RO82085B - PROCEDEU PENTRU PREPARAREA ACIZILOR ALCANOICI AVîND UN SUBSTITUENT ALFA- AROMATIC SAU A ESTERILOR ACESTORA - Google Patents
PROCEDEU PENTRU PREPARAREA ACIZILOR ALCANOICI AVîND UN SUBSTITUENT ALFA- AROMATIC SAU A ESTERILOR ACESTORAInfo
- Publication number
- RO82085B RO82085B RO105287A RO10528781A RO82085B RO 82085 B RO82085 B RO 82085B RO 105287 A RO105287 A RO 105287A RO 10528781 A RO10528781 A RO 10528781A RO 82085 B RO82085 B RO 82085B
- Authority
- RO
- Romania
- Prior art keywords
- alpha
- esters
- preparation
- radical
- general formula
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/24—Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/30—Compounds having groups
- C07C43/307—Compounds having groups having acetal carbon atoms bound to carbon atoms of six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C43/00—Ethers; Compounds having groups, groups or groups
- C07C43/30—Compounds having groups
- C07C43/315—Compounds having groups containing oxygen atoms singly bound to carbon atoms not being acetal carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
- C07C45/46—Friedel-Crafts reactions
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
- C07C45/61—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups
- C07C45/63—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by reactions not involving the formation of >C = O groups by introduction of halogen; by substitution of halogen atoms by other halogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
- C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
- C07C49/80—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C57/00—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms
- C07C57/30—Unsaturated compounds having carboxyl groups bound to acyclic carbon atoms containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
- C07C59/40—Unsaturated compounds
- C07C59/58—Unsaturated compounds containing ether groups, groups, groups, or groups
- C07C59/64—Unsaturated compounds containing ether groups, groups, groups, or groups containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C07D209/46—Iso-indoles; Hydrogenated iso-indoles with an oxygen atom in position 1
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/48—Compounds containing oxirane rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
- C07D317/20—Free hydroxyl or mercaptan
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
- C07D317/24—Radicals substituted by singly bound oxygen or sulfur atoms esterified
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D333/00—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
- C07D333/02—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings
- C07D333/04—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom
- C07D333/06—Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom not condensed with other rings not substituted on the ring sulphur atom with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
- C07D333/22—Radicals substituted by doubly bound hetero atoms, or by two hetero atoms other than halogen singly bound to the same carbon atom
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
Prezenta inventie se refera la un procedeu de preparare a acizilor alfa-aromatic sau a esterilor acestora, cu formula generala I: (vezi formula) în care Ar reprezinta o grupa fenil, naftil sau tienil, eventula substituita si R1 reprezinta un atom de hidrogen sau o grupa alchil 1...5 atomi de carbon sau Ar si R1 împreuna cu atomul de carbon la care sunt legati pot forma un inel indanic, si R2 reprezinta un atom de hidrigen, un radical alchil sau un substituent hidroxialchil conform caruia un acetal de alfa-sulfoniloxi-acetona cu formula generala II: (vezi formula) în care R3 si R4, în mod independent unul de altul, reprezinta un radical alchilen, R5 reprezinta un radical alchil substituit sau nesubstituit sau un radical aromatic si Ar si R1 sunt definiti mai sus, este hidrolizat la o temperatura cuprinsa între temperatura de reflux si 250 degree C, hidroliza este facuta într-un solvent polar aprotic, în conditii neutre sau bazice, de preferinta în prezenta unei baze, fiind utilizata într-o cantitate cel putin egala cu 1 echivalent per mol din compusul cu formula II.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP55125355A JPS5750956A (en) | 1980-09-11 | 1980-09-11 | Alpha-sulfonyloxyalkanophenone acetal |
JP55143042A JPS5767535A (en) | 1980-10-15 | 1980-10-15 | Preparation of alpha-aromatic group substituted alkanecarboxylic acid |
JP55157049A JPS5798232A (en) | 1980-11-10 | 1980-11-10 | 1-(6-methoxy-2-naphthyl)-2-oxy-1-alkanone acetal |
JP1170081A JPS57128661A (en) | 1981-01-30 | 1981-01-30 | 1-(4-substituted aminophenyl)-2-oxy-1-alkanone acetal |
JP9097981A JPS5810537A (ja) | 1981-06-15 | 1981-06-15 | α−芳香族基置換アルカン酸類の製造方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
RO82085B true RO82085B (ro) | 1983-06-30 |
RO82085A RO82085A (ro) | 1983-07-07 |
Family
ID=27519313
Family Applications (3)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RO110734A RO86227B (ro) | 1980-09-11 | 1981-09-11 | Procedeu de preparare a unor acetali de alfa-sulfoniloxifenone substituite |
RO110733A RO85818B (ro) | 1980-09-11 | 1981-09-11 | PROCEDEU PENTRU PREPARAREA ACIZILOR ALCANOICI SUBSTITUITI îN ALFA CU UN SUBSTITUENT AROMATIC SI A ESTERILOR ACESTORA |
RO81105287A RO82085A (ro) | 1980-09-11 | 1981-09-11 | Procedeu pentru prepararea acizilor alcanoici avind un substituent alfa aromatic sau esteric |
Family Applications Before (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RO110734A RO86227B (ro) | 1980-09-11 | 1981-09-11 | Procedeu de preparare a unor acetali de alfa-sulfoniloxifenone substituite |
RO110733A RO85818B (ro) | 1980-09-11 | 1981-09-11 | PROCEDEU PENTRU PREPARAREA ACIZILOR ALCANOICI SUBSTITUITI îN ALFA CU UN SUBSTITUENT AROMATIC SI A ESTERILOR ACESTORA |
Country Status (22)
Country | Link |
---|---|
EP (2) | EP0048136B1 (ro) |
AR (1) | AR228067A1 (ro) |
AU (1) | AU599006B2 (ro) |
CA (1) | CA1186318A (ro) |
DD (1) | DD202866A5 (ro) |
DE (1) | DE3174810D1 (ro) |
DK (3) | DK161020C (ro) |
FI (1) | FI73195C (ro) |
GR (1) | GR75077B (ro) |
HK (1) | HK20589A (ro) |
IE (1) | IE53333B1 (ro) |
IL (3) | IL63791A0 (ro) |
IN (1) | IN155107B (ro) |
MY (1) | MY8700825A (ro) |
NO (1) | NO157616C (ro) |
NZ (1) | NZ198271A (ro) |
PH (3) | PH17798A (ro) |
PL (1) | PL133927B1 (ro) |
PT (1) | PT73624B (ro) |
RO (3) | RO86227B (ro) |
SG (1) | SG98187G (ro) |
YU (2) | YU43500B (ro) |
Families Citing this family (12)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2423863A (en) * | 1940-11-16 | 1947-07-15 | George F Wales | Sheet metal compartment with shelf supports and method of manufacture |
IL65629A (en) * | 1981-04-30 | 1987-08-31 | Syntex Pharma Int | Preparation of alpha-arylalkanoic acids and esters and salts thereof |
JPS5810525A (ja) * | 1981-06-15 | 1983-01-21 | Sagami Chem Res Center | 光学活性な1−芳香族基置換−1−アルカノン類の製造方法 |
FI82680C (fi) * | 1981-12-11 | 1991-04-10 | Syntex Pharma Int | Framstaellning av - arylalkansyror. |
IT1173216B (it) * | 1984-02-03 | 1987-06-18 | Zambon Spa | Processo per la preparazione di acidi alfa-idrossiaril-alcanoici |
EP0160241B1 (en) * | 1984-04-14 | 1988-11-30 | Kyowa Hakko Kogyo Co., Ltd. | Process for producing an alpha-aromatic group substituted alkanoic acid derivative |
IT1188181B (it) * | 1985-07-31 | 1988-01-07 | Zambon Spa | Processo per la preparazione di acidi carbossilici otticamente attivi e relativi intermedi |
JPS62263153A (ja) * | 1986-05-28 | 1987-11-16 | エフ・ホフマン―ラ ロシユ アーゲー | カルバゾ−ル誘導体 |
IT1197800B (it) * | 1986-08-01 | 1988-12-06 | Zambon Spa | Processo per la sintesi di acidi carbossilici |
EP0380316A3 (en) * | 1989-01-25 | 1990-11-28 | Syntex Pharmaceuticals International Limited | Preparation of alpha-methylareneacetic acids |
IT1251958B (it) * | 1991-10-18 | 1995-05-27 | Zambon Spa | Processo per la dealogenazione di derivati del naftalene |
US9226907B2 (en) | 2008-02-01 | 2016-01-05 | Abbvie Inc. | Extended release hydrocodone acetaminophen and related methods and uses thereof |
Family Cites Families (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IT1109200B (it) * | 1979-02-20 | 1985-12-16 | Montedison Spa | Processo per la preparazione di esteri di acidi arilacetici da alfa-alo-alchilarilchetoni |
IE50897B1 (en) * | 1980-02-26 | 1986-08-06 | Blaschim Spa | Process for preparing esters of alkanoic acids via rearrangement of alpha-haloketals |
IL65629A (en) * | 1981-04-30 | 1987-08-31 | Syntex Pharma Int | Preparation of alpha-arylalkanoic acids and esters and salts thereof |
FI82680C (fi) * | 1981-12-11 | 1991-04-10 | Syntex Pharma Int | Framstaellning av - arylalkansyror. |
-
1981
- 1981-09-04 NZ NZ198271A patent/NZ198271A/en unknown
- 1981-09-04 IE IE2057/81A patent/IE53333B1/en not_active IP Right Cessation
- 1981-09-07 PT PT73624A patent/PT73624B/pt not_active IP Right Cessation
- 1981-09-08 DK DK396581A patent/DK161020C/da not_active IP Right Cessation
- 1981-09-08 GR GR65980A patent/GR75077B/el unknown
- 1981-09-09 YU YU2161/81A patent/YU43500B/xx unknown
- 1981-09-09 AR AR286701A patent/AR228067A1/es active
- 1981-09-10 PH PH26181A patent/PH17798A/en unknown
- 1981-09-10 EP EP81304154A patent/EP0048136B1/en not_active Expired
- 1981-09-10 DE DE8181304154T patent/DE3174810D1/de not_active Expired
- 1981-09-10 IL IL63791A patent/IL63791A0/xx not_active IP Right Cessation
- 1981-09-10 NO NO813088A patent/NO157616C/no unknown
- 1981-09-10 FI FI812820A patent/FI73195C/fi not_active IP Right Cessation
- 1981-09-10 IN IN1023/CAL/81A patent/IN155107B/en unknown
- 1981-09-10 IL IL74744A patent/IL74744A/xx not_active IP Right Cessation
- 1981-09-10 EP EP84113585A patent/EP0151702B1/en not_active Expired
- 1981-09-11 DD DD81233229A patent/DD202866A5/de not_active IP Right Cessation
- 1981-09-11 RO RO110734A patent/RO86227B/ro unknown
- 1981-09-11 RO RO110733A patent/RO85818B/ro unknown
- 1981-09-11 PL PL1981232991A patent/PL133927B1/pl unknown
- 1981-09-11 CA CA000385670A patent/CA1186318A/en not_active Expired
- 1981-09-11 RO RO81105287A patent/RO82085A/ro unknown
-
1983
- 1983-07-18 PH PH29248A patent/PH21746A/en unknown
- 1983-07-18 PH PH29246A patent/PH21751A/en unknown
-
1985
- 1985-03-28 IL IL74744A patent/IL74744A0/xx unknown
- 1985-08-07 AU AU45889/85A patent/AU599006B2/en not_active Ceased
-
1986
- 1986-12-31 YU YU2288/86A patent/YU45076B/xx unknown
-
1987
- 1987-11-04 SG SG981/87A patent/SG98187G/en unknown
- 1987-12-30 MY MY825/87A patent/MY8700825A/xx unknown
-
1989
- 1989-03-09 HK HK205/89A patent/HK20589A/xx unknown
-
1990
- 1990-03-02 DK DK055790A patent/DK163056C/da not_active IP Right Cessation
- 1990-03-02 DK DK055690A patent/DK163179C/da active
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