MX2007005159A - Derivados de pirimidina biciclicos inhibidores del vih. - Google Patents
Derivados de pirimidina biciclicos inhibidores del vih.Info
- Publication number
- MX2007005159A MX2007005159A MX2007005159A MX2007005159A MX2007005159A MX 2007005159 A MX2007005159 A MX 2007005159A MX 2007005159 A MX2007005159 A MX 2007005159A MX 2007005159 A MX2007005159 A MX 2007005159A MX 2007005159 A MX2007005159 A MX 2007005159A
- Authority
- MX
- Mexico
- Prior art keywords
- substituted
- 6alkyl
- amino
- optionally substituted
- 6alkyloxy
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/16—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
- C07D473/24—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 one nitrogen and one sulfur atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
- C07D473/32—Nitrogen atom
- C07D473/34—Nitrogen atom attached in position 6, e.g. adenine
Abstract
Inhibidores de replicacion del VIH de formula (ve formula) N-oxidos, sales de adicion farmaceuticamente aceptables, aminas cuaternarias o sus formas estereoisomericas, en los cuales -a1=a2-a3=a4-es -CH=CH-CH=CH-, -N=CH-CH=CH-, -N=CH-N=CH-, -N=CH-CH=N, -N=N-CH=CH-; -b1=b2-b3=b4- es -CH=CH-CH=CH-, -N=CH-CH=CH-, -N=CH-N=CH-, -N=CH-CH=N, -N=N-CH=CH-; n y m es 0, 1, 2, 3 y en ciertos casos tambien 4,R1 es hidrogeno; arilo, formilo, alquilcarbonilo C1-6; alquilo C1-6 sustituido en forma opcional; alquiloxicarbonilo C1-6; R2 es OH; halogeno; alquilo C1-6 sustituido en forma opcional, alquenilo C2-6 o alquinilo C2-6; carbonilo sustituido; carboxilo; CN; nitro; amino; amino sustituido; polihalogenometilo; polihalogenometiltio; -S(=O)PR6, C(=NH)R6; R2a es CN; amino, amino sustituido, alquilo C1-6 sustituido en forma opcional; halogeno; alcoxi C1-6 sustituido en forma opcional; carbonilo sustituido; -CH=N-NH-C(=O)-R16; alquiloxi C1-6 sustituido en forma opcional; alquenilo C2-6 sustituido o alquinilo C2-6; -C(=N-O-R8)-alquilo C1-4; R7 o -X-R7; R3 es CN; amino; alquilo C1-6; halogeno; alquiloxi C1-6 sustituido en forma opcional; carbonilo sustituido; -CH=N-NH-C(=O)-R16; alquilo C1-6 sustituido; alquiloxi C1-6 alquilo C1-6 sustituido en forma opcional; alquenilo C2-6 sustituido o alquinilo C2-6; -C(=N-O-R8)-alquilo C1-4; R7; R4 es halogeno; OH; alquilo C1-6 sustituido en forma opcional, alquenilo C2-6 o alquinilo C2-6; cicloalquilo C3-7; alquiloxi C1-6; CON; nitro; polihalogenoalquilo C1-6; polihalogenoalquiloxi C1-6; carbonilo sustituido; formilo; amino; mono- o di(alquil C1-4-)amino o R7; -A-B- es -CR5=N-, -N=N-, -CH2-CH2-, -CS-NH-, -CO-NH-, -CH=CH-; composiciones farmaceuticas que los comprenden; metodos para la preparacion de estos compuestos y estas composiciones; el uso de estos compuestos para la prevencion o el tratamiento de la infeccion por VIH.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP04105419 | 2004-10-29 | ||
PCT/EP2005/055589 WO2006045828A1 (en) | 2004-10-29 | 2005-10-27 | Hiv inhibiting bicyclic pyrimidine derivatives |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2007005159A true MX2007005159A (es) | 2007-06-26 |
Family
ID=34929789
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2007005159A MX2007005159A (es) | 2004-10-29 | 2005-10-27 | Derivados de pirimidina biciclicos inhibidores del vih. |
Country Status (16)
Country | Link |
---|---|
US (5) | US8153640B2 (es) |
EP (1) | EP1807430B1 (es) |
JP (1) | JP5118972B2 (es) |
KR (1) | KR20070085286A (es) |
CN (1) | CN101048410B (es) |
AR (1) | AR051410A1 (es) |
AU (1) | AU2005298637B8 (es) |
BR (1) | BRPI0517272A (es) |
CA (1) | CA2577588C (es) |
ES (1) | ES2508766T3 (es) |
IL (1) | IL180963A (es) |
MX (1) | MX2007005159A (es) |
RU (1) | RU2403254C2 (es) |
TW (1) | TW200630370A (es) |
WO (1) | WO2006045828A1 (es) |
ZA (1) | ZA200703444B (es) |
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2005
- 2005-10-27 US US11/718,181 patent/US8153640B2/en active Active
- 2005-10-27 RU RU2007119784/04A patent/RU2403254C2/ru active
- 2005-10-27 BR BRPI0517272-1A patent/BRPI0517272A/pt not_active Application Discontinuation
- 2005-10-27 MX MX2007005159A patent/MX2007005159A/es active IP Right Grant
- 2005-10-27 AU AU2005298637A patent/AU2005298637B8/en not_active Ceased
- 2005-10-27 KR KR1020077009261A patent/KR20070085286A/ko not_active Application Discontinuation
- 2005-10-27 EP EP05801379.8A patent/EP1807430B1/en active Active
- 2005-10-27 JP JP2007538423A patent/JP5118972B2/ja not_active Expired - Fee Related
- 2005-10-27 CA CA2577588A patent/CA2577588C/en not_active Expired - Fee Related
- 2005-10-27 WO PCT/EP2005/055589 patent/WO2006045828A1/en active Application Filing
- 2005-10-27 CN CN2005800369335A patent/CN101048410B/zh not_active Expired - Fee Related
- 2005-10-27 ES ES05801379.8T patent/ES2508766T3/es active Active
- 2005-10-28 TW TW094137858A patent/TW200630370A/zh unknown
- 2005-10-31 AR ARP050104552A patent/AR051410A1/es not_active Application Discontinuation
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2007
- 2007-01-25 IL IL180963A patent/IL180963A/en active IP Right Grant
- 2007-04-26 ZA ZA200703444A patent/ZA200703444B/xx unknown
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2012
- 2012-03-02 US US13/410,779 patent/US9487518B2/en active Active
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2016
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2017
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