RU2005131842A - Моноклональное антитело и продуцирующая его гибридома - Google Patents
Моноклональное антитело и продуцирующая его гибридома Download PDFInfo
- Publication number
- RU2005131842A RU2005131842A RU2005131842/13A RU2005131842A RU2005131842A RU 2005131842 A RU2005131842 A RU 2005131842A RU 2005131842/13 A RU2005131842/13 A RU 2005131842/13A RU 2005131842 A RU2005131842 A RU 2005131842A RU 2005131842 A RU2005131842 A RU 2005131842A
- Authority
- RU
- Russia
- Prior art keywords
- monoclonal antibody
- hepr
- hybridoma
- producing hybrid
- recognizes
- Prior art date
Links
- 101001056707 Homo sapiens Proepiregulin Proteins 0.000 claims 7
- 102000043415 human EREG Human genes 0.000 claims 7
- 210000004408 hybridoma Anatomy 0.000 claims 5
- 238000000034 method Methods 0.000 claims 3
- 206010028980 Neoplasm Diseases 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 238000000338 in vitro Methods 0.000 claims 2
- 238000011895 specific detection Methods 0.000 claims 1
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/22—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against growth factors ; against growth regulators
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/24—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against cytokines, lymphokines or interferons
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/10—Cells modified by introduction of foreign genetic material
- C12N5/12—Fused cells, e.g. hybridomas
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
- G01N33/57419—Specifically defined cancers of colon
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/574—Immunoassay; Biospecific binding assay; Materials therefor for cancer
- G01N33/57407—Specifically defined cancers
- G01N33/57423—Specifically defined cancers of lung
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Biotechnology (AREA)
- Genetics & Genomics (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- General Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Physics & Mathematics (AREA)
- Food Science & Technology (AREA)
- Pathology (AREA)
- Oncology (AREA)
- Hospice & Palliative Care (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Engineering & Computer Science (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Claims (9)
1. Гибридома, продуцирующая моноклональное антитело, которое специфически распознает человеческий эпирегулин (hEPR).
2. Гибридома по п.1, которая имеет номер доступа FERM BP-08647.
3. Гибридома по п.1, которая имеет номер доступа FERM BP-08648.
4. Моноклональное антитело, продуцируемое гибридомой по любому из пп.1-3.
5. Моноклональное антитело, которое распознает эпитоп, который распознается моноклональным антителом, продуцируемым гибридомой по п.2 или 3, и специфически распознает hEPR.
6. Способ специфического выявления hEPR в образце in vitro, отличающийся тем, что используются моноклональное антитело по п.4 и поликлональное антитело, которое распознает hEPR (hEPR-PoAb).
7. Способ выявления клеток, экспрессирующих hEPR in vitro, отличающийся тем, что используется моноклональное антитело по п.4.
8. Способ по п.7, при котором клетки, экспрессирующие hEPR, представляют собой опухоль человека.
9. Набор для выявления опухоли человека, включающий моноклональное антитело по п.4.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2003-070864 | 2003-03-14 | ||
| JP2003070864 | 2003-03-14 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2005131842A true RU2005131842A (ru) | 2006-02-10 |
| RU2312109C2 RU2312109C2 (ru) | 2007-12-10 |
Family
ID=32984673
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2005131842/13A RU2312109C2 (ru) | 2003-03-14 | 2004-03-15 | Моноклональное антитело и продуцирующая его гибридома |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US7435590B2 (ru) |
| EP (1) | EP1607404A4 (ru) |
| JP (1) | JPWO2004081047A1 (ru) |
| KR (1) | KR20050108389A (ru) |
| CN (1) | CN1761682A (ru) |
| AU (1) | AU2004220156B2 (ru) |
| CA (1) | CA2519105A1 (ru) |
| MX (1) | MXPA05009751A (ru) |
| NO (1) | NO20054351L (ru) |
| RU (1) | RU2312109C2 (ru) |
| WO (1) | WO2004081047A1 (ru) |
Families Citing this family (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE60134679D1 (de) | 2000-10-20 | 2008-08-14 | Eisai R&D Man Co Ltd | Stickstoff enthaltende aromatische Heterozyklen |
| EP1604665B1 (en) * | 2003-03-10 | 2011-05-11 | Eisai R&D Management Co., Ltd. | C-kit kinase inhibitor |
| EP1683785B1 (en) * | 2003-11-11 | 2013-10-16 | Eisai R&D Management Co., Ltd. | Urea derivative and process for producing the same |
| ES2322175T3 (es) | 2004-09-17 | 2009-06-17 | EISAI R&D MANAGEMENT CO., LTD. | Composicion medicinal con estabilidad mejorada y gelificacion reducida. |
| WO2007015569A1 (ja) * | 2005-08-01 | 2007-02-08 | Eisai R & D Management Co., Ltd. | 血管新生阻害物質の効果を予測する方法 |
| JP4989476B2 (ja) | 2005-08-02 | 2012-08-01 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 血管新生阻害物質の効果を検定する方法 |
| AU2006309551B2 (en) | 2005-11-07 | 2012-04-19 | Eisai R & D Management Co., Ltd. | Use of combination of anti-angiogenic substance and c-kit kinase inhibitor |
| EP1964837A4 (en) * | 2005-11-22 | 2010-12-22 | Eisai R&D Man Co Ltd | Antitumor agent against multiple myeloma |
| CN104706637A (zh) * | 2006-05-18 | 2015-06-17 | 卫材R&D管理有限公司 | 针对甲状腺癌的抗肿瘤剂 |
| JPWO2008001956A1 (ja) * | 2006-06-29 | 2009-12-03 | エーザイ・アール・アンド・ディー・マネジメント株式会社 | 肝線維症治療剤 |
| CN101511793B (zh) * | 2006-08-28 | 2011-08-03 | 卫材R&D管理有限公司 | 针对未分化型胃癌的抗肿瘤剂 |
| AU2007312367B2 (en) * | 2006-10-12 | 2012-09-06 | Chugai Seiyaku Kabushiki Kaisha | Diagnosis and treatment of cancer using anti-EREG antibody |
| AU2012261543B2 (en) * | 2006-10-12 | 2016-05-26 | Chugai Seiyaku Kabushiki Kaisha | Diagnosis and treatment of cancer using anti-EREG antibody |
| WO2008093855A1 (ja) * | 2007-01-29 | 2008-08-07 | Eisai R & D Management Co., Ltd. | 未分化型胃癌治療用組成物 |
| CA2704000C (en) | 2007-11-09 | 2016-12-13 | Eisai R&D Management Co., Ltd. | Combination of anti-angiogenic substance and anti-tumor platinum complex |
| CN102036962B (zh) * | 2008-01-29 | 2013-08-07 | 卫材R&D管理有限公司 | 血管生成抑制剂和紫杉烷的组合使用 |
| EP2425227B1 (en) | 2009-04-27 | 2020-10-14 | Becton Dickinson and Company | Sample preparation device and associated method |
| EP2436397B1 (en) | 2009-05-29 | 2017-05-10 | Chugai Seiyaku Kabushiki Kaisha | Pharmaceutical composition containing antagonist of egf family ligand as component |
| EP3434694B1 (en) * | 2010-04-09 | 2020-12-30 | Critical Care Diagnostics, Inc. | Soluble human st-2 antibodies and assays |
| EP2586443B1 (en) | 2010-06-25 | 2016-03-16 | Eisai R&D Management Co., Ltd. | Antitumor agent using compounds having kinase inhibitory effect in combination |
| AU2012246490B2 (en) | 2011-04-18 | 2016-08-04 | Eisai R&D Management Co., Ltd. | Therapeutic agent for tumor |
| CA2834243C (en) * | 2011-04-28 | 2019-08-27 | Sbi Biotech Co., Ltd. | Anti-human receptor-type protein tyrosine phosphatase .sigma. antibody |
| US9945862B2 (en) | 2011-06-03 | 2018-04-17 | Eisai R&D Management Co., Ltd. | Biomarkers for predicting and assessing responsiveness of thyroid and kidney cancer subjects to lenvatinib compounds |
| TWI593705B (zh) * | 2011-12-28 | 2017-08-01 | Chugai Pharmaceutical Co Ltd | Humanized anti-epiregulin antibody and cancer therapeutic agent containing the antibody as an active ingredient |
| US9334239B2 (en) | 2012-12-21 | 2016-05-10 | Eisai R&D Management Co., Ltd. | Amorphous form of quinoline derivative, and method for producing same |
| AU2014266223B2 (en) | 2013-05-14 | 2020-06-25 | Eisai R&D Management Co., Ltd. | Biomarkers for predicting and assessing responsiveness of endometrial cancer subjects to lenvatinib compounds |
| PL3524595T3 (pl) | 2014-08-28 | 2022-10-31 | Eisai R&D Management Co., Ltd. | Pochodna chinoliny o wysokiej czystości i sposób jej wytwarzania |
| HUE064614T2 (hu) | 2015-02-25 | 2024-04-28 | Eisai R&D Man Co Ltd | Eljárás egy kinolin-származék keserû ízének elnyomására |
| BR112017027227B1 (pt) | 2015-06-16 | 2023-12-12 | Eisai R&D Management Co., Ltd | Agente anti-câncer |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5783417A (en) | 1993-06-04 | 1998-07-21 | Taisho Pharmaceutical Co., Ltd. | Human-derived tumor cell growth inhibitors |
| JP2001149079A (ja) * | 1999-11-26 | 2001-06-05 | Japan Science & Technology Corp | 新規の増殖因子タンパク質および該タンパク質をコードする遺伝子 |
| CA2418496A1 (en) * | 2000-02-24 | 2001-08-30 | Incyte Genomics, Inc. | Secretory polypeptides and corresponding polynucleotides |
| EP1287029A2 (en) * | 2000-06-09 | 2003-03-05 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of colon cancer |
| KR100801388B1 (ko) * | 2002-01-02 | 2008-02-05 | 제넨테크, 인크. | 종양의 진단 및 치료 방법 및 이를 위한 조성물 |
-
2004
- 2004-03-15 AU AU2004220156A patent/AU2004220156B2/en not_active Ceased
- 2004-03-15 MX MXPA05009751A patent/MXPA05009751A/es active IP Right Grant
- 2004-03-15 CN CNA2004800069196A patent/CN1761682A/zh active Pending
- 2004-03-15 CA CA002519105A patent/CA2519105A1/en not_active Abandoned
- 2004-03-15 JP JP2005503621A patent/JPWO2004081047A1/ja active Pending
- 2004-03-15 WO PCT/JP2004/003424 patent/WO2004081047A1/ja active IP Right Grant
- 2004-03-15 EP EP04720764A patent/EP1607404A4/en not_active Withdrawn
- 2004-03-15 RU RU2005131842/13A patent/RU2312109C2/ru not_active IP Right Cessation
- 2004-03-15 KR KR1020057017073A patent/KR20050108389A/ko not_active Application Discontinuation
- 2004-03-15 US US10/548,591 patent/US7435590B2/en not_active Expired - Fee Related
-
2005
- 2005-09-20 NO NO20054351A patent/NO20054351L/no not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| US20060252105A1 (en) | 2006-11-09 |
| EP1607404A1 (en) | 2005-12-21 |
| JPWO2004081047A1 (ja) | 2006-06-29 |
| WO2004081047A1 (ja) | 2004-09-23 |
| AU2004220156A1 (en) | 2004-09-23 |
| CA2519105A1 (en) | 2004-09-23 |
| EP1607404A4 (en) | 2008-01-23 |
| US7435590B2 (en) | 2008-10-14 |
| AU2004220156B2 (en) | 2007-04-19 |
| MXPA05009751A (es) | 2005-10-26 |
| CN1761682A (zh) | 2006-04-19 |
| NO20054351D0 (no) | 2005-09-20 |
| NO20054351L (no) | 2005-11-28 |
| KR20050108389A (ko) | 2005-11-16 |
| RU2312109C2 (ru) | 2007-12-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | The patent is invalid due to non-payment of fees |
Effective date: 20110316 |