DK2903618T3 - Rho-kinase-inhibitorer - Google Patents

Rho-kinase-inhibitorer Download PDF

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Publication number
DK2903618T3
DK2903618T3 DK13843426.1T DK13843426T DK2903618T3 DK 2903618 T3 DK2903618 T3 DK 2903618T3 DK 13843426 T DK13843426 T DK 13843426T DK 2903618 T3 DK2903618 T3 DK 2903618T3
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Prior art keywords
kinase inhibitors
rho kinase
rho
inhibitors
kinase
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DK13843426.1T
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English (en)
Inventor
Ji-In Kim
Kevin Liu
Alexandra Zanin-Zhorov
Masha Poyurovsky
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Kadmon Corp Llc
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    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
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    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/32—One oxygen, sulfur or nitrogen atom
    • C07D239/42—One nitrogen atom
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing three or more hetero rings
DK13843426.1T 2012-10-05 2013-10-07 Rho-kinase-inhibitorer DK2903618T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261710373P 2012-10-05 2012-10-05
US201361840288P 2013-06-27 2013-06-27
PCT/US2013/063752 WO2014055996A2 (en) 2012-10-05 2013-10-07 Rho kinase inhibitors

Publications (1)

Publication Number Publication Date
DK2903618T3 true DK2903618T3 (da) 2022-08-22

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ID=50435589

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DK13843426.1T DK2903618T3 (da) 2012-10-05 2013-10-07 Rho-kinase-inhibitorer

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US (4) US9815820B2 (da)
EP (2) EP2903618B1 (da)
JP (2) JP6419076B2 (da)
CN (5) CN113637008A (da)
CA (2) CA3151343A1 (da)
DK (1) DK2903618T3 (da)
EA (1) EA201500362A1 (da)
ES (1) ES2924915T3 (da)
HR (1) HRP20220913T1 (da)
HU (1) HUE059305T2 (da)
LT (1) LT2903618T (da)
PL (1) PL2903618T3 (da)
PT (1) PT2903618T (da)
RS (1) RS63503B1 (da)
SI (1) SI2903618T1 (da)
WO (1) WO2014055996A2 (da)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11008359B2 (en) * 2002-08-23 2021-05-18 Illumina Cambridge Limited Labelled nucleotides
HRP20220913T1 (hr) 2012-10-05 2022-10-28 Kadmon Corporation, Llc Inhibitori rho kinaze
US11311541B2 (en) * 2014-04-09 2022-04-26 Kadmon Corporation, Llc Treatment of GVHD
WO2016028971A1 (en) 2014-08-21 2016-02-25 Bristol-Myers Squibb Company Tied-back benzamide derivatives as potent rock inhibitors
CA2995344C (en) 2014-10-07 2021-05-04 Kadmon Corporation, Llc Human anti-vegfr-2/kdr antibodies
EP3262041A4 (en) 2015-02-27 2018-08-01 Lycera Corporation Indazolyl thiadiazolamines and related compounds for inhibition of rho-associated protein kinase and the treatment of disease
EP3283479B1 (en) * 2015-04-01 2022-12-14 Rigel Pharmaceuticals, Inc. Tgf-beta inhibitors
US9937154B2 (en) 2015-06-10 2018-04-10 Hackensak University Medical Center Use of telmisartan to prevent and treat graft versus host disease and other alloimmune and autoimmune diseases
EP3313825A4 (en) * 2015-06-26 2019-03-13 Kadmon Corporation, LLC GLUCOSE ABSORPTION INHIBITORS
CN109310755A (zh) * 2016-02-02 2019-02-05 卡德门企业有限公司 Pd-l1和kdr的双特异性结合蛋白
SG11201900027XA (en) * 2016-08-05 2019-02-27 Medimmune Llc Anti-o2 antibodies and uses thereof
EP3504204A4 (en) 2016-08-26 2020-05-27 Lycera Corporation INDAZOLYL-L, 2,4-THIADIAZOLAMINE AND RELATED COMPOUNDS FOR INHIBITING RHO-ASSOCIATED PROTEIN KINASES AND FOR TREATING DISEASES
CN109843917B (zh) 2016-10-19 2023-10-03 免疫医疗有限责任公司 抗o1抗体及其用途
CN106916145B (zh) * 2017-03-06 2019-06-04 上海应用技术大学 SLx-2119的合成方法
IT201700047189A1 (it) * 2017-05-02 2018-11-02 Fondazione St Italiano Tecnologia Composti e composizioni per il trattamento di cancro, disordini della retina e cardiomiopatie
US10323023B2 (en) 2017-06-30 2019-06-18 Beijing Tide Pharmaceutical Co., Ltd. Rho-associated protein kinase inhibitor, pharmaceutical composition comprising the same, as well as preparation method and use thereof
US10329282B2 (en) 2017-06-30 2019-06-25 Beijing Tide Pharmaceutical Co., Ltd. Rho-associated protein kinase inhibitor, pharmaceutical composition comprising the same, as well as preparation method and use thereof
CN111217797B (zh) 2017-06-30 2021-02-05 北京泰德制药股份有限公司 Rho相关蛋白激酶抑制剂、包含其的药物组合物及其制备方法和用途
EA202090572A1 (ru) * 2017-09-01 2020-07-06 Кадмон Корпорейшн, Ллк ИНГИБИТОРЫ Rho-АССОЦИИРОВАННОЙ, СОДЕРЖАЩЕЙ СУПЕРСПИРАЛЬ ПРОТЕИНКИНАЗЫ
EP3676262A4 (en) 2017-09-03 2021-03-31 Angion Biomedica Corp. VINYLHETEROCYCLENE AS RHO-ASSOCIATED COILED COIL KINASE (ROCK) INHIBITORS
WO2019201297A1 (zh) 2018-04-18 2019-10-24 南京明德新药研发有限公司 作为rho激酶抑制剂的苯并吡唑类化合物
US11248004B2 (en) 2018-11-06 2022-02-15 Cervello Therapeutics, Llc. Substituted isoquinolines as rock kinase inhibitors
KR20210093269A (ko) 2018-11-06 2021-07-27 써벨로 테라퓨틱스, 엘엘씨 Rock 키나아제 저해제
WO2020210382A1 (en) * 2019-04-08 2020-10-15 The General Hospital Corporation Enhancement of melanocyte migration using rock inhibitors
JP7252417B2 (ja) 2019-10-18 2023-04-04 メッドシャイン ディスカバリー インコーポレイテッド Ｒｈｏキナーゼ阻害剤としてのベンゾピラゾール化合物の塩形、結晶形及びその製造方法
WO2021129589A1 (zh) * 2019-12-27 2021-07-01 广东东阳光药业有限公司 Kd-025的新晶型及其制备方法
IL299985A (en) * 2020-07-22 2023-03-01 Beijing Tide Pharmaceutical Co Ltd A method for treating graft-versus-Maschen disease caused by hematopoietic stem cell transplantation
CA3186800A1 (en) 2020-07-22 2022-01-27 Teva Pharmaceuticals International Gmbh Solid state forms of belumosudil and belumosudil salts
WO2022042666A1 (zh) * 2020-08-28 2022-03-03 杭州邦顺制药有限公司 选择性rock2激酶抑制剂
JP2024503021A (ja) 2021-01-11 2024-01-24 インサイト・コーポレイション Ｊａｋ経路阻害剤及びｒｏｃｋ阻害剤を含む併用療法
WO2022170864A1 (zh) * 2021-02-09 2022-08-18 苏州科睿思制药有限公司 Belumosudil甲磺酸盐的晶型及其制备方法和用途
WO2022229351A1 (en) 2021-04-28 2022-11-03 Graviton Bioscience Bv Selective inhibitors of rock2 for the treatment of muscular dystrophy
WO2023285706A1 (en) 2021-07-16 2023-01-19 Sandoz Ag Solid-state forms of 2-(3-(4-(1h-indazol-5-ylamino)quinazolin-2-yl )phenoxy)-n- isopropylacetamide methane sulfonic acid salt
WO2023205153A1 (en) 2022-04-19 2023-10-26 Kadmon Corporation, Llc Belumosudil for treating chronic lung allograft dysfunction
WO2024015068A1 (en) 2022-07-14 2024-01-18 Kadmon Corporation, Llc Belumosudil metabolites and uses thereof in the treatment of chronic graft-versus-host disease
WO2024015066A1 (en) 2022-07-14 2024-01-18 Kadmon Corporation, Llc Methods of administering belumosudil in combination with cyp3a inducers and/or proton pump inhibitors
WO2024015067A1 (en) 2022-07-14 2024-01-18 Kadmon Corporation, Llc Methods of administering belumosudil for treatment of chronic graft versus host disease
WO2024015065A1 (en) 2022-07-14 2024-01-18 Kadmon Corporation, Llc Methods of administering belumosudil for treatment of chronic graft versus host disease in patient subpopulations
WO2024023276A1 (en) 2022-07-27 2024-02-01 Graviton Bioscience Bv Rock2 inhibitors for the treatment of viral infections
WO2024063770A1 (en) * 2022-09-21 2024-03-28 Kadmon Corporation, Llc Liquid formulation of belumosudil

Family Cites Families (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS59115488A (ja) * 1982-12-22 1984-07-03 Hitachi Ltd 密閉形スクロ−ル圧縮機の軸受装置
MXPA04007191A (es) * 2002-01-23 2005-03-31 Bayer Pharmaceuticals Corp Derivados de pirimidina como inhibidores de rho-quinasa.
EP1781293A1 (en) * 2004-06-04 2007-05-09 Amphora Discovery Corporation Quinoline- and isoquinoline-based compounds exhibiting atp-utilizing enzyme inhibitory activity, and compositions, and uses thereof
CR9465A (es) * 2005-03-25 2008-06-19 Surface Logix Inc Compuestos mejorados farmacocineticamente
US8216575B2 (en) 2006-03-31 2012-07-10 Chengdu Kanghong Biotechnologies Co., Ltd. Inhibition of neovascularization with a soluble chimeric protein comprising VEGF FLT-1 and KDR domains
CA2700988A1 (en) * 2006-09-27 2008-05-08 Surface Logix, Inc. Rho kinase inhibitors
US8648069B2 (en) 2007-06-08 2014-02-11 Abbvie Inc. 5-substituted indazoles as kinase inhibitors
JP5767965B2 (ja) 2008-06-10 2015-08-26 プレキシコン インコーポレーテッドＰｌｅｘｘｉｋｏｎ Ｉｎｃ． キナーゼを調節する５ｈ−ピロロ［２，３−ｂ］ピラジン誘導体、およびその適応症
WO2011062766A2 (en) * 2009-11-17 2011-05-26 The Regents Of The University Of Michigan 1,4-benzodiazepine-2,5-diones and related compounds with therapeutic properties
PL2542528T3 (pl) * 2010-03-02 2013-11-29 Amakem Nv Heterocykliczne amidy jako inhibitory ROCK
US9079880B2 (en) * 2010-07-07 2015-07-14 Boehringer Ingelheim International Gmbh Rho kinase inhibitors
WO2012040499A2 (en) 2010-09-22 2012-03-29 Surface Logix, Inc. Metabolic inhibitors
AU2011329233A1 (en) 2010-11-15 2013-05-23 Abbvie Deutschland Gmbh & Co Kg NAMPT and ROCK inhibitors
GB201107223D0 (en) 2011-04-29 2011-06-15 Amakem Nv Novel rock inhibitors
GB201114854D0 (en) 2011-08-29 2011-10-12 Amakem Nv Novel rock inhibitors
CN103874683A (zh) 2011-08-31 2014-06-18 阿玛克姆股份有限公司 新的rock激酶抑制剂
WO2014055999A2 (en) * 2012-10-05 2014-04-10 Kadmon Corporation, Llc Treatment of ocular disorders
HRP20220913T1 (hr) * 2012-10-05 2022-10-28 Kadmon Corporation, Llc Inhibitori rho kinaze
US11311541B2 (en) * 2014-04-09 2022-04-26 Kadmon Corporation, Llc Treatment of GVHD

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JP2015533125A (ja) 2015-11-19
PL2903618T3 (pl) 2022-09-19
US20210147391A1 (en) 2021-05-20
EP2903618A2 (en) 2015-08-12
SI2903618T1 (sl) 2022-09-30
CA2926478C (en) 2022-05-24
CN105120869A (zh) 2015-12-02
US20150252025A1 (en) 2015-09-10
RS63503B1 (sr) 2022-09-30
EP2903618B1 (en) 2022-06-01
EP2903618A4 (en) 2017-05-10
JP6419076B2 (ja) 2018-11-14
US10696660B2 (en) 2020-06-30
JP6703075B2 (ja) 2020-06-03
JP2019034949A (ja) 2019-03-07
CA3151343A1 (en) 2014-04-10
WO2014055996A2 (en) 2014-04-10
HRP20220913T1 (hr) 2022-10-28
CA2926478A1 (en) 2014-04-10
EP4116293A3 (en) 2023-03-29
EP4116293A2 (en) 2023-01-11
US20190308953A1 (en) 2019-10-10
CN113637008A (zh) 2021-11-12
US9815820B2 (en) 2017-11-14
HUE059305T2 (hu) 2022-11-28
ES2924915T3 (es) 2022-10-11
EA201500362A1 (ru) 2015-08-31
CN113773308A (zh) 2021-12-10
US20180244657A1 (en) 2018-08-30
CN113620933A (zh) 2021-11-09
WO2014055996A3 (en) 2014-06-19
PT2903618T (pt) 2022-08-19
US10183931B2 (en) 2019-01-22
LT2903618T (lt) 2022-08-25
CN113637007A (zh) 2021-11-12

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