RS64315B1 - Fuzioni proteini tgf-beta receptora tipa ii i njihove upotrebe - Google Patents

Fuzioni proteini tgf-beta receptora tipa ii i njihove upotrebe

Info

Publication number
RS64315B1
RS64315B1 RS20230526A RSP20230526A RS64315B1 RS 64315 B1 RS64315 B1 RS 64315B1 RS 20230526 A RS20230526 A RS 20230526A RS P20230526 A RSP20230526 A RS P20230526A RS 64315 B1 RS64315 B1 RS 64315B1
Authority
RS
Serbia
Prior art keywords
tgf
fusion proteins
receptor type
beta receptor
beta
Prior art date
Application number
RS20230526A
Other languages
English (en)
Inventor
Ravindra Kumar
Dianne S Sako
Original Assignee
Acceleron Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Acceleron Pharma Inc filed Critical Acceleron Pharma Inc
Publication of RS64315B1 publication Critical patent/RS64315B1/sr

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/10Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide
    • C07K2319/30Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02ATECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Cell Biology (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Vascular Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Epidemiology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
RS20230526A 2017-05-04 2018-05-03 Fuzioni proteini tgf-beta receptora tipa ii i njihove upotrebe RS64315B1 (sr)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201762501229P 2017-05-04 2017-05-04
US201762510422P 2017-05-24 2017-05-24
US201762578674P 2017-10-30 2017-10-30
PCT/US2018/030816 WO2018204594A1 (en) 2017-05-04 2018-05-03 Tgf-beta receptor type ii fusion proteins and uses thereof
EP18794202.4A EP3628049B1 (en) 2017-05-04 2018-05-03 Tgf-beta receptor type ii fusion proteins and uses thereof

Publications (1)

Publication Number Publication Date
RS64315B1 true RS64315B1 (sr) 2023-08-31

Family

ID=64016255

Family Applications (1)

Application Number Title Priority Date Filing Date
RS20230526A RS64315B1 (sr) 2017-05-04 2018-05-03 Fuzioni proteini tgf-beta receptora tipa ii i njihove upotrebe

Country Status (21)

Country Link
US (2) US11021527B2 (sr)
EP (2) EP4241848A3 (sr)
JP (2) JP7267664B2 (sr)
KR (2) KR20240023201A (sr)
CN (1) CN110785431B (sr)
AU (2) AU2018261131A1 (sr)
BR (1) BR112019023071A2 (sr)
CA (1) CA3061472A1 (sr)
CY (1) CY1126121T1 (sr)
DK (1) DK3628049T3 (sr)
ES (1) ES2948647T3 (sr)
FI (1) FI3628049T3 (sr)
HR (1) HRP20230706T1 (sr)
HU (1) HUE063840T2 (sr)
LT (1) LT3628049T (sr)
MD (1) MD3628049T2 (sr)
PL (1) PL3628049T3 (sr)
PT (1) PT3628049T (sr)
RS (1) RS64315B1 (sr)
SI (1) SI3628049T1 (sr)
WO (1) WO2018204594A1 (sr)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN105658672A (zh) 2013-08-22 2016-06-08 阿塞勒隆制药公司 TGF-β受体II型变体及其用途
AU2016301380B2 (en) 2015-08-04 2021-07-01 Acceleron Pharma Inc. Methods for treating myeloproliferative disorders
EP3496739B1 (en) 2016-07-15 2021-04-28 Acceleron Pharma Inc. Compositions comprising actriia polypeptides for use in treating pulmonary hypertension
IL305536A (en) 2017-03-02 2023-10-01 Nat Res Council Canada TGF–B receptor ectodomain fusion compounds and their uses
BR112020025804A2 (pt) 2018-06-22 2021-03-23 Kite Pharma, Inc. proteínas transmembranares quiméricas e usos das mesmas
JP2021531754A (ja) 2018-07-09 2021-11-25 プレシゲン,インコーポレイテッド 融合構築物およびその使用法
WO2021030662A1 (en) * 2019-08-15 2021-02-18 Nantbio, Inc. Tgf-beta trap
CN110734498A (zh) * 2019-10-15 2020-01-31 上海科棋药业科技有限公司 一种用于解除免疫抑制的融合蛋白及其应用
MX2022004873A (es) 2019-10-23 2022-05-13 Cue Biopharma Inc Polipeptidos de tgf-?.
US20240226235A1 (en) * 2019-11-05 2024-07-11 Acceleron Pharma Inc. Treatments for systemic sclerosis
WO2021218883A1 (zh) * 2020-04-28 2021-11-04 神州细胞工程有限公司 一种TGFβR2胞外区截短分子、其与抗EGFR抗体的融合蛋白及其抗肿瘤用途
US20230416321A1 (en) * 2020-11-23 2023-12-28 Cue Biopharma, Inc. TGF-Beta Polypeptides
EP4351723A2 (en) * 2021-06-11 2024-04-17 Acceleron Pharma Inc. Actrii proteins and uses thereof

Family Cites Families (101)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8529014D0 (en) 1985-11-25 1986-01-02 Biogen Nv Enhanced secretion of heterologous proteins
AU597574B2 (en) 1986-03-07 1990-06-07 Massachusetts Institute Of Technology Method for enhancing glycoprotein stability
DE3883899T3 (de) 1987-03-18 1999-04-22 Sb2, Inc., Danville, Calif. Geänderte antikörper.
US5080891A (en) 1987-08-03 1992-01-14 Ddi Pharmaceuticals, Inc. Conjugates of superoxide dismutase coupled to high molecular weight polyalkylene glycols
US5223409A (en) 1988-09-02 1993-06-29 Protein Engineering Corp. Directed evolution of novel binding proteins
US5571714A (en) 1988-12-22 1996-11-05 Celtrix Pharmaceuticals, Inc. Monoclonal antibodies which bind both transforming growth factors β1 and β2 and methods of use
US5198346A (en) 1989-01-06 1993-03-30 Protein Engineering Corp. Generation and selection of novel DNA-binding proteins and polypeptides
US5096815A (en) 1989-01-06 1992-03-17 Protein Engineering Corporation Generation and selection of novel dna-binding proteins and polypeptides
ZA914750B (en) 1990-06-20 1992-03-25 Bristol Myers Squibb Co Methods of modulating blood pressure using tgf-beta and antagonists thereof
GB9106678D0 (en) 1991-03-28 1991-05-15 Ferguson Mark W J Wound healing
US6008011A (en) 1991-10-31 1999-12-28 Whitehead Institute For Biomedical Research TGF-β type II receptor cDNAs
AU671606B2 (en) 1991-10-31 1996-09-05 Whitehead Institute For Biomedical Research TGF-beta type receptor cDNAs and uses therefor
US5543143A (en) 1992-03-06 1996-08-06 Corixa Corporation Method for activating macrophages/monocytes
AU669256B2 (en) 1992-10-29 1996-05-30 Celtrix Pharmaceuticals, Inc. Uses of TGF-beta receptor fragment as a therapeutic agent
US5677196A (en) 1993-05-18 1997-10-14 University Of Utah Research Foundation Apparatus and methods for multi-analyte homogeneous fluoro-immunoassays
US5885573A (en) 1993-06-01 1999-03-23 Arch Development Corporation Methods and materials for modulation of the immunosuppressive activity and toxicity of monoclonal antibodies
AU691811B2 (en) 1993-06-16 1998-05-28 Celltech Therapeutics Limited Antibodies
ATE355369T1 (de) 1993-10-14 2006-03-15 Harvard College Verfahren zur induzierung und zur erhaltung neuronalen zellen
US5470952A (en) 1993-10-20 1995-11-28 Regeneron Pharmaceuticals, Inc. CNTF and IL-6 antagonists
US5525490A (en) 1994-03-29 1996-06-11 Onyx Pharmaceuticals, Inc. Reverse two-hybrid method
US5541087A (en) 1994-09-14 1996-07-30 Fuji Immunopharmaceuticals Corporation Expression and export technology of proteins as immunofusins
US5814565A (en) 1995-02-23 1998-09-29 University Of Utah Research Foundation Integrated optic waveguide immunosensor
US5866323A (en) 1995-04-07 1999-02-02 Case Western Reserve University Cancer diagnosis prognosis and therapy based on mutation of receptors for transforming growth factor β and homologous growth controlling factors
NZ306767A (en) 1995-04-11 2000-03-27 Univ Johns Hopkins Method of identifying molecular interactions employing counterselection and at least two hybrid molecules or two hybrid systems
US6423501B2 (en) 1996-12-13 2002-07-23 Beth Israel Deaconess Medical Center Calcium-independent negative regulation by CD81 of receptor signaling
DK0975771T3 (da) 1997-04-18 2007-10-22 Biogen Idec Inc Fusionsproteiner af TGF-beta-receptortype II og immunoglobulins konstante region
WO1998047531A2 (en) 1997-04-21 1998-10-29 Arch Development Corporation Fc receptor non-binding anti-cd3 monoclonal antibodies deliver a partial tcr signal and induce clonal anergy
US6294350B1 (en) 1997-06-05 2001-09-25 Dalhousie University Methods for treating fibroproliferative diseases
ZA988461B (en) 1997-09-18 1999-03-30 Idec Pharma Corp Synergistic composition and methods for treating neoplastic or cancerous growths and for restoring or boosting hematopoiesis
ES2532910T3 (es) 1998-04-02 2015-04-01 Genentech, Inc. Variantes de anticuerpos y fragmentos de los mismos
US6194551B1 (en) 1998-04-02 2001-02-27 Genentech, Inc. Polypeptide variants
AU4572899A (en) 1998-06-16 2000-01-05 Biogen, Inc. Variant type ii tgf-beta receptor fusion proteins and methods
ES2146552B1 (es) 1998-11-24 2001-04-16 Inst Cientifico Tecnol Navarra Peptidos inhibidores de tgf/31
WO2001066140A1 (en) 2000-03-09 2001-09-13 Genzyme Corporation Use of tgf-beta antagonists to treat or to prevent loss of renal function
WO2001073128A1 (en) 2000-03-24 2001-10-04 Dzgenes, Llc DIAGNOSTIC POLYMORPHISMS OF TGF-β-RII PROMOTER
US20030028905A1 (en) 2001-07-31 2003-02-06 Petra Knaus Mutant forms of the TGF-beta type II receptor which bind all TGF-beta isoforms
US20030180301A1 (en) 2002-01-22 2003-09-25 Shaf Keshavjee Use of TGF-beta antagonists to treat or to prevent chronic transplant rejection
US7919084B2 (en) 2002-06-17 2011-04-05 St. Vincent's Hospital Sydney Limited Methods of diagnosis, prognosis and treatment of cardiovascular disease
CA2513086A1 (en) 2002-12-19 2004-07-08 Scios Inc. Treatment of obesity and associated conditions with tgf-.beta. inhibitors
WO2004098637A1 (en) 2003-04-30 2004-11-18 Genzyme Corporation Tgf-beta antagonists combined with renin-angiotensin-aldosteron-system antagonists for treating renal insufficiency
WO2005019258A2 (en) 2003-08-11 2005-03-03 Genentech, Inc. Compositions and methods for the treatment of immune related diseases
US20060229266A1 (en) 2003-08-13 2006-10-12 Kumar Nalin M Silencing of tgf-beta receptor type II expression by sirna
US20050148555A1 (en) 2003-08-22 2005-07-07 Boehringer Ingelheim Pharmaceuticals, Inc. Methods of treating COPD and pulmonary hypertension
WO2005113585A2 (en) 2004-05-20 2005-12-01 Acceleron Pharma Inc. Modified tgf-beta superfamily polypeptides
US7786261B2 (en) 2004-09-02 2010-08-31 National Research Council Of Canada Coiled-coil fusion proteins comprising cell receptor domains
WO2006036729A2 (en) 2004-09-22 2006-04-06 Genzyme Corporation USE OF TGF-β ANTAGONISTS TO LIMIT NEPHROTOXICITY OF IMMUNOSUPPRESSIVE AGENTS
US7795389B2 (en) 2004-09-28 2010-09-14 The Board Of Regents Of The University Of Texas System Antagonizing TGF-beta activity with various ectodomains TGF-beta receptors used in combination or as fusion proteins
EP1809324A4 (en) 2004-10-13 2009-02-25 Univ Ohio State Res Found METHODS OF TREATING OR PREVENTING LYMPHOPROLIFERATIVE DISORDERS ASSOCIATED WITH VIRUSES
ES2905923T3 (es) 2005-02-08 2022-04-12 Genzyme Corp Anticuerpos de TGFbeta
JP5342834B2 (ja) 2008-09-05 2013-11-13 日東電工株式会社 骨髄線維症処置剤
ITMI20060181A1 (it) 2006-02-03 2007-08-04 Univ Padova Modulatori del tgf-b e loro uso
EP1998810A4 (en) 2006-03-13 2009-09-02 Univ Johns Hopkins INCREASE OF ENDOTHELIAL THROMBORESISTENTEN
EP2029625A2 (en) 2006-06-05 2009-03-04 Novartis AG Use of tgf-beta antagonists in treatment of parathyroid-related disorders
EP2083863B1 (en) 2006-10-03 2015-03-18 Genzyme Corporation Antibodies to tgf-beta for use in the treatment of infants at risk of developing bronchopulmonary dysplasia
WO2008113185A1 (en) 2007-03-19 2008-09-25 National Research Counsil Of Canada Antagonists of ligands and uses thereof
EP2171062A1 (en) 2007-06-15 2010-04-07 Genzyme Corporation Fusion proteins containing two tgf-beta binding domains of tgf-beta type ii receptor
EA017392B1 (ru) 2007-08-22 2012-12-28 Айрм Ллк Производные 2-гетероариламинопиримидина в качестве ингибиторов киназ
EP2238241B1 (en) 2008-01-18 2013-09-11 The Brigham and Women's Hospital, Inc. Selective differentiation, identification, and modulation of human th17 cells
WO2009143309A2 (en) 2008-05-21 2009-11-26 Trustees Of Dartmouth College Female reproductive tract and anal prophylaxes
WO2009152610A1 (en) 2008-06-20 2009-12-23 The Royal Institution For The Advancement Of Learning/Mcgill University Interleukin-2/soluble tgf-beta type ii receptor b conjugates and methods and uses thereof
KR20110044992A (ko) 2008-07-02 2011-05-03 이머전트 프로덕트 디벨롭먼트 시애틀, 엘엘씨 TGF-β 길항제 다중-표적 결합 단백질
CA2737271C (en) 2008-09-17 2020-06-23 National Research Council Of Canada Hetero-multivalent binding agents for members of the tgf.beta. superfamily
WO2010048273A2 (en) 2008-10-21 2010-04-29 President And Fellows Of Harvard College Methods and compounds for treatment of neurodegenerative disorders
AU2010204985A1 (en) 2009-01-13 2011-08-04 Acceleron Pharma Inc. Methods for increasing adiponectin
WO2010129515A1 (en) 2009-05-08 2010-11-11 The United Satates Of America As Represented By The Secretary, Department Of Health & Human Services Modulation of the tgf-beta and pi3k/akt pathways in the diagnosis and treatment of squamous cell carcinoma
WO2011088148A1 (en) 2010-01-12 2011-07-21 Isis Pharmaceuticals, Inc. Modulation of transforming growth factor-beta 1 expression
PT2542590T (pt) * 2010-03-05 2017-08-31 Univ Johns Hopkins Composições e métodos para anticorpos e proteínas de fusão imunomoduladores direcionados
CN101852804B (zh) 2010-03-29 2013-06-12 中国医学科学院病原生物学研究所 Gdf15蛋白的抗体的新用途
US8080568B1 (en) 2010-06-29 2011-12-20 Ewha University - Industry Collaboration Foundation 2-pyridyl substituted imidazoles as therapeutic ALK5 and/or ALK4 inhibitors
ES2715177T3 (es) 2010-09-01 2019-06-03 Genzyme Corp Tratamiento de infarto de miocardio usando antagonistas de tgf-beta
US20130287688A1 (en) 2010-11-18 2013-10-31 Xtuit Pharmaceuticals, Inc. Novel compositions and uses of anti-hypertension agents for cancer therapy
US8800906B2 (en) 2010-12-27 2014-08-12 The Board Of Trustees Of The Leland Stanford Junior University Use of transforming growth factor-beta neutralizing antibodies and fusion proteins thereof in treating pain
SG191762A1 (en) 2011-01-06 2013-08-30 Glaxo Group Ltd Ligands that bind tgf-beta receptor ii
JP5588086B2 (ja) * 2011-04-19 2014-09-10 メリマック ファーマシューティカルズ インコーポレーティッド 単一特異性および二重特異性抗IGF‐1R抗体および抗ErbB3抗体
CN108178789B (zh) 2011-04-20 2021-11-02 阿塞勒隆制药公司 内皮糖蛋白多肽及其用途
CN102850458B (zh) 2011-06-28 2014-10-01 华博生物医药技术(上海)有限公司 新型重组双功能融合蛋白及其制法和用途
WO2013012648A1 (en) 2011-07-15 2013-01-24 Emory University Gdf15 in diagnostic and therapeutic applications
US9468666B2 (en) 2011-08-01 2016-10-18 Tufts Medical Center, Inc. Treatment of heart failure and related conditions
WO2013059879A1 (en) 2011-10-26 2013-05-02 Howard Florey Institute Of Experimental Physiology And Medicine Compositions and methods for the treatment of fibrosis and fibrotic diseases
PL3489254T3 (pl) 2012-04-30 2023-01-30 Biocon Limited Ukierunkowujące/immunomodulujące białko fuzyjne i sposoby jego otrzymywania
JP2015523966A (ja) 2012-05-16 2015-08-20 アーディジェン, エルエルシー 線維症および炎症状態を処置するための多標的調整
ES2713505T3 (es) 2013-03-11 2019-05-22 Genzyme Corp Anticuerpos anti-TGF-beta modificados genéticamente y fragmentos de unión a antígeno
RU2662991C2 (ru) * 2013-03-12 2018-07-31 Биокон Лтд. Слитые иммуномодулирующие белки и способы их получения
JP6578271B2 (ja) 2013-04-17 2019-09-18 ベイラー カレッジ オブ メディスンBaylor College Of Medicine 免疫抑制TGF−βシグナルコンバーター
CN105658672A (zh) * 2013-08-22 2016-06-08 阿塞勒隆制药公司 TGF-β受体II型变体及其用途
EP3071215B1 (en) 2013-11-21 2020-01-08 The Brigham and Women's Hospital, Inc. Compositions and methods for treating pulmonary hypertension
BR112016014952A2 (pt) 2014-02-10 2017-09-19 Merck Patent Gmbh Inibição direcionada de tgfbeta
KR20170005854A (ko) 2014-05-18 2017-01-16 칠드런'즈 메디컬 센터 코포레이션 엑소솜과 관련된 방법 및 조성물
CN106413740A (zh) 2014-06-13 2017-02-15 诺华股份有限公司 用于降低gdf‑15的serelaxin应用
CA2956256A1 (en) 2014-08-01 2016-02-04 The Brigham And Women's Hospital, Inc. Methods and compositions relating to treatment of pulmonary arterial hypertension
JP6631865B2 (ja) * 2014-08-11 2020-01-15 日本化薬株式会社 TGFβ阻害機能を持つキメラタンパク質
EP3889171A1 (en) 2015-04-06 2021-10-06 Acceleron Pharma Inc. Tgf-beta superfamily type i and type ii receptor heteromultimers and uses thereof
AU2016246602B2 (en) 2015-04-06 2020-11-19 Acceleron Pharma Inc. Single-arm type I and type II receptor fusion proteins and uses thereof
AU2016301380B2 (en) 2015-08-04 2021-07-01 Acceleron Pharma Inc. Methods for treating myeloproliferative disorders
EP3344660A4 (en) 2015-08-31 2019-07-03 National Research Council of Canada TGF-BETA-RECEPTOR-EKTODOMÄNENFUSIONSMOLEKÜLE AND USES THEREOF
WO2017134592A1 (en) 2016-02-03 2017-08-10 Biocon Limited Anti-cd20/immunomodulatory fusion proteins and methods for making same
MX2019001503A (es) 2016-08-12 2019-06-03 Merck Patent Gmbh Tratamiento conjunto contra el cancer.
CN110546168B (zh) 2016-09-27 2024-03-15 埃皮辛特瑞柯斯公司 免疫调节性融合蛋白
BR112019013924A2 (pt) 2017-01-07 2020-02-11 Merck Patent Gmbh Regimes de dosagem e formas de dosagem para inibição de tgf-beta direcionada
IL305536A (en) 2017-03-02 2023-10-01 Nat Res Council Canada TGF–B receptor ectodomain fusion compounds and their uses
JP2021512919A (ja) 2018-02-09 2021-05-20 アクセルロン ファーマ インコーポレイテッド 異所性骨化を処置するための方法

Also Published As

Publication number Publication date
SI3628049T1 (sl) 2023-10-30
KR20200003873A (ko) 2020-01-10
CN110785431A (zh) 2020-02-11
HUE063840T2 (hu) 2024-02-28
US11021527B2 (en) 2021-06-01
CN110785431B (zh) 2024-05-07
PT3628049T (pt) 2023-07-03
BR112019023071A2 (pt) 2020-06-09
ES2948647T3 (es) 2023-09-15
LT3628049T (lt) 2023-08-25
MD3628049T2 (ro) 2023-10-31
EP4241848A3 (en) 2023-11-01
EP3628049B1 (en) 2023-05-10
CY1126121T1 (el) 2023-11-15
US20210324040A1 (en) 2021-10-21
US20180327477A1 (en) 2018-11-15
WO2018204594A1 (en) 2018-11-08
AU2023200218A1 (en) 2023-02-16
PL3628049T3 (pl) 2023-09-25
EP4241848A2 (en) 2023-09-13
DK3628049T3 (da) 2023-08-14
HRP20230706T1 (hr) 2023-10-13
CA3061472A1 (en) 2018-11-08
EP3628049A1 (en) 2020-04-01
KR20240023201A (ko) 2024-02-20
FI3628049T3 (fi) 2023-07-26
AU2018261131A1 (en) 2019-11-07
EP3628049A4 (en) 2021-01-13
JP7267664B2 (ja) 2023-05-02
JP2023055827A (ja) 2023-04-18
JP2020518246A (ja) 2020-06-25
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