RU92004368A - Замещенные пиримидины, способ их получения, фармацевтическая композиция - Google Patents
Замещенные пиримидины, способ их получения, фармацевтическая композицияInfo
- Publication number
- RU92004368A RU92004368A RU92004368/04A RU92004368A RU92004368A RU 92004368 A RU92004368 A RU 92004368A RU 92004368/04 A RU92004368/04 A RU 92004368/04A RU 92004368 A RU92004368 A RU 92004368A RU 92004368 A RU92004368 A RU 92004368A
- Authority
- RU
- Russia
- Prior art keywords
- production
- pharmaceutical composition
- substituted pyrimidines
- treatment
- pyrimidines
- Prior art date
Links
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 150000003230 pyrimidines Chemical class 0.000 title 1
- 206010007559 Cardiac failure congestive Diseases 0.000 claims 1
- 206010020772 Hypertension Diseases 0.000 claims 1
- 238000002399 angioplasty Methods 0.000 claims 1
- 201000006233 congestive heart failure Diseases 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- NGVDGCNFYWLIFO-UHFFFAOYSA-N pyridoxal 5'-phosphate Chemical group CC1=NC=C(COP(O)(O)=O)C(C=O)=C1O NGVDGCNFYWLIFO-UHFFFAOYSA-N 0.000 claims 1
Claims (1)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US782.025 | 1991-10-24 | ||
US07/782,025 US5149699A (en) | 1991-10-24 | 1991-10-24 | Substituted pyridopyrimidines useful as antgiotensin II antagonists |
GB9207560.5 | 1992-04-07 | ||
US782025 | 1992-06-25 | ||
US901485 | 1992-06-25 |
Publications (2)
Publication Number | Publication Date |
---|---|
RU92004368A true RU92004368A (ru) | 1995-03-27 |
RU2113437C1 RU2113437C1 (ru) | 1998-06-20 |
Family
ID=25124708
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU92004368A RU2113437C1 (ru) | 1991-10-24 | 1992-10-23 | Замещенные пиримидины, или их фармацевтически приемлемые соли, или n-оксиды, способы их получения и фармацевтическая композиция на их основе |
Country Status (4)
Country | Link |
---|---|
US (1) | US5149699A (ru) |
PH (1) | PH31071A (ru) |
RU (1) | RU2113437C1 (ru) |
ZA (1) | ZA927569B (ru) |
Families Citing this family (29)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU1625192A (en) * | 1991-05-31 | 1992-12-03 | Zeneca Limited | Heterocyclic derivatives |
PT100631B (pt) * | 1991-06-28 | 1999-06-30 | Smithkline Beecham Corp | Antagonistas biciclicos de fibrinogenio, seu uso e composicoes farmaceuticas que os contem |
US5939412A (en) * | 1992-06-26 | 1999-08-17 | Smithkline Beecham Corporation | Bicyclic fibrinogen antagonists |
TW226375B (ru) * | 1991-10-24 | 1994-07-11 | American Home Prod | |
KR100212257B1 (ko) * | 1991-11-18 | 1999-08-02 | 미리암 디. 메코나헤이 | Aii 수용체 길항물질을 합성하기 위한 테트라졸릴페닐보론산 중간체의 제조 방법 |
GB9125842D0 (en) * | 1991-12-04 | 1992-02-05 | Ici Plc | Heterocyclic derivatives |
FR2696745B1 (fr) * | 1992-10-12 | 1995-05-12 | Synthelabo | Procédé de préparation de dérivés de phényltétrazole. |
FR2696746B1 (fr) * | 1992-10-12 | 1994-11-18 | Synthelabo | Dérivés de l'acide benzèneborinique, leur préparation et leur utilisation comme intermédiaires de synthèse. |
ES2126061T3 (es) * | 1993-03-24 | 1999-03-16 | American Home Prod | Piridopirimidinas substituidas como antihipertensores. |
US5466692A (en) * | 1993-03-24 | 1995-11-14 | American Home Products Corporation | Substituted pyridopyrimidines and antihypertensives |
DE4314964A1 (de) * | 1993-05-06 | 1994-11-10 | Bayer Ag | Pyridinylmethyl-substiutierte Pyridine und Pyridone |
DE4316077A1 (de) * | 1993-05-13 | 1994-11-17 | Bayer Ag | Substituierte Mono- und Bihydridylmethylpyridone |
MA23420A1 (fr) * | 1994-01-07 | 1995-10-01 | Smithkline Beecham Corp | Antagonistes bicycliques de fibrinogene. |
US6458784B1 (en) | 1994-06-29 | 2002-10-01 | Smithkline Beecham Corporation | Vitronectin receptor antagonists |
US5760220A (en) * | 1995-06-07 | 1998-06-02 | American Home Products Corporation | Process for preparation of biphenyl derivatives |
ATE240325T1 (de) * | 1995-06-07 | 2003-05-15 | Wyeth Corp | Verfahren zur herstellung von biphenylderivaten |
US5977101A (en) * | 1995-06-29 | 1999-11-02 | Smithkline Beecham Corporation | Benzimidazoles/Imidazoles Linked to a Fibrinogen Receptor Antagonist Template Having Vitronectin Receptor Antagonist Activity |
IT1292437B1 (it) | 1997-06-30 | 1999-02-08 | Zambon Spa | Processo di orto-metallazione utile per la sintesi di 1 - tetrazol- 5-il) benzeni 2-sostituiti |
US6638937B2 (en) | 1998-07-06 | 2003-10-28 | Bristol-Myers Squibb Co. | Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists |
AU2005286593A1 (en) * | 2004-09-23 | 2006-03-30 | Reddy Us Therapeutics, Inc. | Novel pyridine compounds, process for their preparation and compositions containing them |
AU2008261102B2 (en) | 2007-06-04 | 2013-11-28 | Bausch Health Ireland Limited | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
CA2930674A1 (en) | 2008-06-04 | 2009-12-10 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
JP2011528375A (ja) | 2008-07-16 | 2011-11-17 | シナジー ファーマシューティカルズ インコーポレイテッド | 胃腸障害、炎症、癌、およびその他の障害の治療のために有用なグアニル酸シクラーゼのアゴニスト |
US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
RU2478637C2 (ru) * | 2011-03-24 | 2013-04-10 | Государственное образовательное учреждение высшего профессионального образования "Российский университет дружбы народов" (РУДН) | СПОСОБ ПОЛУЧЕНИЯ ПРОИЗВОДНЫХ 5,8,9,10-ТЕТРАГИДРОПИРИМИДО[4,5-d]АЗОЦИНОВ, ИМЕЮЩИХ В 4-М ПОЛОЖЕНИИ ТРИФЛАТНУЮ, ВТОРИЧНУЮ И ТРЕТИЧНУЮ АМИНОГРУППЫ |
CA2905438A1 (en) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase and their uses |
JP2016514670A (ja) | 2013-03-15 | 2016-05-23 | シナジー ファーマシューティカルズ インコーポレイテッド | 他の薬物と組み合わせたグアニル酸シクラーゼ受容体アゴニスト |
JP6606491B2 (ja) | 2013-06-05 | 2019-11-13 | シナジー ファーマシューティカルズ インコーポレイテッド | グアニル酸シクラーゼcの超高純度アゴニスト、その作成および使用方法 |
Family Cites Families (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA1334092C (en) * | 1986-07-11 | 1995-01-24 | David John Carini | Angiotensin ii receptor blocking imidazoles |
CA1338238C (en) * | 1988-01-07 | 1996-04-09 | David John Carini | Angiotensin ii receptor blocking imidazoles and combinations thereof with diuretics and nsaids |
US5015651A (en) * | 1988-01-07 | 1991-05-14 | E. I. Du Pont De Nemours And Company | Treatment of hypertension with 1,2,4-angiotensin II antagonists |
US4880804A (en) * | 1988-01-07 | 1989-11-14 | E. I. Du Pont De Nemours And Company | Angiotensin II receptor blocking benzimidazoles |
US4916129A (en) * | 1989-01-19 | 1990-04-10 | E. I. Du Pont De Nemours And Company | Combination β-blocking/angiotensin II blocking antihypertensives |
US5064825A (en) * | 1989-06-01 | 1991-11-12 | Merck & Co., Inc. | Angiotensin ii antagonists |
CA2020073A1 (en) * | 1989-07-03 | 1991-01-04 | Eric E. Allen | Substituted quinazolinones as angiotensin ii antagonists |
DE69024556T2 (de) * | 1989-07-28 | 1996-10-17 | Merck & Co Inc | Substituierte Triazolinone, Triazolinthione und Triazolinimine als Angiotensin II-Antagonisten |
ATE113281T1 (de) * | 1989-08-02 | 1994-11-15 | Takeda Chemical Industries Ltd | Pyrazol-derivate, verfahren zu deren herstellung und anwendung. |
PL286445A1 (en) * | 1989-08-11 | 1991-04-22 | Ici Plc | Method of obtaining novel quinoline derivatives |
US5039814A (en) * | 1990-05-02 | 1991-08-13 | Merck & Co., Inc. | Ortho-lithiation process for the synthesis of 2-substituted 1-(tetrazol-5-yl)benzenes |
-
1991
- 1991-10-24 US US07/782,025 patent/US5149699A/en not_active Expired - Lifetime
-
1992
- 1992-10-01 ZA ZA927569A patent/ZA927569B/xx unknown
- 1992-10-23 PH PH45164A patent/PH31071A/en unknown
- 1992-10-23 RU RU92004368A patent/RU2113437C1/ru not_active IP Right Cessation
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