RO81116B - Procedeu pentru prepararea unor corticoide - Google Patents

Procedeu pentru prepararea unor corticoide

Info

Publication number
RO81116B
RO81116B RO102257A RO10225779A RO81116B RO 81116 B RO81116 B RO 81116B RO 102257 A RO102257 A RO 102257A RO 10225779 A RO10225779 A RO 10225779A RO 81116 B RO81116 B RO 81116B
Authority
RO
Romania
Prior art keywords
general formula
lower alkyl
corticoids
group
preparing
Prior art date
Application number
RO102257A
Other languages
English (en)
Other versions
RO81116A (ro
Inventor
Ernst Schottle
Alfred Weber
Mario Kennecke
Helmut Dahl
Original Assignee
Schering Aktiengesellschaft
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE19782803661 external-priority patent/DE2803661A1/de
Priority claimed from DE19782855465 external-priority patent/DE2855465A1/de
Application filed by Schering Aktiengesellschaft filed Critical Schering Aktiengesellschaft
Publication of RO81116B publication Critical patent/RO81116B/ro
Publication of RO81116A publication Critical patent/RO81116A/ro

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0053—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa not substituted in position 16
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J17/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, having an oxygen-containing hetero ring not condensed with the cyclopenta(a)hydrophenanthrene skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J31/00—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring
    • C07J31/006—Normal steroids containing one or more sulfur atoms not belonging to a hetero ring not covered by C07J31/003
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0061—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16
    • C07J5/0069—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group
    • C07J5/0076—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group by an alkyl group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J5/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond
    • C07J5/0046—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa
    • C07J5/0061—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16
    • C07J5/0069—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group
    • C07J5/0084—Normal steroids containing carbon, hydrogen, halogen or oxygen, substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane and substituted in position 21 by only one singly bound oxygen atom, i.e. only one oxygen bound to position 21 by a single bond substituted in position 17 alfa substituted in position 16 by a saturated or unsaturated hydrocarbon group by an alkylene group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/0005—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21
    • C07J7/001—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group
    • C07J7/004—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa
    • C07J7/0045—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms not substituted in position 21 substituted in position 20 by a keto group substituted in position 17 alfa not substituted in position 16
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J7/00—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms
    • C07J7/008—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21
    • C07J7/0085—Normal steroids containing carbon, hydrogen, halogen or oxygen substituted in position 17 beta by a chain of two carbon atoms substituted in position 21 by an halogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • C07J71/0005—Oxygen-containing hetero ring
    • C07J71/001—Oxiranes
    • C07J71/0015—Oxiranes at position 9(11)
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/911—Microorganisms using fungi

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Steroid Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

Inventia se refera la un procedeu pentru prepararea unor corticoide cu formula generala I: (vezi formula) în care simbolul ... reprezinta o legatura simpla sau o legatura dubla carbon carbon. R1 reprezinta hidrogen sau metil, R2 reprezinta o grupa alchil inferioara, de preferinta întrerupta cu un atom de oxigen sau o grupa benzil sau cicloalchil si R3 reprezinta un radical alchil inferior prin tratarea unui 17- hidroxisteroid cu formula generala II: (vezi formula) în care R1 si R3 au semnificatiile de mai sus, iar grupa 11-oxi este protejata în mod uzual, cu un acetal cu formula generala II: (vezi formula) în care R2 are semnificatiile mentionate mai sus, la temperatura de -20...50 degree C, în prezenta de catalizatori acizi si în mediu de solventi organici, apoi produsul de reactie este separat în mod cunoscut.
RO79102257A 1978-01-25 1979-01-23 Procedeu pentru prepararea unor corticoidale RO81116A (ro)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19782803661 DE2803661A1 (de) 1978-01-25 1978-01-25 Neue in 17-position substituierte 11beta-hydroxysteroide der pregnanreihe, ihre herstellung und verwendung
DE19782855465 DE2855465A1 (de) 1978-12-19 1978-12-19 Neue kortikoide, verfahren zu ihrer herstellung, ihre verwendung und diese kortikoide enthaltende pharmazeutische praeparate

Publications (2)

Publication Number Publication Date
RO81116B true RO81116B (ro) 1983-05-30
RO81116A RO81116A (ro) 1983-06-01

Family

ID=25773724

Family Applications (2)

Application Number Title Priority Date Filing Date
RO7996365A RO76163A (ro) 1978-01-25 1979-01-23 Procedeu pentru prepararea 11beta-hidroxisteroidelor
RO79102257A RO81116A (ro) 1978-01-25 1979-01-23 Procedeu pentru prepararea unor corticoidale

Family Applications Before (1)

Application Number Title Priority Date Filing Date
RO7996365A RO76163A (ro) 1978-01-25 1979-01-23 Procedeu pentru prepararea 11beta-hidroxisteroidelor

Country Status (21)

Country Link
US (1) US4207316A (ro)
EP (1) EP0003341B1 (ro)
AU (1) AU529292B2 (ro)
BG (3) BG33738A3 (ro)
CS (1) CS207753B2 (ro)
DD (2) DD150749A5 (ro)
DE (1) DE2967070D1 (ro)
DK (1) DK28779A (ro)
EG (1) EG14273A (ro)
ES (1) ES477162A1 (ro)
FI (1) FI66023C (ro)
FR (1) FR2422689A1 (ro)
GB (1) GB2014150B (ro)
IE (1) IE47729B1 (ro)
IL (1) IL56494A (ro)
NO (1) NO154583C (ro)
NZ (1) NZ189460A (ro)
PH (1) PH18164A (ro)
PT (1) PT69126A (ro)
RO (2) RO76163A (ro)
SU (6) SU876059A3 (ro)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2952003A1 (de) * 1979-12-21 1981-07-02 Schering Ag Berlin Und Bergkamen, 1000 Berlin Neue kortikoid-17-thioacetale, ihre herstellung und verwendung
DE3038855A1 (de) * 1980-10-10 1982-05-27 Schering Ag, 1000 Berlin Und 4619 Bergkamen Neue d-homo-kortikoide, ihre herstellung und verwendung
HU221584B (hu) * 1993-01-08 2002-11-28 Aktiebolaget Astra Új vastagbél- (colon) vagy csípőbél- (ileum) specifikus, cukortartalmú szteroidszármazékok, ezeket tartalmazó gyógyszerkészítmények és előállításuk
US5502222A (en) * 1994-06-01 1996-03-26 Schering Corporation Process for preparing delta 9,11 and 21-chloro corticosteroids
US8729108B2 (en) * 2008-06-17 2014-05-20 Christopher J Dannaker Waterborne topical compositions for the delivery of active ingredients such as azelaic acid

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR6682287D0 (pt) * 1965-08-30 1973-12-04 Merck & Co Inc Processo para preparar 17-alcoxi-progesteronas
NL6605514A (ro) * 1966-04-25 1967-10-26
US3453297A (en) * 1968-07-24 1969-07-01 Merck & Co Inc 17alpha-lower alkoxy-pregna-4,6-diene-3,20-dione steroids

Also Published As

Publication number Publication date
SU890979A3 (ru) 1981-12-15
DD141523A5 (de) 1980-05-07
SU876059A3 (ru) 1981-10-23
SU876060A3 (ru) 1981-10-23
AU4365779A (en) 1979-08-02
IE790134L (en) 1979-07-25
GB2014150B (en) 1982-11-24
BG33736A3 (en) 1983-04-15
BG33737A3 (en) 1983-04-15
PH18164A (en) 1985-04-09
AU529292B2 (en) 1983-06-02
NO790229L (no) 1979-07-26
NZ189460A (en) 1981-11-19
US4207316A (en) 1980-06-10
SU1103797A3 (ru) 1984-07-15
EP0003341A2 (de) 1979-08-08
SU927123A3 (ru) 1982-05-07
FI66023C (fi) 1984-08-10
NO154583C (no) 1986-11-05
RO76163A (ro) 1981-08-17
FI66023B (fi) 1984-04-30
NO154583B (no) 1986-07-28
SU880253A3 (ru) 1981-11-07
FR2422689A1 (fr) 1979-11-09
IL56494A0 (en) 1979-03-12
PT69126A (de) 1979-02-01
IL56494A (en) 1983-02-23
FI790240A (fi) 1979-07-26
EG14273A (en) 1984-06-30
DD150749A5 (de) 1981-09-16
DK28779A (da) 1979-07-26
EP0003341B1 (de) 1984-06-27
CS207753B2 (en) 1981-08-31
EP0003341A3 (en) 1979-08-22
IE47729B1 (en) 1984-05-30
BG33738A3 (en) 1983-04-15
ES477162A1 (es) 1979-07-01
DE2967070D1 (en) 1984-08-02
RO81116A (ro) 1983-06-01
GB2014150A (en) 1979-08-22

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