RS56731B1 - Pirimidopirimidinoni korisni kao inhibitori wee-1 kinaze - Google Patents
Pirimidopirimidinoni korisni kao inhibitori wee-1 kinazeInfo
- Publication number
- RS56731B1 RS56731B1 RS20171338A RSP20171338A RS56731B1 RS 56731 B1 RS56731 B1 RS 56731B1 RS 20171338 A RS20171338 A RS 20171338A RS P20171338 A RSP20171338 A RS P20171338A RS 56731 B1 RS56731 B1 RS 56731B1
- Authority
- RS
- Serbia
- Prior art keywords
- pyrimidopyrimidinones
- wee
- useful
- kinase inhibitors
- kinase
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D475/00—Heterocyclic compounds containing pteridine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
- C07D487/14—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1322602.2A GB201322602D0 (en) | 2013-12-19 | 2013-12-19 | Pharmaceutical compounds |
| EP14815843.9A EP3083625B1 (en) | 2013-12-19 | 2014-12-19 | Pyrimidopyrimidinones useful as wee-1 kinase inhibitors |
| PCT/GB2014/053793 WO2015092431A1 (en) | 2013-12-19 | 2014-12-19 | Pyrimidopyrimidinones useful as wee-1 kinase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RS56731B1 true RS56731B1 (sr) | 2018-03-30 |
Family
ID=50071157
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RS20171338A RS56731B1 (sr) | 2013-12-19 | 2014-12-19 | Pirimidopirimidinoni korisni kao inhibitori wee-1 kinaze |
Country Status (27)
| Country | Link |
|---|---|
| US (1) | US9850247B2 (sr) |
| EP (1) | EP3083625B1 (sr) |
| JP (1) | JP6437559B2 (sr) |
| KR (1) | KR102405462B1 (sr) |
| CN (1) | CN105829315B (sr) |
| AU (1) | AU2014369457B2 (sr) |
| BR (1) | BR112016014151B1 (sr) |
| CA (1) | CA2933755C (sr) |
| CY (1) | CY1120035T1 (sr) |
| DK (1) | DK3083625T3 (sr) |
| ES (1) | ES2650013T3 (sr) |
| GB (1) | GB201322602D0 (sr) |
| HR (1) | HRP20180080T1 (sr) |
| HU (1) | HUE037908T2 (sr) |
| IL (1) | IL245672B (sr) |
| LT (1) | LT3083625T (sr) |
| MX (1) | MX371108B (sr) |
| NO (1) | NO3083625T3 (sr) |
| NZ (1) | NZ720178A (sr) |
| PL (1) | PL3083625T3 (sr) |
| PT (1) | PT3083625T (sr) |
| RS (1) | RS56731B1 (sr) |
| RU (1) | RU2691105C1 (sr) |
| SG (1) | SG11201603814TA (sr) |
| SI (1) | SI3083625T1 (sr) |
| WO (1) | WO2015092431A1 (sr) |
| ZA (1) | ZA201603337B (sr) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108137593B (zh) * | 2015-04-21 | 2021-01-05 | 上海交通大学医学院附属瑞金医院 | 蛋白激酶抑制剂的制备和用途 |
| JP6692423B2 (ja) | 2015-11-01 | 2020-05-13 | ザ リージェンツ オブ ザ ユニヴァーシティ オブ コロラド，ア ボディ コーポレイト | Ｗｅｅ１キナーゼ阻害剤、並びにそれを作製及び使用する方法 |
| AU2017359844B2 (en) * | 2016-11-16 | 2021-09-30 | Impact Therapeutics (Shanghai), Inc | 8,9-dihydroimidazole[1,2-a]pyrimido[5,4-e]pyrimidine-5(6H)-ketone compound |
| US10954216B2 (en) | 2016-12-27 | 2021-03-23 | Riken | BMP-signal-inhibiting compound |
| ES2902050T3 (es) * | 2017-01-23 | 2022-03-24 | Shijiazhuang Sagacity New Drug Dev Co Ltd | Derivado 1,2-dihidro-3H-pirazolo[3,4-D]pirimidin-3-ona como inhibidor de Wee1 |
| GB201703881D0 (en) * | 2017-03-10 | 2017-04-26 | Almac Discovery Ltd | Pharmaceutical compounds |
| KR20190130621A (ko) | 2017-03-31 | 2019-11-22 | 시애틀 지네틱스, 인크. | Chk1 저해제와 wee1 저해제의 조합물 |
| CN110914277B (zh) * | 2017-07-10 | 2022-08-09 | 上海瑛派药业有限公司 | 咪唑并[1,2-b]嘧啶并[4,5-d]哒嗪-5(6H)-酮类化合物及其应用 |
| WO2019037678A1 (zh) * | 2017-08-24 | 2019-02-28 | 上海迪诺医药科技有限公司 | 吡唑并[3,4-d]嘧啶-3-酮衍生物、其药物组合物及应用 |
| WO2019074979A1 (en) | 2017-10-09 | 2019-04-18 | Girafpharma, Llc | HETEROCYCLIC COMPOUNDS AND USES THEREOF |
| CA3078945A1 (en) | 2017-10-09 | 2019-04-18 | Nuvation Bo Inc. | Heterocyclic compounds and uses thereof |
| SG11202003974XA (en) | 2017-11-01 | 2020-05-28 | Shijiazhuang Sagacity New Drug Development Co Ltd | Macrocyclic compound serving as weel inhibitor and applications thereof |
| AU2019227823A1 (en) * | 2018-02-28 | 2020-08-06 | The Regents Of The University Of Colorado, A Body Corporate | WEE1 kinase inhibitors and methods of treating cancer using the same |
| JP7446287B2 (ja) | 2018-09-27 | 2024-03-08 | 貝達薬業股▲ふん▼有限公司 | Ｆｇｆｒ４阻害剤及びその使用 |
| CN112955454A (zh) | 2018-10-26 | 2021-06-11 | 石家庄智康弘仁新药开发有限公司 | 作为Wee1抑制剂的嘧啶并吡唑酮类衍生物及其应用 |
| EP3943496A4 (en) | 2019-03-22 | 2022-05-18 | Shouyao Holdings (Beijing) Co., Ltd. | WEE1 INHIBITOR AND METHOD OF MANUFACTURE AND USE THEREOF |
| CA3136492A1 (en) | 2019-04-09 | 2020-10-15 | Nuvation Bio Inc. | Heterocyclic compounds and uses thereof |
| WO2020210377A1 (en) * | 2019-04-09 | 2020-10-15 | Nuvation Bio Inc. | Heterocyclic compounds and uses thereof |
| US20220168313A1 (en) * | 2019-04-09 | 2022-06-02 | Nuvation Bio Inc. | Heterocyclic compounds and uses thereof |
| WO2020221358A1 (zh) | 2019-04-30 | 2020-11-05 | 石家庄智康弘仁新药开发有限公司 | Wee1抑制剂化合物的晶型及其应用 |
| CN112142763B (zh) * | 2019-06-28 | 2024-01-26 | 上海医药集团股份有限公司 | 一种吡唑酮并嘧啶类化合物、其制备方法及应用 |
| AU2021290701A1 (en) | 2020-06-17 | 2023-02-02 | Wigen Biomedicine Technology (shanghai) Co., Ltd. | Pyrazolo(3,4-d)pyrimidine-3-ketone derivative as Wee-1 inhibitor |
| US20230416247A1 (en) * | 2020-10-01 | 2023-12-28 | University Of Washington | Drug-like molecules and methods for the therapeutic targeting of microrna-21 |
| JP2023554430A (ja) * | 2020-12-18 | 2023-12-27 | グラクソスミスクライン、インテレクチュアル、プロパティー、ディベロップメント、リミテッド | Ｎａｖ１．８阻害剤としての含窒素２，３－ジヒドロキナゾリノン化合物 |
| CN117222648A (zh) | 2021-04-30 | 2023-12-12 | 微境生物医药科技(上海)有限公司 | 作为Wee-1抑制剂的稠环化合物及其制备方法和用途 |
| CN116462687A (zh) | 2022-01-18 | 2023-07-21 | 江苏天士力帝益药业有限公司 | Wee1抑制剂及其制备和用途 |
| CN116836184A (zh) * | 2022-03-25 | 2023-10-03 | 药雅科技(上海)有限公司 | Wee1激酶抑制剂的制备及其应用 |
| WO2023217201A2 (zh) * | 2022-05-10 | 2023-11-16 | 杭州德睿智药科技有限公司 | 作为Wee1抑制剂的新型嘧啶并杂环类新化合物及其应用 |
Family Cites Families (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7504396B2 (en) | 2003-06-24 | 2009-03-17 | Amgen Inc. | Substituted heterocyclic compounds and methods of use |
| AU2005223316A1 (en) | 2004-03-15 | 2005-09-29 | F. Hoffmann-La Roche Ag | Novel dichloro-phenyl-pyrido [2,3-D] pyrimidine derivates, their manufacture and use as pharmaceutical agents |
| FR2896246B1 (fr) | 2006-01-13 | 2008-08-15 | Sanofi Aventis Sa | Derives de pyrido-pyrimidone, leur preparation, leur application en therapeutique. |
| AR060635A1 (es) | 2006-04-27 | 2008-07-02 | Banyu Pharma Co Ltd | Derivados de 1,2-dihidro-3h-pirazolo[3,4-d]pirimidin-3-ona, composiciones farmaceuticas que los comprenden y su uso en el tratamiento del cancer |
| EP2155752B1 (en) | 2007-04-25 | 2018-09-19 | Merck Sharp & Dohme Corp. | Polymorph of dihydropyrazolopyrimidinone derivative as weel kinase.inhibitor |
| EP2168966B1 (en) | 2007-06-15 | 2016-09-28 | Msd K.K. | Bicycloaniline derivative |
| AU2008315048A1 (en) | 2007-10-23 | 2009-04-30 | Msd K.K. | Pyridone-substituted-dihydropyrazolopyrimidinone derivative |
| CA2745959A1 (en) * | 2008-12-12 | 2010-06-17 | Msd K.K. | Dihydropyrimidopyrimidine derivatives |
| CA2745970A1 (en) * | 2008-12-12 | 2010-06-17 | Msd K.K. | Dihydropyrimidopyrimidine derivative |
| JP5886310B2 (ja) * | 2010-12-06 | 2016-03-16 | グラクソ グループ リミテッドＧｌａｘｏ Ｇｒｏｕｐ Ｌｉｍｉｔｅｄ | Ｌｐ−ＰＬＡ２により媒介される疾患または状態の処置における使用のためのピリミジノン化合物 |
| AR084515A1 (es) * | 2010-12-22 | 2013-05-22 | Merz Pharma Gmbh & Co Kgaa | Derivados heterociclicos nitrogenados, composiciones farmaceuticas que los contienen y uso de los mismos en el tratamiento de enfermedades asociadas al sistema nervioso central tales como parkinson y alzheimer, entre otras |
| TWI532742B (zh) * | 2011-02-28 | 2016-05-11 | 艾伯維有限公司 | 激酶之三環抑制劑 |
| EP2731953A1 (en) | 2011-07-15 | 2014-05-21 | Abbvie Inc. | Tricyclic inhibitors of kinases useful for the treatment of proliferative diseases |
| US8796289B2 (en) * | 2011-07-19 | 2014-08-05 | Abbvie Inc. | Pyridazino[4,5-D]pyrimidin-5(6H)-one inhibitors of kinases |
| WO2013059485A1 (en) | 2011-10-20 | 2013-04-25 | Abbvie Inc. | Pyridopyrimidinone inhibitors of kinases |
| EP2817308B1 (en) * | 2012-02-23 | 2016-09-07 | AbbVie Inc. | Pyridopyrimidinone inhibitors of kinases |
| CN102816164A (zh) * | 2012-08-31 | 2012-12-12 | 北京理工大学 | 一种合成7-氨基-2,3-二氢嘧啶[4,5-d]嘧啶-4(1H)-酮的方法 |
-
2013
- 2013-12-19 GB GBGB1322602.2A patent/GB201322602D0/en not_active Ceased
-
2014
- 2014-12-19 SI SI201430580T patent/SI3083625T1/en unknown
- 2014-12-19 NZ NZ720178A patent/NZ720178A/en unknown
- 2014-12-19 AU AU2014369457A patent/AU2014369457B2/en active Active
- 2014-12-19 CA CA2933755A patent/CA2933755C/en active Active
- 2014-12-19 HU HUE14815843A patent/HUE037908T2/hu unknown
- 2014-12-19 MX MX2016007801A patent/MX371108B/es active IP Right Grant
- 2014-12-19 RU RU2016123363A patent/RU2691105C1/ru active
- 2014-12-19 CN CN201480069437.9A patent/CN105829315B/zh active Active
- 2014-12-19 PT PT148158439T patent/PT3083625T/pt unknown
- 2014-12-19 DK DK14815843.9T patent/DK3083625T3/en active
- 2014-12-19 LT LTEP14815843.9T patent/LT3083625T/lt unknown
- 2014-12-19 NO NO14815843A patent/NO3083625T3/no unknown
- 2014-12-19 PL PL14815843T patent/PL3083625T3/pl unknown
- 2014-12-19 BR BR112016014151-2A patent/BR112016014151B1/pt active IP Right Grant
- 2014-12-19 US US15/105,869 patent/US9850247B2/en active Active
- 2014-12-19 EP EP14815843.9A patent/EP3083625B1/en active Active
- 2014-12-19 KR KR1020167019551A patent/KR102405462B1/ko active IP Right Grant
- 2014-12-19 ES ES14815843.9T patent/ES2650013T3/es active Active
- 2014-12-19 JP JP2016541294A patent/JP6437559B2/ja active Active
- 2014-12-19 SG SG11201603814TA patent/SG11201603814TA/en unknown
- 2014-12-19 RS RS20171338A patent/RS56731B1/sr unknown
- 2014-12-19 WO PCT/GB2014/053793 patent/WO2015092431A1/en active Application Filing
-
2016
- 2016-05-17 ZA ZA2016/03337A patent/ZA201603337B/en unknown
- 2016-05-17 IL IL245672A patent/IL245672B/en unknown
-
2018
- 2018-01-15 CY CY20181100041T patent/CY1120035T1/el unknown
- 2018-01-16 HR HRP20180080TT patent/HRP20180080T1/hr unknown
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