RS63503B1 - Inhibitori rho kinaze - Google Patents
Inhibitori rho kinazeInfo
- Publication number
- RS63503B1 RS63503B1 RS20220776A RSP20220776A RS63503B1 RS 63503 B1 RS63503 B1 RS 63503B1 RS 20220776 A RS20220776 A RS 20220776A RS P20220776 A RSP20220776 A RS P20220776A RS 63503 B1 RS63503 B1 RS 63503B1
- Authority
- RS
- Serbia
- Prior art keywords
- kinase inhibitors
- rho kinase
- rho
- inhibitors
- kinase
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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- A—HUMAN NECESSITIES
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- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
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- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/32—One oxygen, sulfur or nitrogen atom
- C07D239/42—One nitrogen atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
Applications Claiming Priority (4)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201261710373P | 2012-10-05 | 2012-10-05 | |
US201361840288P | 2013-06-27 | 2013-06-27 | |
EP13843426.1A EP2903618B1 (en) | 2012-10-05 | 2013-10-07 | Rho kinase inhibitors |
PCT/US2013/063752 WO2014055996A2 (en) | 2012-10-05 | 2013-10-07 | Rho kinase inhibitors |
Publications (1)
Publication Number | Publication Date |
---|---|
RS63503B1 true RS63503B1 (sr) | 2022-09-30 |
Family
ID=50435589
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RS20220776A RS63503B1 (sr) | 2012-10-05 | 2013-10-07 | Inhibitori rho kinaze |
Country Status (16)
Country | Link |
---|---|
US (4) | US9815820B2 (sr) |
EP (2) | EP2903618B1 (sr) |
JP (2) | JP6419076B2 (sr) |
CN (5) | CN113773308A (sr) |
CA (2) | CA2926478C (sr) |
DK (1) | DK2903618T3 (sr) |
EA (1) | EA201500362A1 (sr) |
ES (1) | ES2924915T3 (sr) |
HR (1) | HRP20220913T1 (sr) |
HU (1) | HUE059305T2 (sr) |
LT (1) | LT2903618T (sr) |
PL (1) | PL2903618T3 (sr) |
PT (1) | PT2903618T (sr) |
RS (1) | RS63503B1 (sr) |
SI (1) | SI2903618T1 (sr) |
WO (1) | WO2014055996A2 (sr) |
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CA2995344C (en) * | 2014-10-07 | 2021-05-04 | Kadmon Corporation, Llc | Human anti-vegfr-2/kdr antibodies |
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IT201700047189A1 (it) * | 2017-05-02 | 2018-11-02 | Fondazione St Italiano Tecnologia | Composti e composizioni per il trattamento di cancro, disordini della retina e cardiomiopatie |
CN117343049A (zh) | 2017-06-30 | 2024-01-05 | 北京泰德制药股份有限公司 | Rho相关蛋白激酶抑制剂、包含其的药物组合物及其制备方法和用途 |
JP7039802B2 (ja) * | 2017-06-30 | 2022-03-23 | ベイジン タイド ファーマシューティカル カンパニー リミテッド | Rho-関連プロテインキナーゼ阻害剤、rho-関連プロテインキナーゼ阻害剤を含む医薬組成物、当該医薬組成物の調製方法及び使用 |
WO2019000682A1 (zh) | 2017-06-30 | 2019-01-03 | 北京泰德制药股份有限公司 | Rho相关蛋白激酶抑制剂、包含其的药物组合物及其制备方法和用途 |
EP3675861A4 (en) * | 2017-09-01 | 2021-01-06 | Kadmon Corporation, LLC | ALPHA SUPERWINDING PROTEIN KINASE INHIBITORS ("COILED-COIL") ASSOCIATED WITH RHO |
WO2019046795A1 (en) | 2017-09-03 | 2019-03-07 | Angion Biomedica Corp. | VINYL HETEROCYCLES AS INHIBITORS OF RHO (ROCK) ASSOCIATED BISPIRALIZED KINASE |
US11345678B2 (en) | 2018-04-18 | 2022-05-31 | Medshine Discovery Inc. | Benzopyrazole compound used as RHO kinase inhibitor |
JP2022506572A (ja) | 2018-11-06 | 2022-01-17 | サーベロ・セラピューティクス・エル・エル・シー | Rockキナーゼ阻害剤 |
US11248004B2 (en) | 2018-11-06 | 2022-02-15 | Cervello Therapeutics, Llc. | Substituted isoquinolines as rock kinase inhibitors |
US20220202827A1 (en) * | 2019-04-08 | 2022-06-30 | The General Hospital Corporation | Enhancement of Melanocyte Migration Using ROCK Inhibitors |
WO2021073592A1 (zh) | 2019-10-18 | 2021-04-22 | 南京明德新药研发有限公司 | 作为rho激酶抑制剂的苯并吡唑类化合物的盐型、晶型及其制备方法 |
WO2021129589A1 (zh) * | 2019-12-27 | 2021-07-01 | 广东东阳光药业有限公司 | Kd-025的新晶型及其制备方法 |
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WO2022042666A1 (zh) * | 2020-08-28 | 2022-03-03 | 杭州邦顺制药有限公司 | 选择性rock2激酶抑制剂 |
KR20230157307A (ko) | 2021-01-11 | 2023-11-16 | 인사이트 코포레이션 | Jak 경로 억제제 및 rock 억제제를 포함하는 병용 요법 |
WO2022170864A1 (zh) * | 2021-02-09 | 2022-08-18 | 苏州科睿思制药有限公司 | Belumosudil甲磺酸盐的晶型及其制备方法和用途 |
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WO2012040499A2 (en) * | 2010-09-22 | 2012-03-29 | Surface Logix, Inc. | Metabolic inhibitors |
CN103313968A (zh) | 2010-11-15 | 2013-09-18 | Abbvie公司 | Nampt和rock抑制剂 |
GB201107223D0 (en) | 2011-04-29 | 2011-06-15 | Amakem Nv | Novel rock inhibitors |
GB201114854D0 (en) | 2011-08-29 | 2011-10-12 | Amakem Nv | Novel rock inhibitors |
US9079858B2 (en) | 2011-08-31 | 2015-07-14 | Amakem Nv | Rock kinase inhibitors |
US9815820B2 (en) * | 2012-10-05 | 2017-11-14 | Kadmon Corporation, Llc | Rho kinase inhibitors |
JP2016502502A (ja) * | 2012-10-05 | 2016-01-28 | カドモン コーポレイション,リミティド ライアビリティ カンパニー | 眼疾患の治療 |
WO2015157556A1 (en) * | 2014-04-09 | 2015-10-15 | Kadmon Corporation, Llc | Treatment of gvhd |
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