RU2009129000A - Способы применения аналогов циклопамина - Google Patents
Способы применения аналогов циклопамина Download PDFInfo
- Publication number
- RU2009129000A RU2009129000A RU2009129000/21A RU2009129000A RU2009129000A RU 2009129000 A RU2009129000 A RU 2009129000A RU 2009129000/21 A RU2009129000/21 A RU 2009129000/21A RU 2009129000 A RU2009129000 A RU 2009129000A RU 2009129000 A RU2009129000 A RU 2009129000A
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- RU
- Russia
- Prior art keywords
- alkyl
- alkynyl
- alkenyl
- independently
- hydroxyl
- Prior art date
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- QASFUMOKHFSJGL-LAFRSMQTSA-N Cyclopamine Chemical class C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H](CC2=C3C)[C@@H]1[C@@H]2CC[C@@]13O[C@@H]2C[C@H](C)CN[C@H]2[C@H]1C QASFUMOKHFSJGL-LAFRSMQTSA-N 0.000 title 1
- 125000000217 alkyl group Chemical group 0.000 claims abstract 30
- 125000003342 alkenyl group Chemical group 0.000 claims abstract 25
- 125000000304 alkynyl group Chemical group 0.000 claims abstract 25
- 125000003118 aryl group Chemical group 0.000 claims abstract 20
- 125000000753 cycloalkyl group Chemical group 0.000 claims abstract 20
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract 20
- 150000001875 compounds Chemical class 0.000 claims abstract 16
- 125000003710 aryl alkyl group Chemical group 0.000 claims abstract 15
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims abstract 15
- 125000004475 heteroaralkyl group Chemical group 0.000 claims abstract 10
- 125000001072 heteroaryl group Chemical group 0.000 claims abstract 10
- -1 —OR Chemical group 0.000 claims abstract 10
- 150000003839 salts Chemical class 0.000 claims abstract 8
- 239000003814 drug Substances 0.000 claims abstract 5
- 125000001188 haloalkyl group Chemical group 0.000 claims abstract 5
- 229910052736 halogen Inorganic materials 0.000 claims abstract 5
- 125000005842 heteroatom Chemical group 0.000 claims abstract 5
- 238000004519 manufacturing process Methods 0.000 claims abstract 5
- 150000002825 nitriles Chemical class 0.000 claims abstract 5
- 125000004433 nitrogen atom Chemical group N* 0.000 claims abstract 5
- 229910052760 oxygen Inorganic materials 0.000 claims abstract 5
- 125000004430 oxygen atom Chemical group O* 0.000 claims abstract 5
- 125000004437 phosphorous atom Chemical group 0.000 claims abstract 5
- 125000001424 substituent group Chemical group 0.000 claims abstract 5
- 229910052717 sulfur Inorganic materials 0.000 claims abstract 5
- 125000004434 sulfur atom Chemical group 0.000 claims abstract 5
- 230000003463 hyperproliferative effect Effects 0.000 claims abstract 2
- 125000005843 halogen group Chemical group 0.000 claims 4
- 206010028980 Neoplasm Diseases 0.000 claims 3
- 125000005420 sulfonamido group Chemical group S(=O)(=O)(N*)* 0.000 claims 3
- 208000003174 Brain Neoplasms Diseases 0.000 claims 2
- 230000003042 antagnostic effect Effects 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 230000008410 smoothened signaling pathway Effects 0.000 claims 2
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 208000017604 Hodgkin disease Diseases 0.000 claims 1
- 208000010747 Hodgkins lymphoma Diseases 0.000 claims 1
- 208000000172 Medulloblastoma Diseases 0.000 claims 1
- 208000034578 Multiple myelomas Diseases 0.000 claims 1
- 201000003793 Myelodysplastic syndrome Diseases 0.000 claims 1
- 208000015914 Non-Hodgkin lymphomas Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 1
- 208000000453 Skin Neoplasms Diseases 0.000 claims 1
- 206010041067 Small cell lung cancer Diseases 0.000 claims 1
- 208000008385 Urogenital Neoplasms Diseases 0.000 claims 1
- 210000003169 central nervous system Anatomy 0.000 claims 1
- 210000001035 gastrointestinal tract Anatomy 0.000 claims 1
- 230000009459 hedgehog signaling Effects 0.000 claims 1
- 210000000777 hematopoietic system Anatomy 0.000 claims 1
- 206010073071 hepatocellular carcinoma Diseases 0.000 claims 1
- 208000032839 leukemia Diseases 0.000 claims 1
- 208000014018 liver neoplasm Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
- 230000002685 pulmonary effect Effects 0.000 claims 1
- 208000000587 small cell lung carcinoma Diseases 0.000 claims 1
- 150000002367 halogens Chemical class 0.000 abstract 1
Classifications
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/4747—Quinolines; Isoquinolines spiro-condensed
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- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4355—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having oxygen as a ring hetero atom
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- A61K31/19—Carboxylic acids, e.g. valproic acid
- A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
- A61K31/196—Carboxylic acids, e.g. valproic acid having an amino group the amino group being directly attached to a ring, e.g. anthranilic acid, mefenamic acid, diclofenac, chlorambucil
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- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A61K31/4523—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems
- A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
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- A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
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- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
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- C07J69/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton has been modified by contraction of only one ring by one atom and expansion of only one ring by one atom
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Abstract
1. Применение соединения формулы (1) или его фармацевтически приемлемой соли для получения лекарственного средства для лечения гиперпролиферативного нарушения, где соединение формулы (1) имеет формулу: ! ! где R1 является H, алкилом, -OR, амино, сульфонамидо, сульфамидо, -OC(O)R5, -N(R5)C(O)R5 или сахаром; ! R2 представляет собой H, алкил, алкенил, алкинил, арил, циклоалкил, нитрил или гетероциклоалкил; ! или R1 и R2 вместе образуют =O, =S, =N(OR), =N(R), =N(NR2) или =C(R)2; ! R3 является H, алкилом, алкенилом или алкинилом; ! R4 представляет собой H, алкил, алкенил, алкинил, арил, циклоалкил, гетероциклоалкил, аралкил, гетероарил, гетероаралкил, галогеналкил, -OR5, -C(O)R5, -CO2R5, -SO2R5, -C(O)N(R5)(R5), -[C(R)2]q-R5, -[(W)-N(R)C(O)]qR5, -[(W)-C(O)]qR5, -[(W)-C(O)O]q R5, -[(W)-OC(O)]qR5, -[(W)-SO2]qR5, -[(W)-N(R5)SO2]qR5, -[(W)-C(O)N(R5)]qR5, -[(W)-O]qR5, -[(W)-N(R)]qR5, -W-NR5 3 +X- или -[(W)-S]qR5; ! где каждый W независимо является бирадикалом; ! каждый q в каждом случае независимо принимает значения 1, 2, 3, 4, 5 или 6; ! X- является галоидом; ! каждый R независимо является H, алкилом, алкенилом, алкинилом, арилом, циклоалкилом или аралкилом; ! каждый R5 независимо представляет собой H, алкил, алкенил, алкинил, арил, циклоалкил, гетероциклоалкил, аралкил, гетероарил, гетероаралкил или -[C(R)2]P-R6; где p принимает значение от 0 до 6; или любые два R5, находящиеся у одного заместителя, вместе могут образовывать необязательно замещенное 4-8-членное кольцо, которое содержит от 0 до 3 гетероатомов, выбираемых из атомов N, O, S и P; и ! каждый R6 независимо является гидроксилом, -N(R)COR, -N(R)C(O)OR, -N(R)SO2(R), -C(O)N(R)2 -OC(O)N(R)(R), -SO2N(R)(R), -N(R)(R), -COOR, -C(O)N(OH)(R), -OS(О)2OR, -S(О)2OR, -OP(O)(OR)(OR), -NP(O)(OR)(OR) или -P(O)(OR)(OR). ! 2. Применение по п.1, где, когда R2, R3 и R4 являются H, R1 не является гидроксилом или сахаром; и ! когда R4 является гидроксило
Claims (21)
1. Применение соединения формулы (1) или его фармацевтически приемлемой соли для получения лекарственного средства для лечения гиперпролиферативного нарушения, где соединение формулы (1) имеет формулу:
где R1 является H, алкилом, -OR, амино, сульфонамидо, сульфамидо, -OC(O)R5, -N(R5)C(O)R5 или сахаром;
R2 представляет собой H, алкил, алкенил, алкинил, арил, циклоалкил, нитрил или гетероциклоалкил;
или R1 и R2 вместе образуют =O, =S, =N(OR), =N(R), =N(NR2) или =C(R)2;
R3 является H, алкилом, алкенилом или алкинилом;
R4 представляет собой H, алкил, алкенил, алкинил, арил, циклоалкил, гетероциклоалкил, аралкил, гетероарил, гетероаралкил, галогеналкил, -OR5, -C(O)R5, -CO2R5, -SO2R5, -C(O)N(R5)(R5), -[C(R)2]q-R5, -[(W)-N(R)C(O)]qR5, -[(W)-C(O)]qR5, -[(W)-C(O)O]q R5, -[(W)-OC(O)]qR5, -[(W)-SO2]qR5, -[(W)-N(R5)SO2]qR5, -[(W)-C(O)N(R5)]qR5, -[(W)-O]qR5, -[(W)-N(R)]qR5, -W-NR5 3 +X- или -[(W)-S]qR5;
где каждый W независимо является бирадикалом;
каждый q в каждом случае независимо принимает значения 1, 2, 3, 4, 5 или 6;
X- является галоидом;
каждый R независимо является H, алкилом, алкенилом, алкинилом, арилом, циклоалкилом или аралкилом;
каждый R5 независимо представляет собой H, алкил, алкенил, алкинил, арил, циклоалкил, гетероциклоалкил, аралкил, гетероарил, гетероаралкил или -[C(R)2]P-R6; где p принимает значение от 0 до 6; или любые два R5, находящиеся у одного заместителя, вместе могут образовывать необязательно замещенное 4-8-членное кольцо, которое содержит от 0 до 3 гетероатомов, выбираемых из атомов N, O, S и P; и
каждый R6 независимо является гидроксилом, -N(R)COR, -N(R)C(O)OR, -N(R)SO2(R), -C(O)N(R)2 -OC(O)N(R)(R), -SO2N(R)(R), -N(R)(R), -COOR, -C(O)N(OH)(R), -OS(О)2OR, -S(О)2OR, -OP(O)(OR)(OR), -NP(O)(OR)(OR) или -P(O)(OR)(OR).
2. Применение по п.1, где, когда R2, R3 и R4 являются H, R1 не является гидроксилом или сахаром; и
когда R4 является гидроксилом, тогда R1 не является сахаром или гидроксилом; и
когда R4 является гидроксилом, тогда R1 и R2 вместе не являются C=O.
3. Применение по п.1, где R1 представляет собой сульфонамидо.
4. Применение по любому из пп.1-3, где нарушение выбирают из группы, состоящей из раков кожи, раков центральной нервной системы, раков желудочно-кишечного тракта, раков легочной системы, мочеполовых раков, рака молочной железы, гепатоцеллюлярного рака, раков мозга и раков кроветворной системы.
5. Применение соединения формулы (1) или его фармацевтически приемлемой соли для получения лекарственного средства для лечения состояния, опосредуемого сигнальным путем hedgehog, где соединение формулы (1) имеет формулу:
где R1 представляет собой H, алкил, -OR, амино, сульфонамидо, сульфамидо, -OC(O)R5, -N(R5)C(O)R5 или сахар;
R2 представляет собой H, алкил, алкенил, алкинил, арил, циклоалкил, нитрил или гетероциклоалкил;
или R1 и R2 вместе образуют =O, =S, =N(OR), =N(R), =N(NR2), =C(R)2;
R3 является H, алкилом, алкенилом или алкинилом;
R4 представляет собой H, алкил, алкенил, алкинил, арил, циклоалкил, гетероциклоалкил, аралкил, гетероарил, гетероаралкил, галогеналкил, -OR5, -C(O)R5, -CO2R5, -SO2R5, -C(O)N(R5)(R5), -[C(R)2]q-R5, -[(W)-N(R)C(O)]qR5, -[(W)-C(O)]qR5, -[(W)-C(O)O]qR5, -[(W)-OC(O)]qR5, -[(W)-SO2]qR5, -[(W)-N(R5)SO2]qR5, -[(W)-C(O)N(R5)]qR5, -[(W)-O]qR5, -[(W)-N(R)]qR5, -W-NR5 3 +X- или -[(W)-S]qR5;
где каждый W независимо в каждом случае является бирадикалом;
каждый q независимо в каждом случае принимает значения 1, 2, 3, 4, 5 или 6;
X- является галоидом;
каждый R независимо является H, алкилом, алкенилом, алкинилом, арилом, циклоалкилом или аралкилом;
каждый R5 независимо в каждом случае представляет собой H, алкил, алкенил, алкинил, арил, циклоалкил, гетероциклоалкил, аралкил, гетероарил, гетероаралкил или -[C(R)2]P-R6; где p принимает значения от 0 до 6; или любые два R5, находящиеся у одного заместителя, вместе могут образовывать необязательно замещенное 4-8-членное кольцо, которое содержит от 0 до 3 гетероатомов, выбираемых из атомов N, O, S и P; и
каждый R6 независимо является гидроксилом, -N(R)COR, -N(R)C(O)OR, -N(R)SO2(R), -C(O)N(R)2, -OC(O)N(R)(R), -SO2N(R)(R), -N(R)(R), -COOR, -C(O)N(OH)(R), -OS(О)2OR, -S(О)2OR, -OP(O)(OR)(OR), -NP(O)(OR)(OR) или -P(O)(OR)(OR).
6. Применение по п.5, где, когда R2, R3 и R4 являются H; R1 не является гидроксилом или сахаром; и
когда R4 является гидроксилом, тогда R1 не является сахаром или гидроксилом; и
когда R4 является гидроксилом, тогда R1 и R2 вместе не являются C=O.
7. Применение по п.5, где R1 представляет собой сульфонамидо.
8. Применение по п.5, где состояние представляет собой мелкоклеточный рак легких.
9. Применение по п.5, где состояние представляет собой рак поджелудочной железы.
10. Применение по п.5, где состояние представляет собой медуллобластому.
11. Применение по п.5, где состояние выбирают из группы, состоящей из множественной миеломы, лейкоза, миелодиспластического синдрома, неходжкинской лимфомы и болезни Ходжкина.
12. Применение по любому из пп.5-7, где соединение вводят перорально.
13. Применение по любому из пп.5-7, где соединение вводят внутривенно.
14. Применение по любому из пп.5-7, где соединение вводят местно.
15. Применение соединения формулы (1) или его фармацевтически приемлемой соли для получения лекарственного средства для антагонизации сигнального пути hedgehog у пациента, где соединение формулы (1) имеет структуру:
где R1 представляет собой H, алкил, -OR, амино, сульфонамидо, сульфамидо, -OC(O)R5, -N(R5)C(O)R5 или сахар;
R2 представляет собой H, алкил, алкенил, алкинил, арил, циклоалкил, нитрил или гетероциклоалкил;
или R1 и R2 вместе образуют =O, =S, =N(OR), =N(R), =N(NR2), =C(R)2;
R3 является H, алкилом, алкенилом или алкинилом;
R4 представляет собой H, алкил, алкенил, алкинил, арил, циклоалкил, гетероциклоалкил, аралкил, гетероарил, гетероаралкил, галогеналкил, -OR5, -C(O)R5, -CO2R5, -SO2R5, -C(O)N(R5)(R5), -[C(R)2]q-R5, -[(W)-N(R)C(O)]qR5, -[(W)-C(O)]qR5, -[(W)-C(O)O]qR5, -[(W)-OC(O)]qR5, -[(W)-SO2]qR5, -[(W)-N(R5)SO2]qR5, -[(W)-C(O)N(R5)]qR5, -[(W)-O]qR5, -[(W)-N(R)]qR5, -W-NR5 3 +X- или -[(W)-S]qR5;
где каждый W независимо в каждом случае является бирадикалом;
каждый q независимо в каждом случае принимает значения 1, 2, 3, 4, 5 или 6;
X- является галоидом;
каждый R независимо является H, алкилом, алкенилом, алкинилом, арилом, циклоалкилом или аралкилом;
каждый R5 независимо в каждом случае является H, алкилом, алкенилом, алкинилом, арилом, циклоалкилом, гетероциклоалкилом, аралкилом, гетероарилом, гетероаралкилом или -[C(R)2]P-R ; где p принимает значения от 0 до 6; или любые два R5, находящиеся у одного заместителя, в каждом случае могут вместе образовывать необязательно замещенное 4-8-членное кольцо, которое содержит от 0 до 3 гетероатомов, выбираемых из атомов N, O, S и P; и
каждый R6 независимо является гидроксилом, -N(R)COR, -N(R)C(O)OR, -N(R)SO2(R), -C(O)N(R)2, -OC(O)N(R)(R), -SO2N(R)(R), -N(R)(R), -COOR, -C(O)N(OH)(R), -OS(О)2OR, -S(О)2OR, -OP(O)(OR)(OR), -NP(O)(OR)(OR) или -P(O)(OR)(OR).
16. Применение по п.15, где, когда R2, R3 и R4 являются H, R1 не является гидроксилом или сахаром; и
когда R4 является гидроксилом, тогда R1 не является сахаром или гидроксилом; и
когда R4 является гидроксилом, тогда R1 и R2 вместе не образуют C=O
20. Применение соединения формулы (2) или его фармацевтически приемлемой соли для получения лекарственного средства для антагонизации сигнального пути hedgehog у пациента, где соединение формулы (2) имеет структуру:
где R1 является H, алкилом, -OR, амино, сульфонамидо, сульфамидо, -OC(O)R5, -N(R5)C(O)R5 или сахаром;
R2 является H, алкилом, алкенилом, алкинилом, арилом, циклоалкилом, нитрилом или гетероциклоалкилом;
или R1 и R2 вместе образуют =O, =S, =N(OR),=N(R)-, =N(NR2), =C(R)2;
R3 является H, алкилом, алкенилом или алкинилом;
R4 является H, алкилом, алкенилом, алкинилом, арилом, циклоалкилом, гетероциклоалкилом, аралкилом, гетероарилом, гетероаралкилом, галогеналкилом, -OR5, -C(O)R5, -CO2R5, -SO2R5, -C(O)N(R5)(R5), -[C(R)2]q-R5, -[(W)-N(R)C(O)]qR5, -[(W)-C(O)]qR5, -[(W)-C(O)O]qR5, -[(W)-OC(O)]qR5, -[(W)-SO2]qR5, -[(W)-N(R5)SO2]qR5, -[(W)-C(O)N(R5)]qR5, -[(W)-O]qR5, -[(W)-N(R)]qR5, -W-NR5 3 +X-, или -[(W)-S]qR5;
где каждый W независимо является бирадикалом;
каждый q независимо принимает значения 1, 2, 3, 4, 5 или 6;
X- является галоидом;
каждый R5 независимо представляет собой, H, алкил, алкенил, алкинил, арил, циклоалкил, гетероциклоалкил, аралкил, гетероарил, гетероаралкил или -[C(R)2]P-R6; где p принимает значения от 0 до 6; или любые два R5 у одного заместителя вместе могут образовывать необязательно замещенное 4-8-членное кольцо, которое содержит 0-3 гетероатома выбираемых из атомов N, O, S и P;
каждый R6 независимо является гидроксилом, -N(R)COR, -N(R)C(O)OR, -N(R)SO2(R), -C(O)N(R)2, -OC(O)N(R)(R), -SO2N(R)(R), -N(R)(R), -COOR, -C(O)N(OH)(R), -OS(О)2OR, -S(О)2OR, -OP(O)(OR)(OR), -NP(O)(OR)(OR) или -P(O)(OR)(OR);
где каждый R независимо является H, алкилом, алкенилом, алкинилом, арилом, циклоалкилом или аралкилом;
каждый из R7 и R7' является H; или R7 и R7' вместе образуют =O;
R8 и R9 являются H, или R8 и R9 вместе образуют связь; и
при условии, что, когда R3, R4, R8, R9 являются H, и R7 и R7' вместе образуют =O; R1 не может быть гидроксилом, а R2 не может быть H;
при условии, что, когда R3, R4, R8, R9 являются H, и R7 и R7' вместе образуют =O, R1 не может быть ацетатом и R2 не может быть H;
при условии, что, когда R3, R4, R8, R9 являются H, и R7 является H2, R1 и R2 вместе не могут быть =O; и
при условии, что, когда R3, R4, R8, R9 являются H, и R7 и R7' являются H, R1 и R2 не могут представлять собой H.
21. Применение по п.20, где R1 является сульфонамидо.
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Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU2005280112B2 (en) | 2004-08-27 | 2012-07-19 | Infinity Pharmaceuticals, Inc. | Cyclopamine analogues and methods of use thereof |
TWI433674B (zh) | 2006-12-28 | 2014-04-11 | Infinity Discovery Inc | 環杷明(cyclopamine)類似物類 |
WO2008109184A1 (en) * | 2007-03-07 | 2008-09-12 | Infinity Pharmaceuticals, Inc. | Heterocyclic cyclopamine analogs and methods of use thereof |
AU2008222655B2 (en) | 2007-03-07 | 2014-03-27 | Infinity Pharmaceuticals, Inc. | Cyclopamine lactam analogs and methods of use thereof |
US20100222287A1 (en) * | 2007-12-27 | 2010-09-02 | Mcgovern Karen J | Therapeutic Cancer Treatments |
US8716479B2 (en) | 2007-12-27 | 2014-05-06 | Infinity Pharmaceuticals, Inc. | Methods for stereoselective reduction |
US20100297118A1 (en) * | 2007-12-27 | 2010-11-25 | Macdougall John | Therapeutic Cancer Treatments |
AR070047A1 (es) * | 2007-12-27 | 2010-03-10 | Infinity Pharmaceuticals Inc | Tratamientos terapeuticos contra el cancer. composicion que comprende un inhibidor de hedgehog. |
US8193182B2 (en) | 2008-01-04 | 2012-06-05 | Intellikine, Inc. | Substituted isoquinolin-1(2H)-ones, and methods of use thereof |
WO2009099625A2 (en) * | 2008-02-08 | 2009-08-13 | The Board Of Regents Of The University Of Texas System | Cyclopamine tartrate salt and uses thereof |
US20110275576A1 (en) * | 2009-01-06 | 2011-11-10 | Utah State University | Carbohydrate-Cyclopamine Conjugates as Anticancer Agents |
JP2012515792A (ja) * | 2009-01-23 | 2012-07-12 | キャンサー・リサーチ・テクノロジー・リミテッド | ヘッジホッグ経路阻害剤 |
CN102574791A (zh) * | 2009-08-05 | 2012-07-11 | 无限药品股份有限公司 | 环杷明类似物的酶促转氨基反应 |
US20110065645A1 (en) * | 2009-09-10 | 2011-03-17 | The Regents Of The University Of California | Compositions and Methods for Modulating Neuron Degeneration and Neuron Guidance |
US20110135739A1 (en) * | 2009-11-06 | 2011-06-09 | Bennett Carter | Oral Formulations of a Hedgehog Pathway Inhibitor |
CA2781300A1 (en) * | 2009-11-20 | 2011-05-26 | Infinity Pharmaceuticals, Inc. | Methods and compositions for treating hedgehog-associated cancers |
WO2011088404A1 (en) * | 2010-01-15 | 2011-07-21 | Infinity Pharmaceuticals , Inc | Treatment of fibrotic conditions using hedgehog inhibitors |
WO2011146882A1 (en) | 2010-05-21 | 2011-11-24 | Intellikine, Inc. | Chemical compounds, compositions and methods for kinase modulation |
WO2012037217A1 (en) | 2010-09-14 | 2012-03-22 | Infinity Pharmaceuticals, Inc. | Transfer hydrogenation of cyclopamine analogs |
CA2817577A1 (en) | 2010-11-10 | 2012-05-18 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
KR101875720B1 (ko) | 2011-01-10 | 2018-07-09 | 인피니티 파마슈티칼스, 인코포레이티드 | 이소퀴놀린온 및 이의 고체 형태의 제조 방법 |
KR20140063605A (ko) | 2011-07-19 | 2014-05-27 | 인피니티 파마슈티칼스, 인코포레이티드 | 헤테로사이클릭 화합물 및 그의 용도 |
JP6027610B2 (ja) | 2011-07-19 | 2016-11-16 | インフィニティー ファーマシューティカルズ, インコーポレイテッド | 複素環式化合物及びその使用 |
AR091790A1 (es) | 2011-08-29 | 2015-03-04 | Infinity Pharmaceuticals Inc | Derivados de isoquinolin-1-ona y sus usos |
CA2752008A1 (en) * | 2011-09-13 | 2013-03-13 | Universite De Montreal | Combination therapy using ribavirin as elf4e inhibitor |
WO2013049332A1 (en) | 2011-09-29 | 2013-04-04 | Infinity Pharmaceuticals, Inc. | Inhibitors of monoacylglycerol lipase and methods of their use |
US9301920B2 (en) | 2012-06-18 | 2016-04-05 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
HRP20211377T1 (hr) | 2011-11-23 | 2022-01-07 | Therapeuticsmd, Inc. | Prirodne kombinirane hormonske supstitucijske formulacije i terapije |
MX359210B (es) | 2012-03-06 | 2018-09-19 | Univ Illinois | Composición de combinación de pac-1 y tamoxifeno. |
US8940742B2 (en) | 2012-04-10 | 2015-01-27 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
US10806697B2 (en) | 2012-12-21 | 2020-10-20 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US20150196640A1 (en) | 2012-06-18 | 2015-07-16 | Therapeuticsmd, Inc. | Progesterone formulations having a desirable pk profile |
US10806740B2 (en) | 2012-06-18 | 2020-10-20 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
US20130338122A1 (en) | 2012-06-18 | 2013-12-19 | Therapeuticsmd, Inc. | Transdermal hormone replacement therapies |
HUE033583T2 (hu) | 2012-06-21 | 2017-12-28 | Eisai R&D Man Co Ltd | Új indánszulfamid származékok |
LT2914296T (lt) | 2012-11-01 | 2018-09-25 | Infinity Pharmaceuticals, Inc. | Vėžio gydymas, panaudojant p13 kinazės izoformos moduliatorius |
EP2925363A4 (en) | 2012-11-29 | 2016-11-09 | Strasspharma Llc | METHOD FOR MODULATING FOLLICLE-STIMULATING HORMONACTIVITY |
US10568891B2 (en) | 2012-12-21 | 2020-02-25 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US9180091B2 (en) | 2012-12-21 | 2015-11-10 | Therapeuticsmd, Inc. | Soluble estradiol capsule for vaginal insertion |
US10471072B2 (en) | 2012-12-21 | 2019-11-12 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US11266661B2 (en) | 2012-12-21 | 2022-03-08 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US11246875B2 (en) | 2012-12-21 | 2022-02-15 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US10537581B2 (en) | 2012-12-21 | 2020-01-21 | Therapeuticsmd, Inc. | Vaginal inserted estradiol pharmaceutical compositions and methods |
US20160024051A1 (en) | 2013-03-15 | 2016-01-28 | Infinity Pharmaceuticals, Inc. | Salts and solid forms of isoquinolinones and composition comprising and methods of using the same |
US9192609B2 (en) | 2013-04-17 | 2015-11-24 | Hedgepath Pharmaceuticals, Inc. | Treatment and prognostic monitoring of proliferation disorders using hedgehog pathway inhibitors |
DK3003309T3 (da) | 2013-05-30 | 2020-12-14 | Infinity Pharmaceuticals Inc | Behandling af cancer med PI3-kinase-isoform modulatorer |
US9751888B2 (en) | 2013-10-04 | 2017-09-05 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
EP3052485B1 (en) | 2013-10-04 | 2021-07-28 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
WO2015061204A1 (en) | 2013-10-21 | 2015-04-30 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
EP3085369B1 (en) | 2013-12-19 | 2018-04-04 | Eisai R&D Management Co., Ltd. | Therapeutic and/or preventive agent comprising 1-indansulfamide derivative for pain |
EP4066834A1 (en) | 2014-03-19 | 2022-10-05 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds for use in the treatment of pi3k-gamma mediated disorders |
WO2015160986A2 (en) | 2014-04-16 | 2015-10-22 | Infinity Pharmaceuticals, Inc. | Combination therapies |
WO2015168079A1 (en) | 2014-04-29 | 2015-11-05 | Infinity Pharmaceuticals, Inc. | Pyrimidine or pyridine derivatives useful as pi3k inhibitors |
CA2947767A1 (en) | 2014-05-22 | 2015-11-26 | Therapeuticsmd, Inc. | Natural combination hormone replacement formulations and therapies |
CN105232562B (zh) * | 2014-07-07 | 2019-06-28 | 中国科学院上海巴斯德研究所 | 一种人呼吸道合胞病毒的抑制剂和抗病毒药物设计靶点 |
US9708348B2 (en) | 2014-10-03 | 2017-07-18 | Infinity Pharmaceuticals, Inc. | Trisubstituted bicyclic heterocyclic compounds with kinase activities and uses thereof |
AU2016271468B2 (en) | 2015-06-04 | 2020-01-02 | Sol-Gel Technologies Ltd. | Topical formulations for delivery of hedgehog inhibitor compounds and use thereof |
US10328087B2 (en) | 2015-07-23 | 2019-06-25 | Therapeuticsmd, Inc. | Formulations for solubilizing hormones |
WO2017139497A1 (en) * | 2016-02-11 | 2017-08-17 | PellePharm, Inc. | Hedgehog inhibitor for use in relief of and treatment of pruritus or itching |
CN105622708B (zh) * | 2016-02-14 | 2017-10-10 | 山东大学 | 治疗呼吸道合胞病毒感染的化合物及其制备方法与用途 |
US10722484B2 (en) | 2016-03-09 | 2020-07-28 | K-Gen, Inc. | Methods of cancer treatment |
US10286077B2 (en) | 2016-04-01 | 2019-05-14 | Therapeuticsmd, Inc. | Steroid hormone compositions in medium chain oils |
JP2019513709A (ja) | 2016-04-01 | 2019-05-30 | セラピューティックスエムディー インコーポレーテッドTherapeuticsmd, Inc. | ステロイドホルモン薬学的組成物 |
US10919914B2 (en) | 2016-06-08 | 2021-02-16 | Infinity Pharmaceuticals, Inc. | Heterocyclic compounds and uses thereof |
CN109640999A (zh) | 2016-06-24 | 2019-04-16 | 无限药品股份有限公司 | 组合疗法 |
CA3035473A1 (en) | 2016-09-13 | 2018-03-22 | Allergan, Inc. | Non-protein clostridial toxin compositions |
IL274663B2 (en) | 2017-11-17 | 2024-01-01 | Univ Illinois | Cancer therapy through MEK dual signaling disruption |
US11633405B2 (en) | 2020-02-07 | 2023-04-25 | Therapeuticsmd, Inc. | Steroid hormone pharmaceutical formulations |
CN113461771B (zh) * | 2020-03-31 | 2022-09-30 | 南方科技大学 | 钠钾atp酶抑制剂的制备方法 |
Family Cites Families (146)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JPS6333341A (ja) | 1986-07-28 | 1988-02-13 | Seitetsu Kagaku Co Ltd | 配糖体の処理方法 |
US4843071A (en) | 1986-12-05 | 1989-06-27 | Serotonin Industries Of Charleston | Method and composition for treating obesity, drug abuse, and narcolepsy |
JP2851054B2 (ja) | 1989-03-15 | 1999-01-27 | サントリー株式会社 | ベンズオキセピン誘導体 |
US5169780A (en) | 1989-06-22 | 1992-12-08 | Celgene Corporation | Enantiomeric enrichment and stereoselective synthesis of chiral amines |
FR2656310B1 (fr) | 1989-12-22 | 1992-05-07 | Roussel Uclaf | Nouveaux produits sterouides comportant en position 10, un radical thioethyle substitue, leur procede de preparation et les intermediaires de ce procede, leur application comme medicaments et les compositions pharmaceutiques les renfermant. |
US5378475A (en) | 1991-02-21 | 1995-01-03 | University Of Kentucky Research Foundation | Sustained release drug delivery devices |
ES2123133T3 (es) | 1993-03-10 | 1999-01-01 | Magainin Pharma | Derivados esteroidianos, composiciones farmaceuticas que contienen estos derivados esteroidianos y utilizacion de estos ultimos como antibioticos o desinfectantes. |
IT1265001B1 (it) | 1993-12-16 | 1996-10-17 | Zambon Spa | Composizione farmaceutica per uso topico contenente acido (s)-2-(4- isobutilfenil) propionico |
NZ278765A (en) | 1993-12-30 | 1998-05-27 | Harvard College | Vertebrate proteins involved in spatial arrangements of differentiated tissues called hedgehog proteins, their production and use |
US6281332B1 (en) | 1994-12-02 | 2001-08-28 | The Johns Hopkins University School Of Medicine | Hedgehog-derived polypeptides |
EP0897300A4 (en) | 1995-10-10 | 2000-07-05 | Marilyn Strube | TREATMENT OF PRURITUS WITH VITAMIN D AND ITS ANALOGS |
EP1300381B1 (en) | 1995-12-06 | 2006-03-08 | Japan Science and Technology Agency | Process for preparing optically active alcohols |
US6887820B1 (en) | 1995-12-06 | 2005-05-03 | Japan Science And Technology Corporation | Method for producing optically active compounds |
GB9706321D0 (en) | 1997-03-26 | 1997-05-14 | Zeneca Ltd | Catalytic hydrogenation |
US6238876B1 (en) | 1997-06-20 | 2001-05-29 | New York University | Methods and materials for the diagnosis and treatment of sporadic basal cell carcinoma |
US7709454B2 (en) | 1997-06-20 | 2010-05-04 | New York University | Methods and compositions for inhibiting tumorigenesis |
US7741298B2 (en) | 1997-06-20 | 2010-06-22 | New York University | Method and compositions for inhibiting tumorigenesis |
US7361336B1 (en) | 1997-09-18 | 2008-04-22 | Ivan Bergstein | Methods of cancer therapy targeted against a cancer stem line |
US6231875B1 (en) | 1998-03-31 | 2001-05-15 | Johnson & Johnson Consumer Companies, Inc. | Acidified composition for topical treatment of nail and skin conditions |
US6867216B1 (en) | 1998-04-09 | 2005-03-15 | Johns Hopkins University School Of Medicine | Inhibitors of hedgehog signal pathways, compositions and uses related thereto |
US7291626B1 (en) | 1998-04-09 | 2007-11-06 | John Hopkins University School Of Medicine | Inhibitors of hedgehog signaling pathways, compositions and uses related thereto |
US6432970B2 (en) | 1998-04-09 | 2002-08-13 | Johns Hopkins University School Of Medicine | Inhibitors of hedgehog signaling pathways, compositions and uses related thereto |
EP1105149A1 (en) | 1998-08-13 | 2001-06-13 | University Of Southern California | Methods to increase blood flow to ischemic tissue |
GB9821067D0 (en) | 1998-09-29 | 1998-11-18 | Zeneca Ltd | Transfer hydrogenation process |
US6291516B1 (en) | 1999-01-13 | 2001-09-18 | Curis, Inc. | Regulators of the hedgehog pathway, compositions and uses related thereto |
FR2796938B1 (fr) | 1999-07-29 | 2004-04-02 | Ppg Sipsy | Nouveaux derives chiraux n-substitues de la norephedrine, leur preparation et leur utilisation pour la synthese de composes fonctionnalises optiquement actifs par transfert d'hydrogene |
CA2385736C (en) | 1999-09-16 | 2011-11-15 | Curis, Inc. | Mediators of hedgehog signaling pathways, compositions and uses related thereto |
US20070021493A1 (en) | 1999-09-16 | 2007-01-25 | Curis, Inc. | Mediators of hedgehog signaling pathways, compositions and uses related thereto |
US6993456B2 (en) | 1999-09-30 | 2006-01-31 | Rockwell Automation Technologies, Inc. | Mechanical-electrical template based method and apparatus |
ATE328002T1 (de) | 1999-10-13 | 2006-06-15 | Univ Johns Hopkins Med | Verbindungen zur regulierung des hedgehog- signalwegs, zusammensetzungen und verwendungen davon |
US6552016B1 (en) | 1999-10-14 | 2003-04-22 | Curis, Inc. | Mediators of hedgehog signaling pathways, compositions and uses related thereto |
ATE324876T1 (de) | 1999-10-14 | 2006-06-15 | Curis Inc | VERMITTLER VON ßHEDGEHOGß ÜBERMITTELNDEN BAHNEN, DAZUGEHÖRIGE ZUSAMMENETZUNGEN UND VERWENDUNGEN |
US6893637B1 (en) | 1999-10-21 | 2005-05-17 | Zymogenetics, Inc. | Method of treating fibrosis |
IL133809A0 (en) | 1999-12-30 | 2001-04-30 | Yeda Res & Dev | Steroidal alkaloids and pharmaceutical compositions comprising them |
KR20010077591A (ko) | 2000-02-03 | 2001-08-20 | 복성해 | 아라니콜라 프로테오리티쿠스에서 분리한 신규 금속성단백질 분해효소 및 그의 유전자 |
JP4808895B2 (ja) | 2000-03-30 | 2011-11-02 | キュリス,インコーポレイテッド | 細胞増殖の小型有機分子レギュレーター |
US6613798B1 (en) | 2000-03-30 | 2003-09-02 | Curis, Inc. | Small organic molecule regulators of cell proliferation |
AU2001264595A1 (en) | 2000-05-19 | 2001-12-03 | Guilford Pharmaceuticals Inc. | Sulfonamide and carbamide derivatives of 6(5h)phenanthridinones and their uses |
US7708998B2 (en) | 2000-10-13 | 2010-05-04 | Curis, Inc. | Methods of inhibiting unwanted cell proliferation using hedgehog antagonists |
AU9684401A (en) | 2000-10-13 | 2002-04-22 | Curis Inc | Hedgehog antagonists, methods and uses related thereto |
GB0029356D0 (en) | 2000-12-01 | 2001-01-17 | Avecia Ltd | Transfer hydrogenation |
US6456928B1 (en) | 2000-12-29 | 2002-09-24 | Honeywell International Inc. | Prognostics monitor for systems that are subject to failure |
ATE364380T1 (de) | 2001-03-16 | 2007-07-15 | Alza Corp | Transdermales pflaster zur verabreichung von fentanyl |
AU2002247847A1 (en) | 2001-04-09 | 2002-10-21 | Lorantis Limited | Therapeutic use and identification of modulators of a hedgehog signalling pathway or one of its target pathways |
AUPR602401A0 (en) | 2001-06-29 | 2001-07-26 | Smart Drug Systems Inc | Sustained release delivery system |
RU2308948C2 (ru) * | 2001-07-02 | 2007-10-27 | ТАШ Шинан | Применение циклопамина для лечения базально-клеточной эпителиомы (карциномы) и других опухолей |
CA2452152A1 (en) | 2001-07-02 | 2002-10-10 | Sinan Tas | Use of cyclopamine in the treatment of psoriasis |
DK1401438T3 (da) | 2001-07-02 | 2006-02-13 | Sinan Tas | Anvendelse af cyclopamin i behandlingen af basalt cellecarcinom og andre tumorer |
PL366799A1 (en) | 2001-07-27 | 2005-02-07 | Curis, Inc. | Mediators of hedgehog signaling pathways, compositions and uses related thereto |
JP2003192919A (ja) * | 2001-10-17 | 2003-07-09 | Asahi Denka Kogyo Kk | 難燃性合成樹脂組成物 |
CA2468434A1 (en) | 2001-11-09 | 2003-05-15 | National Research Council Of Canada | Volatile noble metal organometallic complexes |
US7105637B2 (en) | 2002-02-15 | 2006-09-12 | William Marsh Rice University | Dehydro-estriol (8-DHE3) and dehydro-pregnanetriol (7-DHPT), methods of their synthesis |
EP1490031A1 (en) | 2002-03-07 | 2004-12-29 | Vectura Limited | Fast melt multiparticulate formulations for oral delivery |
AU2003225072A1 (en) | 2002-04-19 | 2003-11-03 | Smithkline Beecham Corporation | Novel compounds |
ATE404200T1 (de) | 2002-04-22 | 2008-08-15 | Univ Johns Hopkins Med | Modulatoren von hedgehog signalpfaden, zusammensetzungen und verwandte verwendungen |
GB0210234D0 (en) | 2002-05-03 | 2002-06-12 | Novartis Ag | Process for the manufacture of organic compounds |
US20050203061A1 (en) | 2002-06-20 | 2005-09-15 | Shinya Yamashita | Prodrug, medicinal utilization thereof and process for producing the same |
WO2004020599A2 (en) | 2002-08-29 | 2004-03-11 | Curis, Inc. | Hedgehog antagonists, methods and uses related thereto |
GB0221539D0 (en) | 2002-09-17 | 2002-10-23 | Medical Res Council | Methods of treatment |
GB0230217D0 (en) | 2002-12-27 | 2003-02-05 | Biotica Tech Ltd | Borrelidin-producing polyketide synthase and its uses |
FR2850022B1 (fr) | 2003-01-22 | 2006-09-08 | Centre Nat Rech Scient | Nouvelle utilisation de la mifepristone et de ses derives comme modulateurs de la voie de signalisation des proteines hedgehog et ses applications |
EP1639097B1 (en) | 2003-06-25 | 2013-08-07 | Ottawa Health Research Institute | Methods and compositions for modulating stem cell growth and differentiation |
US20080118493A1 (en) | 2003-07-15 | 2008-05-22 | Beachy Philip A | Elevated Hedgehog Pathway Activity In Digestive System Tumors, And Methods Of Treating Digestive Sytem Tumors Having Elevated Hedgehog Pathway Activity |
US8067608B2 (en) | 2003-09-29 | 2011-11-29 | The Johns Hopkins University | Hedgehog pathway antagonists |
US20080095761A1 (en) | 2003-10-01 | 2008-04-24 | The Johns Hopkins University | Hedgehog Signaling in Prostate Regeneration Neoplasia and Metastasis |
US20070231828A1 (en) | 2003-10-01 | 2007-10-04 | Johns Hopkins University | Methods of predicting behavior of cancers |
EP1673437A4 (en) | 2003-10-01 | 2007-07-11 | Invitrogen Corp | COMPOSITIONS AND METHODS FOR SYNTHESIS, PURIFICATION AND DETECTION OF BIOMOLECULES |
WO2005042700A2 (en) | 2003-10-20 | 2005-05-12 | The Johns Hopkins University | Use of hedgehog pathway inhibitors in small-cell lung cancer |
US20070219250A1 (en) | 2003-11-28 | 2007-09-20 | Romi Singh | Pharmaceutical Compositions of Nateglinide |
CA2565237C (en) | 2004-04-30 | 2012-12-11 | Genentech, Inc. | Quinoxaline inhibitors of hedgehog signalling |
AU2005280112B2 (en) * | 2004-08-27 | 2012-07-19 | Infinity Pharmaceuticals, Inc. | Cyclopamine analogues and methods of use thereof |
EA017262B1 (ru) | 2004-09-02 | 2012-11-30 | Дженентек, Инк. | Соединения 2-(2-галоген-4-аминофенил)пиридиновых ингибиторов передачи сигналов белком hedgehog (варианты), способ их получения, композиция и способы лечения рака и ингибирований ангиогенеза и сигнального пути hedgehog в клетках на их основе |
WO2006039569A1 (en) | 2004-09-30 | 2006-04-13 | The University Of Chicago | Combination therapy of hedgehog inhibitors, radiation and chemotherapeutic agents |
RU2007119637A (ru) | 2004-10-28 | 2008-12-10 | Айрм Ллк (Bm) | Соединения и композиции в качестве модуляторов hedgehog-пути |
US20090208579A1 (en) | 2004-12-27 | 2009-08-20 | Eisai R & D Management Co., Ltd. | Matrix Type Sustained-Release Preparation Containing Basic Drug or Salt Thereof, and Method for Manufacturing the Same |
US20060252073A1 (en) | 2005-04-18 | 2006-11-09 | Regents Of The University Of Michigan | Compositions and methods for the treatment of cancer |
US8668905B2 (en) | 2005-05-12 | 2014-03-11 | University Of South Florida | P53 vaccines for the treatment of cancers |
JP5435946B2 (ja) | 2005-08-22 | 2014-03-05 | ジョンズ ホプキンス ユニバーシティ | 疾患を処置するためのヘッジホッグ経路アンタゴニスト |
JP4712524B2 (ja) | 2005-10-28 | 2011-06-29 | 富士通コンポーネント株式会社 | 入力デバイス及び電子機器 |
CA2625210A1 (en) | 2005-10-31 | 2007-05-10 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
US20070117815A1 (en) | 2005-11-04 | 2007-05-24 | James Pluda | Method of treating cancers with SAHA and pemetrexed |
EP1945202A2 (en) | 2005-11-11 | 2008-07-23 | Licentia OY | Mammalian hedgehog signaling inhiabitors |
CA2629814C (en) | 2005-11-14 | 2013-12-31 | Genentech, Inc. | Bisamide inhibitors of hedgehog signaling |
US20090263317A1 (en) | 2005-12-15 | 2009-10-22 | Wei Chen | Method of screening the activity of the smoothened receptor to identify theraputic modulation agents or diagnose disease |
ATE533497T1 (de) | 2005-12-27 | 2011-12-15 | Genentech Inc | Verfahren zur verwendung von hedgehog-kinase- antagonisten zur behandlung von hedgehog- vermittelten krebs |
EP1818411A1 (en) | 2006-02-13 | 2007-08-15 | Lonza AG | Process for the preparation of optically active chiral amines |
US20080019961A1 (en) | 2006-02-21 | 2008-01-24 | Regents Of The University Of Michigan | Hedgehog signaling pathway antagonist cancer treatment |
WO2007123511A2 (en) | 2006-03-24 | 2007-11-01 | Infinity Pharmaceuticals, Inc. | Dosing regimens for the treatment of cancer |
RU2008144805A (ru) | 2006-04-14 | 2010-05-20 | Новартис АГ (CH) | Применение биарилкарбоксамидов в лечении заболеваний, связанных с hedgehog-путем |
UA93548C2 (ru) | 2006-05-05 | 2011-02-25 | Айерем Елелсі | Соединения и композиции kak модуляторы хеджхоговского сигнального пути |
DE102006031358A1 (de) * | 2006-07-05 | 2008-01-17 | Schott Ag | Verfahren zur Gehäusung optischer oder optoelektronischer Bauteile, sowie verfahrensgemäß herstellbares optisches oder optoelektronisches Gehäuseelement |
US20100048944A1 (en) | 2006-07-19 | 2010-02-25 | Farhad Parhami | Interactions of hedgehog and liver x receptor signaling pathways |
PE20080948A1 (es) | 2006-07-25 | 2008-09-10 | Irm Llc | Derivados de imidazol como moduladores de la senda de hedgehog |
EP2082037A1 (en) | 2006-09-29 | 2009-07-29 | Vib Vzw | Plant cell lines established from the medicinal plant veratrum californicum |
CN101583379B (zh) | 2006-10-05 | 2013-04-03 | 约翰斯霍普金斯大学 | 使用优良聚合物纳米粒子的水溶性差药物的水可分散性口服,肠胃外和局部制剂 |
EP2078036A2 (en) | 2006-10-31 | 2009-07-15 | Government of the United States of America, Represented by the Secretary, Department of Health and Human Services | Smoothened polypeptides and methods of use |
US20080103116A1 (en) | 2006-11-01 | 2008-05-01 | Jennings-Spring Barbara L | Method of treatment and compositions of D-chiro inositol and phosphates thereof |
WO2008057497A2 (en) | 2006-11-02 | 2008-05-15 | Curis, Inc. | Small organic molecule regulators of cell proliferation |
JP4903270B2 (ja) | 2006-11-20 | 2012-03-28 | トムソン ライセンシング | 冗長の接続を除去する方法 |
AU2006350960B2 (en) | 2006-11-20 | 2013-09-12 | Satori Pharmaceuticals, Inc. | Compounds useful for treating neurodegenerative disorders |
TWI433674B (zh) | 2006-12-28 | 2014-04-11 | Infinity Discovery Inc | 環杷明(cyclopamine)類似物類 |
WO2008089123A2 (en) | 2007-01-12 | 2008-07-24 | Infinity Discovery, Inc. | Methods for analysis of hedgehog pathway inhibitors |
FI123481B (fi) | 2007-02-05 | 2013-05-31 | Upm Kymmene Corp | Menetelmä painopaperin valmistamiseksi ja seoskoostumus |
AU2008222655B2 (en) | 2007-03-07 | 2014-03-27 | Infinity Pharmaceuticals, Inc. | Cyclopamine lactam analogs and methods of use thereof |
WO2008109184A1 (en) | 2007-03-07 | 2008-09-12 | Infinity Pharmaceuticals, Inc. | Heterocyclic cyclopamine analogs and methods of use thereof |
MX2009009786A (es) | 2007-03-14 | 2009-09-24 | Exelixis Inc | Inhibidores de la via de hedgehog. |
PE20090188A1 (es) | 2007-03-15 | 2009-03-20 | Novartis Ag | Compuestos heterociclicos como moduladores de la senda de hedgehog |
US9095589B2 (en) | 2007-04-05 | 2015-08-04 | Johns Hopkins University | Chirally pure isomers of itraconazole for use as angiogenesis inhibitors |
WO2008130552A1 (en) | 2007-04-18 | 2008-10-30 | Merck & Co., Inc. | Triazole derivatives which are smo antagonists |
US20090054517A1 (en) | 2007-04-20 | 2009-02-26 | Lubahn Dennis B | Phytoestrogens As Regulators Of Hedgehog Signaling And Methods Of Their Use In Cancer Treatment |
CA2717788A1 (en) | 2007-07-09 | 2009-01-15 | Eastern Virginia Medical School | Substituted nucleoside derivatives with antiviral and antimicrobial properties |
US8636982B2 (en) | 2007-08-07 | 2014-01-28 | Foamix Ltd. | Wax foamable vehicle and pharmaceutical compositions thereof |
WO2009049258A1 (en) | 2007-10-12 | 2009-04-16 | The Johns Hopkins University | Compounds for hedgehog pathway blockade in proliferative disorders, including hematopoietic malignancies |
WO2009074300A2 (en) | 2007-12-13 | 2009-06-18 | Siena Biotech S.P.A. | Hedgehog pathway antagonists and therapeutic applications thereof |
US8716479B2 (en) | 2007-12-27 | 2014-05-06 | Infinity Pharmaceuticals, Inc. | Methods for stereoselective reduction |
US20100297118A1 (en) | 2007-12-27 | 2010-11-25 | Macdougall John | Therapeutic Cancer Treatments |
US20100222287A1 (en) | 2007-12-27 | 2010-09-02 | Mcgovern Karen J | Therapeutic Cancer Treatments |
AR070047A1 (es) | 2007-12-27 | 2010-03-10 | Infinity Pharmaceuticals Inc | Tratamientos terapeuticos contra el cancer. composicion que comprende un inhibidor de hedgehog. |
WO2009099625A2 (en) | 2008-02-08 | 2009-08-13 | The Board Of Regents Of The University Of Texas System | Cyclopamine tartrate salt and uses thereof |
US20090246841A1 (en) | 2008-03-26 | 2009-10-01 | Jamieson Andrew C | Methods and compositions for production of acetaldehyde |
US20110217294A1 (en) | 2008-04-11 | 2011-09-08 | Daniel Fults | Combination of hgf inhibitor and hedgehog inhibitor to treat cancer |
CL2009001479A1 (es) | 2008-07-02 | 2010-01-04 | Infinity Pharmaceuticals Inc | Metodo para aislar un alcaloide del veratrum desglicosilado que comprende proporcionar un material de planta veratrum, poner en contacto con una solucion acuosa y extraer el material de la planta veratrum con un solvente para proporcionar un extracto que comprende dicho alcaloide. |
CA2636807A1 (en) | 2008-07-04 | 2010-01-04 | Steven Splinter | Methods for obtaining cyclopamine |
US20100041663A1 (en) | 2008-07-18 | 2010-02-18 | Novartis Ag | Organic Compounds as Smo Inhibitors |
BRPI0918629B8 (pt) | 2008-09-17 | 2021-05-25 | Novartis Ag | sal de n-[6-cis-2,6-dimetilmorfolin-4-il]piridina-3-il]-2-metil-4'-(trifluormetóxi)[1-1'-bifenil]-3-carboxamida, e composição farmacêutica |
EP3492492A1 (en) | 2008-09-22 | 2019-06-05 | Aileron Therapeutics, Inc. | Methods for preparing purified polypeptide compositions |
US20100081637A1 (en) | 2008-10-01 | 2010-04-01 | Innovia Skincare Corp. | Eczema treatment with vitamin D and analogs thereof method, composition and cream |
JP2012515792A (ja) | 2009-01-23 | 2012-07-12 | キャンサー・リサーチ・テクノロジー・リミテッド | ヘッジホッグ経路阻害剤 |
AR077490A1 (es) | 2009-07-21 | 2011-08-31 | Novartis Ag | Composiciones farmaceuticas topicas para el tratamiento de una condicion hiperproliferativa de la piel |
CN102574791A (zh) | 2009-08-05 | 2012-07-11 | 无限药品股份有限公司 | 环杷明类似物的酶促转氨基反应 |
US20110135739A1 (en) * | 2009-11-06 | 2011-06-09 | Bennett Carter | Oral Formulations of a Hedgehog Pathway Inhibitor |
CA2781300A1 (en) | 2009-11-20 | 2011-05-26 | Infinity Pharmaceuticals, Inc. | Methods and compositions for treating hedgehog-associated cancers |
WO2011088404A1 (en) | 2010-01-15 | 2011-07-21 | Infinity Pharmaceuticals , Inc | Treatment of fibrotic conditions using hedgehog inhibitors |
GB201010954D0 (en) | 2010-06-29 | 2010-08-11 | Edko Pazarlama Tanitim Ticaret | Compositions |
WO2012006589A2 (en) | 2010-07-08 | 2012-01-12 | Infinity Pharmaceuticals, Inc. | Methods and compositions for identification, assessment and treatment of cancers associated with hedgehog signaling |
US20120010229A1 (en) | 2010-07-08 | 2012-01-12 | Macdougall John R | Therapeutic regimens for hedgehog-associated cancers |
WO2012037217A1 (en) | 2010-09-14 | 2012-03-22 | Infinity Pharmaceuticals, Inc. | Transfer hydrogenation of cyclopamine analogs |
CN102085176A (zh) | 2010-12-31 | 2011-06-08 | 江苏中丹制药有限公司 | 一种纳米级伊曲康唑外用制剂、其制备方法及其用途 |
US8865765B2 (en) | 2011-01-12 | 2014-10-21 | The William M. Yarbrough Foundation | Method for treating eczema |
US9072660B2 (en) | 2011-09-09 | 2015-07-07 | The Board Of Trustees Of The Leland Stanford Junior University | Topical itraconazole formulations and uses thereof |
WO2013049332A1 (en) | 2011-09-29 | 2013-04-04 | Infinity Pharmaceuticals, Inc. | Inhibitors of monoacylglycerol lipase and methods of their use |
KR20210050585A (ko) | 2012-12-14 | 2021-05-07 | 트레비 테라퓨틱스, 인코포레이티드 | 소양증을 치료하는 방법 |
US9452139B2 (en) | 2013-03-14 | 2016-09-27 | Novartis Ag | Respirable agglomerates of porous carrier particles and micronized drug |
US9938292B2 (en) | 2014-03-24 | 2018-04-10 | Guangdong Zhongsheng Pharmaceutical Co., Ltd | Quinoline derivatives as SMO inhibitors |
AU2016271468B2 (en) | 2015-06-04 | 2020-01-02 | Sol-Gel Technologies Ltd. | Topical formulations for delivery of hedgehog inhibitor compounds and use thereof |
WO2017139497A1 (en) | 2016-02-11 | 2017-08-17 | PellePharm, Inc. | Hedgehog inhibitor for use in relief of and treatment of pruritus or itching |
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