RS50966B - Agonisti pyy i njihova upotreba - Google Patents

Agonisti pyy i njihova upotreba

Info

Publication number
RS50966B
RS50966B RSP-2009/0210A RSP20090210A RS50966B RS 50966 B RS50966 B RS 50966B RS P20090210 A RSP20090210 A RS P20090210A RS 50966 B RS50966 B RS 50966B
Authority
RS
Serbia
Prior art keywords
pyy agonists
pyy
agonists
npyy3
polypeptide
Prior art date
Application number
RSP-2009/0210A
Other languages
English (en)
Inventor
Rory Francis Finn
Ned Roger Siegel
Neena Lynne Summers
Nancy Ann Nardone
Original Assignee
Pfizer Products Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Products Inc. filed Critical Pfizer Products Inc.
Publication of RS50966B publication Critical patent/RS50966B/sr

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
    • A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
    • A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/48—Drugs for disorders of the endocrine system of the pancreatic hormones
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Diabetes (AREA)
  • Biophysics (AREA)
  • Endocrinology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Immunology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Polipeptid (E10C)nPYY3-36, naznačen time što ima amino kiselinu sekvence IKPEAPGCDASPEELNRYYASLRHYLNLVTRQRY-NH2 [SEQ ID No.:3] ili njenufemaceutski prihvatljivu so.Prijava sadrži još 22 zavisna patentna zahteva.
RSP-2009/0210A 2005-02-04 2006-01-30 Agonisti pyy i njihova upotreba RS50966B (sr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US65036605P 2005-02-04 2005-02-04
US73365605P 2005-11-04 2005-11-04
PCT/IB2006/000270 WO2006082517A1 (en) 2005-02-04 2006-01-30 Pyy agonists and uses thereof

Publications (1)

Publication Number Publication Date
RS50966B true RS50966B (sr) 2010-10-31

Family

ID=36175074

Family Applications (1)

Application Number Title Priority Date Filing Date
RSP-2009/0210A RS50966B (sr) 2005-02-04 2006-01-30 Agonisti pyy i njihova upotreba

Country Status (33)

Country Link
US (3) US20060178501A1 (sr)
EP (2) EP1846445B1 (sr)
JP (1) JP4314304B2 (sr)
KR (1) KR100892545B1 (sr)
AP (1) AP2007004069A0 (sr)
AR (1) AR052108A1 (sr)
AT (1) ATE426614T1 (sr)
AU (1) AU2006211039A1 (sr)
BR (1) BRPI0606142A2 (sr)
CA (1) CA2596977C (sr)
CY (1) CY1109054T1 (sr)
DE (1) DE602006005902D1 (sr)
DK (1) DK1846445T3 (sr)
DO (1) DOP2006000025A (sr)
EA (1) EA011882B1 (sr)
ES (1) ES2322293T3 (sr)
GT (1) GT200600038A (sr)
HR (1) HRP20090245T1 (sr)
IL (1) IL184324A0 (sr)
MA (1) MA29243B1 (sr)
MX (1) MX2007009389A (sr)
NL (2) NL1031067C2 (sr)
NO (1) NO20074498L (sr)
PA (1) PA8660701A1 (sr)
PE (1) PE20061412A1 (sr)
PL (1) PL1846445T3 (sr)
PT (1) PT1846445E (sr)
RS (1) RS50966B (sr)
SI (1) SI1846445T1 (sr)
TN (1) TNSN07305A1 (sr)
TW (1) TWI310038B (sr)
UY (1) UY29357A1 (sr)
WO (1) WO2006082517A1 (sr)

Families Citing this family (82)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1499277B1 (en) 2001-09-24 2009-01-07 Imperial Innovations Limited Pyy3-36 for the reduction or prevention of obesity
US7214660B2 (en) 2001-10-10 2007-05-08 Neose Technologies, Inc. Erythropoietin: remodeling and glycoconjugation of erythropoietin
US7173003B2 (en) 2001-10-10 2007-02-06 Neose Technologies, Inc. Granulocyte colony stimulating factor: remodeling and glycoconjugation of G-CSF
PL1615945T3 (pl) 2003-04-09 2012-03-30 Ratiopharm Gmbh Sposoby glikopegylacji i białka/peptydy wytwarzane tymi sposobami
WO2005012484A2 (en) 2003-07-25 2005-02-10 Neose Technologies, Inc. Antibody-toxin conjugates
US20080305992A1 (en) 2003-11-24 2008-12-11 Neose Technologies, Inc. Glycopegylated erythropoietin
US8633157B2 (en) 2003-11-24 2014-01-21 Novo Nordisk A/S Glycopegylated erythropoietin
WO2005070138A2 (en) 2004-01-08 2005-08-04 Neose Technologies, Inc. O-linked glycosylation of peptides
JP2007530569A (ja) * 2004-03-23 2007-11-01 アムジエン・インコーポレーテツド 化学修飾タンパク質組成物及び方法
WO2006010143A2 (en) 2004-07-13 2006-01-26 Neose Technologies, Inc. Branched peg remodeling and glycosylation of glucagon-like peptide-1 [glp-1]
JP5948627B2 (ja) 2004-10-29 2016-07-20 レイショファーム ゲーエムベーハー 線維芽細胞成長因子（ｆｇｆ）のリモデリングと糖質ペグ化
WO2006074467A2 (en) 2005-01-10 2006-07-13 Neose Technologies, Inc. Glycopegylated granulocyte colony stimulating factor
WO2006121569A2 (en) 2005-04-08 2006-11-16 Neose Technologies, Inc. Compositions and methods for the preparation of protease resistant human growth hormone glycosylation mutants
WO2006135930A2 (en) * 2005-06-13 2006-12-21 Nastech Pharmaceutical Company Inc. Transmucosal delivery of peptide derivatives
US20070105755A1 (en) 2005-10-26 2007-05-10 Neose Technologies, Inc. One pot desialylation and glycopegylation of therapeutic peptides
WO2007026772A1 (ja) * 2005-08-31 2007-03-08 Kaneka Corporation ネコ由来タンパク質のコード配列を含む外来性遺伝子を含むトランスジェニック鳥類およびその作製法
US20090048440A1 (en) 2005-11-03 2009-02-19 Neose Technologies, Inc. Nucleotide Sugar Purification Using Membranes
WO2007085887A1 (en) * 2006-01-27 2007-08-02 Pfizer Products Inc. Pyy agonists and uses thereof
US20080280818A1 (en) 2006-07-21 2008-11-13 Neose Technologies, Inc. Glycosylation of peptides via o-linked glycosylation sequences
JP2008069073A (ja) * 2006-09-12 2008-03-27 Yokohama Tlo Co Ltd ラクトフェリン複合体及びその製造方法
EP2054521A4 (en) 2006-10-03 2012-12-19 Novo Nordisk As METHODS OF PURIFYING CONJUGATES OF POLYPEPTIDES
HUE036502T2 (hu) * 2006-10-04 2018-07-30 Novo Nordisk As Glicerinhez kapcsolódó pegilált cukrok és glükopeptidek
TWI428346B (zh) 2006-12-13 2014-03-01 Imp Innovations Ltd 新穎化合物及其等對進食行為影響
KR20150064246A (ko) 2007-04-03 2015-06-10 바이오제너릭스 게엠베하 글리코페길화 ｇ―ｃｓｆ를 이용하는 치료 방법
ES2551123T3 (es) 2007-06-12 2015-11-16 Ratiopharm Gmbh Proceso mejorado para la producción de azúcares de nucleótido
RU2573587C2 (ru) 2008-02-27 2016-01-20 Ново Нордиск А/С Конъюгированные молекулы фактора viii
WO2010016936A1 (en) * 2008-08-07 2010-02-11 Ipsen Pharma S.A.S. Pharmaceutical compositions of analogues of glucose-dependent insulinotropic polypeptide
CA2742710A1 (en) 2008-11-04 2010-05-14 Janssen Pharmaceutica Nv Crhr2 peptide agonists and uses thereof
WO2010067233A1 (en) 2008-12-08 2010-06-17 Pfizer Inc. 1,2,4 triazolo [4, 3 -a] [1,5] benzodiazepin-5 (6h) -ones as agonists of the cholecystokinin-1 receptor (cck-ir)
EP2389374A1 (en) 2009-01-20 2011-11-30 Pfizer Inc. Substituted pyrazinone amides
TW201038580A (en) 2009-02-02 2010-11-01 Pfizer 4-amino-5-oxo-7,8-dihydropyrimido[5,4-f][1,4]oxazepin-6(5H)-yl)phenyl derivatives
TW201040174A (en) 2009-02-03 2010-11-16 Pfizer 4-amino-7,8-dihydropyrido[4,3-d]pyrimidin-5(6H)-one derivatives
JP2012516885A (ja) 2009-02-04 2012-07-26 ファイザー・インク ４−アミノ−７，８−ジヒドロピリド［４，３−ｄ］ピリミジン−５（６Ｈ）−オン誘導体
US20110319379A1 (en) 2009-03-11 2011-12-29 Corbett Jeffrey W Substituted Indazole Amides And Their Use As Glucokinase Activators
EP2604604A1 (en) 2009-03-11 2013-06-19 Pfizer Inc Benzofuranyl derivatives used as glucokinase inhibitors
WO2010106457A2 (en) 2009-03-20 2010-09-23 Pfizer Inc. 3-oxa-7-azabicyclo[3.3.1]nonanes
GEP20135907B (en) 2009-06-05 2013-08-12 Pfizer L-(piperidin-4-yl)-pyrazole derivatives as gpr 119 modulators
CA2772188A1 (en) 2009-09-23 2011-03-31 Pfizer Inc. Gpr 119 modulators
KR101426180B1 (ko) 2009-11-02 2014-07-31 화이자 인코포레이티드 디옥사-비시클로［3.2.1］옥탄-2,3,4-트리올 유도체
CA2778316A1 (en) 2009-11-10 2011-05-19 Pfizer Inc. N-2 pyrazolospiroketone acetyl-coa carboxylase inhibitors
NZ599815A (en) 2009-11-10 2013-04-26 Pfizer N1-pyrazolospiroketone acetyl-coa carboxylase inhibitors
CA2780463A1 (en) 2009-11-23 2011-05-26 Pfizer Inc. Imidazo-pyrazoles as gpr119 inhibitors
ES2557895T3 (es) 2010-03-19 2016-01-29 Pfizer Inc Derivados de 2,3-dihidro-1H-inden-1-il-2,7-diazaespiro[3.6]nonano y su uso como antagonistas o agonistas inversos del receptor de grelina
WO2011158149A1 (en) 2010-06-18 2011-12-22 Pfizer Inc. 2-(3,5-disubstitutedphenyl)pyrimidin-4(3h)-one derivatives
PT2621493T (pt) 2010-09-30 2016-11-14 Pfizer Inibidores de n1-pirazolospirocetona acetil-coa carboxilase
CA2815169C (en) 2010-10-29 2015-10-06 Pfizer Inc. N1/n2-lactam acetyl-coa carboxylase inhibitors
KR101506829B1 (ko) 2010-12-23 2015-03-30 화이자 인코포레이티드 글루카곤 수용체 조절제
GEP20156351B (en) 2011-02-08 2015-08-25 Pfizer Glucagon receptor modulator
PL2699576T3 (pl) 2011-04-22 2016-05-31 Pfizer Pochodne pirazolospiroketonu do zastosowania jako inhibitory karboksylazy acetylo-COA
WO2013011402A1 (en) 2011-07-15 2013-01-24 Pfizer Inc. Gpr 119 modulators
CA2841237C (en) 2011-07-22 2016-05-10 Pfizer Inc. Quinolinyl glucagon receptor modulators
EP2751116B1 (en) 2011-08-31 2016-10-12 Pfizer Inc Hexahydropyrano [3,4-d][1,3]thiazin-2-amine compounds
JP6067754B2 (ja) 2012-02-24 2017-01-25 アルテオジェン インコーポレイテッドＡｌｔｅｏｇｅｎ Ｉｎｃ． システイン残基を含むモチーフが結合した修飾抗体、前記修飾抗体を含む修飾抗体−薬物複合体及びその製造方法
US9296745B2 (en) 2012-04-06 2016-03-29 Pfizer Inc. Diacylglycerol acyltransferase 2 inhibitors
US8889730B2 (en) 2012-04-10 2014-11-18 Pfizer Inc. Indole and indazole compounds that activate AMPK
WO2013164730A1 (en) 2012-05-04 2013-11-07 Pfizer Inc. Heterocyclic substituted hexahydropyrano [3,4-d] [1,3] thiazin- 2 -amine compounds as inhibitors of app, bace1 and bace 2.
WO2014045162A1 (en) 2012-09-20 2014-03-27 Pfizer Inc. ALKYL-SUBSTITUTED HEXAHYDROPYRANO[3,4-d] [1,3]THIAZIN-2-ANIME COMPOUNDS
JP2016502978A (ja) 2012-12-11 2016-02-01 ファイザー・インク ＢＡＣＥ１の阻害剤としてのヘキサヒドロピラノ［３，４−ｄ］［１，３］チアジン−２−アミン化合物
US9403846B2 (en) 2012-12-19 2016-08-02 Pfizer Inc. Carbocyclic- and heterocyclic-substituted hexahydropyrano[3,4-d][1,3]thiazin-2-amine compounds
EP2956458B1 (en) 2013-02-13 2017-08-09 Pfizer Inc Heteroaryl-substituted hexahydropyrano[3,4-d][1,3]thiazin-2-amine compounds
US9233981B1 (en) 2013-02-15 2016-01-12 Pfizer Inc. Substituted phenyl hexahydropyrano[3,4-d][1,3]thiazin-2-amine compounds
SG11201508469YA (en) 2013-05-02 2015-11-27 Glaxosmithkline Ip Dev Ltd Therapeutic peptides
JP6348582B2 (ja) 2013-10-09 2018-06-27 ファイザー・インク プロスタグランジンｅｐ３受容体の拮抗薬
KR20160098278A (ko) * 2013-12-20 2016-08-18 에프. 호프만-라 로슈 아게 Ｃ-말단 아미드화를 위한 펩티딜글라이신 알파-아미드화 모노옥시게나제 (ｐａｍ) 의 용도
ES2674240T3 (es) 2014-03-17 2018-06-28 Pfizer Inc. Inhibidores de diacilglicerol aciltransferasa 2 para su uso en el tratamiento de trastornos metabólicos y relacionados
CA2944971C (en) 2014-04-10 2019-05-07 Pfizer Inc. 2-amino-6-methyl-4,4a,5,6-tetrahydropyrano[3,4-d][1,3]thiazin-8a(8h)-yl-1,3-thiazol-4-yl amides
WO2016092413A1 (en) 2014-12-10 2016-06-16 Pfizer Inc. Indole and indazole compounds that activate ampk
JP2017538769A (ja) 2014-12-22 2017-12-28 ファイザー・インク プロスタグランジンｅｐ３受容体の拮抗薬
WO2016124687A1 (en) * 2015-02-04 2016-08-11 Novo Nordisk A/S Selective pyy compounds and uses thereof
PE20180478A1 (es) 2015-06-17 2018-03-07 Pfizer Compuestos triciclicos y su uso como inhibidores de la fosfodiesterasa
JP2018531923A (ja) 2015-09-24 2018-11-01 ファイザー・インク Ｎ−［２−（２−アミノ−６，６−二置換−４，４ａ，５，６−テトラヒドロピラノ［３，４−ｄ］［１，３］チアジン−８ａ（８Ｈ）−イル）−１，３−チアゾール−４−イル］アミド
EP3353174A1 (en) 2015-09-24 2018-08-01 Pfizer Inc N-[2-(3-amino-2,5-dimethyl-1,1-dioxido-5,6-dihydro-2h-1,2,4-thiadiazin-5-yl)-1,3-thiazol-4-yl]amides useful as bace inhibitors
EP3353182A1 (en) 2015-09-24 2018-08-01 Pfizer Inc Tetrahydropyrano[3,4-d][1,3]oxazin derivatives and their use as bace inhibitors
GEP20207147B (en) 2015-12-29 2020-09-10 Pfizer Substituted 3-azabicyclo[3.1.0]hexanes as ketohexokinase inhibitors
AR109179A1 (es) 2016-08-19 2018-11-07 Pfizer Inhibidores de diacilglicerol aciltransferasa 2
EP3717508A1 (en) 2017-12-01 2020-10-07 The University of Copenhagen Peptide hormone with one or more o-glycans
WO2019210154A1 (en) * 2018-04-26 2019-10-31 Colorado State University Research Foundation Methods and compositions for tracking vegetation
TWI718644B (zh) 2018-08-31 2021-02-11 美商輝瑞股份有限公司 用於治療ｎａｓｈ／ｎａｆｌｄ和相關疾病之組合
CN113874019A (zh) 2019-05-20 2021-12-31 辉瑞大药厂 用于治疗nash/nafld及相关疾病的包含作为glp-1r激动剂的苯并二氧杂环戊烯的组合
WO2023283392A1 (en) * 2021-07-08 2023-01-12 Gila Therapeutics, Inc. Compositions and methods for activating a neural receptor
WO2023026180A1 (en) 2021-08-26 2023-03-02 Pfizer Inc. Amorphous form of (s)-2-(5-((3-ethoxypyridin-2-yl)oxy)pyridin-3-yl)-n-(tetrahydrofuran-3- yl)pyrimidine-5-carboxamide
WO2024118524A1 (en) 2022-11-28 2024-06-06 Cerevel Therapeutics, Llc Azaindole compounds and their use as phosphodiesterase inhibitors

Family Cites Families (145)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US141985A (en) * 1873-08-19 Improvement in sewing-machine tables
US176643A (en) * 1876-04-25 Improvement in ironing-tables
US176630A (en) * 1876-04-25 Improvement in wagon-locks
US244041A (en) * 1881-07-12 Machine for blocking and shaping hats
US2919901A (en) * 1957-01-25 1960-01-05 Thor Power Tool Co Drill system with suction
US5508815A (en) * 1981-12-14 1996-04-16 Smart Vcr Limited Partnership Schedule display system for video recorder programming
US4908713A (en) * 1981-12-14 1990-03-13 Levine Michael R VCR Programmer
US4586158A (en) * 1983-02-22 1986-04-29 International Business Machines Corp. Screen management system
US6319685B1 (en) 1984-09-27 2001-11-20 Unigene Laboratories, Inc. Alpha-amidating enzyme compositions and processes for their production and use
US4708934A (en) 1984-09-27 1987-11-24 Unigene Laboratories, Inc. α-amidation enzyme
US6492107B1 (en) 1986-11-20 2002-12-10 Stuart Kauffman Process for obtaining DNA, RNA, peptides, polypeptides, or protein, by recombinant DNA technique
GB2183661B (en) 1985-03-30 1989-06-28 Marc Ballivet Method for obtaining dna, rna, peptides, polypeptides or proteins by means of a dna recombinant technique
US4821097A (en) * 1987-03-05 1989-04-11 General Instrument Corporation Apparatus and method for providing digital audio on the sound carrier of a standard television signal
US5789234A (en) 1987-08-14 1998-08-04 Unigene Laboratories, Inc. Expression systems for amidating enzyme
US4930160A (en) * 1987-09-02 1990-05-29 Vogel Peter S Automatic censorship of video programs
US4984152A (en) * 1987-10-06 1991-01-08 Bell Communications Research, Inc. System for controlling computer processing utilizing a multifunctional cursor with decoupling of pointer and image functionalities in space and time
US4827250A (en) * 1987-10-26 1989-05-02 Tektronix, Inc. Graphics display system having data transform circuit
GB8823869D0 (en) 1988-10-12 1988-11-16 Medical Res Council Production of antibodies
US4991011A (en) * 1988-12-23 1991-02-05 Scientific-Atlanta, Inc. Interactive television terminal with programmable background audio or video
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
JP2877509B2 (ja) 1989-05-19 1999-03-31 アムジエン・インコーポレーテツド メタロプロテイナーゼ阻害剤
US5727060A (en) * 1989-10-30 1998-03-10 Starsight Telecast, Inc. Television schedule system
DK0463151T3 (da) 1990-01-12 1996-07-01 Cell Genesys Inc Frembringelse af xenogene antistoffer
JP2938569B2 (ja) 1990-08-29 1999-08-23 ジェンファーム インターナショナル，インコーポレイティド 異種免疫グロブリンを作る方法及びトランスジェニックマウス
US5293357A (en) * 1990-09-10 1994-03-08 The Superguide Corporation Method and apparatus for controlling a television program recording device
US5247347A (en) * 1991-09-27 1993-09-21 Bell Atlantic Network Services, Inc. Pstn architecture for video-on-demand services
JP2654283B2 (ja) * 1991-09-30 1997-09-17 株式会社東芝 アイコン表示方法
US5317391A (en) * 1991-11-29 1994-05-31 Scientific-Atlanta, Inc. Method and apparatus for providing message information to subscribers in a cable television system
US5291554A (en) * 1992-05-28 1994-03-01 Tv Answer, Inc. Shared-price custom video rentals via interactive TV
FR2692575B1 (fr) 1992-06-23 1995-06-30 Sanofi Elf Nouveaux derives du pyrazole, procede pour leur preparation et compositions pharmaceutiques les contenant.
JPH07509137A (ja) 1992-07-24 1995-10-12 セル　ジェネシス，インク． 異種抗体の生産
JPH06139671A (ja) * 1992-10-27 1994-05-20 Sony Corp 記録再生システム
DE69228711T2 (de) * 1992-10-30 1999-10-07 Juki Corp., Chofu SCHNEIDEEINHEIT FüR KUVERTIER- UND VERSCHLIESSMASCHINEN
US5592551A (en) * 1992-12-01 1997-01-07 Scientific-Atlanta, Inc. Method and apparatus for providing interactive electronic programming guide
US5715515A (en) * 1992-12-02 1998-02-03 Scientific-Atlanta, Inc. Method and apparatus for downloading on-screen graphics and captions to a television terminal
US5410326A (en) * 1992-12-04 1995-04-25 Goldstein; Steven W. Programmable remote control device for interacting with a plurality of remotely controlled devices
DE69333713T2 (de) * 1992-12-09 2005-07-21 Sedna Patent Services, Llc Vorrichtung und Verfahren zur Bereitstellen von Rundfunkdatendiensten
US5600364A (en) * 1992-12-09 1997-02-04 Discovery Communications, Inc. Network controller for cable television delivery systems
US5483277A (en) * 1992-12-15 1996-01-09 Alcatel Network Systems Simplified set-top converter for broadband switched network
US5598524A (en) * 1993-03-03 1997-01-28 Apple Computer, Inc. Method and apparatus for improved manipulation of data between an application program and the files system on a computer-controlled display system
CN1124927A (zh) * 1993-03-29 1996-06-19 辛辛那提大学 Yy肽类似物及其应用
US5594509A (en) * 1993-06-22 1997-01-14 Apple Computer, Inc. Method and apparatus for audio-visual interface for the display of multiple levels of information on a display
US5621456A (en) * 1993-06-22 1997-04-15 Apple Computer, Inc. Methods and apparatus for audio-visual interface for the display of multiple program categories
US5414455A (en) * 1993-07-07 1995-05-09 Digital Equipment Corporation Segmented video on demand system
US5410344A (en) * 1993-09-22 1995-04-25 Arrowsmith Technologies, Inc. Apparatus and method of selecting video programs based on viewers' preferences
US5398071A (en) * 1993-11-02 1995-03-14 Texas Instruments Incorporated Film-to-video format detection for digital television
US5481542A (en) * 1993-11-10 1996-01-02 Scientific-Atlanta, Inc. Interactive information services control system
US5422674A (en) * 1993-12-22 1995-06-06 Digital Equipment Corporation Remote display of an image by transmitting compressed video frames representing background and overlay portions thereof
US5516653A (en) * 1993-12-28 1996-05-14 Synaptic Pharmaceutical Corporation DNA encoding a human neuropeptide Y/peptide YY/pancreatic polypeptide receptor (Y4) and uses thereof
JPH07244781A (ja) * 1994-03-07 1995-09-19 C S K Sogo Kenkyusho:Kk ソフトウェアレンタル方法および装置ならびに流通媒体
US5629732A (en) * 1994-03-29 1997-05-13 The Trustees Of Columbia University In The City Of New York Viewer controllable on-demand multimedia service
US5512958A (en) * 1994-04-29 1996-04-30 Matsushita Electric Corporation Of America System for controlling the effects of noise in television receivers
US5521631A (en) * 1994-05-25 1996-05-28 Spectravision, Inc. Interactive digital video services system with store and forward capabilities
JP3575063B2 (ja) * 1994-07-04 2004-10-06 ソニー株式会社 再生装置、再生方法
US5596106A (en) 1994-07-15 1997-01-21 Eli Lilly And Company Cannabinoid receptor antagonists
EP0699000B1 (en) * 1994-08-24 2001-06-20 Hyundai Electronics America A video server and system employing the same
US5682325A (en) * 1994-09-12 1997-10-28 Bell Atlantic Network Services, Inc. Level 1 gateway for video tone networks
US5619249A (en) * 1994-09-14 1997-04-08 Time Warner Entertainment Company, L.P. Telecasting service for providing video programs on demand with an interactive interface for facilitating viewer selection of video programs
DE4435477A1 (de) 1994-10-04 1996-04-11 Bayer Ag Cycloalkano-indol- und -azaindol-derivate
US5614940A (en) * 1994-10-21 1997-03-25 Intel Corporation Method and apparatus for providing broadcast information with indexing
NZ295353A (en) 1994-10-27 1998-08-26 Janssen Pharmaceutica Nv Heterocyclyl-thiomethyl substituted dioxolane derivatives and medicaments compositions thereof
US5521186A (en) 1994-10-27 1996-05-28 Janssen Pharmaceutica N.V. Apolipoprotein-β synthesis inhibitors
US5724521A (en) * 1994-11-03 1998-03-03 Intel Corporation Method and apparatus for providing electronic advertisements to end users in a consumer best-fit pricing manner
US5623613A (en) * 1994-11-29 1997-04-22 Microsoft Corporation System for displaying programming information
US5912227A (en) * 1995-01-27 1999-06-15 North Carolina State University Method of enhancing nutrient uptake
US5619247A (en) * 1995-02-24 1997-04-08 Smart Vcr Limited Partnership Stored program pay-per-play
US5632681A (en) * 1995-03-07 1997-05-27 International Business Machines Corporation Universal electronic video game renting/distributing system
US5651010A (en) * 1995-03-16 1997-07-22 Bell Atlantic Network Services, Inc. Simultaneous overlapping broadcasting of digital programs
EP0822830B1 (en) 1995-04-27 2008-04-02 Amgen Fremont Inc. Human anti-IL-8 antibodies, derived from immunized xenomice
US5721829A (en) * 1995-05-05 1998-02-24 Microsoft Corporation System for automatic pause/resume of content delivered on a channel in response to switching to and from that channel and resuming so that a portion of the content is repeated
US6558708B1 (en) * 1995-05-17 2003-05-06 Cedars-Sinai Medical Center Methods for manipulating upper gastrointestinal transit, blood flow, and satiety, and for treating visceral hyperalgesia
US5740549A (en) * 1995-06-12 1998-04-14 Pointcast, Inc. Information and advertising distribution system and method
US5751282A (en) * 1995-06-13 1998-05-12 Microsoft Corporation System and method for calling video on demand using an electronic programming guide
US5724106A (en) * 1995-07-17 1998-03-03 Gateway 2000, Inc. Hand held remote control device with trigger button
US5745837A (en) * 1995-08-25 1998-04-28 Terayon Corporation Apparatus and method for digital data transmission over a CATV system using an ATM transport protocol and SCDMA
US5737028A (en) * 1995-11-01 1998-04-07 International Business Machines Corporation Previous channel listing with cursor controlled user interface for television video displays
US5919901A (en) * 1996-04-08 1999-07-06 Bayer Corporation Neuropeptide Y receptor Y5 and nucleic acid sequences
US5721897A (en) * 1996-04-09 1998-02-24 Rubinstein; Seymour I. Browse by prompted keyword phrases with an improved user interface
US5721827A (en) * 1996-10-02 1998-02-24 James Logan System for electrically distributing personalized information
EP2262243A1 (en) * 1996-12-10 2010-12-15 United Video Properties, Inc. Internet television program guide system
US6654933B1 (en) * 1999-09-21 2003-11-25 Kasenna, Inc. System and method for media stream indexing
DK1005526T3 (da) 1997-04-16 2011-02-07 Unigene Lab Inc Direkte ekspression af peptider i kulturmedium
IL121230A (en) * 1997-07-03 2004-05-12 Nds Ltd Intelligent electronic program guide
US6342220B1 (en) 1997-08-25 2002-01-29 Genentech, Inc. Agonist antibodies
KR20010024296A (ko) 1997-09-26 2001-03-26 아더시스 인코포레이티드 벡터 구조체와 세포 ｄｎａ의 비상동 재조합법에 의한내생 유전자 발현
US6046167A (en) * 1998-03-25 2000-04-04 University Of Cincinnati Peptide YY analogs
US6505348B1 (en) * 1998-07-29 2003-01-07 Starsight Telecast, Inc. Multiple interactive electronic program guide system and methods
US6360053B1 (en) * 1998-08-07 2002-03-19 Replaytv, Inc. Method and apparatus for fast forwarding and rewinding in a video recording device
KR100652994B1 (ko) 1998-09-11 2006-11-30 아방티 파르마 소시에테 아노님 아제티딘 유도체, 이의 제조방법 및 이를 함유하는 약제
US20020026638A1 (en) * 2000-08-31 2002-02-28 Eldering Charles A. Internet-based electronic program guide advertisement insertion method and apparatus
FR2789079B3 (fr) 1999-02-01 2001-03-02 Sanofi Synthelabo Derive d'acide pyrazolecarboxylique, sa preparation, les compositions pharmaceutiques en contenant
DK1189629T3 (da) * 1999-02-10 2011-01-03 Curis Inc Peptid YY (PYY) til behandling af glucosestofskiftesygdomme
US7086077B2 (en) * 1999-04-01 2006-08-01 Sedna Patent Services, Llc Service rate change method and apparatus
US6832386B1 (en) * 1999-06-11 2004-12-14 Scientific-Atlanta, Inc. System and method for allowing a user to quickly navigate within a program guide to an established reference point
US7150031B1 (en) * 2000-06-09 2006-12-12 Scientific-Atlanta, Inc. System and method for reminders of upcoming rentable media offerings
US7010801B1 (en) * 1999-06-11 2006-03-07 Scientific-Atlanta, Inc. Video on demand system with parameter-controlled bandwidth deallocation
US6986156B1 (en) * 1999-06-11 2006-01-10 Scientific Atlanta, Inc Systems and methods for adaptive scheduling and dynamic bandwidth resource allocation management in a digital broadband delivery system
US7228556B2 (en) * 1999-12-21 2007-06-05 Tivo Inc. Distributed, interactive television program guide; system and method
US20030030679A1 (en) * 2000-01-06 2003-02-13 Anuj Kumar Jain User-definable images in bookmarks
AU2001253042A1 (en) * 2000-03-31 2001-10-15 Liquid Engines, Inc. System and method for implementing electronic markets
CA2403240C (en) * 2000-03-31 2013-12-03 United Video Properties, Inc. Interactive media system and method for presenting pause-time content
US20020007485A1 (en) * 2000-04-03 2002-01-17 Rodriguez Arturo A. Television service enhancements
GB0008691D0 (en) * 2000-04-07 2000-05-31 Post Impressions Systems Ltd Input and output systems for data processing
US7934232B1 (en) * 2000-05-04 2011-04-26 Jerding Dean F Navigation paradigm for access to television services
US8069259B2 (en) * 2000-06-09 2011-11-29 Rodriguez Arturo A Managing removal of media titles from a list
US7685520B2 (en) * 2000-06-22 2010-03-23 Intel Corporation Electronic programming guide with selectable categories
US7962370B2 (en) * 2000-06-29 2011-06-14 Rodriguez Arturo A Methods in a media service system for transaction processing
JP4356226B2 (ja) * 2000-09-12 2009-11-04 ソニー株式会社 サーバ装置、配信システム、配信方法、及び端末装置
US8302127B2 (en) * 2000-09-25 2012-10-30 Thomson Licensing System and method for personalized TV
AR030870A1 (es) * 2000-10-11 2003-09-03 United Video Properties Inc Disposicion y metodo para construir listas de medios de usuario
US20020049978A1 (en) * 2000-10-20 2002-04-25 Rodriguez Arturo A. System and method for access and placement of media content information items on a screen display with a remote control device
US6924291B2 (en) 2001-01-23 2005-08-02 Merck & Co., Inc. Process for making spiro isobenzofuranone compounds
BR0205602A (pt) 2001-03-22 2003-07-08 Solvay Pharm Bv EnantiÈmero possuindo a configuração s na posição-4 dos seu anel pirazol de um composto, composição farmacêutica, método para a preparação de composições farmacêuticas, processo para a preparação de compostos, e, métodos de tratamento de distúrbios que envolvem neurotransmissão canabinóide
EP1456360B1 (en) 2001-04-19 2015-06-03 The Scripps Research Institute Methods and composition for the production of orthoganal trna-aminoacyltrna synthetase pairs
SI1404653T1 (sl) 2001-06-28 2008-12-31 Pfizer Prod Inc S triamidom substituirani indoli, benzofurani in benzotiofeni kot zaviralci mikrosomske prenašalnebeljakovine za trigliceride (MTP) in/ali izločanja apolipoproteina B (APO B)
US8006262B2 (en) * 2001-06-29 2011-08-23 Rodriguez Arturo A Graphic user interfaces for purchasable and recordable media (PRM) downloads
EP1499277B1 (en) * 2001-09-24 2009-01-07 Imperial Innovations Limited Pyy3-36 for the reduction or prevention of obesity
US7142590B2 (en) * 2001-10-11 2006-11-28 Utstarcom Inc. Method and system for oversubscribing a DSL modem
US20030074257A1 (en) * 2001-10-12 2003-04-17 Michael Saveliev Method and apparatus for advertising adjacent to a beverage dispenser to facilitate advertising income device placement in high traffic venues
US7334251B2 (en) * 2002-02-11 2008-02-19 Scientific-Atlanta, Inc. Management of television advertising
US20050171161A1 (en) 2002-03-06 2005-08-04 Fong Tung M. Method of treatment or prevention of obesity
JP2005528366A (ja) 2002-03-26 2005-09-22 メルク　エンド　カムパニー　インコーポレーテッド カンナビノイド受容体モジュレータとしてのスピロ環式アミド
KR100741231B1 (ko) 2002-07-29 2007-07-19 에프. 호프만-라 로슈 아게 신규 벤조다이옥솔
WO2004012671A2 (en) 2002-08-02 2004-02-12 Merck & Co., Inc. Substituted furo [2,3-b] pyridine derivatives
US7129239B2 (en) 2002-10-28 2006-10-31 Pfizer Inc. Purine compounds and uses thereof
MY134457A (en) 2002-11-22 2007-12-31 Merck & Co Inc Substituted amides
CA2510199A1 (en) 2002-12-17 2004-07-08 Nastech Pharmaceutical Company Inc. Compositions and methods for enhanced mucosal delivery of y2 receptor-binding peptides and methods for treating and preventing obesity
US7186692B2 (en) 2002-12-17 2007-03-06 Nastech Pharmaceutical Company Inc. Compositions and methods for enhanced mucosal delivery and non-infused administration of Y2 receptor-binding peptides and methods for treating and preventing obesity
AU2003289118A1 (en) * 2002-12-18 2004-07-09 International Business Machines Corporation Web service providing system, server device for the same, control method for controlling computer system as server device for web service providing system, program for executing the control method, and recording medium
US7329658B2 (en) 2003-02-06 2008-02-12 Pfizer Inc Cannabinoid receptor ligands and uses thereof
WO2004089279A2 (en) * 2003-04-08 2004-10-21 Yeda Research And Development Co. Ltd. Long-acting derivatives of pyy agonists
US7145012B2 (en) 2003-04-23 2006-12-05 Pfizer Inc. Cannabinoid receptor ligands and uses thereof
US7141669B2 (en) 2003-04-23 2006-11-28 Pfizer Inc. Cannabiniod receptor ligands and uses thereof
US20050009748A1 (en) 2003-05-14 2005-01-13 Emisphere Technologies, Inc. Compositions for delivering peptide YY and PYY agonists
ES2425221T3 (es) 2003-05-30 2013-10-14 Amylin Pharmaceuticals, Llc Nuevos métodos y composiciones para suministro por vía transmucosa potenciado de péptidos y proteínas
US7274740B2 (en) * 2003-06-25 2007-09-25 Sharp Laboratories Of America, Inc. Wireless video transmission system
US20050091693A1 (en) * 2003-10-22 2005-04-28 Rochelle Communications, Inc. Dual mode set-top box that optimizes the delivery and user selection of audio or video programming over data networks
US7151097B2 (en) 2003-11-07 2006-12-19 Pfizer Inc. Bicyclic pyrazolyl and imidazolyl compounds and uses thereof
EP1716137A1 (en) 2004-02-04 2006-11-02 Pfizer Products Incorporated Substituted quinoline compounds
WO2005077094A2 (en) * 2004-02-11 2005-08-25 Amylin Pharmaceuticals, Inc. Pancreatic polypeptide family motifs and polypeptides comprising the same
EP1718671A2 (en) * 2004-02-23 2006-11-08 Rheoscience A/S Peptide yy analogues
US7954129B2 (en) * 2004-09-24 2011-05-31 Smartvue Corporation Wireless video surveillance system and method with remote viewing
US20060088105A1 (en) * 2004-10-27 2006-04-27 Bo Shen Method and system for generating multiple transcoded outputs based on a single input
US7620065B2 (en) * 2005-07-22 2009-11-17 Trellia Networks, Inc. Mobile connectivity solution
US8189472B2 (en) * 2005-09-07 2012-05-29 Mcdonald James F Optimizing bandwidth utilization to a subscriber premises

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