RU2007106862A - Способы и композиции для модуляции фактора роста гепатоцитов - Google Patents

Способы и композиции для модуляции фактора роста гепатоцитов Download PDF

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Publication number
RU2007106862A
RU2007106862A RU2007106862/13A RU2007106862A RU2007106862A RU 2007106862 A RU2007106862 A RU 2007106862A RU 2007106862/13 A RU2007106862/13 A RU 2007106862/13A RU 2007106862 A RU2007106862 A RU 2007106862A RU 2007106862 A RU2007106862 A RU 2007106862A
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Prior art keywords
hgf
pro
substrate
sample
hepsin
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RU2007106862/13A
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RU2405041C2 (ru
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Дэниел К. КИРХХОФЕР (US)
Дэниел К. КИРХХОФЕР
Пол М. МОРАН (US)
Пол М. МОРАН
Марк Д. ПИК (US)
Марк Д. ПИК
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Дженентек, Инк. (Us)
Дженентек, Инк.
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6872—Intracellular protein regulatory factors and their receptors, e.g. including ion channels
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/34—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase
    • C12Q1/37—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving hydrolase involving peptidase or proteinase
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/74—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving hormones or other non-cytokine intercellular protein regulatory factors such as growth factors, including receptors to hormones and growth factors
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/475—Assays involving growth factors
    • G01N2333/4753—Hepatocyte growth factor; Scatter factor; Tumor cytotoxic factor II
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00—Screening for compounds of potential therapeutic value
    • G01N2500/02—Screening involving studying the effect of compounds C on the interaction between interacting molecules A and B (e.g. A = enzyme and B = substrate for A, or A = receptor and B = ligand for the receptor)

Claims (7)

1. Способ идентификации ингибирующего вещества-кандидата, которое ингибирует активацию HGF гепсином, где указанный способ включает в себя (a) приведение вещества-кандидата в контакт с первым образцом, содержащим гепсин и субстрат про-HGF, и (b) сравнение степени активации субстрата про-HGF в образце со степенью активации субстрата про-HGF в эталонном образце, содержащем равные с первым образцом количества гепсина и субстрата про-HGF, но не контактировавшим с указанным веществом-кандидатом, согласно которому уменьшение степени активации субстрата про-HGF в первом образце по сравнению с эталонным образцом означает, что вещество-кандидат способно ингибировать активацию одноцепочечного HGF (про-HGF) гепсином.
2. Способ по п.1, где гепсин в образце находится в эффективном для активации указанного про-HGF количестве.
3. Способ по п.1, где субстрат про-HGF представляет собой полипептид, содержащий HGF или его фрагмент, содержащий форму пептидной связи R494-V495 дикого типа.
4. Способ по п.1, где субстрат про-HGF содержит участок расщепления человеческого HGF, соответствующий консенсусному участку расщепления протеаз, где участок расщепления содержит основный остаток в положении P1 и два гидрофобных аминокислотных остатка в положениях P1' и P2'.
5. Молекула-антагонист, ингибирующая взаимодействие гепсина и фактора роста гепатоцитов.
6. Молекула-антагонист по п.5, где молекула содержит антитело или его фрагмент.
7. Молекула-антагонист по п.5, где молекула содержит полипептид, содержащий последовательность домена 1 Кунитца.
RU2007106862/10A 2004-07-26 2005-07-25 Способы и композиции для модуляции активации фактора роста гепатоцитов RU2405041C2 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US59133904P 2004-07-26 2004-07-26
US60/591,339 2004-07-26

Publications (2)

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RU2007106862A true RU2007106862A (ru) 2008-09-10
RU2405041C2 RU2405041C2 (ru) 2010-11-27

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Country Status (16)

Country Link
US (3) US7432044B2 (ru)
EP (1) EP1774022B1 (ru)
JP (2) JP5226308B2 (ru)
KR (1) KR101222254B1 (ru)
CN (1) CN101023182B (ru)
AU (1) AU2005269463B2 (ru)
BR (1) BRPI0512482A (ru)
CA (1) CA2570323C (ru)
ES (1) ES2532610T3 (ru)
HK (1) HK1100294A1 (ru)
IL (1) IL179917A0 (ru)
MX (1) MX2007001064A (ru)
NZ (1) NZ551908A (ru)
RU (1) RU2405041C2 (ru)
WO (1) WO2006014928A1 (ru)
ZA (1) ZA200700745B (ru)

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Publication number Priority date Publication date Assignee Title
RU2539772C2 (ru) * 2009-10-22 2015-01-27 Дженентек, Инк. Способы и композиции для модуляции гепсином стимулирующего макрофаги белка
RU2559533C2 (ru) * 2009-10-22 2015-08-10 Дженентек, Инк. Антитела против гепсина и способы их применения

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Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2539772C2 (ru) * 2009-10-22 2015-01-27 Дженентек, Инк. Способы и композиции для модуляции гепсином стимулирующего макрофаги белка
RU2559533C2 (ru) * 2009-10-22 2015-08-10 Дженентек, Инк. Антитела против гепсина и способы их применения

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ES2532610T3 (es) 2015-03-30
EP1774022A1 (en) 2007-04-18
HK1100294A1 (en) 2007-09-14
JP2012196217A (ja) 2012-10-18
JP2008507295A (ja) 2008-03-13
US20100209956A1 (en) 2010-08-19
KR20070037499A (ko) 2007-04-04
ZA200700745B (en) 2008-07-30
BRPI0512482A (pt) 2008-03-11
CN101023182B (zh) 2013-04-17
KR101222254B1 (ko) 2013-01-16
CA2570323A1 (en) 2006-02-09
EP1774022B1 (en) 2014-12-31
AU2005269463B2 (en) 2011-08-18
NZ551908A (en) 2009-10-30
IL179917A0 (en) 2007-05-15
RU2405041C2 (ru) 2010-11-27
MX2007001064A (es) 2007-04-12
CN101023182A (zh) 2007-08-22
US20060084120A1 (en) 2006-04-20
CA2570323C (en) 2014-08-26
US20090075317A1 (en) 2009-03-19
JP5226308B2 (ja) 2013-07-03
US7432044B2 (en) 2008-10-07
AU2005269463A1 (en) 2006-02-09
WO2006014928A1 (en) 2006-02-09

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