RU93041766A - Способ получения 9-амино-6-деметил-6-деокситетрациклина - Google Patents
Способ получения 9-амино-6-деметил-6-деокситетрациклинаInfo
- Publication number
- RU93041766A RU93041766A RU93041766/04A RU93041766A RU93041766A RU 93041766 A RU93041766 A RU 93041766A RU 93041766/04 A RU93041766/04 A RU 93041766/04A RU 93041766 A RU93041766 A RU 93041766A RU 93041766 A RU93041766 A RU 93041766A
- Authority
- RU
- Russia
- Prior art keywords
- amino
- demethyl
- obtaining
- ticycline
- deoxytetra
- Prior art date
Links
- GUXHBMASAHGULD-SEYHBJAFSA-N (4S,4aS,5aS,6S,12aR)-7-chloro-4-(dimethylamino)-1,6,10,11,12a-pentahydroxy-3,12-dioxo-4a,5,5a,6-tetrahydro-4H-tetracene-2-carboxamide Chemical compound C1([C@H]2O)=C(Cl)C=CC(O)=C1C(O)=C1[C@@H]2C[C@H]2[C@H](N(C)C)C(=O)C(C(N)=O)=C(O)[C@@]2(O)C1=O GUXHBMASAHGULD-SEYHBJAFSA-N 0.000 claims 1
- 239000004098 Tetracycline Substances 0.000 claims 1
- 229940040944 Tetracyclines Drugs 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 125000002147 dimethylamino group Chemical group [H]C([H])([H])N(*)C([H])([H])[H] 0.000 claims 1
- 238000003786 synthesis reaction Methods 0.000 claims 1
- 230000002194 synthesizing Effects 0.000 claims 1
- 235000019364 tetracycline Nutrition 0.000 claims 1
- 150000003522 tetracyclines Chemical class 0.000 claims 1
Claims (1)
- Изобретение относится к новому методу получения [4S-(4 альфа, 12а альфа)]-9-амино-4-(диметиламино)-1,4,4а,5,5а,6,11,12а-октагидро-3,10,12,12а-тетрагидро-1,11-диоксо-2-нафтаценкарбоксамида, названного ниже 9-амино-6-деметил-6-деокситетрациклин, являющегося важным промышленным соединением для синтеза тетрациклинов.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US07/928,587 US5248797A (en) | 1992-08-13 | 1992-08-13 | Method for the production of 9-amino-6-demethyl-6-deoxytetracycline |
| FR07/928,587 | 1992-08-13 | ||
| US07/928,587 | 1992-08-13 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU93041766A true RU93041766A (ru) | 1996-06-20 |
| RU2124000C1 RU2124000C1 (ru) | 1998-12-27 |
Family
ID=25456482
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU93041766A RU2124000C1 (ru) | 1992-08-13 | 1993-08-12 | Способ получения сульфата 9-амино-6-деметил-6-деокситетрациклина (варианты) |
Country Status (25)
| Country | Link |
|---|---|
| US (1) | US5248797A (ru) |
| EP (1) | EP0582791B1 (ru) |
| JP (1) | JP3686685B2 (ru) |
| KR (1) | KR100280971B1 (ru) |
| CN (1) | CN1037905C (ru) |
| AT (1) | ATE152096T1 (ru) |
| AU (1) | AU660834B2 (ru) |
| CA (1) | CA2103839C (ru) |
| CZ (1) | CZ286004B6 (ru) |
| DE (1) | DE69310048T2 (ru) |
| DK (1) | DK0582791T3 (ru) |
| ES (1) | ES2101159T3 (ru) |
| FI (1) | FI112939B (ru) |
| GR (1) | GR3024076T3 (ru) |
| HU (1) | HU212648B (ru) |
| IL (1) | IL106675A (ru) |
| MX (1) | MX9304648A (ru) |
| NO (1) | NO301823B1 (ru) |
| NZ (1) | NZ248355A (ru) |
| PH (1) | PH30009A (ru) |
| PL (1) | PL173730B1 (ru) |
| RU (1) | RU2124000C1 (ru) |
| SK (1) | SK279462B6 (ru) |
| TW (1) | TW221412B (ru) |
| ZA (1) | ZA935895B (ru) |
Families Citing this family (37)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5494903A (en) * | 1991-10-04 | 1996-02-27 | American Cyanamid Company | 7-substituted-9-substituted amino-6-demethyl-6-deoxytetracyclines |
| US5442059A (en) * | 1992-08-13 | 1995-08-15 | American Cyanamid Company | 9-[(substituted glycyl)amido)]-6-demethyl-6-deoxytetracyclines |
| EP1251550B1 (en) | 1994-04-18 | 2005-03-30 | Micron Technology, Inc. | Method and apparatus for automatically positioning electronic die within component packages |
| US5675030A (en) * | 1994-11-16 | 1997-10-07 | American Cyanamid Company | Method for selective extracting a 7-(hydrogen or substituted amino)-9- (substituted glycyl) amido!-6-demethyl-6-deoxytetracycline compound |
| US5563130A (en) * | 1994-12-13 | 1996-10-08 | American Cyanamid Company | Methods for inhibiting angiogenesis, proliferation of endothelial or tumor cells and tumor growth |
| US5843925A (en) * | 1994-12-13 | 1998-12-01 | American Cyanamid Company | Methods for inhibiting angiogenesis, proliferation of endothelial or tumor cells and tumor growth |
| US5567693A (en) * | 1994-12-13 | 1996-10-22 | American Cyanamid Company | Method for inhibiting angiogenesis, proliferation of endothelial or tumor cells and tumor growth |
| US5574026A (en) * | 1994-12-13 | 1996-11-12 | American Cyanamid Company | Methods for inhibiting angiogenesis proliferation of endothelial or tumor cells and tumor growth |
| US6072236A (en) * | 1996-03-07 | 2000-06-06 | Micron Technology, Inc. | Micromachined chip scale package |
| CN1074460C (zh) * | 1999-05-26 | 2001-11-07 | 贾晓峰 | 四环素发酵方法 |
| US8106225B2 (en) * | 1999-09-14 | 2012-01-31 | Trustees Of Tufts College | Methods of preparing substituted tetracyclines with transition metal-based chemistries |
| ES2260051T3 (es) * | 1999-09-14 | 2006-11-01 | Trustees Of Tufts College | Metodo para preparar tetraciclinas substituidas con quimicas basadas en metales de transicion. |
| HUP0300082A2 (en) * | 2000-03-31 | 2003-05-28 | Paratek Pharmaceuticals | 7- and 9-carbamate, urea, thiourea, thiocarbamate, and heteroaryl-amino substituted tetracycline derivatives, process for their preparation and use and pharmaceutical compositions containing them |
| US20020132798A1 (en) | 2000-06-16 | 2002-09-19 | Nelson Mark L. | 7-phenyl-substituted tetracycline compounds |
| WO2001098236A2 (en) * | 2000-06-16 | 2001-12-27 | Trustees Of Tufts College | 7-phenyl-substituted tetracycline compounds |
| US7094806B2 (en) * | 2000-07-07 | 2006-08-22 | Trustees Of Tufts College | 7, 8 and 9-substituted tetracycline compounds |
| ATE544745T1 (de) | 2000-07-07 | 2012-02-15 | Tufts College | 9-substituierte minocyclinverbindungen |
| AU2001271642B2 (en) * | 2000-07-07 | 2006-01-05 | Paratek Pharmaceuticals, Inc. | 7-substituted tetracycline compounds |
| EP1241160A1 (en) * | 2001-03-13 | 2002-09-18 | Glaxo Group Limited | Tetracycline derivatives and their use as antibiotic agents |
| US7553828B2 (en) * | 2001-03-13 | 2009-06-30 | Paratek Pharmaceuticals, Inc. | 9-aminomethyl substituted minocycline compounds |
| MXPA03008165A (es) | 2001-03-13 | 2003-12-12 | Paratek Pharm Innc | Compuestos tetraciclina sustituidos en la posicion 7,9. |
| US20030181371A1 (en) * | 2001-12-28 | 2003-09-25 | Angiotech Pharmaceuticals, Inc. | Compositions and methods of using collajolie |
| EA201000491A1 (ru) * | 2002-03-08 | 2010-08-30 | Паратек Фармасьютикалс, Инк. | Аминометилзамещенные тетрациклиновые соединения |
| WO2003079984A2 (en) * | 2002-03-21 | 2003-10-02 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds |
| EP2298323A3 (en) | 2003-07-09 | 2011-05-11 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds |
| US20060287283A1 (en) * | 2003-07-09 | 2006-12-21 | Paratek Pharmaceuticals, Inc. | Prodrugs of 9-aminomethyl tetracycline compounds |
| CA2585248A1 (en) | 2004-10-25 | 2006-05-04 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds |
| US8088755B2 (en) | 2005-02-04 | 2012-01-03 | Paratek Pharmaceuticals, Inc. | 11a, 12-derivatives of tetracycline compounds |
| AR057033A1 (es) * | 2005-05-27 | 2007-11-14 | Wyeth Corp | Tigeciclina y metodos para preparar 9-nitrominociclina |
| AR057032A1 (es) * | 2005-05-27 | 2007-11-14 | Wyeth Corp | Tigeciclina y metodos de preparacion |
| AR057324A1 (es) * | 2005-05-27 | 2007-11-28 | Wyeth Corp | Tigeciclina y metodos para preparar 9-aminominociclina |
| AR057034A1 (es) * | 2005-05-27 | 2007-11-14 | Wyeth Corp | Metodos para purificar tigeciclina |
| CA2649221A1 (en) * | 2006-04-17 | 2007-10-25 | Evgeny Tsiperman | Isolation of tetracycline derivatives |
| US7871993B2 (en) * | 2006-04-24 | 2011-01-18 | Teva Pharmaceutical Industries Ltd. | Tigecycline crystalline forms and processes for preparation thereof |
| EP2084126A1 (en) * | 2006-11-30 | 2009-08-05 | Teva Pharmaceutical Industries Ltd. | Processes for preparation of 9-haloacetamidominocyclines |
| EP2114865A1 (en) * | 2007-03-01 | 2009-11-11 | Teva Pharmaceutical Industries Ltd. | Processes for purification of tigecycline |
| EP2406213A1 (en) * | 2009-03-12 | 2012-01-18 | Wyeth LLC | Nitration of tetracyclines |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| USRE26271E (en) * | 1967-09-26 | Reductive alkylation process | ||
| US3036129A (en) * | 1959-10-09 | 1962-05-22 | American Cyanamid Co | Preparation of 7-halo-6-deoxy-tetracyclines |
| US3043875A (en) * | 1959-10-22 | 1962-07-10 | Pfizer & Co C | Halogenated tetracycline derivatives and processes for their preparation |
| US3338963A (en) * | 1960-10-28 | 1967-08-29 | American Cyanamid Co | Tetracycline compounds |
| USRE26253E (en) * | 1963-05-17 | 1967-08-15 | And z-alkylamino-g-deoxytetracycline | |
| US3423457A (en) * | 1966-11-29 | 1969-01-21 | American Cyanamid Co | Substitution products of 7-chloro-6-demethyltetracycline |
| SG47520A1 (en) * | 1992-08-13 | 1998-04-17 | American Cyanamid Co | New method for the production of 9-amino-6-demethyl-6-deoxytetracycline |
| US5284963A (en) * | 1992-08-13 | 1994-02-08 | American Cyanamid Company | Method of producing 7-(substituted)-9-[(substituted glycyl)-amidol]-6-demethyl-6-deoxytetra-cyclines |
-
1992
- 1992-08-13 US US07/928,587 patent/US5248797A/en not_active Expired - Lifetime
- 1992-11-03 TW TW081108728A patent/TW221412B/zh active
-
1993
- 1993-05-12 DK DK93107720.0T patent/DK0582791T3/da active
- 1993-05-12 AT AT93107720T patent/ATE152096T1/de not_active IP Right Cessation
- 1993-05-12 EP EP93107720A patent/EP0582791B1/en not_active Expired - Lifetime
- 1993-05-12 DE DE69310048T patent/DE69310048T2/de not_active Expired - Fee Related
- 1993-05-12 ES ES93107720T patent/ES2101159T3/es not_active Expired - Lifetime
- 1993-06-11 CN CN93106625A patent/CN1037905C/zh not_active Expired - Fee Related
- 1993-08-02 MX MX9304648A patent/MX9304648A/es unknown
- 1993-08-04 CZ CZ931583A patent/CZ286004B6/cs not_active IP Right Cessation
- 1993-08-06 SK SK851-93A patent/SK279462B6/sk not_active IP Right Cessation
- 1993-08-08 PH PH46659A patent/PH30009A/en unknown
- 1993-08-09 NZ NZ248355A patent/NZ248355A/en not_active IP Right Cessation
- 1993-08-10 JP JP21685593A patent/JP3686685B2/ja not_active Expired - Fee Related
- 1993-08-11 CA CA002103839A patent/CA2103839C/en not_active Expired - Fee Related
- 1993-08-12 AU AU44602/93A patent/AU660834B2/en not_active Ceased
- 1993-08-12 KR KR1019930015642A patent/KR100280971B1/ko not_active IP Right Cessation
- 1993-08-12 HU HU9302334A patent/HU212648B/hu not_active IP Right Cessation
- 1993-08-12 NO NO932868A patent/NO301823B1/no not_active IP Right Cessation
- 1993-08-12 RU RU93041766A patent/RU2124000C1/ru not_active IP Right Cessation
- 1993-08-12 FI FI933563A patent/FI112939B/fi active
- 1993-08-12 ZA ZA935895A patent/ZA935895B/xx unknown
- 1993-08-12 IL IL10667593A patent/IL106675A/en not_active IP Right Cessation
- 1993-08-12 PL PL93300065A patent/PL173730B1/pl not_active IP Right Cessation
-
1997
- 1997-07-09 GR GR970401732T patent/GR3024076T3/el unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU93041766A (ru) | Способ получения 9-амино-6-деметил-6-деокситетрациклина | |
| FI933563A0 (fi) | Nytt foerfarande foer framstaellning av 9-amino-6-demetyl-6-deoxitetracyklin | |
| NO2017037I1 (no) | Tygacil er et antibiotika inneholdende en tetracyklinforbindelse betegnet tigecyklin | |
| DE69417285T2 (de) | Diagnosesystem der Verschlechterung eines Katalysators | |
| DE69402332D1 (de) | Hemmung der katalytischen Oxidation eines Kohlenstoff-Kohlenstoff-Verbundwerkstoffs | |
| ITMI922938A0 (it) | Procedimento catalitico per la produzione di gas di sintesi | |
| DE69201567D1 (de) | Ueberwachung des wirkungsgrades eines katalytischen konverters. | |
| IT1265119B1 (it) | Procedimento di produzione di fenilalcani utilizzante un catalizzatore a base di zeolite y modificata | |
| DE59600215D1 (de) | Weiterverwendung des Verdünnungsgases aus der Gasphasen-Partialoxidation einer organischen Verbindung | |
| HU216537B (hu) | Eljárás dikarbonsav-diklorid előállítására, izolálására és tisztítására, és az előállított S-(-)-izomer | |
| DK0487319T3 (da) | Hidtil ukendt heptamethylindanforbindelse | |
| BRPI9809153A (pt) | composto, processo para a preparação da 5-amino-2,4,6-triiodo-n,n'-bis(2,3-dihidroxipropil)-isoftalamida, e, uso da mesma | |
| IT9002952A0 (it) | Composto per la costituzione di guarnizioni di tenuta a baderna | |
| NO895128D0 (no) | Selektiv hydrogenolyse av perhalogenderivater av etan. | |
| ATE175960T1 (de) | Neue alpha-mannosidase-inhibitoren | |
| RU93013226A (ru) | Способ получения триалкилортоформиатов | |
| IT9021673A0 (it) | Processo a due stadi per la sintesi del fluoroglucinolo | |
| BR9202833A (pt) | Processo para a sintese de pirazois 1,4-dissubstituidos | |
| ES2088353A1 (es) | Control de nematodos fitoparasitos con trans-chalcona. |