SA113340398B1 - استخدام (s-(rs- سيكلوبروبيل-s-(4-{[4-{[(1r, 2r)-2- هيدروكسي-1- ميثيل بروبيل] أوكسي}-5-(تراي فلوروميثيل) بيريميدين-2- يل] أمينو} فنيل) سلفوكسيميد من أجل علاج أورام معينة - Google Patents

استخدام (s-(rs- سيكلوبروبيل-s-(4-{[4-{[(1r, 2r)-2- هيدروكسي-1- ميثيل بروبيل] أوكسي}-5-(تراي فلوروميثيل) بيريميدين-2- يل] أمينو} فنيل) سلفوكسيميد من أجل علاج أورام معينة

Info

Publication number
SA113340398B1
SA113340398B1 SA113340398A SA113340398A SA113340398B1 SA 113340398 B1 SA113340398 B1 SA 113340398B1 SA 113340398 A SA113340398 A SA 113340398A SA 113340398 A SA113340398 A SA 113340398A SA 113340398 B1 SA113340398 B1 SA 113340398B1
Authority
SA
Saudi Arabia
Prior art keywords
sulphoximide
methylpropyl
pyrimidin
cyclopropyl
oxy
Prior art date
Application number
SA113340398A
Other languages
English (en)
Inventor
كورناكر مارتين
Original Assignee
باير انتليكتشوال بروبرتي جي ام بي اتش
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=47891732&utm_source=***_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SA113340398(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by باير انتليكتشوال بروبرتي جي ام بي اتش filed Critical باير انتليكتشوال بروبرتي جي ام بي اتش
Publication of SA113340398B1 publication Critical patent/SA113340398B1/ar

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

يتعلق الاختراع باستخدام (R)-S-cyclopropyl-S-(4-{[4-{[(1R, 2R)-2-hydroxy-1-methylpropyl]oxy}-5-(trifluoromethyl)pyrimidin-2-yl]amino}phenyl)sulphoximide و/أو (S)-S-cyclopropyl-S-(4-{[4-{[(1R, 2R)-2-hydroxy-1-methyl propyl] oxy}-5-(trifluoro methyl)pyrimidin-2-yl]amino}phenyl)sulphoximide لعلاج أورام معينة.
SA113340398A 2012-03-21 2013-03-20 استخدام (s-(rs- سيكلوبروبيل-s-(4-{[4-{[(1r, 2r)-2- هيدروكسي-1- ميثيل بروبيل] أوكسي}-5-(تراي فلوروميثيل) بيريميدين-2- يل] أمينو} فنيل) سلفوكسيميد من أجل علاج أورام معينة SA113340398B1 (ar)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102012204506 2012-03-21

Publications (1)

Publication Number Publication Date
SA113340398B1 true SA113340398B1 (ar) 2016-04-04

Family

ID=47891732

Family Applications (1)

Application Number Title Priority Date Filing Date
SA113340398A SA113340398B1 (ar) 2012-03-21 2013-03-20 استخدام (s-(rs- سيكلوبروبيل-s-(4-{[4-{[(1r, 2r)-2- هيدروكسي-1- ميثيل بروبيل] أوكسي}-5-(تراي فلوروميثيل) بيريميدين-2- يل] أمينو} فنيل) سلفوكسيميد من أجل علاج أورام معينة

Country Status (20)

Country Link
US (1) US20150051232A1 (ar)
EP (1) EP2827871A1 (ar)
JP (1) JP2015510910A (ar)
KR (1) KR20140135215A (ar)
CN (1) CN104220075A (ar)
AP (1) AP2014007915A0 (ar)
AU (1) AU2013234451A1 (ar)
CA (1) CA2867746A1 (ar)
CL (1) CL2014002472A1 (ar)
EA (1) EA201491732A1 (ar)
HK (1) HK1204294A1 (ar)
MA (1) MA35943B1 (ar)
MX (1) MX2014011240A (ar)
PH (1) PH12014502075A1 (ar)
SA (1) SA113340398B1 (ar)
SG (1) SG11201405386SA (ar)
TN (1) TN2014000391A1 (ar)
TW (1) TW201338779A (ar)
WO (1) WO2013139734A1 (ar)
ZA (1) ZA201406986B (ar)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015071231A1 (de) * 2013-11-14 2015-05-21 Bayer Pharma Aktiengesellschaft Kombinationen von (rs)-s-cyclopropyl-s-(4-{[4-{[(1r, 2r)-2-hydroxy-1-methylpropyl]oxy}-5-(trifluormethyl)pyrimidin-2-yl]amino}phenyl)sulfoximid zur behandlung von tumoren
ES2951596T3 (es) 2014-06-13 2023-10-23 Bach Biosciences Llc Agentes terapéuticos activados por FAP y usos relacionados con los mismos

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1307271A (en) 1970-06-25 1973-02-14 Shell Int Research Sulphoximine derivatives and their use in herbicidal compositions
DE4029650A1 (de) 1990-09-19 1992-03-26 Hoechst Ag 2-anilino-pyrimidine, verfahren zu ihrer herstellung, sie enthaltene mittel und ihre verwendung als fungizide
EP1017394B1 (en) 1997-07-12 2005-12-07 Cancer Research Technology Limited Cyclin dependent kinase inhibiting purine derivatives
US6440965B1 (en) 1997-10-15 2002-08-27 Krenitsky Pharmaceuticals, Inc. Substituted pyrimidine derivatives, their preparation and their use in the treatment of neurodegenerative or neurological disorders of the central nervous system
ATE336484T1 (de) 1998-08-29 2006-09-15 Astrazeneca Ab Pyrimidine verbindungen
GB9828511D0 (en) 1998-12-24 1999-02-17 Zeneca Ltd Chemical compounds
JP4771576B2 (ja) * 2000-06-12 2011-09-14 譲治 稲澤 Ｇａｓｃ１遺伝子
GB0016877D0 (en) 2000-07-11 2000-08-30 Astrazeneca Ab Chemical compounds
EP1392662B1 (de) 2001-05-29 2009-01-07 Bayer Schering Pharma Aktiengesellschaft Cdk inhibitorische pyrimidine, deren herstellung und verwendung als arzneimittel
EP1483260A1 (de) 2002-03-11 2004-12-08 Schering Aktiengesellschaft Cdk inhibitorische 2-heteroaryl-pyrimidine, deren herstellung und verwendung als arzneimittel
WO2004041267A1 (en) * 2002-11-06 2004-05-21 Cyclacel Limited Combination comprising a cdk inhibitor and cisplatin
DE10349423A1 (de) 2003-10-16 2005-06-16 Schering Ag Sulfoximinsubstituierte Parimidine als CDK- und/oder VEGF-Inhibitoren, deren Herstellung und Verwendung als Arzneimittel
EP2179991A1 (de) * 2008-10-21 2010-04-28 Bayer Schering Pharma Aktiengesellschaft Sulfoximinsubstituierte Anilino-Pyrimidinderivate als CDK-Inhibitoren, deren Herstellung und Verwendung als Arzneimittel
CN102223885B (zh) * 2008-11-24 2013-04-03 内尔维阿诺医学科学有限公司 用于治疗间皮瘤的cdk抑制剂
EP2424843B1 (en) * 2009-04-30 2014-03-26 Novartis AG Imidazole derivatives and their use as modulators of cyclin dependent kinases
DE102010014426A1 (de) * 2010-04-01 2011-10-06 Bayer Schering Pharma Aktiengesellschaft Verwendung neuer pan-CDK-Inhibitoren zur Behandlung von Tumoren
DE102010014427A1 (de) 2010-04-01 2011-10-06 Bayer Schering Pharma Aktiengesellschaft Kombinationen neuer pan-CDK-Inhibitoren zur Behandlung von Tumoren

Also Published As

Publication number Publication date
ZA201406986B (en) 2016-08-31
AU2013234451A1 (en) 2014-09-25
TN2014000391A1 (en) 2015-12-21
AP2014007915A0 (en) 2014-09-30
CN104220075A (zh) 2014-12-17
MA35943B1 (fr) 2014-12-01
EA201491732A1 (ru) 2015-08-31
MX2014011240A (es) 2014-10-15
CA2867746A1 (en) 2013-09-26
JP2015510910A (ja) 2015-04-13
TW201338779A (zh) 2013-10-01
KR20140135215A (ko) 2014-11-25
CL2014002472A1 (es) 2014-12-12
WO2013139734A1 (de) 2013-09-26
SG11201405386SA (en) 2014-11-27
PH12014502075A1 (en) 2014-12-10
US20150051232A1 (en) 2015-02-19
EP2827871A1 (de) 2015-01-28
HK1204294A1 (en) 2015-11-13

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