NO169123C - Analogifremgangsmaate til fremstilling av terapeutisk aktive karbocykliske 2',3'-dideoksy-2',3'-didehydropurinnukleosidanaloger - Google Patents

Analogifremgangsmaate til fremstilling av terapeutisk aktive karbocykliske 2',3'-dideoksy-2',3'-didehydropurinnukleosidanaloger

Info

Publication number: NO169123C
Authority: NO; Norway
Prior art keywords: didehydropurin; dideoxy; preparation; therapeutically active; nucleoside analogs
Prior art date: 1988-01-20

Application number

NO890253A

Other languages

English (en)

Other versions

NO890253D0 (no

NO169123B (no

NO890253L (no

Inventor

Robert Vince

Mei Hua

Peter Leslie Myers

Richard Storer

Original Assignee

Univ Minnesota

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1988-01-20

Filing date

1989-01-19

Publication date

1992-05-13

1988-01-20 Priority claimed from US07/146,252 external-priority patent/US4916224A/en

1988-09-07 Priority claimed from GB888821011A external-priority patent/GB8821011D0/en

1988-12-05 Priority claimed from US07/278,652 external-priority patent/US4931559A/en

1989-01-19 Application filed by Univ Minnesota filed Critical Univ Minnesota

1989-01-19 Publication of NO890253D0 publication Critical patent/NO890253D0/no

1989-07-21 Publication of NO890253L publication Critical patent/NO890253L/no

1992-02-03 Publication of NO169123B publication Critical patent/NO169123B/no

1992-05-13 Publication of NO169123C publication Critical patent/NO169123C/no

Links

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D473/00—Heterocyclic compounds containing purine ring systems
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Veterinary Medicine (AREA)
Public Health (AREA)
Animal Behavior & Ethology (AREA)
Pharmacology & Pharmacy (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Virology (AREA)
Oncology (AREA)
Communicable Diseases (AREA)
Molecular Biology (AREA)
Tropical Medicine & Parasitology (AREA)
AIDS & HIV (AREA)
Engineering & Computer Science (AREA)
Biochemistry (AREA)
Biotechnology (AREA)
Genetics & Genomics (AREA)
Epidemiology (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Saccharide Compounds (AREA)

NO890253A 1988-01-20 1989-01-19 Analogifremgangsmaate til fremstilling av terapeutisk aktive karbocykliske 2',3'-dideoksy-2',3'-didehydropurinnukleosidanaloger NO169123C (no)

Applications Claiming Priority (3)

Application Number	Priority Date	Filing Date	Title
US07/146,252 US4916224A (en)	1988-01-20	1988-01-20	Dideoxycarbocyclic nucleosides
GB888821011A GB8821011D0 (en)	1988-09-07	1988-09-07	Chemical compounds
US07/278,652 US4931559A (en)	1988-01-20	1988-12-05	Optically-active isomers of dideoxycarbocyclic nucleosides

Publications (4)

Publication Number	Publication Date
NO890253D0 NO890253D0 (no)	1989-01-19
NO890253L NO890253L (no)	1989-07-21
NO169123B NO169123B (no)	1992-02-03
NO169123C true NO169123C (no)	1992-05-13

Family

ID=27264063

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
NO890253A NO169123C (no)	1988-01-20	1989-01-19	Analogifremgangsmaate til fremstilling av terapeutisk aktive karbocykliske 2',3'-dideoksy-2',3'-didehydropurinnukleosidanaloger

Country Status (29)

Country	Link
JP (1)	JP2793825B2 (no)
KR (1)	KR0127137B1 (no)
AT (1)	AT397801B (no)
AU (2)	AU626278B2 (no)
BE (1)	BE1003815A4 (no)
CA (1)	CA1339896C (no)
CH (1)	CH679152A5 (no)
DE (1)	DE3901502C2 (no)
DK (1)	DK175131B1 (no)
ES (1)	ES2010091A6 (no)
FI (1)	FI93546C (no)
FR (1)	FR2626002B1 (no)
GB (1)	GB2217320B (no)
GR (1)	GR890100033A (no)
HU (1)	HU203755B (no)
IE (1)	IE62275B1 (no)
IL (1)	IL88999A (no)
IT (1)	IT1229531B (no)
LU (1)	LU87437A1 (no)
MY (1)	MY103801A (no)
NL (1)	NL8900122A (no)
NO (1)	NO169123C (no)
NZ (1)	NZ227663A (no)
OA (1)	OA09031A (no)
PL (1)	PL163814B1 (no)
PT (1)	PT89482B (no)
RU (1)	RU2114846C1 (no)
SE (1)	SE505213C2 (no)
YU (1)	YU47791B (no)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
IT1215339B (it) *	1987-01-14	1990-02-08	Co Pharma Corp Srl	Procedimento per la preparazione di 9-(idrossialchil)-ipoxantine
US5631370A (en)	1988-01-20	1997-05-20	Regents Of The University Of Minnesota	Optically-active isomers of dideoxycarbocyclic nucleosides
GB8815265D0 (en) *	1988-06-27	1988-08-03	Wellcome Found	Therapeutic nucleosides
US4939252A (en) *	1989-04-20	1990-07-03	Hoffmann-La Roche Inc.	Novel intermediates for the preparation of Carbovir
ES2136061T3 (es) *	1989-06-27	1999-11-16	Wellcome Found	Nucleosidos terapeuticos.
GB8916479D0 (en) *	1989-07-19	1989-09-06	Glaxo Group Ltd	Chemical process
GB8916480D0 (en) *	1989-07-19	1989-09-06	Glaxo Group Ltd	Chemical process
GB8916477D0 (en) *	1989-07-19	1989-09-06	Glaxo Group Ltd	Chemical process
GB8916478D0 (en) *	1989-07-19	1989-09-06	Glaxo Group Ltd	Chemical process
MY104575A (en) *	1989-12-22	1994-04-30	The Wellcome Foundation Ltd	Therapeutic nucleosides.
US5126452A (en) *	1990-04-06	1992-06-30	Glaxo Inc.	Synthesis of purine substituted cyclopentene derivatives
US5144034A (en) *	1990-04-06	1992-09-01	Glaxo Inc.	Process for the synthesis of cyclopentene derivatives of purines
US5057630A (en) *	1990-04-06	1991-10-15	Glaxo Inc.	Synthesis of cyclopentene derivatives
US5241069A (en) *	1990-04-06	1993-08-31	Glaxo Inc.	Carbonate intermediates for the synthesis of purine substituted cyclopentene derivatives
GB9108376D0 (en) *	1991-04-19	1991-06-05	Enzymatix Ltd	Cyclopentenes
HUT74989A (en) *	1993-11-12	1997-03-28	Merrell Pharma Inc	6-oxo-nucleosides useful as immunosuppressants
GB9721780D0 (en) *	1997-10-14	1997-12-10	Glaxo Group Ltd	Process for the synthesis of chloropurine intermediates
DE59905679D1 (de)	1998-10-30	2003-06-26	Lonza Ag	Verfahren zur herstellung von 4-[(2',5'-diamino-6'-halogenpyrimidin-4'-yl)amino]-cyclopent-2-enylmethanolen
DK1124805T3 (da) *	1998-10-30	2003-09-15	Lonza Ag	Fremgangsmåde til fremstilling af 4-[(2',5'-diamino-6'-halogenpyrimidin-4'-yl)amino]cyclopent-2-enylmethanoler
TWI229674B (en)	1998-12-04	2005-03-21	Astra Pharma Prod	Novel triazolo[4,5-d]pyrimidine compounds, pharmaceutical composition containing the same, their process for preparation and uses
GB9903091D0 (en) *	1999-02-12	1999-03-31	Glaxo Group Ltd	Therapeutic nucleoside compound
AR039540A1 (es) *	2002-05-13	2005-02-23	Tibotec Pharm Ltd	Compuestos microbicidas con contenido de pirimidina o triazina
EP3831388B1 (en)	2018-07-27	2024-02-28	FUJIFILM Corporation	Cyclopentenyl purine derivative or salt thereof for use in suppressing adenovirus
EP4125840A1 (en)	2020-03-27	2023-02-08	Som Innovation Biotech, S.A.	Compounds for use in the treatment of synucleinopathies

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4268672A (en) *	1977-02-09	1981-05-19	The Regents Of The University Of Minnesota	Adenosine deaminase resistant antiviral purine nucleosides and method of preparation
US4742064A (en) *	1985-09-10	1988-05-03	Regents Of The University Of Minnesota	Antiviral carbocyclic analogs of xylofuranosylpurines
JPS62177234A (ja) *	1986-01-30	1987-08-04	Mitsubishi Heavy Ind Ltd	遠心紡糸によるカ−ボン繊維の製造装置
IN164556B (no) *	1986-03-06	1989-04-08	Takeda Chemical Industries Ltd
NZ229453A (en) *	1988-06-10	1991-08-27	Univ Minnesota & Southern Rese	A pharmaceutical composition containing purine derivatives with nucleosides such as azt, as antiviral agents
GB8815265D0 (en) *	1988-06-27	1988-08-03	Wellcome Found	Therapeutic nucleosides
MY104575A (en) *	1989-12-22	1994-04-30	The Wellcome Foundation Ltd	Therapeutic nucleosides.

1989
- 1989-01-19 IT IT8947546A patent/IT1229531B/it active
- 1989-01-19 JP JP1008744A patent/JP2793825B2/ja not_active Expired - Lifetime
- 1989-01-19 AT AT0010689A patent/AT397801B/de not_active IP Right Cessation
- 1989-01-19 NO NO890253A patent/NO169123C/no not_active IP Right Cessation
- 1989-01-19 ES ES8900184A patent/ES2010091A6/es not_active Expired
- 1989-01-19 CA CA000588614A patent/CA1339896C/en not_active Expired - Lifetime
- 1989-01-19 OA OA59510A patent/OA09031A/xx unknown
- 1989-01-19 RU RU92004364A patent/RU2114846C1/ru active
- 1989-01-19 DE DE3901502A patent/DE3901502C2/de not_active Expired - Lifetime
- 1989-01-19 FR FR8900592A patent/FR2626002B1/fr not_active Expired - Lifetime
- 1989-01-19 HU HU89210A patent/HU203755B/hu unknown
- 1989-01-19 KR KR1019890000551A patent/KR0127137B1/ko not_active IP Right Cessation
- 1989-01-19 BE BE8900061A patent/BE1003815A4/fr active
- 1989-01-19 YU YU12389A patent/YU47791B/sh unknown
- 1989-01-19 CH CH172/89A patent/CH679152A5/de not_active IP Right Cessation
- 1989-01-19 SE SE8900192A patent/SE505213C2/sv not_active IP Right Cessation
- 1989-01-19 GR GR890100033A patent/GR890100033A/el not_active IP Right Cessation
- 1989-01-19 PT PT89482A patent/PT89482B/pt not_active IP Right Cessation
- 1989-01-19 PL PL89277261A patent/PL163814B1/pl unknown
- 1989-01-19 IL IL8899989A patent/IL88999A/en unknown
- 1989-01-19 IE IE15389A patent/IE62275B1/en not_active IP Right Cessation
- 1989-01-19 FI FI890286A patent/FI93546C/fi not_active IP Right Cessation
- 1989-01-19 LU LU87437A patent/LU87437A1/fr unknown
- 1989-01-19 NL NL8900122A patent/NL8900122A/nl not_active Application Discontinuation
- 1989-01-19 GB GB8901187A patent/GB2217320B/en not_active Expired - Lifetime
- 1989-01-19 MY MYPI89000064A patent/MY103801A/en unknown
- 1989-01-19 DK DK198900234A patent/DK175131B1/da not_active IP Right Cessation
- 1989-01-19 NZ NZ227663A patent/NZ227663A/xx unknown
- 1989-01-20 AU AU28671/89A patent/AU626278B2/en not_active Expired
1992
- 1992-01-13 AU AU10180/92A patent/AU637015B2/en not_active Expired

Also Published As

Publication number	Publication date
IE62275B1 (en)	1995-01-25
IE890153L (en)	1989-07-20
NO890253D0 (no)	1989-01-19
FI890286A0 (fi)	1989-01-19
DE3901502A1 (de)	1989-07-27
SE505213C2 (sv)	1997-07-14
FI93546C (fi)	1995-04-25
NO169123B (no)	1992-02-03
ATA10689A (de)	1993-11-15
GB8901187D0 (en)	1989-03-15
CA1339896C (en)	1998-06-02
PT89482A (pt)	1989-10-04
SE8900192L (sv)	1989-07-21
IL88999A0 (en)	1989-08-15
PL277261A1 (en)	1989-09-18
YU47791B (sr)	1996-01-09
PT89482B (pt)	1994-02-28
RU2114846C1 (ru)	1998-07-10
KR0127137B1 (ko)	1997-12-29
IT8947546A0 (it)	1989-01-19
CH679152A5 (no)	1991-12-31
IL88999A (en)	1994-12-29
GB2217320B (en)	1992-04-08
YU12389A (en)	1991-10-31
AU626278B2 (en)	1992-07-30
DK23489D0 (da)	1989-01-19
NL8900122A (nl)	1989-08-16
MY103801A (en)	1993-09-30
JPH02196788A (ja)	1990-08-03
FI890286A (fi)	1989-07-21
DE3901502C2 (de)	2002-06-13
IT1229531B (it)	1991-09-04
FI93546B (fi)	1995-01-13
HU203755B (en)	1991-09-30
GR890100033A (el)	1994-03-31
NZ227663A (en)	1990-09-26
SE8900192D0 (sv)	1989-01-19
KR890011902A (ko)	1989-08-23
AU1018092A (en)	1992-03-12
FR2626002A1 (fr)	1989-07-21
NO890253L (no)	1989-07-21
PL163814B1 (en)	1994-05-31
ES2010091A6 (es)	1989-10-16
AT397801B (de)	1994-07-25
AU2867189A (en)	1989-07-20
OA09031A (en)	1991-03-31
AU637015B2 (en)	1993-05-13
FR2626002B1 (fr)	1994-01-28
DK23489A (da)	1989-07-21
JP2793825B2 (ja)	1998-09-03
LU87437A1 (fr)	1989-08-30
DK175131B1 (da)	2004-06-14
BE1003815A4 (fr)	1992-06-23
HUT48887A (en)	1989-07-28
GB2217320A (en)	1989-10-25

Legal Events

Date	Code	Title	Description
2009-03-16	MK1K	Patent expired

Publication	Publication Date	Title
NO169123C (no)	1992-05-13	Analogifremgangsmaate til fremstilling av terapeutisk aktive karbocykliske 2',3'-dideoksy-2',3'-didehydropurinnukleosidanaloger
NO870390L (no)	1987-08-03	Fremgangsmaate for fremstilling av terapeutisk aktive n6-substituerte adenosiner.
NO170155C (no)	1992-09-16	Analogifremgangsmaate til fremstilling av terapeutisk aktive substituerte tieno(3,4-d)imidazolderivater
NO161372C (no)	1989-08-09	Analogifremgangsmaate for fremstilling av terapeutisk aktive guaninderivater.
NO171367C (no)	1993-03-03	Fremgangsmaate for fremstilling av 2',3'-dideoksy-2',3'-didehydronukleosider
NO170884C (no)	1992-12-23	Analogifremgangsmaate ved fremstilling av terapeutisk aktive pyrimidinderivater
NO864879D0 (no)	1986-12-04	Fremgangsmaate for fremstilling av terapeutisk aktive tiasolforbindelser.
NO169842C (no)	1992-08-12	Analogifremgangsmaate til fremstilling av terapeutisk aktive, kondenserte pyrimidiner
NO166083C (no)	1991-05-29	Analogifremgangsmaate ved fremstilling av terapeutisk aktive pyridazodiazepinderivater.
NO895170D0 (no)	1989-12-21	Fremgangsmaate for fremstilling av terapeutisk aktive 7-oksabicykloheptyl-substituerte heterocyklisk amid-prostaglandinanaloger.
NO163619C (no)	1990-06-27	Analogifremgangsmaate for fremstilling av terapeutisk aktive tetrahydro- 2-heterocykloalkylpyrido(4,3)indoler.
NO171507C (no)	1993-03-24	Analogifremgangsmaate ved fremstilling av terapeutisk aktive nukleotidderivater
NO171412C (no)	1993-03-10	Analogifremgangsmaate for fremstilling av terapeutisk aktive 1,3-oksatiolan- eller 1,3-ditiolanderivater
NO173503C (no)	1993-12-22	Analogifremgangsmaate for fremstilling av terapeutisk aktive tetrahydroimidayo (1,4) benzodiazepin-2-tioner
NO164897C (no)	1990-11-28	Analogifremgangsmaate for fremstilling av terapeutisk aktive oxazolidinonderivater.
NO164020C (no)	1990-08-22	Analogifremgangsmaate ved fremstilling av terapeutisk aktive fenetanolaminderivater.
NO169652C (no)	1992-07-22	Analogifremgangsmaate til fremstilling av terapeutisk aktive guaninderivater
NO169962C (no)	1992-08-26	Analogifremgangsmaate ved fremstilling av terapeutisk aktive pyrimidinderivater
NO167668C (no)	1991-11-27	Analogifremgangsmaate til fremstilling av terapeutisk aktive epipodofyllotoksinglukosid-4'-acylderivater.
NO171211C (no)	1993-02-10	Analogifremgangsmaate for fremstilling av terapeutisk aktive 1,3-dioksaner
NO168040C (no)	1992-01-08	Analogifremgangsmaate for fremstilling av terapeutisk aktive 3'-demetoksyepipodofyllotoksin-glukosidderivater.
NO162072C (no)	1989-11-01	Analogifremgangsmaate for fremstilling av terapeutisk aktive tienopyridinderivater.
NO162468C (no)	1990-01-10	Analogifremgangsmaate for fremstilling av terapeutisk aktive 12-amino-pyridazino (4[,5[;3,4)-pyrrolo-( 2,1-a)-isokinolinderivater.
NO167801C (no)	1991-12-11	Analogifremgangsmaate for fremstilling av terapeutisk aktive 2,2'-bi-1h-imidazolderivater.
NO171728C (no)	1993-04-28	Analogifremgangsmaate til fremstilling av terapeutisk aktive 4'-demetylepipodofyllotoksin-glukosider