RU92004368A - SUBSTITUTED PYRIMIDINES, METHOD OF THEIR PRODUCTION, PHARMACEUTICAL COMPOSITION - Google Patents

SUBSTITUTED PYRIMIDINES, METHOD OF THEIR PRODUCTION, PHARMACEUTICAL COMPOSITION

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Publication number
RU92004368A
RU92004368A RU92004368/04A RU92004368A RU92004368A RU 92004368 A RU92004368 A RU 92004368A RU 92004368/04 A RU92004368/04 A RU 92004368/04A RU 92004368 A RU92004368 A RU 92004368A RU 92004368 A RU92004368 A RU 92004368A
Authority
RU
Russia
Prior art keywords
production
pharmaceutical composition
substituted pyrimidines
treatment
pyrimidines
Prior art date
Application number
RU92004368/04A
Other languages
Russian (ru)
Other versions
RU2113437C1 (en
Inventor
Ватсон Эллингвой Джон
Никайдо Маделен
Фрамрос Бажли Жак
Original Assignee
Американ Хоум Продактс Корпорейшн
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/782,025 external-priority patent/US5149699A/en
Application filed by Американ Хоум Продактс Корпорейшн filed Critical Американ Хоум Продактс Корпорейшн
Publication of RU92004368A publication Critical patent/RU92004368A/en
Application granted granted Critical
Publication of RU2113437C1 publication Critical patent/RU2113437C1/en

Links

Claims (1)

Предлагаемое изобретение относится к пирроло-, пиридо-, азепино- и азоцианопиримидинам общей формулы I
Figure 00000001

которые могут использоваться для лечения гипертензии или застойной сердечной недостаточности, а также для профилактики или лечения растеноза после пластических операций на сосудах.The present invention relates to pyrrolo, pyrido, azepino and azocyanopyrimidines of general formula I
Figure 00000001

which can be used for the treatment of hypertension or congestive heart failure, as well as for the prevention or treatment of planting after angioplasty.
RU92004368A 1991-10-24 1992-10-23 Substituted pyrimidines or their pharmaceutically acceptable salts, or n-oxides, methods of their synthesis and pharmaceutical composition based on thereof RU2113437C1 (en)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US782.025 1991-10-24
US07/782,025 US5149699A (en) 1991-10-24 1991-10-24 Substituted pyridopyrimidines useful as antgiotensin II antagonists
US782025 1991-10-24
GB9207560.5 1992-04-07
US901485 1992-06-25

Publications (2)

Publication Number Publication Date
RU92004368A true RU92004368A (en) 1995-03-27
RU2113437C1 RU2113437C1 (en) 1998-06-20

Family

ID=25124708

Family Applications (1)

Application Number Title Priority Date Filing Date
RU92004368A RU2113437C1 (en) 1991-10-24 1992-10-23 Substituted pyrimidines or their pharmaceutically acceptable salts, or n-oxides, methods of their synthesis and pharmaceutical composition based on thereof

Country Status (4)

Country Link
US (1) US5149699A (en)
PH (1) PH31071A (en)
RU (1) RU2113437C1 (en)
ZA (1) ZA927569B (en)

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AU1625192A (en) * 1991-05-31 1992-12-03 Zeneca Limited Heterocyclic derivatives
NZ243326A (en) * 1991-06-28 1995-10-26 Smithkline Beecham Corp Benzodiazepine, benzazepine; benzothiazepine and benzoxazepine derivatives; pharmaceutical compositions
US5939412A (en) * 1992-06-26 1999-08-17 Smithkline Beecham Corporation Bicyclic fibrinogen antagonists
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ES2203614T3 (en) * 1991-11-18 2004-04-16 E.I. Du Pont De Nemours And Company TETRAZOLILPHENILBORONIC ACID INTERMEDIATES FOR SYNTHESIS OF ANTAGONISTS OF AII RECEIVERS.
GB9125842D0 (en) * 1991-12-04 1992-02-05 Ici Plc Heterocyclic derivatives
FR2696746B1 (en) * 1992-10-12 1994-11-18 Synthelabo Benzeneborinic acid derivatives, their preparation and their use as synthesis intermediates.
FR2696745B1 (en) * 1992-10-12 1995-05-12 Synthelabo Process for the preparation of phenyltetrazole derivatives.
ATE175413T1 (en) * 1993-03-24 1999-01-15 American Home Prod SUBSTITUTED PYRIDOPYRIMIDINES AS ANTIHYPERTENSIVES
US5466692A (en) * 1993-03-24 1995-11-14 American Home Products Corporation Substituted pyridopyrimidines and antihypertensives
DE4314964A1 (en) * 1993-05-06 1994-11-10 Bayer Ag Pyridinylmethyl-substituted pyridines and pyridones
DE4316077A1 (en) * 1993-05-13 1994-11-17 Bayer Ag Substituted mono- and bihydridylmethylpyridones
MA23420A1 (en) * 1994-01-07 1995-10-01 Smithkline Beecham Corp BICYCLIC FIBRINOGEN ANTAGONISTS.
US6458784B1 (en) 1994-06-29 2002-10-01 Smithkline Beecham Corporation Vitronectin receptor antagonists
JPH11507625A (en) * 1995-06-07 1999-07-06 アメリカン・ホーム・プロダクツ・コーポレイション Method for producing biphenyl derivative
US5760220A (en) * 1995-06-07 1998-06-02 American Home Products Corporation Process for preparation of biphenyl derivatives
US5977101A (en) * 1995-06-29 1999-11-02 Smithkline Beecham Corporation Benzimidazoles/Imidazoles Linked to a Fibrinogen Receptor Antagonist Template Having Vitronectin Receptor Antagonist Activity
IT1292437B1 (en) 1997-06-30 1999-02-08 Zambon Spa ORTHO-METALLATION PROCESS USEFUL FOR THE SYNTHESIS OF 1 - TETRAZOL- 5-IL) 2-SUBSTITUTED BENZENES
US6638937B2 (en) 1998-07-06 2003-10-28 Bristol-Myers Squibb Co. Biphenyl sulfonamides as dual angiotensin endothelin receptor antagonists
AU2005286593A1 (en) * 2004-09-23 2006-03-30 Reddy Us Therapeutics, Inc. Novel pyridine compounds, process for their preparation and compositions containing them
US8969514B2 (en) 2007-06-04 2015-03-03 Synergy Pharmaceuticals, Inc. Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases
CA2688161C (en) 2007-06-04 2020-10-20 Kunwar Shailubhai Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
ES2522968T3 (en) 2008-06-04 2014-11-19 Synergy Pharmaceuticals Inc. Guanylate cyclase agonists useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders
ES2624828T3 (en) 2008-07-16 2017-07-17 Synergy Pharmaceuticals Inc. Guanylate cyclase agonists useful for the treatment of gastrointestinal disorders, inflammation, cancer and others
US9616097B2 (en) 2010-09-15 2017-04-11 Synergy Pharmaceuticals, Inc. Formulations of guanylate cyclase C agonists and methods of use
RU2478637C2 (en) * 2011-03-24 2013-04-10 Государственное образовательное учреждение высшего профессионального образования "Российский университет дружбы народов" (РУДН) METHOD FOR PREPARING 5,8,9,10-TETRAHYDROPYRIMIDINO[4,5-d]AZOCINE DERIVATIVES HAVING TRIFLATE, SECONDARY AND TERTIARY AMINO GROUPS IN 4-TH POSITION
EP2970384A1 (en) 2013-03-15 2016-01-20 Synergy Pharmaceuticals Inc. Agonists of guanylate cyclase and their uses
US9486494B2 (en) 2013-03-15 2016-11-08 Synergy Pharmaceuticals, Inc. Compositions useful for the treatment of gastrointestinal disorders
JP6606491B2 (en) 2013-06-05 2019-11-13 シナジー ファーマシューティカルズ インコーポレイテッド Ultra high purity agonist of guanylate cyclase C, method for producing and using the same

Family Cites Families (11)

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CA1334092C (en) * 1986-07-11 1995-01-24 David John Carini Angiotensin ii receptor blocking imidazoles
CA1338238C (en) * 1988-01-07 1996-04-09 David John Carini Angiotensin ii receptor blocking imidazoles and combinations thereof with diuretics and nsaids
US4880804A (en) * 1988-01-07 1989-11-14 E. I. Du Pont De Nemours And Company Angiotensin II receptor blocking benzimidazoles
US5015651A (en) * 1988-01-07 1991-05-14 E. I. Du Pont De Nemours And Company Treatment of hypertension with 1,2,4-angiotensin II antagonists
US4916129A (en) * 1989-01-19 1990-04-10 E. I. Du Pont De Nemours And Company Combination β-blocking/angiotensin II blocking antihypertensives
US5064825A (en) * 1989-06-01 1991-11-12 Merck & Co., Inc. Angiotensin ii antagonists
CA2020073A1 (en) * 1989-07-03 1991-01-04 Eric E. Allen Substituted quinazolinones as angiotensin ii antagonists
EP0412594B1 (en) * 1989-07-28 1996-01-03 Merck & Co. Inc. Substituted triazolinones, triazolinethiones, and triazolinimines as angiotensin II antagonists
DE69013607T2 (en) * 1989-08-02 1995-03-02 Takeda Chemical Industries Ltd Pyrazole derivatives, process for their preparation and use.
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US5039814A (en) * 1990-05-02 1991-08-13 Merck & Co., Inc. Ortho-lithiation process for the synthesis of 2-substituted 1-(tetrazol-5-yl)benzenes

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