DK3628049T3 - Tgf-beta-receptortype-ii-fusionsproteiner og anvendelser deraf - Google Patents
Tgf-beta-receptortype-ii-fusionsproteiner og anvendelser deraf Download PDFInfo
- Publication number
- DK3628049T3 DK3628049T3 DK18794202.4T DK18794202T DK3628049T3 DK 3628049 T3 DK3628049 T3 DK 3628049T3 DK 18794202 T DK18794202 T DK 18794202T DK 3628049 T3 DK3628049 T3 DK 3628049T3
- Authority
- DK
- Denmark
- Prior art keywords
- tgf
- fusion proteins
- receptor type
- beta receptor
- beta
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Biochemistry (AREA)
- Toxicology (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- Cell Biology (AREA)
- Urology & Nephrology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- Peptides Or Proteins (AREA)
- Epidemiology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762501229P | 2017-05-04 | 2017-05-04 | |
US201762510422P | 2017-05-24 | 2017-05-24 | |
US201762578674P | 2017-10-30 | 2017-10-30 | |
PCT/US2018/030816 WO2018204594A1 (en) | 2017-05-04 | 2018-05-03 | Tgf-beta receptor type ii fusion proteins and uses thereof |
Publications (1)
Publication Number | Publication Date |
---|---|
DK3628049T3 true DK3628049T3 (da) | 2023-08-14 |
Family
ID=64016255
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK18794202.4T DK3628049T3 (da) | 2017-05-04 | 2018-05-03 | Tgf-beta-receptortype-ii-fusionsproteiner og anvendelser deraf |
Country Status (21)
Country | Link |
---|---|
US (2) | US11021527B2 (da) |
EP (2) | EP4241848A3 (da) |
JP (2) | JP7267664B2 (da) |
KR (2) | KR102635723B1 (da) |
CN (1) | CN110785431B (da) |
AU (2) | AU2018261131A1 (da) |
BR (1) | BR112019023071A2 (da) |
CA (1) | CA3061472A1 (da) |
CY (1) | CY1126121T1 (da) |
DK (1) | DK3628049T3 (da) |
ES (1) | ES2948647T3 (da) |
FI (1) | FI3628049T3 (da) |
HR (1) | HRP20230706T1 (da) |
HU (1) | HUE063840T2 (da) |
LT (1) | LT3628049T (da) |
MD (1) | MD3628049T2 (da) |
PL (1) | PL3628049T3 (da) |
PT (1) | PT3628049T (da) |
RS (1) | RS64315B1 (da) |
SI (1) | SI3628049T1 (da) |
WO (1) | WO2018204594A1 (da) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2015027082A1 (en) | 2013-08-22 | 2015-02-26 | Acceleron Pharma, Inc. | Tgf-beta receptor type ii variants and uses thereof |
CA2994413A1 (en) | 2015-08-04 | 2017-02-09 | Acceleron Pharma, Inc. | Methods for treating myeloproliferative disorders |
EP3496739B1 (en) | 2016-07-15 | 2021-04-28 | Acceleron Pharma Inc. | Compositions comprising actriia polypeptides for use in treating pulmonary hypertension |
EP3589663A4 (en) | 2017-03-02 | 2020-10-21 | National Research Council of Canada | TGF-ß RECEPTOR EECTODOMAN FUSION MOLECULES AND USES THEREOF |
US11708401B2 (en) | 2018-06-22 | 2023-07-25 | Kite Pharma, Inc. | Chimeric transmembrane proteins and uses thereof |
KR20210042909A (ko) | 2018-07-09 | 2021-04-20 | 프레시전 인코포레이티드 | 융합 구조물 및 그의 이용 방법 |
CA3149810A1 (en) * | 2019-08-15 | 2021-02-18 | Nantbio, Inc. | Tgf-beta trap |
CN110734498A (zh) * | 2019-10-15 | 2020-01-31 | 上海科棋药业科技有限公司 | 一种用于解除免疫抑制的融合蛋白及其应用 |
CN114728072A (zh) | 2019-10-23 | 2022-07-08 | 库尔生物制药有限公司 | TGF-β多肽 |
WO2021092079A1 (en) * | 2019-11-05 | 2021-05-14 | Acceleron Pharma Inc. | Treatments for systemic sclerosis |
BR112022021785A2 (pt) * | 2020-04-28 | 2022-12-06 | Sinocelltech Ltd | Molécula truncada de domínio extracelular tgfbr2, proteína de fusão de molécula truncada de domínio extracelular tgfbr2 e anticorpo anti-egfr e uso antitumoral de proteína de fusão |
JP2023550626A (ja) * | 2020-11-23 | 2023-12-04 | キュー バイオファーマ,インコーポレーテッド | TGF-βポリペプチド |
EP4351723A2 (en) * | 2021-06-11 | 2024-04-17 | Acceleron Pharma Inc. | Actrii proteins and uses thereof |
Family Cites Families (101)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8529014D0 (en) | 1985-11-25 | 1986-01-02 | Biogen Nv | Enhanced secretion of heterologous proteins |
EP0272253A4 (en) | 1986-03-07 | 1990-02-05 | Massachusetts Inst Technology | METHOD FOR IMPROVING GLYCOPROTE INSTABILITY. |
JP3101690B2 (ja) | 1987-03-18 | 2000-10-23 | エス・ビィ・2・インコーポレイテッド | 変性抗体の、または変性抗体に関する改良 |
US5080891A (en) | 1987-08-03 | 1992-01-14 | Ddi Pharmaceuticals, Inc. | Conjugates of superoxide dismutase coupled to high molecular weight polyalkylene glycols |
US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
US5571714A (en) | 1988-12-22 | 1996-11-05 | Celtrix Pharmaceuticals, Inc. | Monoclonal antibodies which bind both transforming growth factors β1 and β2 and methods of use |
US5198346A (en) | 1989-01-06 | 1993-03-30 | Protein Engineering Corp. | Generation and selection of novel DNA-binding proteins and polypeptides |
US5096815A (en) | 1989-01-06 | 1992-03-17 | Protein Engineering Corporation | Generation and selection of novel dna-binding proteins and polypeptides |
WO1991019513A1 (en) | 1990-06-20 | 1991-12-26 | Bristol-Myers Squibb Company | METHODS OF MODULATING BLOOD PRESSURE USING TGF-β AND ANTAGONISTS THEREOF |
GB9106678D0 (en) | 1991-03-28 | 1991-05-15 | Ferguson Mark W J | Wound healing |
DE69232986T2 (de) | 1991-10-31 | 2003-12-11 | Whitehead Biomedical Inst | TGF-BETA TYP III REZEPTOR, DAFüR KODIERENDE CDNS UND DEREN VERWENDUNG |
US6008011A (en) | 1991-10-31 | 1999-12-28 | Whitehead Institute For Biomedical Research | TGF-β type II receptor cDNAs |
US5543143A (en) | 1992-03-06 | 1996-08-06 | Corixa Corporation | Method for activating macrophages/monocytes |
ES2174868T3 (es) | 1992-10-29 | 2002-11-16 | Celtrix Pharma | Fragmento del receptor de fijacion a tgf-beta tipoii como agente terapeutico. |
US5677196A (en) | 1993-05-18 | 1997-10-14 | University Of Utah Research Foundation | Apparatus and methods for multi-analyte homogeneous fluoro-immunoassays |
US5885573A (en) | 1993-06-01 | 1999-03-23 | Arch Development Corporation | Methods and materials for modulation of the immunosuppressive activity and toxicity of monoclonal antibodies |
WO1994029351A2 (en) | 1993-06-16 | 1994-12-22 | Celltech Limited | Antibodies |
AU701623B2 (en) | 1993-10-14 | 1999-02-04 | President And Fellows Of Harvard College | Method of inducing and maintaining neuronal cells |
US5470952A (en) | 1993-10-20 | 1995-11-28 | Regeneron Pharmaceuticals, Inc. | CNTF and IL-6 antagonists |
US5525490A (en) | 1994-03-29 | 1996-06-11 | Onyx Pharmaceuticals, Inc. | Reverse two-hybrid method |
US5541087A (en) | 1994-09-14 | 1996-07-30 | Fuji Immunopharmaceuticals Corporation | Expression and export technology of proteins as immunofusins |
US5814565A (en) | 1995-02-23 | 1998-09-29 | University Of Utah Research Foundation | Integrated optic waveguide immunosensor |
US5866323A (en) | 1995-04-07 | 1999-02-02 | Case Western Reserve University | Cancer diagnosis prognosis and therapy based on mutation of receptors for transforming growth factor β and homologous growth controlling factors |
WO1996032503A1 (en) | 1995-04-11 | 1996-10-17 | The General Hospital Corporation | Reverse two-hybrid systems |
US6423501B2 (en) | 1996-12-13 | 2002-07-23 | Beth Israel Deaconess Medical Center | Calcium-independent negative regulation by CD81 of receptor signaling |
WO1998048024A1 (en) | 1997-04-18 | 1998-10-29 | Biogen, Inc. | Type ii tgf-beta receptor/immunoglobulin constant region fusion proteins |
AU7467898A (en) | 1997-04-21 | 1998-11-13 | Arch Development Corporation | Fc receptor non-binding anti-cd3 monoclonal antibodies deliver a partial cr signal and induce clonal anergy |
US6294350B1 (en) | 1997-06-05 | 2001-09-25 | Dalhousie University | Methods for treating fibroproliferative diseases |
MY131805A (en) | 1997-09-18 | 2007-09-28 | Biogen Idec Inc | Synergistic composition and methods for treating neoplastic or cancerous growths and for restoring or boosting hematopoiesis. |
ATE375365T1 (de) | 1998-04-02 | 2007-10-15 | Genentech Inc | Antikörper varianten und fragmente davon |
US6194551B1 (en) | 1998-04-02 | 2001-02-27 | Genentech, Inc. | Polypeptide variants |
AU4572899A (en) | 1998-06-16 | 2000-01-05 | Biogen, Inc. | Variant type ii tgf-beta receptor fusion proteins and methods |
ES2146552B1 (es) | 1998-11-24 | 2001-04-16 | Inst Cientifico Tecnol Navarra | Peptidos inhibidores de tgf/31 |
JP2004502644A (ja) | 2000-03-09 | 2004-01-29 | ジェンザイム、コーポレーション | 腎機能の喪失を治療または予防するためのTGF−β拮抗薬の使用 |
WO2001073128A1 (en) | 2000-03-24 | 2001-10-04 | Dzgenes, Llc | DIAGNOSTIC POLYMORPHISMS OF TGF-β-RII PROMOTER |
US20030028905A1 (en) | 2001-07-31 | 2003-02-06 | Petra Knaus | Mutant forms of the TGF-beta type II receptor which bind all TGF-beta isoforms |
JP4564261B2 (ja) | 2002-01-22 | 2010-10-20 | ジェンザイム、コーポレーション | 慢性的移植片拒絶反応の治療と予防のためのTGF−β拮抗薬の使用 |
US7919084B2 (en) | 2002-06-17 | 2011-04-05 | St. Vincent's Hospital Sydney Limited | Methods of diagnosis, prognosis and treatment of cardiovascular disease |
JP2006512369A (ja) | 2002-12-19 | 2006-04-13 | サイオス・インコーポレーテツド | TGF−β阻害剤を用いる肥満症および関連症状の処置 |
US20060286105A1 (en) | 2003-04-30 | 2006-12-21 | Steven Ledbetter | Tgf-beta antagonists combined with renin-angiotensin-aldosteron-system antagonists for treating renal insufficiency |
WO2005019258A2 (en) | 2003-08-11 | 2005-03-03 | Genentech, Inc. | Compositions and methods for the treatment of immune related diseases |
US20060229266A1 (en) | 2003-08-13 | 2006-10-12 | Kumar Nalin M | Silencing of tgf-beta receptor type II expression by sirna |
EP1658060A2 (en) | 2003-08-22 | 2006-05-24 | Boehringer Ingelheim Pharmaceuticals Inc. | Methods of treating copd and pulmonary hypertension |
WO2005113585A2 (en) | 2004-05-20 | 2005-12-01 | Acceleron Pharma Inc. | Modified tgf-beta superfamily polypeptides |
US7786261B2 (en) | 2004-09-02 | 2010-08-31 | National Research Council Of Canada | Coiled-coil fusion proteins comprising cell receptor domains |
BRPI0515588A (pt) | 2004-09-22 | 2008-07-29 | Genzyme Corp | uso de antagonistas de tgf-beta para limitar a nefrotoxicidade de agentes imunossupressivos |
US7795389B2 (en) | 2004-09-28 | 2010-09-14 | The Board Of Regents Of The University Of Texas System | Antagonizing TGF-beta activity with various ectodomains TGF-beta receptors used in combination or as fusion proteins |
JP5481028B2 (ja) | 2004-10-13 | 2014-04-23 | ザ オハイオ ステート ユニバーシティー リサーチ ファウンデーション | ウイルス関連リンパ増殖性障害を処置または予防するための方法 |
CA2930677A1 (en) | 2005-02-08 | 2006-08-17 | Genzyme Corporation | Antibodies to tgfbeta |
JP5342834B2 (ja) | 2008-09-05 | 2013-11-13 | 日東電工株式会社 | 骨髄線維症処置剤 |
ITMI20060181A1 (it) | 2006-02-03 | 2007-08-04 | Univ Padova | Modulatori del tgf-b e loro uso |
EP1998810A4 (en) | 2006-03-13 | 2009-09-02 | Univ Johns Hopkins | INCREASE OF ENDOTHELIAL THROMBORESISTENTEN |
JP2009539842A (ja) | 2006-06-05 | 2009-11-19 | ノバルティス アクチエンゲゼルシャフト | 副甲状腺関連障害の処置におけるTGF−βアンタゴニストの使用 |
HUE035575T2 (en) | 2006-10-03 | 2018-05-28 | Genzyme Corp | Use of TGF-beta antagonists to treat children at risk of developing bronchopulmonary dysplasia |
EP2140005B1 (en) | 2007-03-19 | 2013-12-11 | National Research Council of Canada | Fusion proteins comprising two tgf-beta binding domains |
JP2010529859A (ja) | 2007-06-15 | 2010-09-02 | ジェンザイム、コーポレーション | TGF−βII型受容体の2つのTGF−β結合ドメインを含有する融合タンパク質 |
BRPI0815572A2 (pt) | 2007-08-22 | 2015-02-18 | Irm Llc | Compostos e composições como inibidores de quinases |
JP2011509676A (ja) | 2008-01-18 | 2011-03-31 | ザ ブライハム アンド ウイメンズ ホスピタル, インコーポレイテッド | ヒトTh17細胞の選択的分化、同定および調節 |
US20110104121A1 (en) | 2008-05-21 | 2011-05-05 | Wira Charles R | Female Reproductive Tract and Anal Prophylaxes |
WO2009152610A1 (en) | 2008-06-20 | 2009-12-23 | The Royal Institution For The Advancement Of Learning/Mcgill University | Interleukin-2/soluble tgf-beta type ii receptor b conjugates and methods and uses thereof |
KR20110044992A (ko) | 2008-07-02 | 2011-05-03 | 이머전트 프로덕트 디벨롭먼트 시애틀, 엘엘씨 | TGF-β 길항제 다중-표적 결합 단백질 |
CA2737271C (en) | 2008-09-17 | 2020-06-23 | National Research Council Of Canada | Hetero-multivalent binding agents for members of the tgf.beta. superfamily |
US20120010178A1 (en) | 2008-10-21 | 2012-01-12 | President And Fellows Of Harvard College | Methods and compounds for treatment of neurodegenerative disorders |
EP2387412A4 (en) | 2009-01-13 | 2013-04-03 | Acceleron Pharma Inc | METHODS FOR INCREASING ADIPONECTIN |
WO2010129515A1 (en) | 2009-05-08 | 2010-11-11 | The United Satates Of America As Represented By The Secretary, Department Of Health & Human Services | Modulation of the tgf-beta and pi3k/akt pathways in the diagnosis and treatment of squamous cell carcinoma |
WO2011088148A1 (en) | 2010-01-12 | 2011-07-21 | Isis Pharmaceuticals, Inc. | Modulation of transforming growth factor-beta 1 expression |
IL300733A (en) | 2010-03-05 | 2023-04-01 | Univ Johns Hopkins | Compositions and methods for antibodies and fusion proteins targeting immune modulation |
CN101852804B (zh) | 2010-03-29 | 2013-06-12 | 中国医学科学院病原生物学研究所 | Gdf15蛋白的抗体的新用途 |
US8080568B1 (en) | 2010-06-29 | 2011-12-20 | Ewha University - Industry Collaboration Foundation | 2-pyridyl substituted imidazoles as therapeutic ALK5 and/or ALK4 inhibitors |
NZ624382A (en) | 2010-09-01 | 2015-05-29 | Genzyme Corp | Treatment of myocardial infarction using tgf - beta antagonists |
US20130287688A1 (en) | 2010-11-18 | 2013-10-31 | Xtuit Pharmaceuticals, Inc. | Novel compositions and uses of anti-hypertension agents for cancer therapy |
US8800906B2 (en) | 2010-12-27 | 2014-08-12 | The Board Of Trustees Of The Leland Stanford Junior University | Use of transforming growth factor-beta neutralizing antibodies and fusion proteins thereof in treating pain |
PE20140982A1 (es) | 2011-01-06 | 2014-08-22 | Glaxo Group Ltd | Ligandos que se unen al receptor ii del factor de crecimiento transformante-beta |
TWI631136B (zh) * | 2011-04-19 | 2018-08-01 | 莫瑞麥克製藥公司 | 單特異性及雙特異性抗igf-1r及抗erbb3抗體 |
CN103781798B (zh) | 2011-04-20 | 2018-03-13 | 阿塞勒隆制药公司 | 内皮糖蛋白多肽及其用途 |
CN102850458B (zh) | 2011-06-28 | 2014-10-01 | 华博生物医药技术(上海)有限公司 | 新型重组双功能融合蛋白及其制法和用途 |
WO2013012648A1 (en) | 2011-07-15 | 2013-01-24 | Emory University | Gdf15 in diagnostic and therapeutic applications |
EP3530275A1 (en) | 2011-08-01 | 2019-08-28 | Tufts Medical Center, Inc. | Treatment of heart failure and related conditions |
AU2013202269A1 (en) | 2011-10-26 | 2013-05-16 | Howard Florey Institute Of Experimental Physiology And Medicine | Compositions and methods for the treatment of fibrosis and fibrotic diseases |
EP4219536A3 (en) | 2012-04-30 | 2023-08-23 | Biocon Limited | Targeted/immunomodulatory fusion proteins and methods for making same |
CA2873745A1 (en) | 2012-05-16 | 2013-11-21 | Aadigen, Llc | Multi-target modulation for treating fibrosis and inflammatory conditions |
SG10201707021RA (en) | 2013-03-11 | 2017-10-30 | Genzyme Corp | Engineered anti-tgf-beta antibodies and antigen-binding fragments |
RU2662991C2 (ru) | 2013-03-12 | 2018-07-31 | Биокон Лтд. | Слитые иммуномодулирующие белки и способы их получения |
US10584158B2 (en) | 2013-04-17 | 2020-03-10 | Baylor College Of Medicine | Immunosuppressive TGF-β signal converter |
WO2015027082A1 (en) | 2013-08-22 | 2015-02-26 | Acceleron Pharma, Inc. | Tgf-beta receptor type ii variants and uses thereof |
ES2778201T3 (es) | 2013-11-21 | 2020-08-10 | Brigham & Womens Hospital Inc | Composiciones y métodos para tratar la hipertensión pulmonar |
JP6731346B2 (ja) | 2014-02-10 | 2020-07-29 | メルク パテント ゲーエムベーハー | 標的TGFβ阻害 |
JP6773563B2 (ja) | 2014-05-18 | 2020-10-21 | ザ チルドレンズ メディカル センター コーポレーション | エキソソームに関連する方法および組成物 |
EP3154559B1 (en) | 2014-06-13 | 2021-09-01 | Novartis AG | Use of serelaxin to reduce gdf-15 |
AU2015296037B2 (en) | 2014-08-01 | 2021-04-29 | The Brigham And Women's Hospital, Inc. | Methods and compositions relating to treatment of pulmonary arterial hypertension |
JP6631865B2 (ja) * | 2014-08-11 | 2020-01-15 | 日本化薬株式会社 | TGFβ阻害機能を持つキメラタンパク質 |
KR20180002661A (ko) | 2015-04-06 | 2018-01-08 | 악셀레론 파마 인코포레이티드 | ALK7:ActRIIB 이형다합체와 이의 용도 |
CN107849114B (zh) * | 2015-04-06 | 2021-08-20 | 阿塞勒隆制药公司 | 单臂i型和ii型受体融合蛋白和其用途 |
CA2994413A1 (en) * | 2015-08-04 | 2017-02-09 | Acceleron Pharma, Inc. | Methods for treating myeloproliferative disorders |
US20200231652A1 (en) | 2015-08-31 | 2020-07-23 | National Research Council Of Canada | Tgf-b-receptor ectodomain fusion molecules and uses thereof |
WO2017134592A1 (en) * | 2016-02-03 | 2017-08-10 | Biocon Limited | Anti-cd20/immunomodulatory fusion proteins and methods for making same |
CA3031168A1 (en) | 2016-08-12 | 2018-02-15 | Merck Patent Gmbh | Combination therapy for cancer |
KR20240014617A (ko) | 2016-09-27 | 2024-02-01 | 에피센트알엑스, 인코포레이티드 | 면역조정 융합 단백질 |
KR20190102059A (ko) | 2017-01-07 | 2019-09-02 | 메르크 파텐트 게엠베하 | 표적화된 TGF-β 억제를 위한 투약 레지멘 및 투여 형태 |
EP3589663A4 (en) | 2017-03-02 | 2020-10-21 | National Research Council of Canada | TGF-ß RECEPTOR EECTODOMAN FUSION MOLECULES AND USES THEREOF |
AU2019216761A1 (en) | 2018-02-09 | 2020-09-03 | Acceleron Pharma Inc. | Methods for treating heterotopic ossification |
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2018
- 2018-05-03 HR HRP20230706TT patent/HRP20230706T1/hr unknown
- 2018-05-03 JP JP2019559817A patent/JP7267664B2/ja active Active
- 2018-05-03 CA CA3061472A patent/CA3061472A1/en active Pending
- 2018-05-03 DK DK18794202.4T patent/DK3628049T3/da active
- 2018-05-03 BR BR112019023071A patent/BR112019023071A2/pt unknown
- 2018-05-03 RS RS20230526A patent/RS64315B1/sr unknown
- 2018-05-03 FI FIEP18794202.4T patent/FI3628049T3/fi active
- 2018-05-03 ES ES18794202T patent/ES2948647T3/es active Active
- 2018-05-03 KR KR1020197035693A patent/KR102635723B1/ko active IP Right Grant
- 2018-05-03 MD MDE20200304T patent/MD3628049T2/ro unknown
- 2018-05-03 PL PL18794202.4T patent/PL3628049T3/pl unknown
- 2018-05-03 CN CN201880041794.2A patent/CN110785431B/zh active Active
- 2018-05-03 HU HUE18794202A patent/HUE063840T2/hu unknown
- 2018-05-03 SI SI201830937T patent/SI3628049T1/sl unknown
- 2018-05-03 KR KR1020247004165A patent/KR20240023201A/ko active Application Filing
- 2018-05-03 EP EP23171804.0A patent/EP4241848A3/en active Pending
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- 2018-05-03 WO PCT/US2018/030816 patent/WO2018204594A1/en unknown
- 2018-05-03 AU AU2018261131A patent/AU2018261131A1/en not_active Abandoned
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- 2018-05-03 US US15/969,957 patent/US11021527B2/en active Active
- 2018-05-03 PT PT187942024T patent/PT3628049T/pt unknown
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2021
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Also Published As
Publication number | Publication date |
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JP7267664B2 (ja) | 2023-05-02 |
EP4241848A2 (en) | 2023-09-13 |
FI3628049T3 (fi) | 2023-07-26 |
RS64315B1 (sr) | 2023-08-31 |
US20180327477A1 (en) | 2018-11-15 |
PT3628049T (pt) | 2023-07-03 |
CA3061472A1 (en) | 2018-11-08 |
ES2948647T3 (es) | 2023-09-15 |
AU2018261131A1 (en) | 2019-11-07 |
SI3628049T1 (sl) | 2023-10-30 |
HRP20230706T1 (hr) | 2023-10-13 |
CN110785431A (zh) | 2020-02-11 |
EP3628049A4 (en) | 2021-01-13 |
MD3628049T2 (ro) | 2023-10-31 |
JP2023055827A (ja) | 2023-04-18 |
EP3628049A1 (en) | 2020-04-01 |
HUE063840T2 (hu) | 2024-02-28 |
EP4241848A3 (en) | 2023-11-01 |
KR20240023201A (ko) | 2024-02-20 |
AU2023200218A1 (en) | 2023-02-16 |
WO2018204594A1 (en) | 2018-11-08 |
PL3628049T3 (pl) | 2023-09-25 |
CN110785431B (zh) | 2024-05-07 |
KR102635723B1 (ko) | 2024-02-08 |
JP2020518246A (ja) | 2020-06-25 |
US11021527B2 (en) | 2021-06-01 |
CY1126121T1 (el) | 2023-11-15 |
LT3628049T (lt) | 2023-08-25 |
US20210324040A1 (en) | 2021-10-21 |
BR112019023071A2 (pt) | 2020-06-09 |
EP3628049B1 (en) | 2023-05-10 |
KR20200003873A (ko) | 2020-01-10 |
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