RU93054537A - Производные гуанидиналкил-1,1-бисфосфоновой кислоты, способ их получения и их применение - Google Patents
Производные гуанидиналкил-1,1-бисфосфоновой кислоты, способ их получения и их применениеInfo
- Publication number
- RU93054537A RU93054537A RU93054537/04A RU93054537A RU93054537A RU 93054537 A RU93054537 A RU 93054537A RU 93054537/04 A RU93054537/04 A RU 93054537/04A RU 93054537 A RU93054537 A RU 93054537A RU 93054537 A RU93054537 A RU 93054537A
- Authority
- RU
- Russia
- Prior art keywords
- guanidinalkyl
- derivatives
- producing
- bisphosphonic acid
- formula
- Prior art date
Links
- 238000004519 manufacturing process Methods 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims 2
- 208000003432 Bone Disease Diseases 0.000 claims 1
- 230000003412 degenerative Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 229940079593 drugs Drugs 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
Claims (1)
- Соединение таутомерной формулы Iа, Iб или Iс
где R - остаток формулы
являются эффективными соединениями для лечения и профилактики дегенеративных заболеваний костей. Они находят применение в качестве лекарственных средств.
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4240422 | 1992-12-02 | ||
| DEP4240422.3 | 1992-12-02 | ||
| DE19934316019 DE4316019A1 (de) | 1993-05-13 | 1993-05-13 | Benzoylguanidinalkyl-1,1-bisphosphonsäuren, Verfahren zu ihrer Herstellung und ihre Verwendung |
| DEP4316019.0 | 1993-05-13 | ||
| DE4332362 | 1993-09-23 | ||
| DEP4332362.6 | 1993-09-23 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU93054537A true RU93054537A (ru) | 1996-12-27 |
| RU2114855C1 RU2114855C1 (ru) | 1998-07-10 |
Family
ID=27204511
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU93054537A RU2114855C1 (ru) | 1992-12-02 | 1993-12-01 | Производные гуанидиналкил-1,1-бис-фосфоновых кислот и способ их получения |
Country Status (15)
| Country | Link |
|---|---|
| US (3) | US5395826A (ru) |
| EP (1) | EP0600371B1 (ru) |
| JP (1) | JP3499905B2 (ru) |
| KR (1) | KR100347423B1 (ru) |
| AT (1) | ATE176476T1 (ru) |
| AU (1) | AU663983B2 (ru) |
| BR (1) | BR9304910A (ru) |
| CA (1) | CA2110443C (ru) |
| DE (1) | DE59309360D1 (ru) |
| DK (1) | DK0600371T3 (ru) |
| ES (1) | ES2129485T3 (ru) |
| FI (1) | FI108034B (ru) |
| GR (1) | GR3030020T3 (ru) |
| NZ (1) | NZ250322A (ru) |
| RU (1) | RU2114855C1 (ru) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4223940A1 (de) * | 1992-07-21 | 1994-01-27 | Boehringer Mannheim Gmbh | Neue acyclische Amidingruppen-haltige Diphosphonsäurederivate, Verfahren zu deren Herstellung und diese Verbindungen enthaltende Arzneimittel |
| ATE176476T1 (de) * | 1992-12-02 | 1999-02-15 | Hoechst Ag | Guanidinalkyl-1, 1-bisphosphonsäurederivate, verfahren zu ihrer herstellung und ihre verwendung |
| US6169107B1 (en) | 1993-04-28 | 2001-01-02 | Sumitomo Pharmaceutical Co., Ltd. | Indoloylguanidine derivatives |
| DE4404183A1 (de) * | 1994-02-10 | 1995-08-17 | Merck Patent Gmbh | 4-Amino-1-piperidylbenzoylguanidine |
| DE4421495A1 (de) * | 1994-06-20 | 1995-12-21 | Merck Patent Gmbh | Heterocyclyloxy-benzoylguanidine |
| CA2160600A1 (en) * | 1994-10-18 | 1996-04-19 | Masahumi Kitano | Indoloylguanidine derivatives |
| DE19540995A1 (de) * | 1995-11-03 | 1997-05-07 | Hoechst Ag | Substituierte Sulfonimidamide, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| DE19542306A1 (de) * | 1995-11-14 | 1997-05-15 | Hoechst Ag | Sulfonylamino-substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament |
| PL316439A1 (en) * | 1995-11-20 | 1997-05-26 | Hoechst Ag | Novel substituted derivatives of benzoyloguanidine, method of obtaining them, their application in production of pharmaceutic and diagnostic agents and pharmaceutic agent as such |
| DE19601303A1 (de) * | 1996-01-16 | 1997-07-17 | Boehringer Ingelheim Kg | Neuartige Benzoylguanidin-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung bei der Herstellung von Arzneimitteln |
| WO1998039344A1 (en) * | 1997-03-07 | 1998-09-11 | Metabasis Therapeutics, Inc. | Novel purine inhibitors of fructose-1,6-bisphosphatase |
| ES2210728T3 (es) | 1997-03-07 | 2004-07-01 | Metabasis Therapeutics, Inc. | Nuevos inhibidores bencimidazol de la fructosa-1, 6-bifosfatasa. |
| AU6691798A (en) | 1997-03-07 | 1998-09-22 | Metabasis Therapeutics, Inc. | Novel indole and azaindole inhibitors of fructose-1,6-bisphosphatase |
| US6558784B1 (en) | 1999-03-02 | 2003-05-06 | Adc Composites, Llc | Composite footwear upper and method of manufacturing a composite footwear upper |
| JP2003519183A (ja) * | 2000-01-04 | 2003-06-17 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 心臓および動脈の石灰化を抑制する低用量ビスホスホネートの使用 |
| JP2004528365A (ja) * | 2001-05-02 | 2004-09-16 | ノバルティス アクチエンゲゼルシャフト | 骨再吸収症および骨粗しょう症の処置または予防におけるビスホスホネートの吸入投与方法 |
| KR100620672B1 (ko) * | 2002-12-14 | 2006-09-13 | 주식회사 하이닉스반도체 | 포토레지스트 조성물 |
| WO2005090370A1 (en) | 2004-02-05 | 2005-09-29 | The Regents Of The University Of California | Pharmacologically active agents containing esterified phosphonates and methods for use thereof |
| EP2842559A3 (en) | 2005-04-08 | 2015-03-18 | Chimerix, Inc. | Compounds, compositions and methods for the treatment of viral infections and other medical disorders |
| EP1868628B1 (en) | 2005-04-08 | 2014-06-11 | Chimerix, Inc. | Compounds, compositions and methods for the treatment of poxvirus infections |
| AU2007324044A1 (en) * | 2006-11-21 | 2008-05-29 | Teikoku Pharma Usa, Inc. | Biphosphonate inhalant formulations and methods for using the same |
| EP2254582B1 (en) * | 2008-01-25 | 2016-01-20 | Chimerix, Inc. | Methods of treating viral infections |
| US20100034752A1 (en) * | 2008-08-11 | 2010-02-11 | Toru Hibi | Inhalant formulations comprising a bisphosphonate and a pyrazolone derivative and methods for using the same |
| WO2011011519A1 (en) | 2009-07-21 | 2011-01-27 | Chimerix, Inc. | Compounds, compositions and methods for treating ocular conditions |
| EP2462152A4 (en) | 2009-08-03 | 2013-02-13 | Chimerix Inc | COMPOSITION AND METHODS FOR TREATING VIRAL INFECTIONS AND TUMORS OF VIRAL ORIGIN |
| US9006218B2 (en) | 2010-02-12 | 2015-04-14 | Chimerix Inc. | Nucleoside phosphonate salts |
| EP2563367A4 (en) | 2010-04-26 | 2013-12-04 | Chimerix Inc | METHODS OF TREATING RETROVIRAL INFECTIONS AND ASSOCIATED DOSAGE REGIMES |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2838437A1 (de) * | 1978-09-02 | 1980-03-20 | Benckiser Gmbh Joh A | N,n'-dialkyl-ureidomethan-diphosphonsaeure, deren herstellung und verwendung |
| IL77243A (en) * | 1984-12-21 | 1996-11-14 | Procter & Gamble | Pharmaceutical compositions containing geminal diphosphonic acid compounds and certain such novel compounds |
| DE3623397A1 (de) * | 1986-07-11 | 1988-01-14 | Boehringer Mannheim Gmbh | Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel |
| IL86951A (en) * | 1987-07-06 | 1996-07-23 | Procter & Gamble Pharma | Methylene phosphonoalkylphosphinates and pharmaceutical preparations containing them |
| JPH0248587A (ja) * | 1988-08-10 | 1990-02-19 | Yamanouchi Pharmaceut Co Ltd | 複素環置換ビスフォスフォン酸誘導体及びその医薬 |
| DE3929582A1 (de) * | 1989-09-06 | 1991-03-07 | Hoechst Ag | Benzoylguanidine, verfahren zu ihrer herstellung, ihre verwendung als medikament sowie sie enthaltendes medikament |
| TW222637B (ru) * | 1991-12-12 | 1994-04-21 | Hoechst Ag | |
| ATE176476T1 (de) * | 1992-12-02 | 1999-02-15 | Hoechst Ag | Guanidinalkyl-1, 1-bisphosphonsäurederivate, verfahren zu ihrer herstellung und ihre verwendung |
-
1993
- 1993-11-25 AT AT93118992T patent/ATE176476T1/de not_active IP Right Cessation
- 1993-11-25 EP EP93118992A patent/EP0600371B1/de not_active Expired - Lifetime
- 1993-11-25 DE DE59309360T patent/DE59309360D1/de not_active Expired - Fee Related
- 1993-11-25 DK DK93118992T patent/DK0600371T3/da active
- 1993-11-25 ES ES93118992T patent/ES2129485T3/es not_active Expired - Lifetime
- 1993-11-30 FI FI935360A patent/FI108034B/fi not_active IP Right Cessation
- 1993-11-30 AU AU52040/93A patent/AU663983B2/en not_active Ceased
- 1993-11-30 US US08/159,119 patent/US5395826A/en not_active Expired - Fee Related
- 1993-11-30 NZ NZ250322A patent/NZ250322A/en unknown
- 1993-12-01 BR BR9304910A patent/BR9304910A/pt not_active Application Discontinuation
- 1993-12-01 JP JP30142893A patent/JP3499905B2/ja not_active Expired - Fee Related
- 1993-12-01 RU RU93054537A patent/RU2114855C1/ru not_active IP Right Cessation
- 1993-12-01 CA CA002110443A patent/CA2110443C/en not_active Expired - Fee Related
- 1993-12-02 KR KR1019930026202A patent/KR100347423B1/ko not_active IP Right Cessation
-
1994
- 1994-11-23 US US08/346,239 patent/US5498617A/en not_active Expired - Fee Related
-
1996
- 1996-03-01 US US08/609,473 patent/US5661174A/en not_active Expired - Fee Related
-
1999
- 1999-04-21 GR GR990401101T patent/GR3030020T3/el unknown
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