RU2015118135A - Содержащие заместители бензольные соединения - Google Patents

Содержащие заместители бензольные соединения Download PDF

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RU2015118135A
RU2015118135A RU2015118135A RU2015118135A RU2015118135A RU 2015118135 A RU2015118135 A RU 2015118135A RU 2015118135 A RU2015118135 A RU 2015118135A RU 2015118135 A RU2015118135 A RU 2015118135A RU 2015118135 A RU2015118135 A RU 2015118135A
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compound
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pharmaceutically acceptable
cancer
ezh2
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Кевин Уэйн КУНТЦ
Джон Эммерсон КЭМПБЕЛЛ
Масаси СЕКИ
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Эпизайм, Инк.
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/44—Radicals substituted by doubly-bound oxygen, sulfur, or nitrogen atoms, or by two such atoms singly-bound to the same carbon atom
    • C07D213/46—Oxygen atoms
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    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/62—Oxygen or sulfur atoms
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    • C07D213/64—One oxygen atom attached in position 2 or 6
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
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    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Abstract

1. Соединение, выбранное из группы, состоящей изи их фармацевтически приемлемых солей.2. Соединение по п. 1, отличающееся тем, что указанное соединение представляет собойили его фармацевтически приемлемую соль.3. Соединение по п. 1, отличающееся тем, что указанное соединение представляет собой.4. Соединение по п. 1, отличающееся тем, что указанноесоединение представляет собойили его фармацевтически приемлемую соль.5. Соединение по п. 1, отличающееся тем, что указанное соединение представляет собой.6. Соединение по п. 1, отличающееся тем, что указанное соединение представляет собойили его фармацевтически приемлемую соль.7. Соединение по п. 1, отличающееся тем, что указанное соединение представляет собой.8. Фармацевтическая композиция, содержащая соединение по любому из пп. 1-7 и фармацевтически приемлемый носитель.9. Способ лечения EZH2-опосредуемого нарушения, включающий введение нуждающемуся в этом субъекту терапевтически эффективного количества соединения по любому из пп. 1-7.10. Способ по п. 9, отличающийся тем, что EZH2-опосредуемое нарушение представляет собой рак.11. Способ по п. 10, отличающийся тем, что рак представляет собой лимфому, лейкоз или меланому.12. Способ по п. 10, отличающийся тем, что рак представляет собой диффузную крупноклеточную В-клеточную лимфому (ДКВЛ), неходжкинскую лимфому (НХЛ), фолликулярную лимфому, хронический миелогенный лейкоз (ХМЛ), острый миелоидный лейкоз, острый лимфоцитарный лейкоз, недифференцированный лейкоз или миелодиспластические синдромы (МДС).13. Способ по п. 10, отличающийся тем, что рак представляет собой злокачественную рабдоидную опухоль или опухоль с дефицитом INI1.14. Соединение по любому из пп. 1-7 для применения в способе лечения

Claims (16)

1. Соединение, выбранное из группы, состоящей из
Figure 00000001
и их фармацевтически приемлемых солей.
2. Соединение по п. 1, отличающееся тем, что указанное соединение представляет собой
Figure 00000002
или его фармацевтически приемлемую соль.
3. Соединение по п. 1, отличающееся тем, что указанное соединение представляет собой
Figure 00000003
.
4. Соединение по п. 1, отличающееся тем, что указанное
соединение представляет собой
Figure 00000004
или его фармацевтически приемлемую соль.
5. Соединение по п. 1, отличающееся тем, что указанное соединение представляет собой
Figure 00000005
.
6. Соединение по п. 1, отличающееся тем, что указанное соединение представляет собой
Figure 00000006
или его фармацевтически приемлемую соль.
7. Соединение по п. 1, отличающееся тем, что указанное соединение представляет собой
Figure 00000007
.
8. Фармацевтическая композиция, содержащая соединение по любому из пп. 1-7 и фармацевтически приемлемый носитель.
9. Способ лечения EZH2-опосредуемого нарушения, включающий введение нуждающемуся в этом субъекту терапевтически эффективного количества соединения по любому из пп. 1-7.
10. Способ по п. 9, отличающийся тем, что EZH2-опосредуемое нарушение представляет собой рак.
11. Способ по п. 10, отличающийся тем, что рак представляет собой лимфому, лейкоз или меланому.
12. Способ по п. 10, отличающийся тем, что рак представляет собой диффузную крупноклеточную В-клеточную лимфому (ДКВЛ), неходжкинскую лимфому (НХЛ), фолликулярную лимфому, хронический миелогенный лейкоз (ХМЛ), острый миелоидный лейкоз, острый лимфоцитарный лейкоз, недифференцированный лейкоз или миелодиспластические синдромы (МДС).
13. Способ по п. 10, отличающийся тем, что рак представляет собой злокачественную рабдоидную опухоль или опухоль с дефицитом INI1.
14. Соединение по любому из пп. 1-7 для применения в способе лечения EZH2-опосредуемого нарушения.
15. Применение соединения по любому из пп. 1-7 для изготовления лекарственного средства для лечения EZH2-опосредуемого нарушения.
16. Фармацевтическая композиция для лечения EZH2-опосредуемого нарушения, содержащая соединение по любому из пп. 1-7 в качестве основного ингредиента.
RU2015118135A 2012-10-15 2013-10-15 Содержащие заместители бензольные соединения RU2662436C2 (ru)

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US201261714140P 2012-10-15 2012-10-15
US201261714145P 2012-10-15 2012-10-15
US61/714,140 2012-10-15
US61/714,145 2012-10-15
US201361780703P 2013-03-13 2013-03-13
US61/780,703 2013-03-13
US201361786277P 2013-03-14 2013-03-14
US61/786,277 2013-03-14
PCT/US2013/065126 WO2014062732A1 (en) 2012-10-15 2013-10-15 Substituted benzene compounds

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