소티칼 엘엘씨 전립선암 치료를 위한 디하이드로피라지노-피라진 화합물 및 안드로겐 수용체 길항제를 포함하는 조합 요법
KR102271344B1 (ko) 2013-04-17 2021-07-01 시그날 파마소티칼 엘엘씨 디하이드로피라지노-피라진을 사용한 암의 치료
KR102240356B1 (ko) 2013-04-17 2021-04-14 시그날 파마소티칼 엘엘씨 Ｔｏｒ 키나제 억제제와 5-치환된 퀴나졸리논 화합물을 포함하는 암 치료용 조합 요법
WO2014193912A1 (en) 2013-05-29 2014-12-04 Signal Pharmaceuticals, Llc Pharmaceutical compositions of 7-(6-(2-hydroxypropan-2-yl)pyridin-3-yl)-1-((trans)-4-methoxycyclohexyl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1h)-one, a solid form thereof and methods of their use
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NZ714742A (en) * 2014-04-16 2017-04-28 Signal Pharm Llc Solid forms of 1-ethyl-7-(2-methyl-6-(1h-1,2,4-triazol-3-yl)pyridin-3-yl)-3,4-dihydropyrazino[2,3-b]pyrazin-2(1h)-one, compositions thereof and methods of their use
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