ES2531396T3 - Proceso para preparar compuestos de piridinona - Google Patents
Proceso para preparar compuestos de piridinona Download PDFInfo
- Publication number
- ES2531396T3 ES2531396T3 ES09703743T ES09703743T ES2531396T3 ES 2531396 T3 ES2531396 T3 ES 2531396T3 ES 09703743 T ES09703743 T ES 09703743T ES 09703743 T ES09703743 T ES 09703743T ES 2531396 T3 ES2531396 T3 ES 2531396T3
- Authority
- ES
- Spain
- Prior art keywords
- formula
- compound
- haloalkyl
- halogen
- zero
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/04—Antineoplastic agents specific for metastasis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/62—Oxygen or sulfur atoms
- C07D213/63—One oxygen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Pyridine Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
Un proceso para preparar un compuesto de Fórmula (I):**Fórmula** que comprende las etapas de: (a) hacer reaccionar un compuesto de ácido carboxílico de Fórmula (III):**Fórmula** o un compuesto de ácido carboxílico activado del mismo, y un compuesto de anilina de Fórmula (II):**Fórmula** en la que PAm es un grupo amino protegido, seleccionado entre iminas, alquilaminas, arilaminas, carbamatos, amidas, imidas, bencilaminas, alilaminas, sililaminas, fosfonamidas, sulfonamidas y triazinanonas, para proporcionar un compuesto de Fórmula (IV):**Fórmula** y (b) convertir dicho grupo amino protegido unido a dicho compuesto de Fórmula (IV) en un grupo amino para proporcionar dicho compuesto de Fórmula (I);**Fórmula** en la que: Gis**Fórmula** cada R1 es independientemente alquilo, haloalquilo, halógeno o CN; cada R2 es independientemente alquilo, haloalquilo, halógeno o CN; R3 es fenilo sustituido con alquilo, haloalquilo, halógeno o CN; cada R4 es independientemente alquilo, haloalquilo, alcoxi, halógeno o CN; m es cero, 1, 2, 3 o 4; n es cero, 1, 2 o 3; p es cero, 1 o 2; y q es cero, 1, 2 o 3.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US2284808P | 2008-01-23 | 2008-01-23 | |
US12193108P | 2008-12-12 | 2008-12-12 | |
PCT/US2009/031665 WO2009094427A1 (en) | 2008-01-23 | 2009-01-22 | 4-pyridinone compounds and their use for cancer |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2531396T3 true ES2531396T3 (es) | 2015-03-13 |
Family
ID=40668147
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES09703743T Active ES2531396T3 (es) | 2008-01-23 | 2009-01-22 | Proceso para preparar compuestos de piridinona |
Country Status (7)
Country | Link |
---|---|
US (2) | US8558000B2 (es) |
EP (1) | EP2235001B1 (es) |
JP (1) | JP5693239B2 (es) |
KR (1) | KR101608096B1 (es) |
CN (1) | CN101977905B (es) |
ES (1) | ES2531396T3 (es) |
WO (1) | WO2009094427A1 (es) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2398335T3 (es) | 2008-01-23 | 2013-03-15 | Bristol-Myers Squibb Company | Compuestos de 4-piridinona y su uso para el cáncer |
CN102099036B (zh) | 2008-06-03 | 2015-05-27 | 英特芒尼公司 | 用于治疗炎性疾患和纤维化疾患的化合物和方法 |
CA2800998A1 (en) | 2010-04-29 | 2011-11-10 | Deciphera Pharmaceuticals, Llc | Pyridone amides and analogs exhibiting anti-cancer and anti-proliferative activities |
CN102971296B (zh) | 2010-04-30 | 2015-11-25 | 百时美施贵宝公司 | 包含n-(4-(2-氨基-3-氯吡啶-4-基氧基)-3-氟苯基)-4-乙氧基-1-(4-氟苯基)-2-氧代-1,2-二氢吡啶-3-羧酰胺的药物组合物 |
JO3438B1 (ar) | 2011-04-13 | 2019-10-20 | Epizyme Inc | مركبات بنزين مستبدلة بأريل أو أريل غير متجانس |
TWI598336B (zh) * | 2011-04-13 | 2017-09-11 | 雅酶股份有限公司 | 經取代之苯化合物 |
CN104302292A (zh) | 2011-11-22 | 2015-01-21 | 德西费拉制药有限责任公司 | 表现出抗癌和抗增殖活性的吡啶酮酰胺以及类似物 |
TWI537259B (zh) | 2012-01-31 | 2016-06-11 | 第一三共股份有限公司 | 吡啶酮衍生物 |
US8975282B2 (en) | 2012-07-28 | 2015-03-10 | Sunshine Lake Pharma Co., Ltd. | Substituted pyrazolone compounds and methods of use |
RU2650895C2 (ru) | 2012-07-28 | 2018-04-18 | Саншайн Лейк Фарма Ко., Лтд. | Соединения замещенных пиразолонов и способы использования |
AR092742A1 (es) | 2012-10-02 | 2015-04-29 | Intermune Inc | Piridinonas antifibroticas |
WO2014062733A2 (en) | 2012-10-15 | 2014-04-24 | Epizyme, Inc. | Substituted benzene compounds |
CA2943363A1 (en) | 2014-04-02 | 2015-10-08 | Intermune, Inc. | Anti-fibrotic pyridinones |
TWI723572B (zh) | 2014-07-07 | 2021-04-01 | 日商第一三共股份有限公司 | 具有四氫吡喃基甲基之吡啶酮衍生物及其用途 |
CN105153026B (zh) * | 2015-08-21 | 2018-02-02 | 江西科技师范大学 | 含联芳基酰胺结构的索拉非尼衍生物及其制备方法和应用 |
CN105924389A (zh) * | 2015-12-18 | 2016-09-07 | 重庆两江药物研发中心有限公司 | 瑞戈非尼中间体的制备方法 |
WO2019186429A1 (en) * | 2018-03-30 | 2019-10-03 | Sun Pharmaceutical Industries Limited | A process for the preparation of bosutinib |
CN110330479A (zh) * | 2019-07-19 | 2019-10-15 | 南京华威医药科技集团有限公司 | 一种用作axl抑制剂的抗肿瘤化合物及其用途 |
Family Cites Families (41)
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US3646202A (en) | 1967-11-22 | 1972-02-29 | Merck & Co Inc | Liver fluke compositions containing salicylic acid derivatives |
US4547218A (en) | 1982-10-18 | 1985-10-15 | The Dow Chemical Company | Certain 3-nitro-6-phenoxy-2-pyridyl-oxy-propionates having herbicidal activity |
GB8925368D0 (en) * | 1989-11-09 | 1989-12-28 | Oppolzer Wolfgang | Process for preparing enatiomerically pure alpha-amino acids |
ZA988967B (en) | 1997-10-03 | 2000-04-03 | Du Pont Pharm Co | Lactam metalloprotease inhibitors. |
US6121471A (en) | 1997-12-22 | 2000-09-19 | Eli Lilly And Company | Catalyst and method for amide formation |
WO1999065867A1 (en) | 1998-06-17 | 1999-12-23 | Du Pont Pharmaceuticals Company | Cyclic hydroxamic acids as metalloproteinase inhibitors |
RU2264389C3 (ru) | 2000-10-20 | 2018-06-01 | Эйсай Ар Энд Ди Менеджмент Ко., Лтд. | Азотсодержащие ароматические производные, их применение, лекарственное средство на их основе и способ лечения |
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EP1344525A4 (en) | 2000-12-22 | 2005-05-25 | Ishihara Sangyo Kaisha | ANILINE DERIVATIVES OR ITS SALTS AND CYTOKINE PRODUCTION INHIBITORS CONTAINING THEM |
AU2002344567A1 (en) | 2001-11-28 | 2003-06-10 | Daiso Co., Ltd. | Heterocyclic amide compounds as apolipoprotein b inhibitors |
FR2836915B1 (fr) | 2002-03-11 | 2008-01-11 | Aventis Pharma Sa | Derives d'aminoindazoles, procede de preparation et intermediaires de ce procede a titre de medicaments et compositions pharmaceutiques les renfermant |
US6806221B2 (en) | 2002-07-15 | 2004-10-19 | Dow Global Technologies Inc. | Method for preparing a spray-dried composition for use as a polymerization catalyst |
CA2531856C (en) | 2003-07-11 | 2013-07-30 | Merck Patent Gesellschaft Mit Beschraenkter Haftung | Benzimidazole carboxamides as raf kinase inhibitors |
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-
2009
- 2009-01-22 ES ES09703743T patent/ES2531396T3/es active Active
- 2009-01-22 US US12/863,713 patent/US8558000B2/en active Active
- 2009-01-22 KR KR1020107018581A patent/KR101608096B1/ko active IP Right Grant
- 2009-01-22 CN CN200980110025.4A patent/CN101977905B/zh active Active
- 2009-01-22 WO PCT/US2009/031665 patent/WO2009094427A1/en active Application Filing
- 2009-01-22 EP EP09703743.6A patent/EP2235001B1/en active Active
- 2009-01-22 JP JP2010544406A patent/JP5693239B2/ja active Active
-
2013
- 2013-09-13 US US14/026,628 patent/US8754230B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
CN101977905B (zh) | 2014-07-02 |
KR101608096B1 (ko) | 2016-03-31 |
CN101977905A (zh) | 2011-02-16 |
US8558000B2 (en) | 2013-10-15 |
US8754230B2 (en) | 2014-06-17 |
EP2235001A1 (en) | 2010-10-06 |
US20110295015A1 (en) | 2011-12-01 |
WO2009094427A1 (en) | 2009-07-30 |
US20140012007A1 (en) | 2014-01-09 |
JP2011510089A (ja) | 2011-03-31 |
KR20100118581A (ko) | 2010-11-05 |
JP5693239B2 (ja) | 2015-04-01 |
EP2235001B1 (en) | 2014-12-24 |
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